Intracholecystic papillary neoplasm arising in a patient with pancreaticobiliary maljunction: a case report View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-11-09

AUTHORS

Toshimitsu Iwasaki, Yasuhiro Otsuka, Yoichi Miyata, Takahiro Einama, Hironori Tsujimoto, Hideki Ueno, Sho Ogata, Yoji Kishi

ABSTRACT

BACKGROUND: Pancreaticobiliary maljunction (PBM) is a congenital abnormality in which the pancreatic and biliary ducts join anatomically outside the duodenal wall resulting in the regurgitation of pancreatic juice into the biliary tract (pancreatobiliary reflux). Persistent pancreatobiliary reflux causes injury to the epithelium of the biliary tract and promotes the risk of biliary cancer. Intracholecyctic papillary neoplasm (ICPN) has been highlighted in the context of a cholecystic counterpart of intraductal papillary mucinous neoplasm of the pancreas and the bile duct, but the tumorigenesis of ICPNs remains unclear. CASE PRESENTATION: A 52-year-old Japanese woman was referred for the assessment of dilation of the bile duct. Computed tomography which revealed an enhanced mass in the gallbladder and endoscopic retrograde cholangiopancreatography confirmed that the confluence of the main pancreatic duct and extrahepatic bile duct (EHBD) was located outside the duodenal wall. Under the diagnosis of gallbladder cancer with PBM, cholecystectomy with full thickness dissection, EHBD resection, lymph node dissection, and hepaticojejunostomy were performed. Macroscopic examination of the resected specimen showed that the cystic duct was dilated and joined into the EHBD just above its confluence with the pancreatic duct, and the inflamed change of non-tumorous mucosa of gallbladder indicating that there was considerable mucosal injury due to pancreatobiliary reflux to the gallbladder. Histopathological examination revealed that the gallbladder tumor was a gastric-type ICPN with non-invasive component. Either KRAS gene mutation or p53 protein expression that were known to be associated with the carcinogenesis of biliary cancer under the condition of pancreatobiliary reflux was not detected in the tumor cells of ICPN. CONCLUSION: The present case might suggest that there was no association between PBM and ICPN. To reveal the tumorigenesis of ICPN and its attribution to pancreatobiliary reflux, however, further study is warranted. More... »

PAGES

292

References to SciGraph publications

  • 1997-09. Congenital choledochal dilatation: Classification, clinical features, and long-term results in JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
  • 1993-12. The role ofras mutation in pancreatic cancer, precancerous lesions, and chronic pancreatitis in JOURNAL OF GASTROINTESTINAL CANCER
  • 2018-04-06. Three cases of intracystic papillary neoplasm of gallbladder in ABDOMINAL RADIOLOGY
  • 2009-01-30. p53 gene mutation and p53 protein overexpression in a patient with simultaneous double cancer of the gallbladder and bile duct associated with pancreaticobiliary maljunction in JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
  • 2016-10-04. Biliary carcinogenesis in pancreaticobiliary maljunction in JOURNAL OF GASTROENTEROLOGY
  • 1994-06. Diagnostic criteria of pancreaticobiliary maljunction in JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
  • 2012-06-22. Japanese clinical practice guidelines for pancreaticobiliary maljunction in JOURNAL OF GASTROENTEROLOGY
  • 2002-02. Recent advances in pancreaticobiliary maljunction in JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
  • 2006-12-15. The biological sense of cancer: a hypothesis in THEORETICAL BIOLOGY AND MEDICAL MODELLING
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12957-020-02072-7

    DOI

    http://dx.doi.org/10.1186/s12957-020-02072-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1132451946

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/33168026


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cholangiopancreatography, Endoscopic Retrograde", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gallbladder Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pancreas", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pancreatic Ducts", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pancreaticobiliary Maljunction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prognosis", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513 Japan", 
              "id": "http://www.grid.ac/institutes/grid.416614.0", 
              "name": [
                "Department of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513 Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Iwasaki", 
            "givenName": "Toshimitsu", 
            "id": "sg:person.013604237471.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013604237471.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513 Japan", 
              "id": "http://www.grid.ac/institutes/grid.416614.0", 
              "name": [
                "Department of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513 Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Otsuka", 
            "givenName": "Yasuhiro", 
            "id": "sg:person.010616566213.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010616566213.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513 Japan", 
              "id": "http://www.grid.ac/institutes/grid.416614.0", 
              "name": [
                "Department of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513 Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Miyata", 
            "givenName": "Yoichi", 
            "id": "sg:person.013243332734.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013243332734.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513 Japan", 
              "id": "http://www.grid.ac/institutes/grid.416614.0", 
              "name": [
                "Department of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513 Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Einama", 
            "givenName": "Takahiro", 
            "id": "sg:person.01065226661.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065226661.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513 Japan", 
              "id": "http://www.grid.ac/institutes/grid.416614.0", 
              "name": [
                "Department of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513 Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tsujimoto", 
            "givenName": "Hironori", 
            "id": "sg:person.01022371461.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022371461.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513 Japan", 
              "id": "http://www.grid.ac/institutes/grid.416614.0", 
              "name": [
                "Department of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513 Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ueno", 
            "givenName": "Hideki", 
            "id": "sg:person.01053200431.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053200431.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology and Laboratory Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-0042 Japan", 
              "id": "http://www.grid.ac/institutes/grid.416614.0", 
              "name": [
                "Department of Pathology and Laboratory Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-0042 Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ogata", 
            "givenName": "Sho", 
            "id": "sg:person.01354422232.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354422232.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513 Japan", 
              "id": "http://www.grid.ac/institutes/grid.416614.0", 
              "name": [
                "Department of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513 Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kishi", 
            "givenName": "Yoji", 
            "id": "sg:person.0651772025.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651772025.08"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00261-018-1595-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103181903", 
              "https://doi.org/10.1007/s00261-018-1595-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02391070", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014640116", 
              "https://doi.org/10.1007/bf02391070"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1742-4682-3-43", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023352471", 
              "https://doi.org/10.1186/1742-4682-3-43"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02489025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001195827", 
              "https://doi.org/10.1007/bf02489025"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00535-012-0611-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024415315", 
              "https://doi.org/10.1007/s00535-012-0611-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00534-008-0030-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016341904", 
              "https://doi.org/10.1007/s00534-008-0030-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00535-016-1268-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039846041", 
              "https://doi.org/10.1007/s00535-016-1268-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s005340200004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019638890", 
              "https://doi.org/10.1007/s005340200004"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02784932", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082656827", 
              "https://doi.org/10.1007/bf02784932"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2020-11-09", 
        "datePublishedReg": "2020-11-09", 
        "description": "BACKGROUND: Pancreaticobiliary maljunction (PBM) is a congenital abnormality in which the pancreatic and biliary ducts join anatomically outside the duodenal wall resulting in the regurgitation of pancreatic juice into the biliary tract (pancreatobiliary reflux). Persistent pancreatobiliary reflux causes injury to the epithelium of the biliary tract and promotes the risk of biliary cancer. Intracholecyctic papillary neoplasm (ICPN) has been highlighted in the context of a cholecystic counterpart of intraductal papillary mucinous neoplasm of the pancreas and the bile duct, but the tumorigenesis of ICPNs remains unclear.\nCASE PRESENTATION: A 52-year-old Japanese woman was referred for the assessment of dilation of the bile duct. Computed tomography which revealed an enhanced mass in the gallbladder and endoscopic retrograde cholangiopancreatography confirmed that the confluence of the main pancreatic duct and extrahepatic bile duct (EHBD) was located outside the duodenal wall. Under the diagnosis of gallbladder cancer with PBM, cholecystectomy with full thickness dissection, EHBD resection, lymph node dissection, and hepaticojejunostomy were performed. Macroscopic examination of the resected specimen showed that the cystic duct was dilated and joined into the EHBD just above its confluence with the pancreatic duct, and the inflamed change of non-tumorous mucosa of gallbladder indicating that there was considerable mucosal injury due to pancreatobiliary reflux to the gallbladder. Histopathological examination revealed that the gallbladder tumor was a gastric-type ICPN with non-invasive component. Either KRAS gene mutation or p53 protein expression that were known to be associated with the carcinogenesis of biliary cancer under the condition of pancreatobiliary reflux was not detected in the tumor cells of ICPN.\nCONCLUSION: The present case might suggest that there was no association between PBM and ICPN. To reveal the tumorigenesis of ICPN and its attribution to pancreatobiliary reflux, however, further study is warranted.", 
        "genre": "article", 
        "id": "sg:pub.10.1186/s12957-020-02072-7", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1032056", 
            "issn": [
              "1477-7819"
            ], 
            "name": "World Journal of Surgical Oncology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "18"
          }
        ], 
        "keywords": [
          "extrahepatic bile duct", 
          "pancreaticobiliary maljunction", 
          "pancreatobiliary reflux", 
          "bile duct", 
          "biliary cancer", 
          "biliary tract", 
          "papillary neoplasm", 
          "duodenal wall", 
          "pancreatic duct", 
          "intraductal papillary mucinous neoplasm", 
          "non-invasive component", 
          "lymph node dissection", 
          "endoscopic retrograde cholangiopancreatography", 
          "main pancreatic duct", 
          "papillary mucinous neoplasm", 
          "non-tumorous mucosa", 
          "KRAS gene mutations", 
          "intracholecystic papillary neoplasm", 
          "p53 protein expression", 
          "full-thickness dissection", 
          "EHBD resection", 
          "node dissection", 
          "mucosal injury", 
          "cystic duct", 
          "mucinous neoplasms", 
          "retrograde cholangiopancreatography", 
          "histopathological examination", 
          "gallbladder tumor", 
          "gallbladder cancer", 
          "case report", 
          "biliary ducts", 
          "computed tomography", 
          "congenital abnormalities", 
          "Japanese women", 
          "enhanced mass", 
          "pancreatic juice", 
          "tumor cells", 
          "reflux", 
          "neoplasms", 
          "gallbladder", 
          "macroscopic examination", 
          "protein expression", 
          "cancer", 
          "gene mutations", 
          "present case", 
          "maljunction", 
          "Further studies", 
          "injury", 
          "duct", 
          "tract", 
          "dissection", 
          "tumorigenesis", 
          "examination", 
          "hepaticojejunostomy", 
          "cholecystectomy", 
          "resection", 
          "regurgitation", 
          "cholangiopancreatography", 
          "patients", 
          "mucosa", 
          "tumors", 
          "pancreas", 
          "abnormalities", 
          "diagnosis", 
          "epithelium", 
          "women", 
          "carcinogenesis", 
          "dilation", 
          "tomography", 
          "risk", 
          "association", 
          "report", 
          "cells", 
          "expression", 
          "mutations", 
          "assessment", 
          "juice", 
          "wall", 
          "cases", 
          "study", 
          "confluence", 
          "changes", 
          "mass", 
          "specimen", 
          "counterparts", 
          "components", 
          "conditions", 
          "attribution", 
          "context", 
          "Persistent pancreatobiliary reflux", 
          "ICPN", 
          "cholecystic counterpart", 
          "tumorigenesis of ICPNs", 
          "assessment of dilation", 
          "thickness dissection", 
          "inflamed change", 
          "considerable mucosal injury", 
          "gastric-type ICPN"
        ], 
        "name": "Intracholecystic papillary neoplasm arising in a patient with pancreaticobiliary maljunction: a case report", 
        "pagination": "292", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1132451946"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s12957-020-02072-7"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "33168026"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s12957-020-02072-7", 
          "https://app.dimensions.ai/details/publication/pub.1132451946"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-01-01T18:59", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_873.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1186/s12957-020-02072-7"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12957-020-02072-7'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12957-020-02072-7'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12957-020-02072-7'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12957-020-02072-7'


     

    This table displays all metadata directly associated to this object as RDF triples.

    282 TRIPLES      22 PREDICATES      142 URIs      125 LITERALS      16 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s12957-020-02072-7 schema:about N0135aa608ddc4a368a9c1568848b2e17
    2 N1d8003a656e14f829222cf174396f3ff
    3 N356b58a5ab544383bf9036a020a86ed0
    4 N627b4bda429f48609eea1b0102c47d7a
    5 Na1c733cefc9a4940a1afdc08027a5747
    6 Na45476e257a34c82ae34508b200ae977
    7 Nc83527f4526f4556a098efe5bcdacc90
    8 Ndc9d5cb5389c4e099cb63383a03ef0ee
    9 Nfe02fa066c6a4cff81b30ee947850ee8
    10 anzsrc-for:11
    11 anzsrc-for:1112
    12 schema:author N2e46583dd0c14647abe100d5a72ee664
    13 schema:citation sg:pub.10.1007/bf02391070
    14 sg:pub.10.1007/bf02489025
    15 sg:pub.10.1007/bf02784932
    16 sg:pub.10.1007/s00261-018-1595-z
    17 sg:pub.10.1007/s00534-008-0030-1
    18 sg:pub.10.1007/s005340200004
    19 sg:pub.10.1007/s00535-012-0611-2
    20 sg:pub.10.1007/s00535-016-1268-z
    21 sg:pub.10.1186/1742-4682-3-43
    22 schema:datePublished 2020-11-09
    23 schema:datePublishedReg 2020-11-09
    24 schema:description BACKGROUND: Pancreaticobiliary maljunction (PBM) is a congenital abnormality in which the pancreatic and biliary ducts join anatomically outside the duodenal wall resulting in the regurgitation of pancreatic juice into the biliary tract (pancreatobiliary reflux). Persistent pancreatobiliary reflux causes injury to the epithelium of the biliary tract and promotes the risk of biliary cancer. Intracholecyctic papillary neoplasm (ICPN) has been highlighted in the context of a cholecystic counterpart of intraductal papillary mucinous neoplasm of the pancreas and the bile duct, but the tumorigenesis of ICPNs remains unclear. CASE PRESENTATION: A 52-year-old Japanese woman was referred for the assessment of dilation of the bile duct. Computed tomography which revealed an enhanced mass in the gallbladder and endoscopic retrograde cholangiopancreatography confirmed that the confluence of the main pancreatic duct and extrahepatic bile duct (EHBD) was located outside the duodenal wall. Under the diagnosis of gallbladder cancer with PBM, cholecystectomy with full thickness dissection, EHBD resection, lymph node dissection, and hepaticojejunostomy were performed. Macroscopic examination of the resected specimen showed that the cystic duct was dilated and joined into the EHBD just above its confluence with the pancreatic duct, and the inflamed change of non-tumorous mucosa of gallbladder indicating that there was considerable mucosal injury due to pancreatobiliary reflux to the gallbladder. Histopathological examination revealed that the gallbladder tumor was a gastric-type ICPN with non-invasive component. Either KRAS gene mutation or p53 protein expression that were known to be associated with the carcinogenesis of biliary cancer under the condition of pancreatobiliary reflux was not detected in the tumor cells of ICPN. CONCLUSION: The present case might suggest that there was no association between PBM and ICPN. To reveal the tumorigenesis of ICPN and its attribution to pancreatobiliary reflux, however, further study is warranted.
    25 schema:genre article
    26 schema:inLanguage en
    27 schema:isAccessibleForFree true
    28 schema:isPartOf N807a45e8d5f44bd9aea7eee69be09e33
    29 Ndc1b28cb37844488a14c7e68cbf1ef3d
    30 sg:journal.1032056
    31 schema:keywords EHBD resection
    32 Further studies
    33 ICPN
    34 Japanese women
    35 KRAS gene mutations
    36 Persistent pancreatobiliary reflux
    37 abnormalities
    38 assessment
    39 assessment of dilation
    40 association
    41 attribution
    42 bile duct
    43 biliary cancer
    44 biliary ducts
    45 biliary tract
    46 cancer
    47 carcinogenesis
    48 case report
    49 cases
    50 cells
    51 changes
    52 cholangiopancreatography
    53 cholecystectomy
    54 cholecystic counterpart
    55 components
    56 computed tomography
    57 conditions
    58 confluence
    59 congenital abnormalities
    60 considerable mucosal injury
    61 context
    62 counterparts
    63 cystic duct
    64 diagnosis
    65 dilation
    66 dissection
    67 duct
    68 duodenal wall
    69 endoscopic retrograde cholangiopancreatography
    70 enhanced mass
    71 epithelium
    72 examination
    73 expression
    74 extrahepatic bile duct
    75 full-thickness dissection
    76 gallbladder
    77 gallbladder cancer
    78 gallbladder tumor
    79 gastric-type ICPN
    80 gene mutations
    81 hepaticojejunostomy
    82 histopathological examination
    83 inflamed change
    84 injury
    85 intracholecystic papillary neoplasm
    86 intraductal papillary mucinous neoplasm
    87 juice
    88 lymph node dissection
    89 macroscopic examination
    90 main pancreatic duct
    91 maljunction
    92 mass
    93 mucinous neoplasms
    94 mucosa
    95 mucosal injury
    96 mutations
    97 neoplasms
    98 node dissection
    99 non-invasive component
    100 non-tumorous mucosa
    101 p53 protein expression
    102 pancreas
    103 pancreatic duct
    104 pancreatic juice
    105 pancreaticobiliary maljunction
    106 pancreatobiliary reflux
    107 papillary mucinous neoplasm
    108 papillary neoplasm
    109 patients
    110 present case
    111 protein expression
    112 reflux
    113 regurgitation
    114 report
    115 resection
    116 retrograde cholangiopancreatography
    117 risk
    118 specimen
    119 study
    120 thickness dissection
    121 tomography
    122 tract
    123 tumor cells
    124 tumorigenesis
    125 tumorigenesis of ICPNs
    126 tumors
    127 wall
    128 women
    129 schema:name Intracholecystic papillary neoplasm arising in a patient with pancreaticobiliary maljunction: a case report
    130 schema:pagination 292
    131 schema:productId N2f12c8a18c364c8b96f2b8d2056e929a
    132 N60b7cf812d2e479c9695943cf9c7f3fd
    133 Nbbf58dfc52204bf9bfba7d4e80f46b46
    134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1132451946
    135 https://doi.org/10.1186/s12957-020-02072-7
    136 schema:sdDatePublished 2022-01-01T18:59
    137 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    138 schema:sdPublisher Ne72393de94d64cea82605de8fcedaa18
    139 schema:url https://doi.org/10.1186/s12957-020-02072-7
    140 sgo:license sg:explorer/license/
    141 sgo:sdDataset articles
    142 rdf:type schema:ScholarlyArticle
    143 N0135aa608ddc4a368a9c1568848b2e17 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Pancreatic Ducts
    145 rdf:type schema:DefinedTerm
    146 N1d8003a656e14f829222cf174396f3ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Gallbladder Neoplasms
    148 rdf:type schema:DefinedTerm
    149 N2c4aefe404e144b48a972330d5acf401 rdf:first sg:person.010616566213.29
    150 rdf:rest N503e875aac394998b18afef2255ca46a
    151 N2e46583dd0c14647abe100d5a72ee664 rdf:first sg:person.013604237471.51
    152 rdf:rest N2c4aefe404e144b48a972330d5acf401
    153 N2f12c8a18c364c8b96f2b8d2056e929a schema:name doi
    154 schema:value 10.1186/s12957-020-02072-7
    155 rdf:type schema:PropertyValue
    156 N356b58a5ab544383bf9036a020a86ed0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Cholangiopancreatography, Endoscopic Retrograde
    158 rdf:type schema:DefinedTerm
    159 N3a5e97ae91024c36bf2f0a470611ae67 rdf:first sg:person.01053200431.41
    160 rdf:rest Nb9e949477a18437fb9b44ea4874c3ac1
    161 N3e5b45ebaac2451091bb190ee9a8a315 rdf:first sg:person.01065226661.83
    162 rdf:rest Nf02af78193054ec4a6bea7accc86d052
    163 N503e875aac394998b18afef2255ca46a rdf:first sg:person.013243332734.44
    164 rdf:rest N3e5b45ebaac2451091bb190ee9a8a315
    165 N60b7cf812d2e479c9695943cf9c7f3fd schema:name dimensions_id
    166 schema:value pub.1132451946
    167 rdf:type schema:PropertyValue
    168 N627b4bda429f48609eea1b0102c47d7a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    169 schema:name Pancreaticobiliary Maljunction
    170 rdf:type schema:DefinedTerm
    171 N807a45e8d5f44bd9aea7eee69be09e33 schema:issueNumber 1
    172 rdf:type schema:PublicationIssue
    173 Na1c733cefc9a4940a1afdc08027a5747 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    174 schema:name Female
    175 rdf:type schema:DefinedTerm
    176 Na45476e257a34c82ae34508b200ae977 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    177 schema:name Humans
    178 rdf:type schema:DefinedTerm
    179 Nb9e949477a18437fb9b44ea4874c3ac1 rdf:first sg:person.01354422232.06
    180 rdf:rest Ne9351411246546c596812f90ba7a7a47
    181 Nbbf58dfc52204bf9bfba7d4e80f46b46 schema:name pubmed_id
    182 schema:value 33168026
    183 rdf:type schema:PropertyValue
    184 Nc83527f4526f4556a098efe5bcdacc90 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    185 schema:name Pancreas
    186 rdf:type schema:DefinedTerm
    187 Ndc1b28cb37844488a14c7e68cbf1ef3d schema:volumeNumber 18
    188 rdf:type schema:PublicationVolume
    189 Ndc9d5cb5389c4e099cb63383a03ef0ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Middle Aged
    191 rdf:type schema:DefinedTerm
    192 Ne72393de94d64cea82605de8fcedaa18 schema:name Springer Nature - SN SciGraph project
    193 rdf:type schema:Organization
    194 Ne9351411246546c596812f90ba7a7a47 rdf:first sg:person.0651772025.08
    195 rdf:rest rdf:nil
    196 Nf02af78193054ec4a6bea7accc86d052 rdf:first sg:person.01022371461.19
    197 rdf:rest N3a5e97ae91024c36bf2f0a470611ae67
    198 Nfe02fa066c6a4cff81b30ee947850ee8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    199 schema:name Prognosis
    200 rdf:type schema:DefinedTerm
    201 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    202 schema:name Medical and Health Sciences
    203 rdf:type schema:DefinedTerm
    204 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    205 schema:name Oncology and Carcinogenesis
    206 rdf:type schema:DefinedTerm
    207 sg:journal.1032056 schema:issn 1477-7819
    208 schema:name World Journal of Surgical Oncology
    209 schema:publisher Springer Nature
    210 rdf:type schema:Periodical
    211 sg:person.01022371461.19 schema:affiliation grid-institutes:grid.416614.0
    212 schema:familyName Tsujimoto
    213 schema:givenName Hironori
    214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022371461.19
    215 rdf:type schema:Person
    216 sg:person.01053200431.41 schema:affiliation grid-institutes:grid.416614.0
    217 schema:familyName Ueno
    218 schema:givenName Hideki
    219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053200431.41
    220 rdf:type schema:Person
    221 sg:person.010616566213.29 schema:affiliation grid-institutes:grid.416614.0
    222 schema:familyName Otsuka
    223 schema:givenName Yasuhiro
    224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010616566213.29
    225 rdf:type schema:Person
    226 sg:person.01065226661.83 schema:affiliation grid-institutes:grid.416614.0
    227 schema:familyName Einama
    228 schema:givenName Takahiro
    229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065226661.83
    230 rdf:type schema:Person
    231 sg:person.013243332734.44 schema:affiliation grid-institutes:grid.416614.0
    232 schema:familyName Miyata
    233 schema:givenName Yoichi
    234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013243332734.44
    235 rdf:type schema:Person
    236 sg:person.01354422232.06 schema:affiliation grid-institutes:grid.416614.0
    237 schema:familyName Ogata
    238 schema:givenName Sho
    239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354422232.06
    240 rdf:type schema:Person
    241 sg:person.013604237471.51 schema:affiliation grid-institutes:grid.416614.0
    242 schema:familyName Iwasaki
    243 schema:givenName Toshimitsu
    244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013604237471.51
    245 rdf:type schema:Person
    246 sg:person.0651772025.08 schema:affiliation grid-institutes:grid.416614.0
    247 schema:familyName Kishi
    248 schema:givenName Yoji
    249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651772025.08
    250 rdf:type schema:Person
    251 sg:pub.10.1007/bf02391070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014640116
    252 https://doi.org/10.1007/bf02391070
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1007/bf02489025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001195827
    255 https://doi.org/10.1007/bf02489025
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1007/bf02784932 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082656827
    258 https://doi.org/10.1007/bf02784932
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1007/s00261-018-1595-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1103181903
    261 https://doi.org/10.1007/s00261-018-1595-z
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1007/s00534-008-0030-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016341904
    264 https://doi.org/10.1007/s00534-008-0030-1
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1007/s005340200004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019638890
    267 https://doi.org/10.1007/s005340200004
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1007/s00535-012-0611-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024415315
    270 https://doi.org/10.1007/s00535-012-0611-2
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1007/s00535-016-1268-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1039846041
    273 https://doi.org/10.1007/s00535-016-1268-z
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1186/1742-4682-3-43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023352471
    276 https://doi.org/10.1186/1742-4682-3-43
    277 rdf:type schema:CreativeWork
    278 grid-institutes:grid.416614.0 schema:alternateName Department of Pathology and Laboratory Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-0042 Japan
    279 Department of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513 Japan
    280 schema:name Department of Pathology and Laboratory Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-0042 Japan
    281 Department of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513 Japan
    282 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...