IDH1 R132C mutation is detected in clear cell hepatocellular carcinoma by pyrosequencing View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-04-12

AUTHORS

Jung Hee Lee, Dong Hoon Shin, Won Young Park, Nari Shin, Ahrong Kim, Hyun Jung Lee, Young Keum Kim, Kyung Un Choi, Jee Yeon Kim, Young Il Yang, Chang Hun Lee, Mee Young Sol

ABSTRACT

BACKGROUND: Isocitrate dehydrogenase 1 (IDH1) mutation is common in low-grade glioma (approximately 80%) and acute myeloid leukemia (approximately 10%). Other than brain tumor or hematologic malignancies, intrahepatic cholangiocarcinoma (iCC) is a well-known solid tumor with IDH1 mutation (6.8-20%). Histologically, poor differentiation and clear cell change are associated with IDH1 mutation in iCC. Since hepatocellular carcinoma (HCC) shares histologic features with iCC, some specific subtypes of HCC might show a higher IDH1 mutation rate than reported before (0.5-1.5%). METHODS: Forty-six cases of iCC and 48 cases of HCC (including 20 cases of clear cell type and 13 cases of pseudoglandular pattern) were tested for IDH1 mutation by pyrosequencing. RESULTS: Three cases in iCC (6.5%) and five cases in HCC (10.4%) had IDH1 mutation, all of which were Arg132Cys. IDH1 mutant HCCs were all clear cell type. Although the IDH1 mutation rate between iCC and HCC demonstrated no significant difference, clear cell HCC revealed statistically increased mutation rate compared to that of HCC without clear cell change (P = 0.009). Presence of IDH1 mutation was related with poor survival in clear cell HCC patients (P = 0.004). CONCLUSIONS: Clear cell HCC showed higher frequency of IDH1 mutation rate than other variants of HCC. This result consolidates the assumption that morphological features of tumors reflect molecular alterations. More... »

PAGES

82

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12957-017-1144-1

DOI

http://dx.doi.org/10.1186/s12957-017-1144-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084745637

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28403884


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma, Clear Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Hepatocellular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "High-Throughput Nucleotide Sequencing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Isocitrate Dehydrogenase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Analysis, DNA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, 50612 South Korea", 
          "id": "http://www.grid.ac/institutes/grid.412591.a", 
          "name": [
            "Department of Pathology, School of Medicine, Pusan National University, Yangsan, 50612 South Korea", 
            "Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, 50612 South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Jung Hee", 
        "id": "sg:person.0731265143.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731265143.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, 50612 South Korea", 
          "id": "http://www.grid.ac/institutes/grid.412591.a", 
          "name": [
            "Department of Pathology, School of Medicine, Pusan National University, Yangsan, 50612 South Korea", 
            "Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, 50612 South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shin", 
        "givenName": "Dong Hoon", 
        "id": "sg:person.011347225605.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011347225605.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, School of Medicine, Pusan National University, Yangsan, 50612 South Korea", 
          "id": "http://www.grid.ac/institutes/grid.262229.f", 
          "name": [
            "Department of Pathology, School of Medicine, Pusan National University, Yangsan, 50612 South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "Won Young", 
        "id": "sg:person.01354173210.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354173210.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, School of Medicine, Pusan National University, Yangsan, 50612 South Korea", 
          "id": "http://www.grid.ac/institutes/grid.262229.f", 
          "name": [
            "Department of Pathology, School of Medicine, Pusan National University, Yangsan, 50612 South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shin", 
        "givenName": "Nari", 
        "id": "sg:person.0767341216.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767341216.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, School of Medicine, Pusan National University, Yangsan, 50612 South Korea", 
          "id": "http://www.grid.ac/institutes/grid.262229.f", 
          "name": [
            "Department of Pathology, School of Medicine, Pusan National University, Yangsan, 50612 South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Ahrong", 
        "id": "sg:person.0722602332.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722602332.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, School of Medicine, Pusan National University, Yangsan, 50612 South Korea", 
          "id": "http://www.grid.ac/institutes/grid.262229.f", 
          "name": [
            "Department of Pathology, School of Medicine, Pusan National University, Yangsan, 50612 South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Hyun Jung", 
        "id": "sg:person.0727134644.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727134644.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, School of Medicine, Pusan National University, Yangsan, 50612 South Korea", 
          "id": "http://www.grid.ac/institutes/grid.262229.f", 
          "name": [
            "Department of Pathology, School of Medicine, Pusan National University, Yangsan, 50612 South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Young Keum", 
        "id": "sg:person.01357231654.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357231654.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, School of Medicine, Pusan National University, Yangsan, 50612 South Korea", 
          "id": "http://www.grid.ac/institutes/grid.262229.f", 
          "name": [
            "Department of Pathology, School of Medicine, Pusan National University, Yangsan, 50612 South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Choi", 
        "givenName": "Kyung Un", 
        "id": "sg:person.01335032703.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335032703.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, School of Medicine, Pusan National University, Yangsan, 50612 South Korea", 
          "id": "http://www.grid.ac/institutes/grid.262229.f", 
          "name": [
            "Department of Pathology, School of Medicine, Pusan National University, Yangsan, 50612 South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Jee Yeon", 
        "id": "sg:person.0630567110.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630567110.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paik Institute for Clinical Research, Inje University College of Medicine, Busan, 47392 South Korea", 
          "id": "http://www.grid.ac/institutes/grid.411612.1", 
          "name": [
            "Paik Institute for Clinical Research, Inje University College of Medicine, Busan, 47392 South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Young Il", 
        "id": "sg:person.0621530336.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621530336.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, School of Medicine, Pusan National University, Yangsan, 50612 South Korea", 
          "id": "http://www.grid.ac/institutes/grid.262229.f", 
          "name": [
            "Department of Pathology, School of Medicine, Pusan National University, Yangsan, 50612 South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Chang Hun", 
        "id": "sg:person.01061244110.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061244110.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, School of Medicine, Pusan National University, Yangsan, 50612 South Korea", 
          "id": "http://www.grid.ac/institutes/grid.262229.f", 
          "name": [
            "Department of Pathology, School of Medicine, Pusan National University, Yangsan, 50612 South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sol", 
        "givenName": "Mee Young", 
        "id": "sg:person.0674563534.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674563534.04"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/onc.2012.315", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046269452", 
          "https://doi.org/10.1038/onc.2012.315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2010.444", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029741281", 
          "https://doi.org/10.1038/onc.2010.444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13059-014-0436-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036483932", 
          "https://doi.org/10.1186/s13059-014-0436-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2291", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002477386", 
          "https://doi.org/10.1038/ng.2291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-010-0647-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018968623", 
          "https://doi.org/10.1007/s00401-010-0647-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/preaccept-1790146428112469", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064134455", 
          "https://doi.org/10.1186/preaccept-1790146428112469"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-04-12", 
    "datePublishedReg": "2017-04-12", 
    "description": "BACKGROUND: Isocitrate dehydrogenase 1 (IDH1) mutation is common in low-grade glioma (approximately 80%) and acute myeloid leukemia (approximately 10%). Other than brain tumor or hematologic malignancies, intrahepatic cholangiocarcinoma (iCC) is a well-known solid tumor with IDH1 mutation (6.8-20%). Histologically, poor differentiation and clear cell change are associated with IDH1 mutation in iCC. Since hepatocellular carcinoma (HCC) shares histologic features with iCC, some specific subtypes of HCC might show a higher IDH1 mutation rate than reported before (0.5-1.5%).\nMETHODS: Forty-six cases of iCC and 48 cases of HCC (including 20 cases of clear cell type and 13 cases of pseudoglandular pattern) were tested for IDH1 mutation by pyrosequencing.\nRESULTS: Three cases in iCC (6.5%) and five cases in HCC (10.4%) had IDH1 mutation, all of which were Arg132Cys. IDH1 mutant HCCs were all clear cell type. Although the IDH1 mutation rate between iCC and HCC demonstrated no significant difference, clear cell HCC revealed statistically increased mutation rate compared to that of HCC without clear cell change (P\u2009=\u20090.009). Presence of IDH1 mutation was related with poor survival in clear cell HCC patients (P\u2009=\u20090.004).\nCONCLUSIONS: Clear cell HCC showed higher frequency of IDH1 mutation rate than other variants of HCC. This result consolidates the assumption that morphological features of tumors reflect molecular alterations.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s12957-017-1144-1", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1032056", 
        "issn": [
          "1477-7819"
        ], 
        "name": "World Journal of Surgical Oncology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "15"
      }
    ], 
    "keywords": [
      "clear cell hepatocellular carcinoma", 
      "intrahepatic cholangiocarcinoma", 
      "clear cell change", 
      "hepatocellular carcinoma", 
      "IDH1 mutation", 
      "variant of HCC", 
      "cases of HCC", 
      "cases of ICC", 
      "cell changes", 
      "acute myeloid leukemia", 
      "low-grade gliomas", 
      "isocitrate dehydrogenase 1 (IDH1) mutation", 
      "clear cell type", 
      "IDH1 R132C mutation", 
      "HCC patients", 
      "hematologic malignancies", 
      "poor differentiation", 
      "myeloid leukemia", 
      "poor survival", 
      "brain tumors", 
      "solid tumors", 
      "specific subtypes", 
      "molecular alterations", 
      "R132C mutation", 
      "tumors", 
      "significant differences", 
      "carcinoma", 
      "cell types", 
      "mutations", 
      "cholangiocarcinoma", 
      "patients", 
      "malignancy", 
      "high frequency", 
      "histologic", 
      "leukemia", 
      "gliomas", 
      "mutation rate", 
      "cases", 
      "subtypes", 
      "rate", 
      "survival", 
      "morphological features", 
      "alterations", 
      "changes", 
      "differentiation", 
      "differences", 
      "variants", 
      "presence", 
      "frequency", 
      "types", 
      "features", 
      "results", 
      "assumption", 
      "dehydrogenase 1 (IDH1) mutation", 
      "higher IDH1 mutation rate", 
      "IDH1 mutation rate", 
      "Arg132Cys", 
      "IDH1 mutant HCCs", 
      "mutant HCCs", 
      "cell HCC", 
      "clear cell HCC patients", 
      "cell HCC patients"
    ], 
    "name": "IDH1 R132C mutation is detected in clear cell hepatocellular carcinoma by pyrosequencing", 
    "pagination": "82", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1084745637"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12957-017-1144-1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28403884"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12957-017-1144-1", 
      "https://app.dimensions.ai/details/publication/pub.1084745637"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:44", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_726.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s12957-017-1144-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12957-017-1144-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12957-017-1144-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12957-017-1144-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12957-017-1144-1'


 

This table displays all metadata directly associated to this object as RDF triples.

303 TRIPLES      22 PREDICATES      112 URIs      98 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12957-017-1144-1 schema:about N0678ab16f69a40569200c9193c3f4dc4
2 N0e6fd9f2603f4292b5322cb2a24f9b0a
3 N2a49a3c7461749cea9e44186547d9b87
4 N36ea623e227842eca86355d1d7f34138
5 N39bfe6a21e8c4b96a512cc1c451b3b61
6 N42c5f3c2edb141dba7ef36c2ca5183ac
7 N486cf2c5ecef4ea1b02f09ef780bebf4
8 N4c5f083c5efc40f09aa97dee32e08a29
9 N6c50692a18c44b6497b92affd07ead2e
10 N7fc62a01a5024f32b213d2747179e32f
11 N8bd881a944e3490ab23f71701223970f
12 N980a4ac76c2742feb76aea5ef882bb76
13 N9dc2b656e2f247968a96bc7b4ef449ac
14 Nb9c2fe54719d4ebf88c78c279d7a6e22
15 Nd6d84e2d78e245bba92d49781ccad263
16 Ne55071e25f8a4dd7bb789a0c03917c48
17 Neaa98956c913485f80ec41179eda66e8
18 Nf214742ca3b74660988ea784e82330c3
19 anzsrc-for:11
20 anzsrc-for:1112
21 schema:author Ne588a37209f84eb5bf1ea81ac45fcf0c
22 schema:citation sg:pub.10.1007/s00401-010-0647-4
23 sg:pub.10.1038/ng.2291
24 sg:pub.10.1038/onc.2010.444
25 sg:pub.10.1038/onc.2012.315
26 sg:pub.10.1186/preaccept-1790146428112469
27 sg:pub.10.1186/s13059-014-0436-9
28 schema:datePublished 2017-04-12
29 schema:datePublishedReg 2017-04-12
30 schema:description BACKGROUND: Isocitrate dehydrogenase 1 (IDH1) mutation is common in low-grade glioma (approximately 80%) and acute myeloid leukemia (approximately 10%). Other than brain tumor or hematologic malignancies, intrahepatic cholangiocarcinoma (iCC) is a well-known solid tumor with IDH1 mutation (6.8-20%). Histologically, poor differentiation and clear cell change are associated with IDH1 mutation in iCC. Since hepatocellular carcinoma (HCC) shares histologic features with iCC, some specific subtypes of HCC might show a higher IDH1 mutation rate than reported before (0.5-1.5%). METHODS: Forty-six cases of iCC and 48 cases of HCC (including 20 cases of clear cell type and 13 cases of pseudoglandular pattern) were tested for IDH1 mutation by pyrosequencing. RESULTS: Three cases in iCC (6.5%) and five cases in HCC (10.4%) had IDH1 mutation, all of which were Arg132Cys. IDH1 mutant HCCs were all clear cell type. Although the IDH1 mutation rate between iCC and HCC demonstrated no significant difference, clear cell HCC revealed statistically increased mutation rate compared to that of HCC without clear cell change (P = 0.009). Presence of IDH1 mutation was related with poor survival in clear cell HCC patients (P = 0.004). CONCLUSIONS: Clear cell HCC showed higher frequency of IDH1 mutation rate than other variants of HCC. This result consolidates the assumption that morphological features of tumors reflect molecular alterations.
31 schema:genre article
32 schema:inLanguage en
33 schema:isAccessibleForFree true
34 schema:isPartOf N3e9f26fad12249cf93a8d4b3a7205dd1
35 Nbc68df546cca43d5aba5da6db6429282
36 sg:journal.1032056
37 schema:keywords Arg132Cys
38 HCC patients
39 IDH1 R132C mutation
40 IDH1 mutant HCCs
41 IDH1 mutation
42 IDH1 mutation rate
43 R132C mutation
44 acute myeloid leukemia
45 alterations
46 assumption
47 brain tumors
48 carcinoma
49 cases
50 cases of HCC
51 cases of ICC
52 cell HCC
53 cell HCC patients
54 cell changes
55 cell types
56 changes
57 cholangiocarcinoma
58 clear cell HCC patients
59 clear cell change
60 clear cell hepatocellular carcinoma
61 clear cell type
62 dehydrogenase 1 (IDH1) mutation
63 differences
64 differentiation
65 features
66 frequency
67 gliomas
68 hematologic malignancies
69 hepatocellular carcinoma
70 high frequency
71 higher IDH1 mutation rate
72 histologic
73 intrahepatic cholangiocarcinoma
74 isocitrate dehydrogenase 1 (IDH1) mutation
75 leukemia
76 low-grade gliomas
77 malignancy
78 molecular alterations
79 morphological features
80 mutant HCCs
81 mutation rate
82 mutations
83 myeloid leukemia
84 patients
85 poor differentiation
86 poor survival
87 presence
88 rate
89 results
90 significant differences
91 solid tumors
92 specific subtypes
93 subtypes
94 survival
95 tumors
96 types
97 variant of HCC
98 variants
99 schema:name IDH1 R132C mutation is detected in clear cell hepatocellular carcinoma by pyrosequencing
100 schema:pagination 82
101 schema:productId N4fef1e3c0fbc482b911291ef0126adf0
102 Nc000b0c6e3d84c2cbdc9c5a93806edf1
103 Ne7f6cf0e094e4f2199c5ac2c82d10b29
104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084745637
105 https://doi.org/10.1186/s12957-017-1144-1
106 schema:sdDatePublished 2022-01-01T18:44
107 schema:sdLicense https://scigraph.springernature.com/explorer/license/
108 schema:sdPublisher N8b7f626e3a4f4374a7b36a4cb2ece697
109 schema:url https://doi.org/10.1186/s12957-017-1144-1
110 sgo:license sg:explorer/license/
111 sgo:sdDataset articles
112 rdf:type schema:ScholarlyArticle
113 N0678ab16f69a40569200c9193c3f4dc4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Liver Neoplasms
115 rdf:type schema:DefinedTerm
116 N0d8e7ca86fb34ea78c891cf800f1b08a rdf:first sg:person.0767341216.52
117 rdf:rest Nb026ad8ab41c43e3a7efafbe9e4cbd93
118 N0e6fd9f2603f4292b5322cb2a24f9b0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Prognosis
120 rdf:type schema:DefinedTerm
121 N184b5920a19148c1b9281a82b04dba2a rdf:first sg:person.011347225605.22
122 rdf:rest N8fc93c04e988441abf03ae992eb4039f
123 N2a49a3c7461749cea9e44186547d9b87 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Carcinoma, Hepatocellular
125 rdf:type schema:DefinedTerm
126 N36ea623e227842eca86355d1d7f34138 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Isocitrate Dehydrogenase
128 rdf:type schema:DefinedTerm
129 N39bfe6a21e8c4b96a512cc1c451b3b61 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Adult
131 rdf:type schema:DefinedTerm
132 N3e9f26fad12249cf93a8d4b3a7205dd1 schema:issueNumber 1
133 rdf:type schema:PublicationIssue
134 N42c5f3c2edb141dba7ef36c2ca5183ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Middle Aged
136 rdf:type schema:DefinedTerm
137 N486cf2c5ecef4ea1b02f09ef780bebf4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name High-Throughput Nucleotide Sequencing
139 rdf:type schema:DefinedTerm
140 N4c5f083c5efc40f09aa97dee32e08a29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Biomarkers, Tumor
142 rdf:type schema:DefinedTerm
143 N4fef1e3c0fbc482b911291ef0126adf0 schema:name doi
144 schema:value 10.1186/s12957-017-1144-1
145 rdf:type schema:PropertyValue
146 N5486d53de4f2480cbce11a5fa9601bf7 rdf:first sg:person.0630567110.07
147 rdf:rest N927223a718a741edbeabd79247324b8a
148 N664f9d18278440dc83010cee2917a467 rdf:first sg:person.01335032703.10
149 rdf:rest N5486d53de4f2480cbce11a5fa9601bf7
150 N69749bba7dd6448899f797bcc0a47c37 rdf:first sg:person.0727134644.46
151 rdf:rest N7096cd6199e24d4c9596750f3462fb7a
152 N6c50692a18c44b6497b92affd07ead2e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Female
154 rdf:type schema:DefinedTerm
155 N7096cd6199e24d4c9596750f3462fb7a rdf:first sg:person.01357231654.14
156 rdf:rest N664f9d18278440dc83010cee2917a467
157 N7fc62a01a5024f32b213d2747179e32f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Mutation
159 rdf:type schema:DefinedTerm
160 N84080d04a0484f35937952fa0e3b5d26 rdf:first sg:person.01061244110.65
161 rdf:rest N999d2c7add06450eadc9ac4884c2ef03
162 N8b7f626e3a4f4374a7b36a4cb2ece697 schema:name Springer Nature - SN SciGraph project
163 rdf:type schema:Organization
164 N8bd881a944e3490ab23f71701223970f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Survival Rate
166 rdf:type schema:DefinedTerm
167 N8fc93c04e988441abf03ae992eb4039f rdf:first sg:person.01354173210.08
168 rdf:rest N0d8e7ca86fb34ea78c891cf800f1b08a
169 N927223a718a741edbeabd79247324b8a rdf:first sg:person.0621530336.35
170 rdf:rest N84080d04a0484f35937952fa0e3b5d26
171 N980a4ac76c2742feb76aea5ef882bb76 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Adenocarcinoma, Clear Cell
173 rdf:type schema:DefinedTerm
174 N999d2c7add06450eadc9ac4884c2ef03 rdf:first sg:person.0674563534.04
175 rdf:rest rdf:nil
176 N9dc2b656e2f247968a96bc7b4ef449ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Neoplasm Staging
178 rdf:type schema:DefinedTerm
179 Nb026ad8ab41c43e3a7efafbe9e4cbd93 rdf:first sg:person.0722602332.16
180 rdf:rest N69749bba7dd6448899f797bcc0a47c37
181 Nb9c2fe54719d4ebf88c78c279d7a6e22 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Sequence Analysis, DNA
183 rdf:type schema:DefinedTerm
184 Nbc68df546cca43d5aba5da6db6429282 schema:volumeNumber 15
185 rdf:type schema:PublicationVolume
186 Nc000b0c6e3d84c2cbdc9c5a93806edf1 schema:name dimensions_id
187 schema:value pub.1084745637
188 rdf:type schema:PropertyValue
189 Nd6d84e2d78e245bba92d49781ccad263 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Follow-Up Studies
191 rdf:type schema:DefinedTerm
192 Ne55071e25f8a4dd7bb789a0c03917c48 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Male
194 rdf:type schema:DefinedTerm
195 Ne588a37209f84eb5bf1ea81ac45fcf0c rdf:first sg:person.0731265143.39
196 rdf:rest N184b5920a19148c1b9281a82b04dba2a
197 Ne7f6cf0e094e4f2199c5ac2c82d10b29 schema:name pubmed_id
198 schema:value 28403884
199 rdf:type schema:PropertyValue
200 Neaa98956c913485f80ec41179eda66e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Aged
202 rdf:type schema:DefinedTerm
203 Nf214742ca3b74660988ea784e82330c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name Humans
205 rdf:type schema:DefinedTerm
206 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
207 schema:name Medical and Health Sciences
208 rdf:type schema:DefinedTerm
209 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
210 schema:name Oncology and Carcinogenesis
211 rdf:type schema:DefinedTerm
212 sg:journal.1032056 schema:issn 1477-7819
213 schema:name World Journal of Surgical Oncology
214 schema:publisher Springer Nature
215 rdf:type schema:Periodical
216 sg:person.01061244110.65 schema:affiliation grid-institutes:grid.262229.f
217 schema:familyName Lee
218 schema:givenName Chang Hun
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061244110.65
220 rdf:type schema:Person
221 sg:person.011347225605.22 schema:affiliation grid-institutes:grid.412591.a
222 schema:familyName Shin
223 schema:givenName Dong Hoon
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011347225605.22
225 rdf:type schema:Person
226 sg:person.01335032703.10 schema:affiliation grid-institutes:grid.262229.f
227 schema:familyName Choi
228 schema:givenName Kyung Un
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335032703.10
230 rdf:type schema:Person
231 sg:person.01354173210.08 schema:affiliation grid-institutes:grid.262229.f
232 schema:familyName Park
233 schema:givenName Won Young
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354173210.08
235 rdf:type schema:Person
236 sg:person.01357231654.14 schema:affiliation grid-institutes:grid.262229.f
237 schema:familyName Kim
238 schema:givenName Young Keum
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357231654.14
240 rdf:type schema:Person
241 sg:person.0621530336.35 schema:affiliation grid-institutes:grid.411612.1
242 schema:familyName Yang
243 schema:givenName Young Il
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621530336.35
245 rdf:type schema:Person
246 sg:person.0630567110.07 schema:affiliation grid-institutes:grid.262229.f
247 schema:familyName Kim
248 schema:givenName Jee Yeon
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630567110.07
250 rdf:type schema:Person
251 sg:person.0674563534.04 schema:affiliation grid-institutes:grid.262229.f
252 schema:familyName Sol
253 schema:givenName Mee Young
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674563534.04
255 rdf:type schema:Person
256 sg:person.0722602332.16 schema:affiliation grid-institutes:grid.262229.f
257 schema:familyName Kim
258 schema:givenName Ahrong
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722602332.16
260 rdf:type schema:Person
261 sg:person.0727134644.46 schema:affiliation grid-institutes:grid.262229.f
262 schema:familyName Lee
263 schema:givenName Hyun Jung
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727134644.46
265 rdf:type schema:Person
266 sg:person.0731265143.39 schema:affiliation grid-institutes:grid.412591.a
267 schema:familyName Lee
268 schema:givenName Jung Hee
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731265143.39
270 rdf:type schema:Person
271 sg:person.0767341216.52 schema:affiliation grid-institutes:grid.262229.f
272 schema:familyName Shin
273 schema:givenName Nari
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767341216.52
275 rdf:type schema:Person
276 sg:pub.10.1007/s00401-010-0647-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018968623
277 https://doi.org/10.1007/s00401-010-0647-4
278 rdf:type schema:CreativeWork
279 sg:pub.10.1038/ng.2291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002477386
280 https://doi.org/10.1038/ng.2291
281 rdf:type schema:CreativeWork
282 sg:pub.10.1038/onc.2010.444 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029741281
283 https://doi.org/10.1038/onc.2010.444
284 rdf:type schema:CreativeWork
285 sg:pub.10.1038/onc.2012.315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046269452
286 https://doi.org/10.1038/onc.2012.315
287 rdf:type schema:CreativeWork
288 sg:pub.10.1186/preaccept-1790146428112469 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064134455
289 https://doi.org/10.1186/preaccept-1790146428112469
290 rdf:type schema:CreativeWork
291 sg:pub.10.1186/s13059-014-0436-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036483932
292 https://doi.org/10.1186/s13059-014-0436-9
293 rdf:type schema:CreativeWork
294 grid-institutes:grid.262229.f schema:alternateName Department of Pathology, School of Medicine, Pusan National University, Yangsan, 50612 South Korea
295 schema:name Department of Pathology, School of Medicine, Pusan National University, Yangsan, 50612 South Korea
296 rdf:type schema:Organization
297 grid-institutes:grid.411612.1 schema:alternateName Paik Institute for Clinical Research, Inje University College of Medicine, Busan, 47392 South Korea
298 schema:name Paik Institute for Clinical Research, Inje University College of Medicine, Busan, 47392 South Korea
299 rdf:type schema:Organization
300 grid-institutes:grid.412591.a schema:alternateName Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, 50612 South Korea
301 schema:name Department of Pathology, School of Medicine, Pusan National University, Yangsan, 50612 South Korea
302 Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, 50612 South Korea
303 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...