ALPPS (associating liver partition and portal vein ligation for staged hepatectomy) does not affect proliferation, apoptosis, or angiogenesis as compared ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-03-07

AUTHORS

Katharina Joechle, Christian Moser, Petra Ruemmele, Katharina M. Schmidt, Jens M. Werner, Edward K. Geissler, Hans J. Schlitt, Sven A. Lang

ABSTRACT

BACKGROUND: ALPPS (associating liver partition and portal vein ligation for staged hepatectomy) is a novel two-stage strategy to induce rapid hypertrophy of the future liver remnant (FLR) when patients are in danger of postoperative liver failure due to insufficient FLR. However, the effects of ALPPS on colorectal liver metastases (CRLM) are not clear so far. The aim of our study was to determine whether ALPPS induces proliferation, apoptosis, or vascularization compared to standard (one-stage) liver resection. METHODS: Six patients who underwent ALPPS were matched with 12 patients undergoing standard liver resection regarding characteristics of the metastases (size, number), time of appearance (syn-/metachronous), preoperative chemotherapy, primary tumor (localization, TNM stage, grading), and patient variables (gender, age). The largest resected metastasis was used for the analyses. Tissue was stained for tumor cell proliferation (Ki67), apoptosis (TUNEL, caspase-3), vascularization (CD31), and pericytes (αSMA). RESULTS: Vascularization (CD31; p = 0.149), proliferation (Mib-1; p = 0.244), and αSMA expression (p = 0.205) did not significantly differ between the two groups, although a trend towards less proliferation and αSMA expression was observed in patients undergoing ALPPS. Concerning apoptosis, caspase-3 staining showed significantly fewer apoptotic cells upon ALPPS (p < 0.0001), but this was not confirmed by TUNEL staining (p = 0.7344). CONCLUSIONS: ALPPS does not induce proliferation, apoptosis, or vascularization of CRLM when compared to standard liver resection. More... »

PAGES

57

References to SciGraph publications

  • 2013-02-06. Increased growth of colorectal liver metastasis following partial hepatectomy in CLINICAL & EXPERIMENTAL METASTASIS
  • 2014-04-19. ALPPS Offers a Better Chance of Complete Resection in Patients with Primarily Unresectable Liver Tumors Compared with Conventional-Staged Hepatectomies: Results of a Multicenter Analysis in WORLD JOURNAL OF SURGERY
  • 2015-06-08. Staged resection of bilobar colorectal liver metastases: surgical strategies in LANGENBECK'S ARCHIVES OF SURGERY
  • 2012-12-05. One-Stage Hepatectomy Following Portal Vein Embolization for Colorectal Liver Metastasis in WORLD JOURNAL OF SURGERY
  • 2013-12-11. ALPPS for Patients with Colorectal Liver Metastases: Effective Liver Hypertrophy, but Early Tumor Recurrence in WORLD JOURNAL OF SURGERY
  • 2014-11-04. Treatment of colorectal liver metastases in Germany: a ten-year population-based analysis of 5772 cases of primary colorectal adenocarcinoma in BMC CANCER
  • 2015-02-18. Long-term results after in-situ split (ISS) liver resection in LANGENBECK'S ARCHIVES OF SURGERY
  • 2009-02-10. Effect of portal vein embolisation on the growth rate of colorectal liver metastases in BRITISH JOURNAL OF CANCER
  • 2006-09-06. Improving Resectability of Hepatic Colorectal Metastases: Expert Consensus Statement in ANNALS OF SURGICAL ONCOLOGY
  • 2016-06-08. Oncological Outcomes of Major Liver Resection Following Portal Vein Embolization: A Systematic Review and Meta-analysis in ANNALS OF SURGICAL ONCOLOGY
  • 2008-12-03. Induction of Tumor Growth After Preoperative Portal Vein Embolization: Is It a Real Problem? in ANNALS OF SURGICAL ONCOLOGY
  • 2014-03-17. Long-term Survival of Patients with Cholangiolocellular Carcinoma After Curative Hepatectomy in ANNALS OF SURGICAL ONCOLOGY
  • 2014-05-27. Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS): an analysis of tumor activity in UPDATES IN SURGERY
  • 2005-12-01. Treatment for multiple bilobar liver metastases of colorectal cancer in LANGENBECK'S ARCHIVES OF SURGERY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12957-017-1121-8

    DOI

    http://dx.doi.org/10.1186/s12957-017-1121-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1084251398

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28270160


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Apoptosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Proliferation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Colorectal Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Follow-Up Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hepatectomy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hypertrophy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ligation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Liver Failure", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Liver Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lymphatic Metastasis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Grading", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Staging", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neovascularization, Pathologic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Portal Vein", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prognosis", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Surgery, University Hospital Regensburg, Franz-Josef-Strauss Allee 11, 93053 Regensburg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.411941.8", 
              "name": [
                "Department of Surgery, University Hospital Regensburg, Franz-Josef-Strauss Allee 11, 93053 Regensburg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Joechle", 
            "givenName": "Katharina", 
            "id": "sg:person.010605234617.78", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010605234617.78"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, University Hospital Regensburg, Franz-Josef-Strauss Allee 11, 93053 Regensburg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.411941.8", 
              "name": [
                "Department of Surgery, University Hospital Regensburg, Franz-Josef-Strauss Allee 11, 93053 Regensburg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Moser", 
            "givenName": "Christian", 
            "id": "sg:person.0722103505.68", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722103505.68"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, University Hospital Regensburg, Franz-Josef-Strauss Allee 11, 93053 Regensburg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.411941.8", 
              "name": [
                "Department of Pathology, University Hospital Regensburg, Franz-Josef-Strauss Allee 11, 93053 Regensburg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ruemmele", 
            "givenName": "Petra", 
            "id": "sg:person.0723461020.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723461020.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, University Hospital Regensburg, Franz-Josef-Strauss Allee 11, 93053 Regensburg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.411941.8", 
              "name": [
                "Department of Surgery, University Hospital Regensburg, Franz-Josef-Strauss Allee 11, 93053 Regensburg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schmidt", 
            "givenName": "Katharina M.", 
            "id": "sg:person.0741756316.88", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741756316.88"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, University Hospital Regensburg, Franz-Josef-Strauss Allee 11, 93053 Regensburg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.411941.8", 
              "name": [
                "Department of Surgery, University Hospital Regensburg, Franz-Josef-Strauss Allee 11, 93053 Regensburg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Werner", 
            "givenName": "Jens M.", 
            "id": "sg:person.01260631176.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260631176.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, University Hospital Regensburg, Franz-Josef-Strauss Allee 11, 93053 Regensburg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.411941.8", 
              "name": [
                "Department of Surgery, University Hospital Regensburg, Franz-Josef-Strauss Allee 11, 93053 Regensburg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Geissler", 
            "givenName": "Edward K.", 
            "id": "sg:person.0646270630.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646270630.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, University Hospital Regensburg, Franz-Josef-Strauss Allee 11, 93053 Regensburg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.411941.8", 
              "name": [
                "Department of Surgery, University Hospital Regensburg, Franz-Josef-Strauss Allee 11, 93053 Regensburg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schlitt", 
            "givenName": "Hans J.", 
            "id": "sg:person.010361144542.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010361144542.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, University Hospital Regensburg, Franz-Josef-Strauss Allee 11, 93053 Regensburg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.411941.8", 
              "name": [
                "Department of Surgery, University Hospital Regensburg, Franz-Josef-Strauss Allee 11, 93053 Regensburg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lang", 
            "givenName": "Sven A.", 
            "id": "sg:person.0655322226.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655322226.34"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00423-015-1285-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041037501", 
              "https://doi.org/10.1007/s00423-015-1285-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s13304-014-0256-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033218242", 
              "https://doi.org/10.1007/s13304-014-0256-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00268-012-1861-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009297647", 
              "https://doi.org/10.1007/s00268-012-1861-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00268-014-2513-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046702298", 
              "https://doi.org/10.1007/s00268-014-2513-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00423-005-0003-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028233288", 
              "https://doi.org/10.1007/s00423-005-0003-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-008-0222-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032245633", 
              "https://doi.org/10.1245/s10434-008-0222-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00268-013-2401-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035433988", 
              "https://doi.org/10.1007/s00268-013-2401-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-016-5264-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040902326", 
              "https://doi.org/10.1245/s10434-016-5264-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-014-3582-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008703200", 
              "https://doi.org/10.1245/s10434-014-3582-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6604872", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053730317", 
              "https://doi.org/10.1038/sj.bjc.6604872"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-14-810", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051796975", 
              "https://doi.org/10.1186/1471-2407-14-810"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00423-015-1310-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024123833", 
              "https://doi.org/10.1007/s00423-015-1310-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10585-013-9572-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029210007", 
              "https://doi.org/10.1007/s10585-013-9572-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-006-9045-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019448373", 
              "https://doi.org/10.1245/s10434-006-9045-5"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-03-07", 
        "datePublishedReg": "2017-03-07", 
        "description": "BACKGROUND: ALPPS (associating liver partition and portal vein ligation for staged hepatectomy) is a novel two-stage strategy to induce rapid hypertrophy of the future liver remnant (FLR) when patients are in danger of postoperative liver failure due to insufficient FLR. However, the effects of ALPPS on colorectal liver metastases (CRLM) are not clear so far. The aim of our study was to determine whether ALPPS induces proliferation, apoptosis, or vascularization compared to standard (one-stage) liver resection.\nMETHODS: Six patients who underwent ALPPS were matched with 12 patients undergoing standard liver resection regarding characteristics of the metastases (size, number), time of appearance (syn-/metachronous), preoperative chemotherapy, primary tumor (localization, TNM stage, grading), and patient variables (gender, age). The largest resected metastasis was used for the analyses. Tissue was stained for tumor cell proliferation (Ki67), apoptosis (TUNEL, caspase-3), vascularization (CD31), and pericytes (\u03b1SMA).\nRESULTS: Vascularization (CD31; p\u2009=\u20090.149), proliferation (Mib-1; p\u2009=\u20090.244), and \u03b1SMA expression (p\u2009=\u20090.205) did not significantly differ between the two groups, although a trend towards less proliferation and \u03b1SMA expression was observed in patients undergoing ALPPS. Concerning apoptosis, caspase-3 staining showed significantly fewer apoptotic cells upon ALPPS (p\u2009<\u20090.0001), but this was not confirmed by TUNEL staining (p\u2009=\u20090.7344).\nCONCLUSIONS: ALPPS does not induce proliferation, apoptosis, or vascularization of CRLM when compared to standard liver resection.", 
        "genre": "article", 
        "id": "sg:pub.10.1186/s12957-017-1121-8", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1032056", 
            "issn": [
              "1477-7819"
            ], 
            "name": "World Journal of Surgical Oncology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "15"
          }
        ], 
        "keywords": [
          "standard liver resection", 
          "colorectal liver metastases", 
          "future liver remnant", 
          "liver resection", 
          "liver metastases", 
          "\u03b1SMA expression", 
          "insufficient future liver remnant", 
          "postoperative liver failure", 
          "caspase-3 staining", 
          "tumor cell proliferation", 
          "preoperative chemotherapy", 
          "liver failure", 
          "liver remnant", 
          "primary tumor", 
          "patient variables", 
          "rapid hypertrophy", 
          "ALPPS", 
          "resection", 
          "patients", 
          "TUNEL staining", 
          "metastasis", 
          "less proliferation", 
          "time of appearance", 
          "cell proliferation", 
          "vascularization", 
          "apoptotic cells", 
          "apoptosis", 
          "proliferation", 
          "staining", 
          "chemotherapy", 
          "hypertrophy", 
          "expression", 
          "tumors", 
          "ALPPS", 
          "pericytes", 
          "angiogenesis", 
          "tissue", 
          "cells", 
          "failure", 
          "group", 
          "aim", 
          "study", 
          "appearance", 
          "effect", 
          "two-stage strategy", 
          "remnants", 
          "strategies", 
          "variables", 
          "time", 
          "analysis", 
          "trends", 
          "characteristics", 
          "danger", 
          "effects of ALPPS", 
          "largest resected metastasis", 
          "resected metastasis", 
          "vascularization of CRLM"
        ], 
        "name": "ALPPS (associating liver partition and portal vein ligation for staged hepatectomy) does not affect proliferation, apoptosis, or angiogenesis as compared to standard liver resection for colorectal liver metastases", 
        "pagination": "57", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1084251398"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s12957-017-1121-8"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28270160"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s12957-017-1121-8", 
          "https://app.dimensions.ai/details/publication/pub.1084251398"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2021-11-01T18:31", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/article/article_744.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1186/s12957-017-1121-8"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12957-017-1121-8'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12957-017-1121-8'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12957-017-1121-8'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12957-017-1121-8'


     

    This table displays all metadata directly associated to this object as RDF triples.

    304 TRIPLES      22 PREDICATES      116 URIs      94 LITERALS      27 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s12957-017-1121-8 schema:about N088f3b40787e47bea98fbb0061fdd595
    2 N124925e691a547d58826781a3dd95ace
    3 N24cb4e7a99494137a93e81f5e3d58d5a
    4 N279d0f9b6f6b47dba64d1676366753b5
    5 N2dfb4ea7a2a54151bca985478f396642
    6 N2fea7589e8f0436daf95b4dd3fb8a4c1
    7 N40e61241f46641dbafa20d5d53f7bb59
    8 N43a83e151aa449718e7fe09885c62960
    9 N6fa83f7490e94fb084bf4b45a5a5c322
    10 N776b878604cb44448ac45dedd6a43f2c
    11 N8bfd5937d38f44ecabf39836ebdc9c72
    12 N92475a218de545f9a1bed3387bbc1baa
    13 N99b6743bac9a41ff8c19872305148ed0
    14 Nae6ff0350f6d477bb816191f09901b19
    15 Nbf01470006194e4882a52301e535141b
    16 Nc8a3fa376ccb483ba7be216d804784e9
    17 Nc971fe3357dc48fb8e889d7de6a4acfd
    18 Ncf26306b1cf44d66b105c198e3f36d4f
    19 Ndcc4293f7e064720a843474dd9b2d411
    20 Ne9aa13d016ab43a1ad479440b28c67b9
    21 anzsrc-for:11
    22 anzsrc-for:1103
    23 schema:author N9244b9e10d47439e8eb5e38c29d39f5a
    24 schema:citation sg:pub.10.1007/s00268-012-1861-0
    25 sg:pub.10.1007/s00268-013-2401-2
    26 sg:pub.10.1007/s00268-014-2513-3
    27 sg:pub.10.1007/s00423-005-0003-7
    28 sg:pub.10.1007/s00423-015-1285-z
    29 sg:pub.10.1007/s00423-015-1310-2
    30 sg:pub.10.1007/s10585-013-9572-y
    31 sg:pub.10.1007/s13304-014-0256-1
    32 sg:pub.10.1038/sj.bjc.6604872
    33 sg:pub.10.1186/1471-2407-14-810
    34 sg:pub.10.1245/s10434-006-9045-5
    35 sg:pub.10.1245/s10434-008-0222-6
    36 sg:pub.10.1245/s10434-014-3582-0
    37 sg:pub.10.1245/s10434-016-5264-6
    38 schema:datePublished 2017-03-07
    39 schema:datePublishedReg 2017-03-07
    40 schema:description BACKGROUND: ALPPS (associating liver partition and portal vein ligation for staged hepatectomy) is a novel two-stage strategy to induce rapid hypertrophy of the future liver remnant (FLR) when patients are in danger of postoperative liver failure due to insufficient FLR. However, the effects of ALPPS on colorectal liver metastases (CRLM) are not clear so far. The aim of our study was to determine whether ALPPS induces proliferation, apoptosis, or vascularization compared to standard (one-stage) liver resection. METHODS: Six patients who underwent ALPPS were matched with 12 patients undergoing standard liver resection regarding characteristics of the metastases (size, number), time of appearance (syn-/metachronous), preoperative chemotherapy, primary tumor (localization, TNM stage, grading), and patient variables (gender, age). The largest resected metastasis was used for the analyses. Tissue was stained for tumor cell proliferation (Ki67), apoptosis (TUNEL, caspase-3), vascularization (CD31), and pericytes (αSMA). RESULTS: Vascularization (CD31; p = 0.149), proliferation (Mib-1; p = 0.244), and αSMA expression (p = 0.205) did not significantly differ between the two groups, although a trend towards less proliferation and αSMA expression was observed in patients undergoing ALPPS. Concerning apoptosis, caspase-3 staining showed significantly fewer apoptotic cells upon ALPPS (p < 0.0001), but this was not confirmed by TUNEL staining (p = 0.7344). CONCLUSIONS: ALPPS does not induce proliferation, apoptosis, or vascularization of CRLM when compared to standard liver resection.
    41 schema:genre article
    42 schema:inLanguage en
    43 schema:isAccessibleForFree true
    44 schema:isPartOf N5322b4f9894641a3a4b26a96f3795331
    45 Na31008d1b5bf493681a2999c80b948bc
    46 sg:journal.1032056
    47 schema:keywords ALPPS
    48 TUNEL staining
    49 aim
    50 analysis
    51 angiogenesis
    52 apoptosis
    53 apoptotic cells
    54 appearance
    55 caspase-3 staining
    56 cell proliferation
    57 cells
    58 characteristics
    59 chemotherapy
    60 colorectal liver metastases
    61 danger
    62 effect
    63 effects of ALPPS
    64 expression
    65 failure
    66 future liver remnant
    67 group
    68 hypertrophy
    69 insufficient future liver remnant
    70 largest resected metastasis
    71 less proliferation
    72 liver failure
    73 liver metastases
    74 liver remnant
    75 liver resection
    76 metastasis
    77 patient variables
    78 patients
    79 pericytes
    80 postoperative liver failure
    81 preoperative chemotherapy
    82 primary tumor
    83 proliferation
    84 rapid hypertrophy
    85 remnants
    86 resected metastasis
    87 resection
    88 staining
    89 standard liver resection
    90 strategies
    91 study
    92 time
    93 time of appearance
    94 tissue
    95 trends
    96 tumor cell proliferation
    97 tumors
    98 two-stage strategy
    99 variables
    100 vascularization
    101 vascularization of CRLM
    102 αSMA expression
    103 schema:name ALPPS (associating liver partition and portal vein ligation for staged hepatectomy) does not affect proliferation, apoptosis, or angiogenesis as compared to standard liver resection for colorectal liver metastases
    104 schema:pagination 57
    105 schema:productId N0bbd5528f43741bab7aba325a9ad53ee
    106 N96edaff903014182b29a5cbfdc3bec97
    107 Nf7988cc4f70d443bab43f57f72505e03
    108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084251398
    109 https://doi.org/10.1186/s12957-017-1121-8
    110 schema:sdDatePublished 2021-11-01T18:31
    111 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    112 schema:sdPublisher N15cc426f739e4ba1a54c88214b2077aa
    113 schema:url https://doi.org/10.1186/s12957-017-1121-8
    114 sgo:license sg:explorer/license/
    115 sgo:sdDataset articles
    116 rdf:type schema:ScholarlyArticle
    117 N0640f54a092c42abb6d88b39617d82d6 rdf:first sg:person.01260631176.20
    118 rdf:rest N81a026b8f75242fe83625ad4cf4184a5
    119 N088f3b40787e47bea98fbb0061fdd595 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    120 schema:name Apoptosis
    121 rdf:type schema:DefinedTerm
    122 N0bbd5528f43741bab7aba325a9ad53ee schema:name doi
    123 schema:value 10.1186/s12957-017-1121-8
    124 rdf:type schema:PropertyValue
    125 N0cf6a88943cf4a8d8fad3acaf6e18c78 rdf:first sg:person.0741756316.88
    126 rdf:rest N0640f54a092c42abb6d88b39617d82d6
    127 N124925e691a547d58826781a3dd95ace schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Aged
    129 rdf:type schema:DefinedTerm
    130 N15cc426f739e4ba1a54c88214b2077aa schema:name Springer Nature - SN SciGraph project
    131 rdf:type schema:Organization
    132 N24cb4e7a99494137a93e81f5e3d58d5a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Prognosis
    134 rdf:type schema:DefinedTerm
    135 N279d0f9b6f6b47dba64d1676366753b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    136 schema:name Middle Aged
    137 rdf:type schema:DefinedTerm
    138 N2dfb4ea7a2a54151bca985478f396642 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Cell Proliferation
    140 rdf:type schema:DefinedTerm
    141 N2fea7589e8f0436daf95b4dd3fb8a4c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Liver Neoplasms
    143 rdf:type schema:DefinedTerm
    144 N40e61241f46641dbafa20d5d53f7bb59 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Neovascularization, Pathologic
    146 rdf:type schema:DefinedTerm
    147 N43a83e151aa449718e7fe09885c62960 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name Neoplasm Staging
    149 rdf:type schema:DefinedTerm
    150 N5322b4f9894641a3a4b26a96f3795331 schema:volumeNumber 15
    151 rdf:type schema:PublicationVolume
    152 N6fa83f7490e94fb084bf4b45a5a5c322 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Female
    154 rdf:type schema:DefinedTerm
    155 N776b878604cb44448ac45dedd6a43f2c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name Neoplasm Grading
    157 rdf:type schema:DefinedTerm
    158 N81a026b8f75242fe83625ad4cf4184a5 rdf:first sg:person.0646270630.63
    159 rdf:rest Ne296f45674244f2bb6b60ceb03d5abba
    160 N8bfd5937d38f44ecabf39836ebdc9c72 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Liver Failure
    162 rdf:type schema:DefinedTerm
    163 N9244b9e10d47439e8eb5e38c29d39f5a rdf:first sg:person.010605234617.78
    164 rdf:rest Nf1aa5e0927d747829117aba141cbf200
    165 N92475a218de545f9a1bed3387bbc1baa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Hypertrophy
    167 rdf:type schema:DefinedTerm
    168 N96edaff903014182b29a5cbfdc3bec97 schema:name pubmed_id
    169 schema:value 28270160
    170 rdf:type schema:PropertyValue
    171 N99b6743bac9a41ff8c19872305148ed0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Portal Vein
    173 rdf:type schema:DefinedTerm
    174 Na31008d1b5bf493681a2999c80b948bc schema:issueNumber 1
    175 rdf:type schema:PublicationIssue
    176 Na3cd3659c3844bbd8cbe8488b2f392d4 rdf:first sg:person.0655322226.34
    177 rdf:rest rdf:nil
    178 Nae6ff0350f6d477bb816191f09901b19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    179 schema:name Humans
    180 rdf:type schema:DefinedTerm
    181 Nbf01470006194e4882a52301e535141b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    182 schema:name Hepatectomy
    183 rdf:type schema:DefinedTerm
    184 Nc8a3fa376ccb483ba7be216d804784e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    185 schema:name Follow-Up Studies
    186 rdf:type schema:DefinedTerm
    187 Nc971fe3357dc48fb8e889d7de6a4acfd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    188 schema:name Lymphatic Metastasis
    189 rdf:type schema:DefinedTerm
    190 Ncf26306b1cf44d66b105c198e3f36d4f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    191 schema:name Colorectal Neoplasms
    192 rdf:type schema:DefinedTerm
    193 Ndcc4293f7e064720a843474dd9b2d411 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    194 schema:name Male
    195 rdf:type schema:DefinedTerm
    196 Ne296f45674244f2bb6b60ceb03d5abba rdf:first sg:person.010361144542.53
    197 rdf:rest Na3cd3659c3844bbd8cbe8488b2f392d4
    198 Ne9aa13d016ab43a1ad479440b28c67b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    199 schema:name Ligation
    200 rdf:type schema:DefinedTerm
    201 Nf1aa5e0927d747829117aba141cbf200 rdf:first sg:person.0722103505.68
    202 rdf:rest Nf76f14d226484f6683f0ef04b5a3fbb2
    203 Nf76f14d226484f6683f0ef04b5a3fbb2 rdf:first sg:person.0723461020.32
    204 rdf:rest N0cf6a88943cf4a8d8fad3acaf6e18c78
    205 Nf7988cc4f70d443bab43f57f72505e03 schema:name dimensions_id
    206 schema:value pub.1084251398
    207 rdf:type schema:PropertyValue
    208 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    209 schema:name Medical and Health Sciences
    210 rdf:type schema:DefinedTerm
    211 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    212 schema:name Clinical Sciences
    213 rdf:type schema:DefinedTerm
    214 sg:journal.1032056 schema:issn 1477-7819
    215 schema:name World Journal of Surgical Oncology
    216 schema:publisher Springer Nature
    217 rdf:type schema:Periodical
    218 sg:person.010361144542.53 schema:affiliation grid-institutes:grid.411941.8
    219 schema:familyName Schlitt
    220 schema:givenName Hans J.
    221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010361144542.53
    222 rdf:type schema:Person
    223 sg:person.010605234617.78 schema:affiliation grid-institutes:grid.411941.8
    224 schema:familyName Joechle
    225 schema:givenName Katharina
    226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010605234617.78
    227 rdf:type schema:Person
    228 sg:person.01260631176.20 schema:affiliation grid-institutes:grid.411941.8
    229 schema:familyName Werner
    230 schema:givenName Jens M.
    231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260631176.20
    232 rdf:type schema:Person
    233 sg:person.0646270630.63 schema:affiliation grid-institutes:grid.411941.8
    234 schema:familyName Geissler
    235 schema:givenName Edward K.
    236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646270630.63
    237 rdf:type schema:Person
    238 sg:person.0655322226.34 schema:affiliation grid-institutes:grid.411941.8
    239 schema:familyName Lang
    240 schema:givenName Sven A.
    241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655322226.34
    242 rdf:type schema:Person
    243 sg:person.0722103505.68 schema:affiliation grid-institutes:grid.411941.8
    244 schema:familyName Moser
    245 schema:givenName Christian
    246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722103505.68
    247 rdf:type schema:Person
    248 sg:person.0723461020.32 schema:affiliation grid-institutes:grid.411941.8
    249 schema:familyName Ruemmele
    250 schema:givenName Petra
    251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723461020.32
    252 rdf:type schema:Person
    253 sg:person.0741756316.88 schema:affiliation grid-institutes:grid.411941.8
    254 schema:familyName Schmidt
    255 schema:givenName Katharina M.
    256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741756316.88
    257 rdf:type schema:Person
    258 sg:pub.10.1007/s00268-012-1861-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009297647
    259 https://doi.org/10.1007/s00268-012-1861-0
    260 rdf:type schema:CreativeWork
    261 sg:pub.10.1007/s00268-013-2401-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035433988
    262 https://doi.org/10.1007/s00268-013-2401-2
    263 rdf:type schema:CreativeWork
    264 sg:pub.10.1007/s00268-014-2513-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046702298
    265 https://doi.org/10.1007/s00268-014-2513-3
    266 rdf:type schema:CreativeWork
    267 sg:pub.10.1007/s00423-005-0003-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028233288
    268 https://doi.org/10.1007/s00423-005-0003-7
    269 rdf:type schema:CreativeWork
    270 sg:pub.10.1007/s00423-015-1285-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1041037501
    271 https://doi.org/10.1007/s00423-015-1285-z
    272 rdf:type schema:CreativeWork
    273 sg:pub.10.1007/s00423-015-1310-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024123833
    274 https://doi.org/10.1007/s00423-015-1310-2
    275 rdf:type schema:CreativeWork
    276 sg:pub.10.1007/s10585-013-9572-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1029210007
    277 https://doi.org/10.1007/s10585-013-9572-y
    278 rdf:type schema:CreativeWork
    279 sg:pub.10.1007/s13304-014-0256-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033218242
    280 https://doi.org/10.1007/s13304-014-0256-1
    281 rdf:type schema:CreativeWork
    282 sg:pub.10.1038/sj.bjc.6604872 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053730317
    283 https://doi.org/10.1038/sj.bjc.6604872
    284 rdf:type schema:CreativeWork
    285 sg:pub.10.1186/1471-2407-14-810 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051796975
    286 https://doi.org/10.1186/1471-2407-14-810
    287 rdf:type schema:CreativeWork
    288 sg:pub.10.1245/s10434-006-9045-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019448373
    289 https://doi.org/10.1245/s10434-006-9045-5
    290 rdf:type schema:CreativeWork
    291 sg:pub.10.1245/s10434-008-0222-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032245633
    292 https://doi.org/10.1245/s10434-008-0222-6
    293 rdf:type schema:CreativeWork
    294 sg:pub.10.1245/s10434-014-3582-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008703200
    295 https://doi.org/10.1245/s10434-014-3582-0
    296 rdf:type schema:CreativeWork
    297 sg:pub.10.1245/s10434-016-5264-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040902326
    298 https://doi.org/10.1245/s10434-016-5264-6
    299 rdf:type schema:CreativeWork
    300 grid-institutes:grid.411941.8 schema:alternateName Department of Pathology, University Hospital Regensburg, Franz-Josef-Strauss Allee 11, 93053 Regensburg, Germany
    301 Department of Surgery, University Hospital Regensburg, Franz-Josef-Strauss Allee 11, 93053 Regensburg, Germany
    302 schema:name Department of Pathology, University Hospital Regensburg, Franz-Josef-Strauss Allee 11, 93053 Regensburg, Germany
    303 Department of Surgery, University Hospital Regensburg, Franz-Josef-Strauss Allee 11, 93053 Regensburg, Germany
    304 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...