Clinical characteristics of synchronous colorectal cancers in Japan View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-10-24

AUTHORS

Takaharu Kato, Sergio Alonso, Yuta Muto, Hiroshi Noda, Yasuyuki Miyakura, Koichi Suzuki, Shingo Tsujinaka, Masaaki Saito, Manuel Perucho, Toshiki Rikiyama

ABSTRACT

BackgroundIncidence and clinical characteristics of synchronous colorectal cancer (sCRC) patients significantly vary among studies, likely due to differences in surveillance methodology. If remain undetected, sCRC can progress to more advanced stages seriously aggravating patient prognosis. We studied the incidence and clinicopathological characteristics of Japanese patients with sCRCs who underwent surgery for primary CRC and received exhaustive perioperative surveillance.MethodsWe recruited 1005 patients with surgically resected CRCs between January 2007 and December 2011. The associations of clinical and pathological factors with sCRC development were assessed by univariate and multivariate logistic regression.ResultsEighty-four patients (8.4 %) developed sCRCs, 16 of them (19.0 %) harboring three or more cancers. Companion sCRCs were smaller and earlier stage than the index lesion (P < 0.0001). In multivariate analysis, advanced age (odds ratio (OR) 1.03 per year; P = 0.009) and left colon tumor location (OR 1.78; P = 0.013) are associated with higher risk of sCRCs, particularly in females. Overall survival did not differ between solitary CRC and sCRC (P = 0.62).ConclusionsOur results highlight the importance of perioperative colonoscopy examination to ensure the absence of sCRCs that, being small and early staged, are more difficult to detect. The incidence of sCRC, and notably of triple or more sCRCs, was higher than previously recognized. Because they are also significantly higher than expected by merely stochastic accumulation of individual cancerous lesions, we suggest that the occurrence of many sCRC reflects a hitherto uncharacterized predisposition condition. More... »

PAGES

272

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12957-016-1027-x

DOI

http://dx.doi.org/10.1186/s12957-016-1027-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030606641

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27776528


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36 schema:description BackgroundIncidence and clinical characteristics of synchronous colorectal cancer (sCRC) patients significantly vary among studies, likely due to differences in surveillance methodology. If remain undetected, sCRC can progress to more advanced stages seriously aggravating patient prognosis. We studied the incidence and clinicopathological characteristics of Japanese patients with sCRCs who underwent surgery for primary CRC and received exhaustive perioperative surveillance.MethodsWe recruited 1005 patients with surgically resected CRCs between January 2007 and December 2011. The associations of clinical and pathological factors with sCRC development were assessed by univariate and multivariate logistic regression.ResultsEighty-four patients (8.4 %) developed sCRCs, 16 of them (19.0 %) harboring three or more cancers. Companion sCRCs were smaller and earlier stage than the index lesion (P < 0.0001). In multivariate analysis, advanced age (odds ratio (OR) 1.03 per year; P = 0.009) and left colon tumor location (OR 1.78; P = 0.013) are associated with higher risk of sCRCs, particularly in females. Overall survival did not differ between solitary CRC and sCRC (P = 0.62).ConclusionsOur results highlight the importance of perioperative colonoscopy examination to ensure the absence of sCRCs that, being small and early staged, are more difficult to detect. The incidence of sCRC, and notably of triple or more sCRCs, was higher than previously recognized. Because they are also significantly higher than expected by merely stochastic accumulation of individual cancerous lesions, we suggest that the occurrence of many sCRC reflects a hitherto uncharacterized predisposition condition.
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43 schema:keywords BackgroundIncidence
44 CRC
45 ConclusionsOur results
46 Japan
47 Japanese patients
48 MethodsWe
49 ResultsEighty-four patients
50 SCRC
51 absence
52 accumulation
53 advanced age
54 advanced stage
55 age
56 analysis
57 association
58 cancer
59 cancer patients
60 cancerous lesions
61 characteristics
62 clinical characteristics
63 clinicopathological characteristics
64 colon tumor location
65 colonoscopy examination
66 colorectal cancer
67 colorectal cancer patients
68 conditions
69 development
70 differences
71 early stages
72 examination
73 factors
74 females
75 high risk
76 importance
77 incidence
78 index lesion
79 lesions
80 location
81 logistic regression
82 methodology
83 more cancers
84 multivariate analysis
85 occurrence
86 overall survival
87 pathological factors
88 patient prognosis
89 patients
90 perioperative surveillance
91 primary CRC
92 prognosis
93 regression
94 results
95 risk
96 sCRC development
97 solitary CRC
98 stage
99 stochastic accumulation
100 study
101 surgery
102 surveillance
103 surveillance methodology
104 survival
105 synchronous colorectal cancer
106 tumor location
107 univariate
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