Multiple primary malignancies involving primary sporadic colorectal cancer in Japan: incidence of gastric cancer with colorectal cancer patients may be ... View Full Text


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Article Info

DATE

2015-02-07

AUTHORS

Takaharu Kato, Koichi Suzuki, Yuta Muto, Junichi Sasaki, Shingo Tsujinaka, Yutaka J Kawamura, Hiroshi Noda, Hisanaga Horie, Fumio Konishi, Toshiki Rikiyama

ABSTRACT

BackgroundImprovement in the prognosis of colorectal cancer (CRC) patients has led to increasing occurrences of multiple primary malignancies (MPMs) alongside CRC but little is known about their characteristics. This study was undertaken to clarify the clinical and pathological features of MPMs, especially those at extra colonic sites, in patients with CRC.MethodsWe reviewed 1,111 patients who underwent operations for primary sporadic CRC in Saitama Medical Center, Jichi Medical University between April 2007 and March 2012. Two patients with familial adenomatous polyposis, one with hereditary non-polyposis colorectal cancer, two with colitic cancer, and any patients with metastasis from CRC were excluded. We compared the clinicopathological features of CRC patients with and without MPMs.As a control, we used a database compiled of patients with gastric cancer (GC) detected by mass screening performed in the Saitama Prefecture in Japan 2010 and compared these with CRC patients with synchronous GC.ResultsMultiple primary malignancies at extracolonic sites were identified in 117 of 1,111 CRC patients (10.5%). The median age was 68 (range, 29 to 96) versus 71 (50 to 92) (P < 0.001). The incidence of GC (44.4% (52 of 117)) was the highest of all MPMs. All CRC patients with GC were older than 57 years. Synchronous GC was detected in 26 patients.By contrast, out of 200,007 screened people, 225 people were diagnosed as having GC in the Saitama Prefecture. The age-standardized incidence of synchronous GC in CRC patients was significantly higher (0.53%) than in the control group (0.03%) (odds ratio, 18.8; 95% confidence interval, 18.6 to 19.0; P < 0.001).ConclusionPatients with CRC who were older than 50 years preferentially developed GC synchronously and metachronously. Thus, this patient group should undergo careful perioperative screening for GC. More... »

PAGES

23

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URI

http://scigraph.springernature.com/pub.10.1186/s12957-014-0432-2

DOI

http://dx.doi.org/10.1186/s12957-014-0432-2

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https://app.dimensions.ai/details/publication/pub.1042972382

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25889477


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33 schema:description BackgroundImprovement in the prognosis of colorectal cancer (CRC) patients has led to increasing occurrences of multiple primary malignancies (MPMs) alongside CRC but little is known about their characteristics. This study was undertaken to clarify the clinical and pathological features of MPMs, especially those at extra colonic sites, in patients with CRC.MethodsWe reviewed 1,111 patients who underwent operations for primary sporadic CRC in Saitama Medical Center, Jichi Medical University between April 2007 and March 2012. Two patients with familial adenomatous polyposis, one with hereditary non-polyposis colorectal cancer, two with colitic cancer, and any patients with metastasis from CRC were excluded. We compared the clinicopathological features of CRC patients with and without MPMs.As a control, we used a database compiled of patients with gastric cancer (GC) detected by mass screening performed in the Saitama Prefecture in Japan 2010 and compared these with CRC patients with synchronous GC.ResultsMultiple primary malignancies at extracolonic sites were identified in 117 of 1,111 CRC patients (10.5%). The median age was 68 (range, 29 to 96) versus 71 (50 to 92) (P < 0.001). The incidence of GC (44.4% (52 of 117)) was the highest of all MPMs. All CRC patients with GC were older than 57 years. Synchronous GC was detected in 26 patients.By contrast, out of 200,007 screened people, 225 people were diagnosed as having GC in the Saitama Prefecture. The age-standardized incidence of synchronous GC in CRC patients was significantly higher (0.53%) than in the control group (0.03%) (odds ratio, 18.8; 95% confidence interval, 18.6 to 19.0; P < 0.001).ConclusionPatients with CRC who were older than 50 years preferentially developed GC synchronously and metachronously. Thus, this patient group should undergo careful perioperative screening for GC.
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41 CRC
42 CRC patients
43 ConclusionPatients
44 Japan
45 Japan 2010
46 Jichi Medical University
47 Medical Center
48 Medical University
49 MethodsWe
50 Prefecture
51 Saitama Medical Center
52 Saitama Prefecture
53 University
54 adenomatous polyposis
55 age
56 age-standardized incidence
57 cancer
58 cancer patients
59 center
60 characteristics
61 clinicopathological features
62 colitic cancer
63 colonic sites
64 colorectal cancer
65 colorectal cancer patients
66 contrast
67 control
68 control group
69 database
70 extracolonic sites
71 familial adenomatous polyposis
72 features
73 gastric cancer
74 group
75 hereditary non-polyposis colorectal cancer
76 incidence
77 incidence of GC
78 malignancy
79 mass screening
80 median age
81 metastasis
82 multiple primary malignancies
83 non-polyposis colorectal cancer
84 occurrence
85 operation
86 pathological features
87 patient group
88 patients
89 people
90 perioperative screening
91 polyposis
92 primary malignancy
93 primary sporadic colorectal cancers
94 prognosis
95 screening
96 sites
97 sporadic CRC
98 sporadic colorectal cancer
99 study
100 synchronous gastric cancer
101 years
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