Polymorphism rs547984 on human chromosome 1q43 is not associated with primary open angle glaucoma in a Saudi cohort View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Taif A. Azad, Nikhil B. Edward, Altaf A. Kondkar, Hatem Kalantan, Saleh Altuwaijri, Tahira Sultan, Faisal A. Al-Mobarak, Saleh A. Al-Obeidan, Khaled K. Abu-Amero

ABSTRACT

BACKGROUND: To investigate the association between polymorphism rs547984, located in close proximity to the Zona Pellucida Glycoprotein 4 (ZP4) gene on human chromosome 1q43 and primary open angle glaucoma (POAG). METHOD: Polymorphism rs547984 was genotyped using Taq-Man® assay in 185 subjects comprising of 90 unrelated POAG cases and 95 controls of Saudi origin. RESULTS: Association analysis between cases and controls revealed no significant genotype distribution under additive (p = 0.356), dominant (p = 0.517) and recessive (p = 0.309) models. Besides, the allele frequency distribution was also found to be non-significant (p = 0.70). The minor "A" allele frequency was found to be 0.49 and 0.50 among POAG cases and controls, respectively. In addition, specific clinical indices used to assess severity of glaucoma such as intraocular pressure (IOP), cup/disc ratio and number of anti-glaucoma medication also did not show any significant genotype distribution in POAG cases. CONCLUSION: Polymorphism rs547984 is neither associated with any clinical indices important for POAG such as IOP and cup/disc ratio nor is a risk factor for POAG in the Saudi cohort. More... »

PAGES

12

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12952-017-0077-0

DOI

http://dx.doi.org/10.1186/s12952-017-0077-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1086218163

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28648143


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