ADAMTS-18 in the host tissues exerts little effect on breast tumor progress in a murine 4T1 breast cancer model View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Min Liu, Tiantian Lu, Fang Jing, Suying Dang, Wei Zhang

ABSTRACT

BACKGROUND: In this study, we aimed to identify a novel extracellular proteinase ADAMTS-18 that could be a potential tumor suppressor gene. RESULTS: We successfully constructed Adamts-18 knockout mice with BALB / c background. RT-PCR analysis showed syngeneic mammary tumor cell line 4 T1 per se has weakly endogenous ADAMTS-18 expression. Orthotopic inoculation of 4 T1 cells within the mammary fat pad of host mice, we found no significant difference in tumor growth and metastasis between Adamts-18 knockout mice and widetype control. CONCLUSIONS: We did not confirm that ADAMTS-18 in the host tissues is relevant for breast tumor progress in a murine 4 T1 breast cancer model. More... »

PAGES

2

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12952-016-0045-0

DOI

http://dx.doi.org/10.1186/s12952-016-0045-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046274582

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26841794


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