Bone-targeted erythrocyte-cancer hybrid membrane-camouflaged nanoparticles for enhancing photothermal and hypoxia-activated chemotherapy of bone invasion by OSCC View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-10-26

AUTHORS

Hongying Chen, Jiang Deng, Xintong Yao, Yungang He, Hanyue Li, Zhixiang Jian, Yi Tang, Xiaoqing Zhang, Jingqing Zhang, Hongwei Dai

ABSTRACT

BackgroundJaw bones are the most common organs to be invaded by oral malignancies, such as oral squamous cell carcinoma (OSCC), because of their special anatomical relationship. Various serious complications, such as pathological fractures and bone pain can significantly decrease the quality of life or even survival outcomes for a patient. Although chemotherapy is a promising strategy for bone invasion treatment, its clinical applications are limited by the lack of tumor-specific targeting and poor permeability in bone tissue. Therefore, it is necessary to develop a smart bone and cancer dual targeting drug delivery platform.ResultsWe designed a dual targeting nano-biomimetic drug delivery vehicle Asp8[H40-TPZ/IR780@(RBC-H)] that has excellent bone and cancer targeting as well as immune escape abilities to treat malignancies in jaw bones. These nanoparticles were camouflaged with a head and neck squamous cell carcinoma WSU-HN6 cell (H) and red blood cell (RBC) hybrid membrane, which were modified by an oligopeptide of eight aspartate acid (Asp8). The spherical morphology and typical core-shell structure of biomimetic nanoparticles were observed by transmission electron microscopy. These nanoparticles exhibited the same surface proteins as those of WSU-HN6 and RBC. Flow cytometry and confocal microscopy showed a greater uptake of the biomimetic nanoparticles when compared to bare H40-PEG nanoparticles. Biodistribution of the nanoparticles in vivo revealed that they were mainly localized in the area of bone invasion by WSU-HN6 cells. Moreover, the Asp8[H40-TPZ/IR780@(RBC-H)] nanoparticles exhibited effective cancer growth inhibition properties when compared to other TPZ or IR780 formulations.ConclusionsAsp8[H40-TPZ/IR780@(RBC-H)] has bone targeting, tumor-homing and immune escape abilities, therefore, it is an efficient multi-targeting drug delivery platform for achieving precise anti-cancer therapy during bone invasion.Graphical Abstract More... »

PAGES

342

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12951-021-01088-9

DOI

http://dx.doi.org/10.1186/s12951-021-01088-9

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https://app.dimensions.ai/details/publication/pub.1142193308

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34702291


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30 schema:description BackgroundJaw bones are the most common organs to be invaded by oral malignancies, such as oral squamous cell carcinoma (OSCC), because of their special anatomical relationship. Various serious complications, such as pathological fractures and bone pain can significantly decrease the quality of life or even survival outcomes for a patient. Although chemotherapy is a promising strategy for bone invasion treatment, its clinical applications are limited by the lack of tumor-specific targeting and poor permeability in bone tissue. Therefore, it is necessary to develop a smart bone and cancer dual targeting drug delivery platform.ResultsWe designed a dual targeting nano-biomimetic drug delivery vehicle Asp8[H40-TPZ/IR780@(RBC-H)] that has excellent bone and cancer targeting as well as immune escape abilities to treat malignancies in jaw bones. These nanoparticles were camouflaged with a head and neck squamous cell carcinoma WSU-HN6 cell (H) and red blood cell (RBC) hybrid membrane, which were modified by an oligopeptide of eight aspartate acid (Asp8). The spherical morphology and typical core-shell structure of biomimetic nanoparticles were observed by transmission electron microscopy. These nanoparticles exhibited the same surface proteins as those of WSU-HN6 and RBC. Flow cytometry and confocal microscopy showed a greater uptake of the biomimetic nanoparticles when compared to bare H40-PEG nanoparticles. Biodistribution of the nanoparticles in vivo revealed that they were mainly localized in the area of bone invasion by WSU-HN6 cells. Moreover, the Asp8[H40-TPZ/IR780@(RBC-H)] nanoparticles exhibited effective cancer growth inhibition properties when compared to other TPZ or IR780 formulations.ConclusionsAsp8[H40-TPZ/IR780@(RBC-H)] has bone targeting, tumor-homing and immune escape abilities, therefore, it is an efficient multi-targeting drug delivery platform for achieving precise anti-cancer therapy during bone invasion.Graphical Abstract
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38 RBCs
39 ResultsWe
40 TPZ
41 WSU-HN6
42 WSU-HN6 cells
43 ability
44 acid
45 anatomical relationship
46 anti-cancer therapy
47 applications
48 area
49 aspartate acid
50 biodistribution
51 biomimetic nanoparticles
52 bone
53 bone invasion
54 bone pain
55 bone targeting
56 bone tissue
57 cancer
58 cancer targeting
59 carcinoma
60 cell carcinoma
61 cells
62 chemotherapy
63 clinical application
64 common organ
65 complications
66 confocal microscopy
67 core-shell structure
68 cytometry
69 delivery platform
70 delivery vehicles
71 drug delivery platform
72 drug delivery vehicles
73 electron microscopy
74 escape ability
75 excellent bone
76 formulation
77 fractures
78 greater uptake
79 growth inhibition properties
80 head
81 hybrid membranes
82 hypoxia
83 immune escape ability
84 inhibition properties
85 invasion
86 invasion treatment
87 jaw bones
88 lack
89 life
90 malignancy
91 membrane
92 microscopy
93 morphology
94 nanoparticles
95 oligopeptides
96 oral malignancies
97 oral squamous cell carcinoma
98 organs
99 outcomes
100 pain
101 pathological fractures
102 patients
103 permeability
104 photothermal
105 platform
106 poor permeability
107 promising strategy
108 properties
109 protein
110 quality
111 quality of life
112 relationship
113 same surface proteins
114 serious complications
115 spherical morphology
116 squamous cell carcinoma
117 strategies
118 structure
119 surface proteins
120 survival outcomes
121 targeting
122 therapy
123 tissue
124 transmission electron microscopy
125 treatment
126 tumor-specific targeting
127 typical core-shell structure
128 uptake
129 vehicles
130 vivo
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