Bone-targeted erythrocyte-cancer hybrid membrane-camouflaged nanoparticles for enhancing photothermal and hypoxia-activated chemotherapy of bone invasion by OSCC View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-10-26

AUTHORS

Hongying Chen, Jiang Deng, Xintong Yao, Yungang He, Hanyue Li, Zhixiang Jian, Yi Tang, Xiaoqing Zhang, Jingqing Zhang, Hongwei Dai

ABSTRACT

BACKGROUND: Jaw bones are the most common organs to be invaded by oral malignancies, such as oral squamous cell carcinoma (OSCC), because of their special anatomical relationship. Various serious complications, such as pathological fractures and bone pain can significantly decrease the quality of life or even survival outcomes for a patient. Although chemotherapy is a promising strategy for bone invasion treatment, its clinical applications are limited by the lack of tumor-specific targeting and poor permeability in bone tissue. Therefore, it is necessary to develop a smart bone and cancer dual targeting drug delivery platform. RESULTS: We designed a dual targeting nano-biomimetic drug delivery vehicle Asp8[H40-TPZ/IR780@(RBC-H)] that has excellent bone and cancer targeting as well as immune escape abilities to treat malignancies in jaw bones. These nanoparticles were camouflaged with a head and neck squamous cell carcinoma WSU-HN6 cell (H) and red blood cell (RBC) hybrid membrane, which were modified by an oligopeptide of eight aspartate acid (Asp8). The spherical morphology and typical core-shell structure of biomimetic nanoparticles were observed by transmission electron microscopy. These nanoparticles exhibited the same surface proteins as those of WSU-HN6 and RBC. Flow cytometry and confocal microscopy showed a greater uptake of the biomimetic nanoparticles when compared to bare H40-PEG nanoparticles. Biodistribution of the nanoparticles in vivo revealed that they were mainly localized in the area of bone invasion by WSU-HN6 cells. Moreover, the Asp8[H40-TPZ/IR780@(RBC-H)] nanoparticles exhibited effective cancer growth inhibition properties when compared to other TPZ or IR780 formulations. CONCLUSIONS: Asp8[H40-TPZ/IR780@(RBC-H)] has bone targeting, tumor-homing and immune escape abilities, therefore, it is an efficient multi-targeting drug delivery platform for achieving precise anti-cancer therapy during bone invasion. More... »

PAGES

342

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12951-021-01088-9

DOI

http://dx.doi.org/10.1186/s12951-021-01088-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1142193308

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34702291


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/10", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Technology", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, 401147 China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "College of Stomatology, Chongqing Medical University, Chongqing, 401147 China", 
            "Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing, 401147 China", 
            "Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, 401147 China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Hongying", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, 401147 China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "College of Stomatology, Chongqing Medical University, Chongqing, 401147 China", 
            "Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing, 401147 China", 
            "Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, 401147 China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Deng", 
        "givenName": "Jiang", 
        "id": "sg:person.012155054701.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012155054701.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Key Laboratory of Biochemistry and Molecular Pharmacology of Chongqing, Chongqing Medical University, Chongqing, 400016 China", 
          "id": "http://www.grid.ac/institutes/grid.203458.8", 
          "name": [
            "Department of Pharmacology, School of Pharmacy, Chongqing Medical University, Chongqing, 400016 China", 
            "Key Laboratory of Biochemistry and Molecular Pharmacology of Chongqing, Chongqing Medical University, Chongqing, 400016 China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yao", 
        "givenName": "Xintong", 
        "id": "sg:person.010106603031.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010106603031.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, 401147 China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "College of Stomatology, Chongqing Medical University, Chongqing, 401147 China", 
            "Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing, 401147 China", 
            "Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, 401147 China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "He", 
        "givenName": "Yungang", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, 401147 China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "College of Stomatology, Chongqing Medical University, Chongqing, 401147 China", 
            "Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing, 401147 China", 
            "Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, 401147 China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Hanyue", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, 401147 China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "College of Stomatology, Chongqing Medical University, Chongqing, 401147 China", 
            "Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing, 401147 China", 
            "Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, 401147 China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jian", 
        "givenName": "Zhixiang", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, 401147 China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "College of Stomatology, Chongqing Medical University, Chongqing, 401147 China", 
            "Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing, 401147 China", 
            "Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, 401147 China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tang", 
        "givenName": "Yi", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, 401147 China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "College of Stomatology, Chongqing Medical University, Chongqing, 401147 China", 
            "Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing, 401147 China", 
            "Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, 401147 China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Xiaoqing", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chongqing Research Center for Pharmaceutical Engineering, Chongqing Medical University, Chongqing, 400016 China", 
          "id": "http://www.grid.ac/institutes/grid.203458.8", 
          "name": [
            "Chongqing Research Center for Pharmaceutical Engineering, Chongqing Medical University, Chongqing, 400016 China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Jingqing", 
        "id": "sg:person.01004146360.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004146360.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, 401147 China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "College of Stomatology, Chongqing Medical University, Chongqing, 401147 China", 
            "Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing, 401147 China", 
            "Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, 401147 China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dai", 
        "givenName": "Hongwei", 
        "id": "sg:person.01032705253.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032705253.13"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/bjc.2017.239", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090892633", 
          "https://doi.org/10.1038/bjc.2017.239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10555-011-9335-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032282589", 
          "https://doi.org/10.1007/s10555-011-9335-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12951-015-0116-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035015350", 
          "https://doi.org/10.1186/s12951-015-0116-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12951-018-0378-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104525333", 
          "https://doi.org/10.1186/s12951-018-0378-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12951-019-0494-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1114207054", 
          "https://doi.org/10.1186/s12951-019-0494-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1477-3155-9-32", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008895070", 
          "https://doi.org/10.1186/1477-3155-9-32"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12951-020-0573-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1124278782", 
          "https://doi.org/10.1186/s12951-020-0573-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-019-51029-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1121576044", 
          "https://doi.org/10.1038/s41598-019-51029-8"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2021-10-26", 
    "datePublishedReg": "2021-10-26", 
    "description": "BACKGROUND: Jaw bones are the most common organs to be invaded by oral malignancies, such as oral squamous cell carcinoma (OSCC), because of their special anatomical relationship. Various serious complications, such as pathological fractures and bone pain can significantly decrease the quality of life or even survival outcomes for a patient. Although chemotherapy is a promising strategy for bone invasion treatment, its clinical applications are limited by the lack of tumor-specific targeting and poor permeability in bone tissue. Therefore, it is necessary to develop a smart bone and cancer dual targeting drug delivery platform.\nRESULTS: We designed a dual targeting nano-biomimetic drug delivery vehicle Asp8[H40-TPZ/IR780@(RBC-H)] that has excellent bone and cancer targeting as well as immune escape abilities to treat malignancies in jaw bones. These nanoparticles were camouflaged with a head and neck squamous cell carcinoma WSU-HN6 cell (H) and red blood cell (RBC) hybrid membrane, which were modified by an oligopeptide of eight aspartate acid (Asp8). The spherical morphology and typical core-shell structure of biomimetic nanoparticles were observed by transmission electron microscopy. These nanoparticles exhibited the same surface proteins as those of WSU-HN6 and RBC. Flow cytometry and confocal microscopy showed a greater uptake of the biomimetic nanoparticles when compared to bare H40-PEG nanoparticles. Biodistribution of the nanoparticles in vivo revealed that they were mainly localized in the area of bone invasion by WSU-HN6 cells. Moreover, the Asp8[H40-TPZ/IR780@(RBC-H)] nanoparticles exhibited effective cancer growth inhibition properties when compared to other TPZ or IR780 formulations.\nCONCLUSIONS: Asp8[H40-TPZ/IR780@(RBC-H)] has bone targeting, tumor-homing and immune escape abilities, therefore, it is an efficient multi-targeting drug delivery platform for achieving precise anti-cancer therapy during bone invasion.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s12951-021-01088-9", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1031280", 
        "issn": [
          "1477-3155"
        ], 
        "name": "Journal of Nanobiotechnology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "keywords": [
      "drug delivery platform", 
      "biomimetic nanoparticles", 
      "immune escape ability", 
      "delivery platform", 
      "typical core-shell structure", 
      "core-shell structure", 
      "oral squamous cell carcinoma", 
      "transmission electron microscopy", 
      "drug delivery vehicles", 
      "tumor-specific targeting", 
      "escape ability", 
      "nanoparticles", 
      "spherical morphology", 
      "cancer targeting", 
      "bone invasion", 
      "delivery vehicles", 
      "electron microscopy", 
      "hybrid membranes", 
      "bone targeting", 
      "growth inhibition properties", 
      "jaw bones", 
      "squamous cell carcinoma", 
      "promising strategy", 
      "quality of life", 
      "microscopy", 
      "poor permeability", 
      "anti-cancer therapy", 
      "bone pain", 
      "pathological fractures", 
      "common organ", 
      "serious complications", 
      "oral malignancies", 
      "survival outcomes", 
      "cell carcinoma", 
      "platform", 
      "clinical applications", 
      "photothermal", 
      "anatomical relationship", 
      "excellent bone", 
      "targeting", 
      "aspartate acid", 
      "WSU-HN6", 
      "chemotherapy", 
      "malignancy", 
      "bone tissue", 
      "bone", 
      "biodistribution", 
      "invasion", 
      "confocal microscopy", 
      "surface proteins", 
      "greater uptake", 
      "morphology", 
      "inhibition properties", 
      "applications", 
      "cells", 
      "pain", 
      "complications", 
      "patients", 
      "carcinoma", 
      "therapy", 
      "cancer", 
      "hypoxia", 
      "cytometry", 
      "outcomes", 
      "treatment", 
      "properties", 
      "organs", 
      "vivo", 
      "RBCs", 
      "tissue", 
      "fractures", 
      "ability", 
      "TPZ", 
      "structure", 
      "head", 
      "uptake", 
      "vehicles", 
      "acid", 
      "protein", 
      "membrane", 
      "life", 
      "lack", 
      "strategies", 
      "oligopeptides", 
      "formulation", 
      "quality", 
      "area", 
      "relationship", 
      "permeability", 
      "invasion treatments", 
      "special anatomical relationship", 
      "bone invasion treatment", 
      "smart bone", 
      "nano-biomimetic drug delivery vehicle", 
      "neck squamous cell carcinoma WSU-HN6 cell", 
      "squamous cell carcinoma WSU-HN6 cell", 
      "cell carcinoma WSU-HN6 cell", 
      "carcinoma WSU-HN6 cell", 
      "WSU-HN6 cell", 
      "red blood cell (RBC) hybrid membrane", 
      "blood cell (RBC) hybrid membrane", 
      "cell (RBC) hybrid membrane", 
      "same surface proteins", 
      "bare H40-PEG nanoparticles", 
      "H40-PEG nanoparticles", 
      "effective cancer growth inhibition properties", 
      "cancer growth inhibition properties", 
      "IR780 formulations", 
      "efficient multi-targeting drug delivery platform", 
      "multi-targeting drug delivery platform", 
      "precise anti-cancer therapy", 
      "Bone-targeted erythrocyte-cancer hybrid membrane-camouflaged nanoparticles", 
      "erythrocyte-cancer hybrid membrane-camouflaged nanoparticles", 
      "hybrid membrane-camouflaged nanoparticles", 
      "membrane-camouflaged nanoparticles"
    ], 
    "name": "Bone-targeted erythrocyte-cancer hybrid membrane-camouflaged nanoparticles for enhancing photothermal and hypoxia-activated chemotherapy of bone invasion by OSCC", 
    "pagination": "342", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1142193308"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12951-021-01088-9"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "34702291"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12951-021-01088-9", 
      "https://app.dimensions.ai/details/publication/pub.1142193308"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:57", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_894.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s12951-021-01088-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12951-021-01088-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12951-021-01088-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12951-021-01088-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12951-021-01088-9'


 

This table displays all metadata directly associated to this object as RDF triples.

269 TRIPLES      22 PREDICATES      148 URIs      133 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12951-021-01088-9 schema:about anzsrc-for:10
2 schema:author Nb2ab2e200f8045e9bca134ec27805db3
3 schema:citation sg:pub.10.1007/s10555-011-9335-7
4 sg:pub.10.1038/bjc.2017.239
5 sg:pub.10.1038/s41598-019-51029-8
6 sg:pub.10.1186/1477-3155-9-32
7 sg:pub.10.1186/s12951-015-0116-2
8 sg:pub.10.1186/s12951-018-0378-6
9 sg:pub.10.1186/s12951-019-0494-y
10 sg:pub.10.1186/s12951-020-0573-0
11 schema:datePublished 2021-10-26
12 schema:datePublishedReg 2021-10-26
13 schema:description BACKGROUND: Jaw bones are the most common organs to be invaded by oral malignancies, such as oral squamous cell carcinoma (OSCC), because of their special anatomical relationship. Various serious complications, such as pathological fractures and bone pain can significantly decrease the quality of life or even survival outcomes for a patient. Although chemotherapy is a promising strategy for bone invasion treatment, its clinical applications are limited by the lack of tumor-specific targeting and poor permeability in bone tissue. Therefore, it is necessary to develop a smart bone and cancer dual targeting drug delivery platform. RESULTS: We designed a dual targeting nano-biomimetic drug delivery vehicle Asp8[H40-TPZ/IR780@(RBC-H)] that has excellent bone and cancer targeting as well as immune escape abilities to treat malignancies in jaw bones. These nanoparticles were camouflaged with a head and neck squamous cell carcinoma WSU-HN6 cell (H) and red blood cell (RBC) hybrid membrane, which were modified by an oligopeptide of eight aspartate acid (Asp8). The spherical morphology and typical core-shell structure of biomimetic nanoparticles were observed by transmission electron microscopy. These nanoparticles exhibited the same surface proteins as those of WSU-HN6 and RBC. Flow cytometry and confocal microscopy showed a greater uptake of the biomimetic nanoparticles when compared to bare H40-PEG nanoparticles. Biodistribution of the nanoparticles in vivo revealed that they were mainly localized in the area of bone invasion by WSU-HN6 cells. Moreover, the Asp8[H40-TPZ/IR780@(RBC-H)] nanoparticles exhibited effective cancer growth inhibition properties when compared to other TPZ or IR780 formulations. CONCLUSIONS: Asp8[H40-TPZ/IR780@(RBC-H)] has bone targeting, tumor-homing and immune escape abilities, therefore, it is an efficient multi-targeting drug delivery platform for achieving precise anti-cancer therapy during bone invasion.
14 schema:genre article
15 schema:inLanguage en
16 schema:isAccessibleForFree true
17 schema:isPartOf N21a9e2020396448a9e078f53dcb50c10
18 Ne81840f1949d4395a37ab579c22fe618
19 sg:journal.1031280
20 schema:keywords Bone-targeted erythrocyte-cancer hybrid membrane-camouflaged nanoparticles
21 H40-PEG nanoparticles
22 IR780 formulations
23 RBCs
24 TPZ
25 WSU-HN6
26 WSU-HN6 cell
27 ability
28 acid
29 anatomical relationship
30 anti-cancer therapy
31 applications
32 area
33 aspartate acid
34 bare H40-PEG nanoparticles
35 biodistribution
36 biomimetic nanoparticles
37 blood cell (RBC) hybrid membrane
38 bone
39 bone invasion
40 bone invasion treatment
41 bone pain
42 bone targeting
43 bone tissue
44 cancer
45 cancer growth inhibition properties
46 cancer targeting
47 carcinoma
48 carcinoma WSU-HN6 cell
49 cell (RBC) hybrid membrane
50 cell carcinoma
51 cell carcinoma WSU-HN6 cell
52 cells
53 chemotherapy
54 clinical applications
55 common organ
56 complications
57 confocal microscopy
58 core-shell structure
59 cytometry
60 delivery platform
61 delivery vehicles
62 drug delivery platform
63 drug delivery vehicles
64 effective cancer growth inhibition properties
65 efficient multi-targeting drug delivery platform
66 electron microscopy
67 erythrocyte-cancer hybrid membrane-camouflaged nanoparticles
68 escape ability
69 excellent bone
70 formulation
71 fractures
72 greater uptake
73 growth inhibition properties
74 head
75 hybrid membrane-camouflaged nanoparticles
76 hybrid membranes
77 hypoxia
78 immune escape ability
79 inhibition properties
80 invasion
81 invasion treatments
82 jaw bones
83 lack
84 life
85 malignancy
86 membrane
87 membrane-camouflaged nanoparticles
88 microscopy
89 morphology
90 multi-targeting drug delivery platform
91 nano-biomimetic drug delivery vehicle
92 nanoparticles
93 neck squamous cell carcinoma WSU-HN6 cell
94 oligopeptides
95 oral malignancies
96 oral squamous cell carcinoma
97 organs
98 outcomes
99 pain
100 pathological fractures
101 patients
102 permeability
103 photothermal
104 platform
105 poor permeability
106 precise anti-cancer therapy
107 promising strategy
108 properties
109 protein
110 quality
111 quality of life
112 red blood cell (RBC) hybrid membrane
113 relationship
114 same surface proteins
115 serious complications
116 smart bone
117 special anatomical relationship
118 spherical morphology
119 squamous cell carcinoma
120 squamous cell carcinoma WSU-HN6 cell
121 strategies
122 structure
123 surface proteins
124 survival outcomes
125 targeting
126 therapy
127 tissue
128 transmission electron microscopy
129 treatment
130 tumor-specific targeting
131 typical core-shell structure
132 uptake
133 vehicles
134 vivo
135 schema:name Bone-targeted erythrocyte-cancer hybrid membrane-camouflaged nanoparticles for enhancing photothermal and hypoxia-activated chemotherapy of bone invasion by OSCC
136 schema:pagination 342
137 schema:productId N21535c23eb734561a8fec6c088fc3960
138 N8835feee82a0402395673aafe8f7265c
139 Nc6902c4889e1450e8ac12126a1a93147
140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1142193308
141 https://doi.org/10.1186/s12951-021-01088-9
142 schema:sdDatePublished 2022-01-01T18:57
143 schema:sdLicense https://scigraph.springernature.com/explorer/license/
144 schema:sdPublisher N173c4175c4ec45dfa54fd91694f462eb
145 schema:url https://doi.org/10.1186/s12951-021-01088-9
146 sgo:license sg:explorer/license/
147 sgo:sdDataset articles
148 rdf:type schema:ScholarlyArticle
149 N05c7423ad60f425aa25bc129912d9cac rdf:first N9572740fcc194272be13c23c4d5fbd52
150 rdf:rest N0b5ca0c79c5d441d8f9fc4ee768a4429
151 N069523e8fc75409a98f1bd112f5e7552 rdf:first sg:person.012155054701.33
152 rdf:rest N7287d82ff90d4bf8ae11e6269ab01bbe
153 N0b5ca0c79c5d441d8f9fc4ee768a4429 rdf:first Nf5ddb5dcf90340acbdcc38964cdbccff
154 rdf:rest N136c530f84ea4fd2880525090097e2d1
155 N136c530f84ea4fd2880525090097e2d1 rdf:first sg:person.01004146360.44
156 rdf:rest N23ae830f4f204da2bbe16dccf974b650
157 N173c4175c4ec45dfa54fd91694f462eb schema:name Springer Nature - SN SciGraph project
158 rdf:type schema:Organization
159 N21535c23eb734561a8fec6c088fc3960 schema:name doi
160 schema:value 10.1186/s12951-021-01088-9
161 rdf:type schema:PropertyValue
162 N21a9e2020396448a9e078f53dcb50c10 schema:volumeNumber 19
163 rdf:type schema:PublicationVolume
164 N23ae830f4f204da2bbe16dccf974b650 rdf:first sg:person.01032705253.13
165 rdf:rest rdf:nil
166 N257b2ac8c1524c3ea90af1e902e2a984 schema:affiliation grid-institutes:None
167 schema:familyName Chen
168 schema:givenName Hongying
169 rdf:type schema:Person
170 N2e28c48cb1294a9e83c8cccd6ef8e637 rdf:first Nd3a230ee42134bed807d9004ab9418bb
171 rdf:rest Na00c606d5883497f91ea966fb8ac8f49
172 N63eef5283719405d83dd1876449d0b50 schema:affiliation grid-institutes:None
173 schema:familyName He
174 schema:givenName Yungang
175 rdf:type schema:Person
176 N66a35e8f7fd146198461119ee811aeeb schema:affiliation grid-institutes:None
177 schema:familyName Jian
178 schema:givenName Zhixiang
179 rdf:type schema:Person
180 N7287d82ff90d4bf8ae11e6269ab01bbe rdf:first sg:person.010106603031.09
181 rdf:rest N72fb1b5b2dd94c258845524fee14b901
182 N72fb1b5b2dd94c258845524fee14b901 rdf:first N63eef5283719405d83dd1876449d0b50
183 rdf:rest N2e28c48cb1294a9e83c8cccd6ef8e637
184 N8835feee82a0402395673aafe8f7265c schema:name pubmed_id
185 schema:value 34702291
186 rdf:type schema:PropertyValue
187 N9572740fcc194272be13c23c4d5fbd52 schema:affiliation grid-institutes:None
188 schema:familyName Tang
189 schema:givenName Yi
190 rdf:type schema:Person
191 Na00c606d5883497f91ea966fb8ac8f49 rdf:first N66a35e8f7fd146198461119ee811aeeb
192 rdf:rest N05c7423ad60f425aa25bc129912d9cac
193 Nb2ab2e200f8045e9bca134ec27805db3 rdf:first N257b2ac8c1524c3ea90af1e902e2a984
194 rdf:rest N069523e8fc75409a98f1bd112f5e7552
195 Nc6902c4889e1450e8ac12126a1a93147 schema:name dimensions_id
196 schema:value pub.1142193308
197 rdf:type schema:PropertyValue
198 Nd3a230ee42134bed807d9004ab9418bb schema:affiliation grid-institutes:None
199 schema:familyName Li
200 schema:givenName Hanyue
201 rdf:type schema:Person
202 Ne81840f1949d4395a37ab579c22fe618 schema:issueNumber 1
203 rdf:type schema:PublicationIssue
204 Nf5ddb5dcf90340acbdcc38964cdbccff schema:affiliation grid-institutes:None
205 schema:familyName Zhang
206 schema:givenName Xiaoqing
207 rdf:type schema:Person
208 anzsrc-for:10 schema:inDefinedTermSet anzsrc-for:
209 schema:name Technology
210 rdf:type schema:DefinedTerm
211 sg:journal.1031280 schema:issn 1477-3155
212 schema:name Journal of Nanobiotechnology
213 schema:publisher Springer Nature
214 rdf:type schema:Periodical
215 sg:person.01004146360.44 schema:affiliation grid-institutes:grid.203458.8
216 schema:familyName Zhang
217 schema:givenName Jingqing
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004146360.44
219 rdf:type schema:Person
220 sg:person.010106603031.09 schema:affiliation grid-institutes:grid.203458.8
221 schema:familyName Yao
222 schema:givenName Xintong
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010106603031.09
224 rdf:type schema:Person
225 sg:person.01032705253.13 schema:affiliation grid-institutes:None
226 schema:familyName Dai
227 schema:givenName Hongwei
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032705253.13
229 rdf:type schema:Person
230 sg:person.012155054701.33 schema:affiliation grid-institutes:None
231 schema:familyName Deng
232 schema:givenName Jiang
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012155054701.33
234 rdf:type schema:Person
235 sg:pub.10.1007/s10555-011-9335-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032282589
236 https://doi.org/10.1007/s10555-011-9335-7
237 rdf:type schema:CreativeWork
238 sg:pub.10.1038/bjc.2017.239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090892633
239 https://doi.org/10.1038/bjc.2017.239
240 rdf:type schema:CreativeWork
241 sg:pub.10.1038/s41598-019-51029-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1121576044
242 https://doi.org/10.1038/s41598-019-51029-8
243 rdf:type schema:CreativeWork
244 sg:pub.10.1186/1477-3155-9-32 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008895070
245 https://doi.org/10.1186/1477-3155-9-32
246 rdf:type schema:CreativeWork
247 sg:pub.10.1186/s12951-015-0116-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035015350
248 https://doi.org/10.1186/s12951-015-0116-2
249 rdf:type schema:CreativeWork
250 sg:pub.10.1186/s12951-018-0378-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104525333
251 https://doi.org/10.1186/s12951-018-0378-6
252 rdf:type schema:CreativeWork
253 sg:pub.10.1186/s12951-019-0494-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1114207054
254 https://doi.org/10.1186/s12951-019-0494-y
255 rdf:type schema:CreativeWork
256 sg:pub.10.1186/s12951-020-0573-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1124278782
257 https://doi.org/10.1186/s12951-020-0573-0
258 rdf:type schema:CreativeWork
259 grid-institutes:None schema:alternateName Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, 401147 China
260 schema:name Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing, 401147 China
261 Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, 401147 China
262 College of Stomatology, Chongqing Medical University, Chongqing, 401147 China
263 rdf:type schema:Organization
264 grid-institutes:grid.203458.8 schema:alternateName Chongqing Research Center for Pharmaceutical Engineering, Chongqing Medical University, Chongqing, 400016 China
265 Key Laboratory of Biochemistry and Molecular Pharmacology of Chongqing, Chongqing Medical University, Chongqing, 400016 China
266 schema:name Chongqing Research Center for Pharmaceutical Engineering, Chongqing Medical University, Chongqing, 400016 China
267 Department of Pharmacology, School of Pharmacy, Chongqing Medical University, Chongqing, 400016 China
268 Key Laboratory of Biochemistry and Molecular Pharmacology of Chongqing, Chongqing Medical University, Chongqing, 400016 China
269 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...