Celastrol-based nanomedicine promotes corneal allograft survival View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-10-26

AUTHORS

Zhanrong Li, Ruixing Liu, Zhihua Guo, Dandan Chu, Lei Zhu, Junjie Zhang, Xintao Shuai, Jingguo Li

ABSTRACT

Effectively promoting corneal allograft survival remains a challenge in corneal transplantation. The emerging therapeutic agents with high pharmacological activities and their appropriate administration routes provide attractive solutions. In the present study, a celastrol-loaded positive nanomedicine (CPNM) was developed to enhance corneal penetration and to promote corneal allograft survival. The in vitro, in vivo and ex vivo results demonstrated the good performance of CPNM prolonging the retention time on ocular surface and opening the tight junction in cornea, which resulted in enhanced corneal permeability of celastrol. Both in vitro and in vivo results demonstrated that celastrol inhibited the recruitment of M1 macrophage and the expression of TLR4 in corneal allografts through the TLR4/MyD88/NF-κB pathway, thereby significantly decreasing secretion of multiple pro-inflammatory cytokines to promote corneal allograft survival. This is the first celastrol-based topical instillation against corneal allograft rejection to provide treatment more potent than conventional eye drops for ocular anterior segment diseases. More... »

PAGES

341

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12951-021-01079-w

DOI

http://dx.doi.org/10.1186/s12951-021-01079-w

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1142180814

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34702273


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