Multifunctional silica nanocomposites prime tumoricidal immunity for efficient cancer immunotherapy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-10-18

AUTHORS

Linnan Yang, Feng Li, Yongsheng Cao, Qiang Liu, Guoxin Jing, Jintong Niu, Feiyue Sun, Yechang Qian, Shilong Wang, Ang Li

ABSTRACT

The tumor immune microenvironment (TIME) has been demonstrated to be the main cause of cancer immunotherapy failure in various malignant tumors, due to poor immunogenicity and existence of immunosuppressive factors. Thus, establishing effective treatments for hostile TIME remodeling has considerable potential to enhance immune response rates for durable tumor growth retardation. This study aims to develop a novel nanocomposite, polyethyleneimine-modified dendritic mesoporous silica nanoparticles loaded with microRNA-125a (DMSN-PEI@125a) to synergistically enhance immune response and immunosuppression reversion, ultimately generating a tumoricidal environment. Our results showed that DMSN-PEI@125a exhibited excellent ability in cellular uptake by murine macrophages and the cervical cancer cell line TC-1, repolarization of tumor associated macrophages (TAMs) to M1 type in a synergistic manner, and promotion of TC-1 immunogenic death. Intratumor injection of DMSN-PEI@125a facilitated the release of more damage-related molecular patterns and enhanced the infiltration of natural killer and CD8+ T cells. Meanwhile, repolarized TAMs could function as a helper to promote antitumor immunity, thus inhibiting tumor growth in TC-1 mouse models in a collaborative manner. Collectively, this work highlights the multifunctional roles of DMSN-PEI@125a in generating an inflammatory TIME and provoking antitumor immunity, which may serve as a potential agent for cancer immunotherapy. More... »

PAGES

328

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12951-021-01073-2

DOI

http://dx.doi.org/10.1186/s12951-021-01073-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1141971411

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34663354


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/10", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Technology", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Central Laboratory, First Affiliated Hospital, Anhui Medical University, Hefei, People\u2019s Republic of China", 
          "id": "http://www.grid.ac/institutes/grid.186775.a", 
          "name": [
            "Research Center for Translational Medicine at East Hospital, School of Life Science and Technology, Tongji University, Shanghai, People\u2019s Republic of China", 
            "Central Laboratory, First Affiliated Hospital, Anhui Medical University, Hefei, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Linnan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Research Center for Translational Medicine at East Hospital, School of Life Science and Technology, Tongji University, Shanghai, People\u2019s Republic of China", 
          "id": "http://www.grid.ac/institutes/grid.24516.34", 
          "name": [
            "Research Center for Translational Medicine at East Hospital, School of Life Science and Technology, Tongji University, Shanghai, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Feng", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Second Department of Urology, Anhui Provincial Children\u2019s Hospital, Hefei, People\u2019s Republic of China", 
          "id": "http://www.grid.ac/institutes/grid.489986.2", 
          "name": [
            "The Second Department of Urology, Anhui Provincial Children\u2019s Hospital, Hefei, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cao", 
        "givenName": "Yongsheng", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Research Center for Translational Medicine at East Hospital, School of Life Science and Technology, Tongji University, Shanghai, People\u2019s Republic of China", 
          "id": "http://www.grid.ac/institutes/grid.24516.34", 
          "name": [
            "Research Center for Translational Medicine at East Hospital, School of Life Science and Technology, Tongji University, Shanghai, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Qiang", 
        "id": "sg:person.012541076474.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012541076474.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Research Center for Translational Medicine at East Hospital, School of Life Science and Technology, Tongji University, Shanghai, People\u2019s Republic of China", 
          "id": "http://www.grid.ac/institutes/grid.24516.34", 
          "name": [
            "Research Center for Translational Medicine at East Hospital, School of Life Science and Technology, Tongji University, Shanghai, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jing", 
        "givenName": "Guoxin", 
        "id": "sg:person.013646611775.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013646611775.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Research Center for Translational Medicine at East Hospital, School of Life Science and Technology, Tongji University, Shanghai, People\u2019s Republic of China", 
          "id": "http://www.grid.ac/institutes/grid.24516.34", 
          "name": [
            "Research Center for Translational Medicine at East Hospital, School of Life Science and Technology, Tongji University, Shanghai, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Niu", 
        "givenName": "Jintong", 
        "id": "sg:person.010027547617.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010027547617.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Research Center for Translational Medicine at East Hospital, School of Life Science and Technology, Tongji University, Shanghai, People\u2019s Republic of China", 
          "id": "http://www.grid.ac/institutes/grid.24516.34", 
          "name": [
            "Research Center for Translational Medicine at East Hospital, School of Life Science and Technology, Tongji University, Shanghai, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sun", 
        "givenName": "Feiyue", 
        "id": "sg:person.010055417665.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010055417665.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Respiratory Disease, Baoshan District Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai, People\u2019s Republic of China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Respiratory Disease, Baoshan District Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Qian", 
        "givenName": "Yechang", 
        "id": "sg:person.01051453631.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051453631.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Research Center for Translational Medicine at East Hospital, School of Life Science and Technology, Tongji University, Shanghai, People\u2019s Republic of China", 
          "id": "http://www.grid.ac/institutes/grid.24516.34", 
          "name": [
            "Research Center for Translational Medicine at East Hospital, School of Life Science and Technology, Tongji University, Shanghai, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Shilong", 
        "id": "sg:person.01367531312.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367531312.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Research Center for Translational Medicine at East Hospital, School of Life Science and Technology, Tongji University, Shanghai, People\u2019s Republic of China", 
          "id": "http://www.grid.ac/institutes/grid.24516.34", 
          "name": [
            "Research Center for Translational Medicine at East Hospital, School of Life Science and Technology, Tongji University, Shanghai, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Ang", 
        "id": "sg:person.0632334505.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632334505.74"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nature21349", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000326025", 
          "https://doi.org/10.1038/nature21349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41591-018-0014-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103565849", 
          "https://doi.org/10.1038/s41591-018-0014-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1256", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043086899", 
          "https://doi.org/10.1038/nrc1256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12951-019-0541-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1121885717", 
          "https://doi.org/10.1186/s12951-019-0541-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc3380", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003607076", 
          "https://doi.org/10.1038/nrc3380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cddis.2017.352", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090951360", 
          "https://doi.org/10.1038/cddis.2017.352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb3371", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041062495", 
          "https://doi.org/10.1038/ncb3371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12951-021-00805-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1135750045", 
          "https://doi.org/10.1186/s12951-021-00805-8"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2021-10-18", 
    "datePublishedReg": "2021-10-18", 
    "description": "The tumor immune microenvironment (TIME) has been demonstrated to be the main cause of cancer immunotherapy failure in various malignant tumors, due to poor immunogenicity and existence of immunosuppressive factors. Thus, establishing effective treatments for hostile TIME remodeling has considerable potential to enhance immune response rates for durable tumor growth retardation. This study aims to develop a novel nanocomposite, polyethyleneimine-modified dendritic mesoporous silica nanoparticles loaded with microRNA-125a (DMSN-PEI@125a) to synergistically enhance immune response and immunosuppression reversion, ultimately generating a tumoricidal environment. Our results showed that DMSN-PEI@125a exhibited excellent ability in cellular uptake by murine macrophages and the cervical cancer cell line TC-1, repolarization of tumor associated macrophages (TAMs) to M1 type in a synergistic manner, and promotion of TC-1 immunogenic death. Intratumor injection of DMSN-PEI@125a facilitated the release of more damage-related molecular patterns and enhanced the infiltration of natural killer and CD8+ T cells. Meanwhile, repolarized TAMs could function as a helper to promote antitumor immunity, thus inhibiting tumor growth in TC-1 mouse models in a collaborative manner. Collectively, this work highlights the multifunctional roles of DMSN-PEI@125a in generating an inflammatory TIME and provoking antitumor immunity, which may serve as a potential agent for cancer immunotherapy.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s12951-021-01073-2", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.8200805", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.8202821", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1031280", 
        "issn": [
          "1477-3155"
        ], 
        "name": "Journal of Nanobiotechnology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "keywords": [
      "tumor immune microenvironment", 
      "antitumor immunity", 
      "cancer immunotherapy", 
      "TC-1 mouse model", 
      "immune response rate", 
      "tumor growth retardation", 
      "efficient cancer immunotherapy", 
      "immunotherapy failure", 
      "natural killer", 
      "immune microenvironment", 
      "immunosuppressive factors", 
      "poor immunogenicity", 
      "immunogenic death", 
      "malignant tumors", 
      "immune response", 
      "effective treatment", 
      "intratumor injection", 
      "mouse model", 
      "M1 type", 
      "response rate", 
      "tumor growth", 
      "growth retardation", 
      "molecular patterns", 
      "microRNA-125a", 
      "immunity", 
      "murine macrophages", 
      "potential agent", 
      "immunotherapy", 
      "tumors", 
      "macrophages", 
      "synergistic manner", 
      "main cause", 
      "TC-1", 
      "cellular uptake", 
      "CD8", 
      "immunogenicity", 
      "repolarization", 
      "multifunctional role", 
      "death", 
      "infiltration", 
      "remodeling", 
      "killer", 
      "treatment", 
      "injection", 
      "dendritic mesoporous silica nanoparticles", 
      "cause", 
      "microenvironment", 
      "helper", 
      "retardation", 
      "cells", 
      "failure", 
      "manner", 
      "agents", 
      "release", 
      "uptake", 
      "response", 
      "TAM", 
      "factors", 
      "study", 
      "role", 
      "promotion", 
      "rate", 
      "DMSN", 
      "considerable potential", 
      "reversion", 
      "mesoporous silica nanoparticles", 
      "patterns", 
      "ability", 
      "types", 
      "potential", 
      "results", 
      "growth", 
      "excellent ability", 
      "multifunctional silica", 
      "model", 
      "novel", 
      "collaborative manner", 
      "existence", 
      "silica nanoparticles", 
      "environment", 
      "work", 
      "polyethyleneimine", 
      "nanoparticles", 
      "silica", 
      "cancer immunotherapy failure", 
      "hostile TIME remodeling", 
      "TIME remodeling", 
      "durable tumor growth retardation", 
      "immunosuppression reversion", 
      "tumoricidal environment", 
      "cervical cancer cell line TC-1", 
      "cancer cell line TC-1", 
      "cell line TC-1", 
      "line TC-1", 
      "repolarization of tumor", 
      "TC-1 immunogenic death", 
      "more damage-related molecular patterns", 
      "damage-related molecular patterns", 
      "inflammatory TIME", 
      "prime tumoricidal immunity", 
      "tumoricidal immunity"
    ], 
    "name": "Multifunctional silica nanocomposites prime tumoricidal immunity for efficient cancer immunotherapy", 
    "pagination": "328", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1141971411"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12951-021-01073-2"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "34663354"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12951-021-01073-2", 
      "https://app.dimensions.ai/details/publication/pub.1141971411"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T19:01", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_903.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s12951-021-01073-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12951-021-01073-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12951-021-01073-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12951-021-01073-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12951-021-01073-2'


 

This table displays all metadata directly associated to this object as RDF triples.

264 TRIPLES      22 PREDICATES      134 URIs      119 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12951-021-01073-2 schema:about anzsrc-for:10
2 schema:author N169753e9707a4d6594fbf000efedab19
3 schema:citation sg:pub.10.1038/cddis.2017.352
4 sg:pub.10.1038/nature21349
5 sg:pub.10.1038/ncb3371
6 sg:pub.10.1038/nrc1256
7 sg:pub.10.1038/nrc3380
8 sg:pub.10.1038/s41591-018-0014-x
9 sg:pub.10.1186/s12951-019-0541-8
10 sg:pub.10.1186/s12951-021-00805-8
11 schema:datePublished 2021-10-18
12 schema:datePublishedReg 2021-10-18
13 schema:description The tumor immune microenvironment (TIME) has been demonstrated to be the main cause of cancer immunotherapy failure in various malignant tumors, due to poor immunogenicity and existence of immunosuppressive factors. Thus, establishing effective treatments for hostile TIME remodeling has considerable potential to enhance immune response rates for durable tumor growth retardation. This study aims to develop a novel nanocomposite, polyethyleneimine-modified dendritic mesoporous silica nanoparticles loaded with microRNA-125a (DMSN-PEI@125a) to synergistically enhance immune response and immunosuppression reversion, ultimately generating a tumoricidal environment. Our results showed that DMSN-PEI@125a exhibited excellent ability in cellular uptake by murine macrophages and the cervical cancer cell line TC-1, repolarization of tumor associated macrophages (TAMs) to M1 type in a synergistic manner, and promotion of TC-1 immunogenic death. Intratumor injection of DMSN-PEI@125a facilitated the release of more damage-related molecular patterns and enhanced the infiltration of natural killer and CD8<sup>+</sup> T cells. Meanwhile, repolarized TAMs could function as a helper to promote antitumor immunity, thus inhibiting tumor growth in TC-1 mouse models in a collaborative manner. Collectively, this work highlights the multifunctional roles of DMSN-PEI@125a in generating an inflammatory TIME and provoking antitumor immunity, which may serve as a potential agent for cancer immunotherapy.
14 schema:genre article
15 schema:inLanguage en
16 schema:isAccessibleForFree true
17 schema:isPartOf Nef7e1919307e47a68096d14f0c2c3cfa
18 Nfd74368866204adcac210cf0bb338413
19 sg:journal.1031280
20 schema:keywords CD8
21 DMSN
22 M1 type
23 TAM
24 TC-1
25 TC-1 immunogenic death
26 TC-1 mouse model
27 TIME remodeling
28 ability
29 agents
30 antitumor immunity
31 cancer cell line TC-1
32 cancer immunotherapy
33 cancer immunotherapy failure
34 cause
35 cell line TC-1
36 cells
37 cellular uptake
38 cervical cancer cell line TC-1
39 collaborative manner
40 considerable potential
41 damage-related molecular patterns
42 death
43 dendritic mesoporous silica nanoparticles
44 durable tumor growth retardation
45 effective treatment
46 efficient cancer immunotherapy
47 environment
48 excellent ability
49 existence
50 factors
51 failure
52 growth
53 growth retardation
54 helper
55 hostile TIME remodeling
56 immune microenvironment
57 immune response
58 immune response rate
59 immunity
60 immunogenic death
61 immunogenicity
62 immunosuppression reversion
63 immunosuppressive factors
64 immunotherapy
65 immunotherapy failure
66 infiltration
67 inflammatory TIME
68 injection
69 intratumor injection
70 killer
71 line TC-1
72 macrophages
73 main cause
74 malignant tumors
75 manner
76 mesoporous silica nanoparticles
77 microRNA-125a
78 microenvironment
79 model
80 molecular patterns
81 more damage-related molecular patterns
82 mouse model
83 multifunctional role
84 multifunctional silica
85 murine macrophages
86 nanoparticles
87 natural killer
88 novel
89 patterns
90 polyethyleneimine
91 poor immunogenicity
92 potential
93 potential agent
94 prime tumoricidal immunity
95 promotion
96 rate
97 release
98 remodeling
99 repolarization
100 repolarization of tumor
101 response
102 response rate
103 results
104 retardation
105 reversion
106 role
107 silica
108 silica nanoparticles
109 study
110 synergistic manner
111 treatment
112 tumor growth
113 tumor growth retardation
114 tumor immune microenvironment
115 tumoricidal environment
116 tumoricidal immunity
117 tumors
118 types
119 uptake
120 work
121 schema:name Multifunctional silica nanocomposites prime tumoricidal immunity for efficient cancer immunotherapy
122 schema:pagination 328
123 schema:productId N1f65cc1080fc47519310a216ace038d3
124 N34f428b9cad74ef4aaee45fba365f7c6
125 Nc75c23c127164924b9fa1316cda6b976
126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1141971411
127 https://doi.org/10.1186/s12951-021-01073-2
128 schema:sdDatePublished 2022-01-01T19:01
129 schema:sdLicense https://scigraph.springernature.com/explorer/license/
130 schema:sdPublisher N37ee6eed6e6e4a4a9efd848282468b9f
131 schema:url https://doi.org/10.1186/s12951-021-01073-2
132 sgo:license sg:explorer/license/
133 sgo:sdDataset articles
134 rdf:type schema:ScholarlyArticle
135 N0e91505c48a240a18f662f27ba7b7f83 rdf:first sg:person.01367531312.52
136 rdf:rest Nbaf8c40ecd494ff98daf71201bb661eb
137 N169753e9707a4d6594fbf000efedab19 rdf:first N8f370ca2f0744e57b34cf8352ee0a2c9
138 rdf:rest Nf1e93f2ca37d458caba957b07526b3d1
139 N1f65cc1080fc47519310a216ace038d3 schema:name doi
140 schema:value 10.1186/s12951-021-01073-2
141 rdf:type schema:PropertyValue
142 N34f428b9cad74ef4aaee45fba365f7c6 schema:name dimensions_id
143 schema:value pub.1141971411
144 rdf:type schema:PropertyValue
145 N37ee6eed6e6e4a4a9efd848282468b9f schema:name Springer Nature - SN SciGraph project
146 rdf:type schema:Organization
147 N38b4ec67d1624438b6e539ba53611f92 schema:affiliation grid-institutes:grid.489986.2
148 schema:familyName Cao
149 schema:givenName Yongsheng
150 rdf:type schema:Person
151 N4cd63fbe67644cb998bce8f5d6c4fa13 schema:affiliation grid-institutes:grid.24516.34
152 schema:familyName Li
153 schema:givenName Feng
154 rdf:type schema:Person
155 N5322d08137fe4deb9466683030dab885 rdf:first sg:person.010055417665.27
156 rdf:rest N5e19eb0543e1436b957e81ce31015931
157 N5e19eb0543e1436b957e81ce31015931 rdf:first sg:person.01051453631.13
158 rdf:rest N0e91505c48a240a18f662f27ba7b7f83
159 N8f370ca2f0744e57b34cf8352ee0a2c9 schema:affiliation grid-institutes:grid.186775.a
160 schema:familyName Yang
161 schema:givenName Linnan
162 rdf:type schema:Person
163 N973c217fd66d4e3296643bf3c370160d rdf:first sg:person.012541076474.90
164 rdf:rest Nfff52877ecff453c84af3f3c23c791c6
165 Nbaf8c40ecd494ff98daf71201bb661eb rdf:first sg:person.0632334505.74
166 rdf:rest rdf:nil
167 Nc75c23c127164924b9fa1316cda6b976 schema:name pubmed_id
168 schema:value 34663354
169 rdf:type schema:PropertyValue
170 Ncb81362d6e404e15aa7310fb07ea57da rdf:first sg:person.010027547617.40
171 rdf:rest N5322d08137fe4deb9466683030dab885
172 Nef7e1919307e47a68096d14f0c2c3cfa schema:volumeNumber 19
173 rdf:type schema:PublicationVolume
174 Nf1e93f2ca37d458caba957b07526b3d1 rdf:first N4cd63fbe67644cb998bce8f5d6c4fa13
175 rdf:rest Nf6bdb99d7ade432890f9a4db418a2f4d
176 Nf6bdb99d7ade432890f9a4db418a2f4d rdf:first N38b4ec67d1624438b6e539ba53611f92
177 rdf:rest N973c217fd66d4e3296643bf3c370160d
178 Nfd74368866204adcac210cf0bb338413 schema:issueNumber 1
179 rdf:type schema:PublicationIssue
180 Nfff52877ecff453c84af3f3c23c791c6 rdf:first sg:person.013646611775.64
181 rdf:rest Ncb81362d6e404e15aa7310fb07ea57da
182 anzsrc-for:10 schema:inDefinedTermSet anzsrc-for:
183 schema:name Technology
184 rdf:type schema:DefinedTerm
185 sg:grant.8200805 http://pending.schema.org/fundedItem sg:pub.10.1186/s12951-021-01073-2
186 rdf:type schema:MonetaryGrant
187 sg:grant.8202821 http://pending.schema.org/fundedItem sg:pub.10.1186/s12951-021-01073-2
188 rdf:type schema:MonetaryGrant
189 sg:journal.1031280 schema:issn 1477-3155
190 schema:name Journal of Nanobiotechnology
191 schema:publisher Springer Nature
192 rdf:type schema:Periodical
193 sg:person.010027547617.40 schema:affiliation grid-institutes:grid.24516.34
194 schema:familyName Niu
195 schema:givenName Jintong
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010027547617.40
197 rdf:type schema:Person
198 sg:person.010055417665.27 schema:affiliation grid-institutes:grid.24516.34
199 schema:familyName Sun
200 schema:givenName Feiyue
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010055417665.27
202 rdf:type schema:Person
203 sg:person.01051453631.13 schema:affiliation grid-institutes:None
204 schema:familyName Qian
205 schema:givenName Yechang
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051453631.13
207 rdf:type schema:Person
208 sg:person.012541076474.90 schema:affiliation grid-institutes:grid.24516.34
209 schema:familyName Liu
210 schema:givenName Qiang
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012541076474.90
212 rdf:type schema:Person
213 sg:person.013646611775.64 schema:affiliation grid-institutes:grid.24516.34
214 schema:familyName Jing
215 schema:givenName Guoxin
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013646611775.64
217 rdf:type schema:Person
218 sg:person.01367531312.52 schema:affiliation grid-institutes:grid.24516.34
219 schema:familyName Wang
220 schema:givenName Shilong
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367531312.52
222 rdf:type schema:Person
223 sg:person.0632334505.74 schema:affiliation grid-institutes:grid.24516.34
224 schema:familyName Li
225 schema:givenName Ang
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632334505.74
227 rdf:type schema:Person
228 sg:pub.10.1038/cddis.2017.352 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090951360
229 https://doi.org/10.1038/cddis.2017.352
230 rdf:type schema:CreativeWork
231 sg:pub.10.1038/nature21349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000326025
232 https://doi.org/10.1038/nature21349
233 rdf:type schema:CreativeWork
234 sg:pub.10.1038/ncb3371 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041062495
235 https://doi.org/10.1038/ncb3371
236 rdf:type schema:CreativeWork
237 sg:pub.10.1038/nrc1256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043086899
238 https://doi.org/10.1038/nrc1256
239 rdf:type schema:CreativeWork
240 sg:pub.10.1038/nrc3380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003607076
241 https://doi.org/10.1038/nrc3380
242 rdf:type schema:CreativeWork
243 sg:pub.10.1038/s41591-018-0014-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1103565849
244 https://doi.org/10.1038/s41591-018-0014-x
245 rdf:type schema:CreativeWork
246 sg:pub.10.1186/s12951-019-0541-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1121885717
247 https://doi.org/10.1186/s12951-019-0541-8
248 rdf:type schema:CreativeWork
249 sg:pub.10.1186/s12951-021-00805-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1135750045
250 https://doi.org/10.1186/s12951-021-00805-8
251 rdf:type schema:CreativeWork
252 grid-institutes:None schema:alternateName Department of Respiratory Disease, Baoshan District Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai, People’s Republic of China
253 schema:name Department of Respiratory Disease, Baoshan District Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai, People’s Republic of China
254 rdf:type schema:Organization
255 grid-institutes:grid.186775.a schema:alternateName Central Laboratory, First Affiliated Hospital, Anhui Medical University, Hefei, People’s Republic of China
256 schema:name Central Laboratory, First Affiliated Hospital, Anhui Medical University, Hefei, People’s Republic of China
257 Research Center for Translational Medicine at East Hospital, School of Life Science and Technology, Tongji University, Shanghai, People’s Republic of China
258 rdf:type schema:Organization
259 grid-institutes:grid.24516.34 schema:alternateName Research Center for Translational Medicine at East Hospital, School of Life Science and Technology, Tongji University, Shanghai, People’s Republic of China
260 schema:name Research Center for Translational Medicine at East Hospital, School of Life Science and Technology, Tongji University, Shanghai, People’s Republic of China
261 rdf:type schema:Organization
262 grid-institutes:grid.489986.2 schema:alternateName The Second Department of Urology, Anhui Provincial Children’s Hospital, Hefei, People’s Republic of China
263 schema:name The Second Department of Urology, Anhui Provincial Children’s Hospital, Hefei, People’s Republic of China
264 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...