A polydopamine nanomedicine used in photothermal therapy for liver cancer knocks down the anti-cancer target NEDD8-E3 ligase ROC1 (RBX1) View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-10-15

AUTHORS

Zhanxia Zhang, Junqian Zhang, Jianhui Tian, Hegen Li

ABSTRACT

Knocking down the oncogene ROC1 with siRNA inhibits the proliferation of cancer cells by suppressing the Neddylation pathway. However, methods for delivering siRNA in vivo to induce this high anticancer activity with low potential side effects are urgently needed. Herein, a folic acid (FA)-modified polydopamine (PDA) nanomedicine used in photothermal therapy was designed for siRNA delivery. The designed nanovector can undergo photothermal conversion with good biocompatibility. Importantly, this genetic nanomedicine was selectively delivered to liver cancer cells by FA through receptor-mediated endocytosis. Subsequently, the siRNA cargo was released from the PDA nanomedicine into the tumor microenvironment by controlled release triggered by pH. More importantly, the genetic nanomedicine not only inhibited liver cancer cell proliferation but also promoted liver cell apoptosis by slowing ROC1 activity, suppressing the Neddylation pathway, enabling the accumulation of apototic factor ATF4 and DNA damage factor P-H2AX. Combined with photothermal therapy, this genetic nanomedicine showed superior inhibition of the growth of liver cancer in vitro and in vivo. Taken together, the results indicate that this biodegradable nanomedicine exhibits good target recognition, an effective pH response, application potential for genetic therapy, photothermal imaging and treatment of liver cancer. Therefore, this work contributes to the design of a multifunctional nanoplatform that combines genetic therapy and photothermal therapy for the treatment of liver cancer. More... »

PAGES

323

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12951-021-01063-4

DOI

http://dx.doi.org/10.1186/s12951-021-01063-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1141921628

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34654435


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/10", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Technology", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 Wanping South Road, Shanghai, 200032 China", 
          "id": "http://www.grid.ac/institutes/grid.412540.6", 
          "name": [
            "Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 Wanping South Road, Shanghai, 200032 China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Zhanxia", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 Wanping South Road, Shanghai, 200032 China", 
          "id": "http://www.grid.ac/institutes/grid.412540.6", 
          "name": [
            "Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 Wanping South Road, Shanghai, 200032 China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Junqian", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 Wanping South Road, Shanghai, 200032 China", 
          "id": "http://www.grid.ac/institutes/grid.412540.6", 
          "name": [
            "Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 Wanping South Road, Shanghai, 200032 China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tian", 
        "givenName": "Jianhui", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medical Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 Wanping South Road, Shanghai, 200032 China", 
          "id": "http://www.grid.ac/institutes/grid.412540.6", 
          "name": [
            "Department of Medical Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 Wanping South Road, Shanghai, 200032 China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Hegen", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s41061-017-0124-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084041101", 
          "https://doi.org/10.1007/s41061-017-0124-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12943-019-0979-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1113181832", 
          "https://doi.org/10.1186/s12943-019-0979-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4939-7471-9_16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100922541", 
          "https://doi.org/10.1007/978-1-4939-7471-9_16"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41419-020-03184-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1132540574", 
          "https://doi.org/10.1038/s41419-020-03184-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep25468", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003835672", 
          "https://doi.org/10.1038/srep25468"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2021-10-15", 
    "datePublishedReg": "2021-10-15", 
    "description": "Knocking down the oncogene ROC1 with siRNA inhibits the proliferation of cancer cells by suppressing the Neddylation pathway. However, methods for delivering siRNA in vivo to induce this high anticancer activity with low potential side effects are urgently needed. Herein, a folic acid (FA)-modified polydopamine (PDA) nanomedicine used in photothermal therapy was designed for siRNA delivery. The designed nanovector can undergo photothermal conversion with good biocompatibility. Importantly, this genetic nanomedicine was selectively delivered to liver cancer cells by FA through receptor-mediated endocytosis. Subsequently, the siRNA cargo was released from the PDA nanomedicine into the tumor microenvironment by controlled release triggered by pH. More importantly, the genetic nanomedicine not only inhibited liver cancer cell proliferation but also promoted liver cell apoptosis by slowing ROC1 activity, suppressing the Neddylation pathway, enabling the accumulation of apototic factor ATF4 and DNA damage factor P-H2AX. Combined with photothermal therapy, this genetic nanomedicine showed superior inhibition of the growth of liver cancer in vitro and in vivo. Taken together, the results indicate that this biodegradable nanomedicine exhibits good target recognition, an effective pH response, application potential for genetic therapy, photothermal imaging and treatment of liver cancer. Therefore, this work contributes to the design of a multifunctional nanoplatform that combines genetic therapy and photothermal therapy for the treatment of liver cancer.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s12951-021-01063-4", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1031280", 
        "issn": [
          "1477-3155"
        ], 
        "name": "Journal of Nanobiotechnology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "keywords": [
      "liver cancer", 
      "liver cancer cell proliferation", 
      "cancer cells", 
      "potential side effects", 
      "liver cell apoptosis", 
      "neddylation pathway", 
      "cancer cell proliferation", 
      "genetic therapies", 
      "lower potential side effects", 
      "side effects", 
      "photothermal therapy", 
      "therapy", 
      "tumor microenvironment", 
      "cancer", 
      "cell apoptosis", 
      "folic acid", 
      "cell proliferation", 
      "receptor-mediated endocytosis", 
      "superior inhibition", 
      "anticancer activity", 
      "higher anticancer activity", 
      "siRNA", 
      "treatment", 
      "vivo", 
      "proliferation", 
      "multifunctional nanoplatform", 
      "siRNA delivery", 
      "siRNA cargo", 
      "biodegradable nanomedicine", 
      "cells", 
      "photothermal imaging", 
      "photothermal conversion", 
      "nanomedicine", 
      "pathway", 
      "good biocompatibility", 
      "application potential", 
      "activity", 
      "vitro", 
      "apoptosis", 
      "inhibition", 
      "microenvironment", 
      "ATF4", 
      "imaging", 
      "delivery", 
      "pH response", 
      "release", 
      "FA", 
      "response", 
      "H2AX", 
      "nanoplatform", 
      "nanovectors", 
      "accumulation", 
      "factor P", 
      "endocytosis", 
      "effect", 
      "biocompatibility", 
      "acid", 
      "Herein", 
      "potential", 
      "better target recognition", 
      "results", 
      "ROC1", 
      "growth", 
      "recognition", 
      "cargo", 
      "target recognition", 
      "conversion", 
      "method", 
      "design", 
      "work", 
      "oncogene ROC1", 
      "polydopamine (PDA) nanomedicine", 
      "genetic nanomedicine", 
      "PDA nanomedicine", 
      "ROC1 activity", 
      "apototic factor ATF4", 
      "factor ATF4", 
      "DNA damage factor P", 
      "damage factor P", 
      "effective pH response", 
      "anti-cancer target NEDD8-E3 ligase ROC1", 
      "target NEDD8-E3 ligase ROC1", 
      "NEDD8-E3 ligase ROC1", 
      "ligase ROC1"
    ], 
    "name": "A polydopamine nanomedicine used in photothermal therapy for liver cancer knocks down the anti-cancer target NEDD8-E3 ligase ROC1 (RBX1)", 
    "pagination": "323", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1141921628"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12951-021-01063-4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "34654435"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12951-021-01063-4", 
      "https://app.dimensions.ai/details/publication/pub.1141921628"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T19:02", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_889.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s12951-021-01063-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12951-021-01063-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12951-021-01063-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12951-021-01063-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12951-021-01063-4'


 

This table displays all metadata directly associated to this object as RDF triples.

180 TRIPLES      22 PREDICATES      114 URIs      102 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12951-021-01063-4 schema:about anzsrc-for:10
2 schema:author N46210b0a79c24583b6d6cb7ee7ff92fc
3 schema:citation sg:pub.10.1007/978-1-4939-7471-9_16
4 sg:pub.10.1007/s41061-017-0124-9
5 sg:pub.10.1038/s41419-020-03184-4
6 sg:pub.10.1038/srep25468
7 sg:pub.10.1186/s12943-019-0979-1
8 schema:datePublished 2021-10-15
9 schema:datePublishedReg 2021-10-15
10 schema:description Knocking down the oncogene ROC1 with siRNA inhibits the proliferation of cancer cells by suppressing the Neddylation pathway. However, methods for delivering siRNA in vivo to induce this high anticancer activity with low potential side effects are urgently needed. Herein, a folic acid (FA)-modified polydopamine (PDA) nanomedicine used in photothermal therapy was designed for siRNA delivery. The designed nanovector can undergo photothermal conversion with good biocompatibility. Importantly, this genetic nanomedicine was selectively delivered to liver cancer cells by FA through receptor-mediated endocytosis. Subsequently, the siRNA cargo was released from the PDA nanomedicine into the tumor microenvironment by controlled release triggered by pH. More importantly, the genetic nanomedicine not only inhibited liver cancer cell proliferation but also promoted liver cell apoptosis by slowing ROC1 activity, suppressing the Neddylation pathway, enabling the accumulation of apototic factor ATF4 and DNA damage factor P-H2AX. Combined with photothermal therapy, this genetic nanomedicine showed superior inhibition of the growth of liver cancer in vitro and in vivo. Taken together, the results indicate that this biodegradable nanomedicine exhibits good target recognition, an effective pH response, application potential for genetic therapy, photothermal imaging and treatment of liver cancer. Therefore, this work contributes to the design of a multifunctional nanoplatform that combines genetic therapy and photothermal therapy for the treatment of liver cancer.
11 schema:genre article
12 schema:inLanguage en
13 schema:isAccessibleForFree true
14 schema:isPartOf Ncb44a41bbb4048988944f5bd9a1376d9
15 Nf41d04d1c623414f92807acad8ecd981
16 sg:journal.1031280
17 schema:keywords ATF4
18 DNA damage factor P
19 FA
20 H2AX
21 Herein
22 NEDD8-E3 ligase ROC1
23 PDA nanomedicine
24 ROC1
25 ROC1 activity
26 accumulation
27 acid
28 activity
29 anti-cancer target NEDD8-E3 ligase ROC1
30 anticancer activity
31 apoptosis
32 apototic factor ATF4
33 application potential
34 better target recognition
35 biocompatibility
36 biodegradable nanomedicine
37 cancer
38 cancer cell proliferation
39 cancer cells
40 cargo
41 cell apoptosis
42 cell proliferation
43 cells
44 conversion
45 damage factor P
46 delivery
47 design
48 effect
49 effective pH response
50 endocytosis
51 factor ATF4
52 factor P
53 folic acid
54 genetic nanomedicine
55 genetic therapies
56 good biocompatibility
57 growth
58 higher anticancer activity
59 imaging
60 inhibition
61 ligase ROC1
62 liver cancer
63 liver cancer cell proliferation
64 liver cell apoptosis
65 lower potential side effects
66 method
67 microenvironment
68 multifunctional nanoplatform
69 nanomedicine
70 nanoplatform
71 nanovectors
72 neddylation pathway
73 oncogene ROC1
74 pH response
75 pathway
76 photothermal conversion
77 photothermal imaging
78 photothermal therapy
79 polydopamine (PDA) nanomedicine
80 potential
81 potential side effects
82 proliferation
83 receptor-mediated endocytosis
84 recognition
85 release
86 response
87 results
88 siRNA
89 siRNA cargo
90 siRNA delivery
91 side effects
92 superior inhibition
93 target NEDD8-E3 ligase ROC1
94 target recognition
95 therapy
96 treatment
97 tumor microenvironment
98 vitro
99 vivo
100 work
101 schema:name A polydopamine nanomedicine used in photothermal therapy for liver cancer knocks down the anti-cancer target NEDD8-E3 ligase ROC1 (RBX1)
102 schema:pagination 323
103 schema:productId Na8866e92db7a4acebd893ac60d3c2b45
104 Ncf7ef6ca87934f20b0adc3b413a2c5b6
105 Nfbe16ca4462a4a78b4710e2b60fafa9f
106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1141921628
107 https://doi.org/10.1186/s12951-021-01063-4
108 schema:sdDatePublished 2022-01-01T19:02
109 schema:sdLicense https://scigraph.springernature.com/explorer/license/
110 schema:sdPublisher Nd2b123e8e62241ed85ec81c717020551
111 schema:url https://doi.org/10.1186/s12951-021-01063-4
112 sgo:license sg:explorer/license/
113 sgo:sdDataset articles
114 rdf:type schema:ScholarlyArticle
115 N143cff6d02434ea592cf36e448901d84 rdf:first N48dbf80b60e04177b0cfaa754cc4c1f1
116 rdf:rest rdf:nil
117 N46210b0a79c24583b6d6cb7ee7ff92fc rdf:first N5f71159a7834406cb5fa536707c03639
118 rdf:rest Nc8db981e05e14b1fbfefc9d3aaffe249
119 N48dbf80b60e04177b0cfaa754cc4c1f1 schema:affiliation grid-institutes:grid.412540.6
120 schema:familyName Li
121 schema:givenName Hegen
122 rdf:type schema:Person
123 N5f71159a7834406cb5fa536707c03639 schema:affiliation grid-institutes:grid.412540.6
124 schema:familyName Zhang
125 schema:givenName Zhanxia
126 rdf:type schema:Person
127 Na8866e92db7a4acebd893ac60d3c2b45 schema:name pubmed_id
128 schema:value 34654435
129 rdf:type schema:PropertyValue
130 Na9a72dde2e38431b895fd0a862f6db44 rdf:first Nfc3fc1ecff634a478c21517abaf7fe7e
131 rdf:rest N143cff6d02434ea592cf36e448901d84
132 Nc8db981e05e14b1fbfefc9d3aaffe249 rdf:first Nebbc762a94f34ce8bea9c813d9a36560
133 rdf:rest Na9a72dde2e38431b895fd0a862f6db44
134 Ncb44a41bbb4048988944f5bd9a1376d9 schema:volumeNumber 19
135 rdf:type schema:PublicationVolume
136 Ncf7ef6ca87934f20b0adc3b413a2c5b6 schema:name doi
137 schema:value 10.1186/s12951-021-01063-4
138 rdf:type schema:PropertyValue
139 Nd2b123e8e62241ed85ec81c717020551 schema:name Springer Nature - SN SciGraph project
140 rdf:type schema:Organization
141 Nebbc762a94f34ce8bea9c813d9a36560 schema:affiliation grid-institutes:grid.412540.6
142 schema:familyName Zhang
143 schema:givenName Junqian
144 rdf:type schema:Person
145 Nf41d04d1c623414f92807acad8ecd981 schema:issueNumber 1
146 rdf:type schema:PublicationIssue
147 Nfbe16ca4462a4a78b4710e2b60fafa9f schema:name dimensions_id
148 schema:value pub.1141921628
149 rdf:type schema:PropertyValue
150 Nfc3fc1ecff634a478c21517abaf7fe7e schema:affiliation grid-institutes:grid.412540.6
151 schema:familyName Tian
152 schema:givenName Jianhui
153 rdf:type schema:Person
154 anzsrc-for:10 schema:inDefinedTermSet anzsrc-for:
155 schema:name Technology
156 rdf:type schema:DefinedTerm
157 sg:journal.1031280 schema:issn 1477-3155
158 schema:name Journal of Nanobiotechnology
159 schema:publisher Springer Nature
160 rdf:type schema:Periodical
161 sg:pub.10.1007/978-1-4939-7471-9_16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100922541
162 https://doi.org/10.1007/978-1-4939-7471-9_16
163 rdf:type schema:CreativeWork
164 sg:pub.10.1007/s41061-017-0124-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084041101
165 https://doi.org/10.1007/s41061-017-0124-9
166 rdf:type schema:CreativeWork
167 sg:pub.10.1038/s41419-020-03184-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1132540574
168 https://doi.org/10.1038/s41419-020-03184-4
169 rdf:type schema:CreativeWork
170 sg:pub.10.1038/srep25468 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003835672
171 https://doi.org/10.1038/srep25468
172 rdf:type schema:CreativeWork
173 sg:pub.10.1186/s12943-019-0979-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113181832
174 https://doi.org/10.1186/s12943-019-0979-1
175 rdf:type schema:CreativeWork
176 grid-institutes:grid.412540.6 schema:alternateName Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 Wanping South Road, Shanghai, 200032 China
177 Department of Medical Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 Wanping South Road, Shanghai, 200032 China
178 schema:name Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 Wanping South Road, Shanghai, 200032 China
179 Department of Medical Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 Wanping South Road, Shanghai, 200032 China
180 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...