Quercetin attenuates neurotoxicity induced by iron oxide nanoparticles View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-10-18

AUTHORS

Akram Bardestani, Shiva Ebrahimpour, Ali Esmaeili, Abolghasem Esmaeili

ABSTRACT

Iron oxide nanoparticles (IONPs) have been proposed as targeted carriers to deliver therapeutic molecules in the central nervous system (CNS). However, IONPs may damage neural tissue via free iron accumulation, protein aggregation, and oxidative stress. Neuroprotective effects of quercetin (QC) have been proven due to its antioxidant and anti-inflammatory properties. However, poor solubility and low bioavailability of QC have also led researchers to make various QC-involved nanoparticles to overcome these limitations. We wondered how high doses or prolonged treatment with quercetin conjugated superparamagnetic iron oxide nanoparticles (QCSPIONs) could improve cognitive dysfunction and promote neurogenesis without any toxicity. It can be explained that the QC inhibits protein aggregation and acts against iron overload via iron-chelating activity, iron homeostasis genes regulation, radical scavenging, and attenuation of Fenton/Haber-Weiss reaction. In this review, first, we present brain iron homeostasis, molecular mechanisms of iron overload that induced neurotoxicity, and the role of iron in dementia-associated diseases. Then by providing evidence of IONPs neurotoxicity, we discuss how QC neutralizes IONPs neurotoxicity, and finally, we make a brief comparison between QC and conventional iron chelators. In this review, we highlight that QC as supplementation and especially in conjugated form reduces iron oxide nanoparticles neurotoxicity in clinical application. More... »

PAGES

327

References to SciGraph publications

  • 2019-05-03. Quercetin conjugated with superparamagnetic iron oxide nanoparticles improves learning and memory better than free quercetin via interacting with proteins involved in LTP in SCIENTIFIC REPORTS
  • 2018-02-01. Uptake, distribution, clearance, and toxicity of iron oxide nanoparticles with different sizes and coatings in SCIENTIFIC REPORTS
  • 2018-04-05. Haemochromatosis in NATURE REVIEWS DISEASE PRIMERS
  • 2010-12-01. Quercetin reduces the elevated matrix metalloproteinases-9 level and improves functional outcome after cerebral focal ischemia in rats in ACTA NEUROCHIRURGICA
  • 2020-01-08. Re-epithelialization and immune cell behaviour in an ex vivo human skin model in SCIENTIFIC REPORTS
  • 2015-11-26. Magnetite-Amyloid-β deteriorates activity and functional organization in an in vitro model for Alzheimer’s disease in SCIENTIFIC REPORTS
  • 2020-07-08. Dextran-coated iron oxide nanoparticle-induced nanotoxicity in neuron cultures in SCIENTIFIC REPORTS
  • 2013-03-02. Protective effect of quercetin and/or l-arginine against nano-zinc oxide-induced cardiotoxicity in rats in JOURNAL OF NANOPARTICLE RESEARCH
  • 2018-08-17. Structural basis for promotion of duodenal iron absorption by enteric ferric reductase with ascorbate in COMMUNICATIONS BIOLOGY
  • 2020-08-18. Deferasirox, a trivalent iron chelator, ameliorates neuronal damage in hemorrhagic stroke models in NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY
  • 2019-05-13. Radical sensing keeps noxious iron at bay in NATURE METABOLISM
  • 2018-03-28. Quercetin inhibits intestinal non-haem iron absorption by regulating iron metabolism genes in the tissues in EUROPEAN JOURNAL OF NUTRITION
  • 2020-06-29. Endocytic regulation of cellular ion homeostasis controls lysosome biogenesis in NATURE CELL BIOLOGY
  • 2013-12-21. Iron and Intracerebral Hemorrhage: From Mechanism to Translation in TRANSLATIONAL STROKE RESEARCH
  • 2021-05-27. How to stop using gadolinium chelates for magnetic resonance imaging: clinical-translational experiences with ferumoxytol in PEDIATRIC RADIOLOGY
  • 2020-09-15. Effects of quercetin-conjugated with superparamagnetic iron oxide nanoparticles on learning and memory improvement through targeting microRNAs/NF-κB pathway in SCIENTIFIC REPORTS
  • 2018-09-25. Using superparamagnetic iron oxide nanoparticles to enhance bioavailability of quercetin in the intact rat brain in BMC PHARMACOLOGY AND TOXICOLOGY
  • 2020-05-14. Quercetin with the potential effect on allergic diseases in ALLERGY, ASTHMA & CLINICAL IMMUNOLOGY
  • 2010-12-17. Clinically available iron chelators induce neuroprotection in the 6-OHDA model of Parkinson’s disease after peripheral administration in JOURNAL OF NEURAL TRANSMISSION
  • 2021-04-21. Quercetin‑conjugated superparamagnetic iron oxide nanoparticles modulate glucose metabolism-related genes and miR-29 family in the hippocampus of diabetic rats in SCIENTIFIC REPORTS
  • 2015-06-23. Iron Oxide Nanoparticles Induce Dopaminergic Damage: In vitro Pathways and In Vivo Imaging Reveals Mechanism of Neuronal Damage in MOLECULAR NEUROBIOLOGY
  • 2010-04-01. Divalent metal transporter, iron, and Parkinson's disease: A pathological relationship in CELL RESEARCH
  • 2003-07. Benefits and Risks of Deferiprone in Iron Overload in Thalassaemia and Other Conditions in DRUG SAFETY
  • 2012-03-21. Mechanistic analysis of iron accumulation by endothelial cells of the BBB in BIOMETALS
  • 2000-02. Transferrin and Transferrin Receptor Function in Brain Barrier Systems in CELLULAR AND MOLECULAR NEUROBIOLOGY
  • 2008. Blood-brain barrier function in intracerebral hemorrhage in CEREBRAL HEMORRHAGE
  • 2011-04-12. Brain iron metabolism and its perturbation in neurological diseases in MONATSHEFTE FÜR CHEMIE - CHEMICAL MONTHLY
  • 2014-12-28. Quercetin Promotes Neuronal and Behavioral Recovery by Suppressing Inflammatory Response and Apoptosis in a Rat Model of Intracerebral Hemorrhage in NEUROCHEMICAL RESEARCH
  • 2018-06-28. Hepatotoxicity and nephrotoxicity of quercetin, iron oxide nanoparticles, and quercetin conjugated with nanoparticles in rats in COMPARATIVE CLINICAL PATHOLOGY
  • 2011-04-07. Quercetin Protects Against Oxidative Stress Associated Damages in a Rat Model of Transient Focal Cerebral Ischemia and Reperfusion in NEUROCHEMICAL RESEARCH
  • 2017-06-26. Iron oxide nanoparticles may damage to the neural tissue through iron accumulation, oxidative stress, and protein aggregation in BMC NEUROSCIENCE
  • 2017-08-08. Antioxidant Activity of Quercetin and Its Glucosides from Propolis: A Theoretical Study in SCIENTIFIC REPORTS
  • 2013-07-03. Iron metabolism in the CNS: implications for neurodegenerative diseases in NATURE REVIEWS NEUROSCIENCE
  • 2015-12-21. Expression of Iron-Related Proteins at the Neurovascular Unit Supports Reduction and Reoxidation of Iron for Transport Through the Blood-Brain Barrier in MOLECULAR NEUROBIOLOGY
  • 2018-01-04. Pharmacokinetics comparison of two pegylated interferon alfa formulations in healthy volunteers in BMC PHARMACOLOGY AND TOXICOLOGY
  • 2009-05-23. Protective Effects of Resveratrol and Quercetin Against MPP+ -Induced Oxidative Stress Act by Modulating Markers of Apoptotic Death in Dopaminergic Neurons in CELLULAR AND MOLECULAR NEUROBIOLOGY
  • 2019-02-18. Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology in MOLECULAR PSYCHIATRY
  • 2020-09-01. Deferoxamine Treatment Prevents Post-Stroke Vasoregression and Neurovascular Unit Remodeling Leading to Improved Functional Outcomes in Type 2 Male Diabetic Rats: Role of Endothelial Ferroptosis in TRANSLATIONAL STROKE RESEARCH
  • 2012-01-29. Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export in NATURE MEDICINE
  • 2020-09-29. Quercetin-conjugated superparamagnetic iron oxide nanoparticles (QCSPIONs) increases Nrf2 expression via miR-27a mediation to prevent memory dysfunction in diabetic rats in SCIENTIFIC REPORTS
  • 2017-05-03. Brain iron chelation by deferiprone in a phase 2 randomised double-blinded placebo controlled clinical trial in Parkinson’s disease in SCIENTIFIC REPORTS
  • 2000-03. On the ability of four flavonoids, baicilein, luteolin, naringenin, and quercetin, to suppress the fenton reaction of the iron-ATP complex in BIOMETALS
  • 2017-10-23. Iron regulatory protein (IRP)-iron responsive element (IRE) signaling pathway in human neurodegenerative diseases in MOLECULAR NEURODEGENERATION
  • 2014-07-05. Clinical Pharmacology of Deferasirox in CLINICAL PHARMACOKINETICS
  • 2020-02-03. Ferroptosis: past, present and future in CELL DEATH & DISEASE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12951-021-01059-0

    DOI

    http://dx.doi.org/10.1186/s12951-021-01059-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1141971410

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/34663344


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/10", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Technology", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Cell and Molecular Biology & Microbiology, Faculty of Biological Science and Technology, University of Isfahan, P.O. Box: 8174673441, Isfahan, Iran", 
              "id": "http://www.grid.ac/institutes/grid.411750.6", 
              "name": [
                "Department of Cell and Molecular Biology & Microbiology, Faculty of Biological Science and Technology, University of Isfahan, P.O. Box: 8174673441, Isfahan, Iran"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bardestani", 
            "givenName": "Akram", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cell and Molecular Biology & Microbiology, Faculty of Biological Science and Technology, University of Isfahan, P.O. Box: 8174673441, Isfahan, Iran", 
              "id": "http://www.grid.ac/institutes/grid.411750.6", 
              "name": [
                "Department of Cell and Molecular Biology & Microbiology, Faculty of Biological Science and Technology, University of Isfahan, P.O. Box: 8174673441, Isfahan, Iran"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ebrahimpour", 
            "givenName": "Shiva", 
            "id": "sg:person.016131754443.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016131754443.75"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran", 
              "id": "http://www.grid.ac/institutes/grid.411036.1", 
              "name": [
                "School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Esmaeili", 
            "givenName": "Ali", 
            "id": "sg:person.07767665514.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07767665514.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cell and Molecular Biology & Microbiology, Faculty of Biological Science and Technology, University of Isfahan, P.O. Box: 8174673441, Isfahan, Iran", 
              "id": "http://www.grid.ac/institutes/grid.411750.6", 
              "name": [
                "Department of Cell and Molecular Biology & Microbiology, Faculty of Biological Science and Technology, University of Isfahan, P.O. Box: 8174673441, Isfahan, Iran"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Esmaeili", 
            "givenName": "Abolghasem", 
            "id": "sg:person.0624466712.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624466712.36"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nrn3453", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009983274", 
              "https://doi.org/10.1038/nrn3453"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep17261", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019922463", 
              "https://doi.org/10.1038/srep17261"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-020-71971-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1131257331", 
              "https://doi.org/10.1038/s41598-020-71971-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41380-019-0375-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1112197704", 
              "https://doi.org/10.1038/s41380-019-0375-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12975-013-0317-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036276721", 
              "https://doi.org/10.1007/s12975-013-0317-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-020-71678-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1130841108", 
              "https://doi.org/10.1038/s41598-020-71678-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13024-017-0218-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092310871", 
              "https://doi.org/10.1186/s13024-017-0218-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12035-015-9582-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036583838", 
              "https://doi.org/10.1007/s12035-015-9582-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-021-87687-w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1137348097", 
              "https://doi.org/10.1038/s41598-021-87687-w"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11064-014-1457-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024537892", 
              "https://doi.org/10.1007/s11064-014-1457-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00247-021-05098-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1138399337", 
              "https://doi.org/10.1007/s00247-021-05098-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00702-010-0531-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043865772", 
              "https://doi.org/10.1007/s00702-010-0531-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2613", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051306196", 
              "https://doi.org/10.1038/nm.2613"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1006948027674", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047079507", 
              "https://doi.org/10.1023/a:1006948027674"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12975-020-00844-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1130505783", 
              "https://doi.org/10.1007/s12975-020-00844-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40360-017-0192-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100192671", 
              "https://doi.org/10.1186/s40360-017-0192-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1009229429250", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031440554", 
              "https://doi.org/10.1023/a:1009229429250"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-017-01402-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085123010", 
              "https://doi.org/10.1038/s41598-017-01402-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12868-017-0369-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086300646", 
              "https://doi.org/10.1186/s12868-017-0369-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/00002018-200326080-00003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045114336", 
              "https://doi.org/10.2165/00002018-200326080-00003"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00706-011-0472-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035033301", 
              "https://doi.org/10.1007/s00706-011-0472-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s42003-018-0121-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106133620", 
              "https://doi.org/10.1038/s42003-018-0121-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrdp.2018.16", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103157573", 
              "https://doi.org/10.1038/nrdp.2018.16"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10571-009-9411-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009920237", 
              "https://doi.org/10.1007/s10571-009-9411-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11051-013-1520-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005214414", 
              "https://doi.org/10.1007/s11051-013-1520-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s42255-019-0070-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1114148232", 
              "https://doi.org/10.1038/s42255-019-0070-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-211-09469-3_15", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053528945", 
              "https://doi.org/10.1007/978-3-211-09469-3_15"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11064-011-0458-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023481375", 
              "https://doi.org/10.1007/s11064-011-0458-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-017-08024-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091025374", 
              "https://doi.org/10.1038/s41598-017-08024-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00210-020-01963-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1130161922", 
              "https://doi.org/10.1007/s00210-020-01963-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-019-43345-w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1113902333", 
              "https://doi.org/10.1038/s41598-019-43345-w"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00580-018-2783-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105202815", 
              "https://doi.org/10.1007/s00580-018-2783-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00394-018-1680-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101823086", 
              "https://doi.org/10.1007/s00394-018-1680-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40360-018-0249-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107230248", 
              "https://doi.org/10.1186/s40360-018-0249-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-018-19628-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100671511", 
              "https://doi.org/10.1038/s41598-018-19628-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41419-020-2298-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1124546105", 
              "https://doi.org/10.1038/s41419-020-2298-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00701-010-0889-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039023198", 
              "https://doi.org/10.1007/s00701-010-0889-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41556-020-0535-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1128829037", 
              "https://doi.org/10.1038/s41556-020-0535-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10534-012-9538-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002269989", 
              "https://doi.org/10.1007/s10534-012-9538-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13223-020-00434-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1127619032", 
              "https://doi.org/10.1186/s13223-020-00434-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-020-67724-w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1129071534", 
              "https://doi.org/10.1038/s41598-020-67724-w"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2010.39", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020089756", 
              "https://doi.org/10.1038/cr.2010.39"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s40262-014-0151-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022276302", 
              "https://doi.org/10.1007/s40262-014-0151-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12035-015-9259-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043864611", 
              "https://doi.org/10.1007/s12035-015-9259-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-019-56847-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1123950493", 
              "https://doi.org/10.1038/s41598-019-56847-4"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2021-10-18", 
        "datePublishedReg": "2021-10-18", 
        "description": "Iron oxide nanoparticles (IONPs) have been proposed as targeted carriers to deliver therapeutic molecules in the central nervous system (CNS). However, IONPs may damage neural tissue via free iron accumulation, protein aggregation, and oxidative stress. Neuroprotective effects of quercetin (QC) have been proven due to its antioxidant and anti-inflammatory properties. However, poor solubility and low bioavailability of QC have also led researchers to make various QC-involved nanoparticles to overcome these limitations. We wondered how high doses or prolonged treatment with quercetin conjugated superparamagnetic iron oxide nanoparticles (QCSPIONs) could improve cognitive dysfunction and promote neurogenesis without any toxicity. It can be explained that the QC inhibits protein aggregation and acts against iron overload via iron-chelating activity, iron homeostasis genes regulation, radical scavenging, and attenuation of Fenton/Haber-Weiss reaction. In this review, first, we present brain iron homeostasis, molecular mechanisms of iron overload that induced neurotoxicity, and the role of iron in dementia-associated diseases. Then by providing evidence of IONPs neurotoxicity, we discuss how QC neutralizes IONPs neurotoxicity, and finally, we make a brief comparison between QC and conventional iron chelators. In this review, we highlight that QC as supplementation and especially in conjugated form reduces iron oxide nanoparticles neurotoxicity in clinical application.", 
        "genre": "article", 
        "id": "sg:pub.10.1186/s12951-021-01059-0", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1031280", 
            "issn": [
              "1477-3155"
            ], 
            "name": "Journal of Nanobiotechnology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "19"
          }
        ], 
        "keywords": [
          "central nervous system", 
          "iron overload", 
          "brain iron homeostasis", 
          "anti-inflammatory properties", 
          "dementia-associated diseases", 
          "neuroprotective effects", 
          "cognitive dysfunction", 
          "nervous system", 
          "high doses", 
          "neurotoxicity", 
          "iron-chelating activity", 
          "role of iron", 
          "iron accumulation", 
          "oxidative stress", 
          "neural tissue", 
          "iron chelators", 
          "clinical applications", 
          "low bioavailability", 
          "Fenton/Haber-Weiss reaction", 
          "therapeutic molecules", 
          "quercetin", 
          "iron homeostasis", 
          "molecular mechanisms", 
          "conjugated forms", 
          "radical scavenging", 
          "Haber-Weiss reaction", 
          "overload", 
          "free iron accumulation", 
          "iron oxide nanoparticles", 
          "review", 
          "dysfunction", 
          "neurogenesis", 
          "disease", 
          "doses", 
          "supplementation", 
          "poor solubility", 
          "treatment", 
          "superparamagnetic iron oxide nanoparticles", 
          "homeostasis", 
          "tissue", 
          "toxicity", 
          "oxide nanoparticles", 
          "protein aggregation", 
          "bioavailability", 
          "chelators", 
          "evidence", 
          "activity", 
          "role", 
          "accumulation", 
          "regulation", 
          "effect", 
          "scavenging", 
          "nanoparticles", 
          "attenuation", 
          "mechanism", 
          "aggregation", 
          "gene regulation", 
          "carriers", 
          "stress", 
          "comparison", 
          "limitations", 
          "molecules", 
          "reaction", 
          "form", 
          "iron", 
          "solubility", 
          "system", 
          "researchers", 
          "properties", 
          "applications", 
          "brief comparison", 
          "QC-involved nanoparticles", 
          "quercetin conjugated superparamagnetic iron oxide nanoparticles", 
          "conjugated superparamagnetic iron oxide nanoparticles", 
          "iron homeostasis genes regulation", 
          "homeostasis genes regulation", 
          "IONPs neurotoxicity", 
          "conventional iron chelators", 
          "iron oxide nanoparticles neurotoxicity", 
          "oxide nanoparticles neurotoxicity", 
          "nanoparticles neurotoxicity"
        ], 
        "name": "Quercetin attenuates neurotoxicity induced by iron oxide nanoparticles", 
        "pagination": "327", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1141971410"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s12951-021-01059-0"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "34663344"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s12951-021-01059-0", 
          "https://app.dimensions.ai/details/publication/pub.1141971410"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-01-01T18:56", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_876.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1186/s12951-021-01059-0"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12951-021-01059-0'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12951-021-01059-0'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12951-021-01059-0'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12951-021-01059-0'


     

    This table displays all metadata directly associated to this object as RDF triples.

    341 TRIPLES      22 PREDICATES      151 URIs      99 LITERALS      7 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s12951-021-01059-0 schema:about anzsrc-for:10
    2 schema:author N6c830a1183aa44a1a7ca969d89d8af37
    3 schema:citation sg:pub.10.1007/978-3-211-09469-3_15
    4 sg:pub.10.1007/s00210-020-01963-6
    5 sg:pub.10.1007/s00247-021-05098-5
    6 sg:pub.10.1007/s00394-018-1680-7
    7 sg:pub.10.1007/s00580-018-2783-5
    8 sg:pub.10.1007/s00701-010-0889-x
    9 sg:pub.10.1007/s00702-010-0531-3
    10 sg:pub.10.1007/s00706-011-0472-z
    11 sg:pub.10.1007/s10534-012-9538-6
    12 sg:pub.10.1007/s10571-009-9411-5
    13 sg:pub.10.1007/s11051-013-1520-x
    14 sg:pub.10.1007/s11064-011-0458-6
    15 sg:pub.10.1007/s11064-014-1457-1
    16 sg:pub.10.1007/s12035-015-9259-2
    17 sg:pub.10.1007/s12035-015-9582-7
    18 sg:pub.10.1007/s12975-013-0317-7
    19 sg:pub.10.1007/s12975-020-00844-7
    20 sg:pub.10.1007/s40262-014-0151-4
    21 sg:pub.10.1023/a:1006948027674
    22 sg:pub.10.1023/a:1009229429250
    23 sg:pub.10.1038/cr.2010.39
    24 sg:pub.10.1038/nm.2613
    25 sg:pub.10.1038/nrdp.2018.16
    26 sg:pub.10.1038/nrn3453
    27 sg:pub.10.1038/s41380-019-0375-7
    28 sg:pub.10.1038/s41419-020-2298-2
    29 sg:pub.10.1038/s41556-020-0535-7
    30 sg:pub.10.1038/s41598-017-01402-2
    31 sg:pub.10.1038/s41598-017-08024-8
    32 sg:pub.10.1038/s41598-018-19628-z
    33 sg:pub.10.1038/s41598-019-43345-w
    34 sg:pub.10.1038/s41598-019-56847-4
    35 sg:pub.10.1038/s41598-020-67724-w
    36 sg:pub.10.1038/s41598-020-71678-4
    37 sg:pub.10.1038/s41598-020-71971-2
    38 sg:pub.10.1038/s41598-021-87687-w
    39 sg:pub.10.1038/s42003-018-0121-8
    40 sg:pub.10.1038/s42255-019-0070-7
    41 sg:pub.10.1038/srep17261
    42 sg:pub.10.1186/s12868-017-0369-9
    43 sg:pub.10.1186/s13024-017-0218-4
    44 sg:pub.10.1186/s13223-020-00434-0
    45 sg:pub.10.1186/s40360-017-0192-z
    46 sg:pub.10.1186/s40360-018-0249-7
    47 sg:pub.10.2165/00002018-200326080-00003
    48 schema:datePublished 2021-10-18
    49 schema:datePublishedReg 2021-10-18
    50 schema:description Iron oxide nanoparticles (IONPs) have been proposed as targeted carriers to deliver therapeutic molecules in the central nervous system (CNS). However, IONPs may damage neural tissue via free iron accumulation, protein aggregation, and oxidative stress. Neuroprotective effects of quercetin (QC) have been proven due to its antioxidant and anti-inflammatory properties. However, poor solubility and low bioavailability of QC have also led researchers to make various QC-involved nanoparticles to overcome these limitations. We wondered how high doses or prolonged treatment with quercetin conjugated superparamagnetic iron oxide nanoparticles (QCSPIONs) could improve cognitive dysfunction and promote neurogenesis without any toxicity. It can be explained that the QC inhibits protein aggregation and acts against iron overload via iron-chelating activity, iron homeostasis genes regulation, radical scavenging, and attenuation of Fenton/Haber-Weiss reaction. In this review, first, we present brain iron homeostasis, molecular mechanisms of iron overload that induced neurotoxicity, and the role of iron in dementia-associated diseases. Then by providing evidence of IONPs neurotoxicity, we discuss how QC neutralizes IONPs neurotoxicity, and finally, we make a brief comparison between QC and conventional iron chelators. In this review, we highlight that QC as supplementation and especially in conjugated form reduces iron oxide nanoparticles neurotoxicity in clinical application.
    51 schema:genre article
    52 schema:inLanguage en
    53 schema:isAccessibleForFree true
    54 schema:isPartOf N0d9826f03fed4b00bbd4028602b225ae
    55 Neb20dc58c582421ba295394ab54a4602
    56 sg:journal.1031280
    57 schema:keywords Fenton/Haber-Weiss reaction
    58 Haber-Weiss reaction
    59 IONPs neurotoxicity
    60 QC-involved nanoparticles
    61 accumulation
    62 activity
    63 aggregation
    64 anti-inflammatory properties
    65 applications
    66 attenuation
    67 bioavailability
    68 brain iron homeostasis
    69 brief comparison
    70 carriers
    71 central nervous system
    72 chelators
    73 clinical applications
    74 cognitive dysfunction
    75 comparison
    76 conjugated forms
    77 conjugated superparamagnetic iron oxide nanoparticles
    78 conventional iron chelators
    79 dementia-associated diseases
    80 disease
    81 doses
    82 dysfunction
    83 effect
    84 evidence
    85 form
    86 free iron accumulation
    87 gene regulation
    88 high doses
    89 homeostasis
    90 homeostasis genes regulation
    91 iron
    92 iron accumulation
    93 iron chelators
    94 iron homeostasis
    95 iron homeostasis genes regulation
    96 iron overload
    97 iron oxide nanoparticles
    98 iron oxide nanoparticles neurotoxicity
    99 iron-chelating activity
    100 limitations
    101 low bioavailability
    102 mechanism
    103 molecular mechanisms
    104 molecules
    105 nanoparticles
    106 nanoparticles neurotoxicity
    107 nervous system
    108 neural tissue
    109 neurogenesis
    110 neuroprotective effects
    111 neurotoxicity
    112 overload
    113 oxidative stress
    114 oxide nanoparticles
    115 oxide nanoparticles neurotoxicity
    116 poor solubility
    117 properties
    118 protein aggregation
    119 quercetin
    120 quercetin conjugated superparamagnetic iron oxide nanoparticles
    121 radical scavenging
    122 reaction
    123 regulation
    124 researchers
    125 review
    126 role
    127 role of iron
    128 scavenging
    129 solubility
    130 stress
    131 superparamagnetic iron oxide nanoparticles
    132 supplementation
    133 system
    134 therapeutic molecules
    135 tissue
    136 toxicity
    137 treatment
    138 schema:name Quercetin attenuates neurotoxicity induced by iron oxide nanoparticles
    139 schema:pagination 327
    140 schema:productId N13daa5de008d48a2a5dc223fe4043d6a
    141 N14db3fe942d246adb1dde1242412b940
    142 N75ee3fffc85c4244bc475fca8d1edb0e
    143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1141971410
    144 https://doi.org/10.1186/s12951-021-01059-0
    145 schema:sdDatePublished 2022-01-01T18:56
    146 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    147 schema:sdPublisher Nd07ecb9cea1a40c3827f2e6c726bbf45
    148 schema:url https://doi.org/10.1186/s12951-021-01059-0
    149 sgo:license sg:explorer/license/
    150 sgo:sdDataset articles
    151 rdf:type schema:ScholarlyArticle
    152 N0d3426e3399d49cc81ac976634cb19ec rdf:first sg:person.0624466712.36
    153 rdf:rest rdf:nil
    154 N0d9826f03fed4b00bbd4028602b225ae schema:issueNumber 1
    155 rdf:type schema:PublicationIssue
    156 N0e4df129100b4a718244ac02f012f8b7 rdf:first sg:person.07767665514.43
    157 rdf:rest N0d3426e3399d49cc81ac976634cb19ec
    158 N13daa5de008d48a2a5dc223fe4043d6a schema:name dimensions_id
    159 schema:value pub.1141971410
    160 rdf:type schema:PropertyValue
    161 N14db3fe942d246adb1dde1242412b940 schema:name pubmed_id
    162 schema:value 34663344
    163 rdf:type schema:PropertyValue
    164 N2eb0ecad43ea4fdb8af021b0543eb11d schema:affiliation grid-institutes:grid.411750.6
    165 schema:familyName Bardestani
    166 schema:givenName Akram
    167 rdf:type schema:Person
    168 N6c830a1183aa44a1a7ca969d89d8af37 rdf:first N2eb0ecad43ea4fdb8af021b0543eb11d
    169 rdf:rest N773c2d454e2247b4bf09b8237660a366
    170 N75ee3fffc85c4244bc475fca8d1edb0e schema:name doi
    171 schema:value 10.1186/s12951-021-01059-0
    172 rdf:type schema:PropertyValue
    173 N773c2d454e2247b4bf09b8237660a366 rdf:first sg:person.016131754443.75
    174 rdf:rest N0e4df129100b4a718244ac02f012f8b7
    175 Nd07ecb9cea1a40c3827f2e6c726bbf45 schema:name Springer Nature - SN SciGraph project
    176 rdf:type schema:Organization
    177 Neb20dc58c582421ba295394ab54a4602 schema:volumeNumber 19
    178 rdf:type schema:PublicationVolume
    179 anzsrc-for:10 schema:inDefinedTermSet anzsrc-for:
    180 schema:name Technology
    181 rdf:type schema:DefinedTerm
    182 sg:journal.1031280 schema:issn 1477-3155
    183 schema:name Journal of Nanobiotechnology
    184 schema:publisher Springer Nature
    185 rdf:type schema:Periodical
    186 sg:person.016131754443.75 schema:affiliation grid-institutes:grid.411750.6
    187 schema:familyName Ebrahimpour
    188 schema:givenName Shiva
    189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016131754443.75
    190 rdf:type schema:Person
    191 sg:person.0624466712.36 schema:affiliation grid-institutes:grid.411750.6
    192 schema:familyName Esmaeili
    193 schema:givenName Abolghasem
    194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624466712.36
    195 rdf:type schema:Person
    196 sg:person.07767665514.43 schema:affiliation grid-institutes:grid.411036.1
    197 schema:familyName Esmaeili
    198 schema:givenName Ali
    199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07767665514.43
    200 rdf:type schema:Person
    201 sg:pub.10.1007/978-3-211-09469-3_15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053528945
    202 https://doi.org/10.1007/978-3-211-09469-3_15
    203 rdf:type schema:CreativeWork
    204 sg:pub.10.1007/s00210-020-01963-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1130161922
    205 https://doi.org/10.1007/s00210-020-01963-6
    206 rdf:type schema:CreativeWork
    207 sg:pub.10.1007/s00247-021-05098-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1138399337
    208 https://doi.org/10.1007/s00247-021-05098-5
    209 rdf:type schema:CreativeWork
    210 sg:pub.10.1007/s00394-018-1680-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101823086
    211 https://doi.org/10.1007/s00394-018-1680-7
    212 rdf:type schema:CreativeWork
    213 sg:pub.10.1007/s00580-018-2783-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105202815
    214 https://doi.org/10.1007/s00580-018-2783-5
    215 rdf:type schema:CreativeWork
    216 sg:pub.10.1007/s00701-010-0889-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039023198
    217 https://doi.org/10.1007/s00701-010-0889-x
    218 rdf:type schema:CreativeWork
    219 sg:pub.10.1007/s00702-010-0531-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043865772
    220 https://doi.org/10.1007/s00702-010-0531-3
    221 rdf:type schema:CreativeWork
    222 sg:pub.10.1007/s00706-011-0472-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1035033301
    223 https://doi.org/10.1007/s00706-011-0472-z
    224 rdf:type schema:CreativeWork
    225 sg:pub.10.1007/s10534-012-9538-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002269989
    226 https://doi.org/10.1007/s10534-012-9538-6
    227 rdf:type schema:CreativeWork
    228 sg:pub.10.1007/s10571-009-9411-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009920237
    229 https://doi.org/10.1007/s10571-009-9411-5
    230 rdf:type schema:CreativeWork
    231 sg:pub.10.1007/s11051-013-1520-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005214414
    232 https://doi.org/10.1007/s11051-013-1520-x
    233 rdf:type schema:CreativeWork
    234 sg:pub.10.1007/s11064-011-0458-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023481375
    235 https://doi.org/10.1007/s11064-011-0458-6
    236 rdf:type schema:CreativeWork
    237 sg:pub.10.1007/s11064-014-1457-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024537892
    238 https://doi.org/10.1007/s11064-014-1457-1
    239 rdf:type schema:CreativeWork
    240 sg:pub.10.1007/s12035-015-9259-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043864611
    241 https://doi.org/10.1007/s12035-015-9259-2
    242 rdf:type schema:CreativeWork
    243 sg:pub.10.1007/s12035-015-9582-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036583838
    244 https://doi.org/10.1007/s12035-015-9582-7
    245 rdf:type schema:CreativeWork
    246 sg:pub.10.1007/s12975-013-0317-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036276721
    247 https://doi.org/10.1007/s12975-013-0317-7
    248 rdf:type schema:CreativeWork
    249 sg:pub.10.1007/s12975-020-00844-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1130505783
    250 https://doi.org/10.1007/s12975-020-00844-7
    251 rdf:type schema:CreativeWork
    252 sg:pub.10.1007/s40262-014-0151-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022276302
    253 https://doi.org/10.1007/s40262-014-0151-4
    254 rdf:type schema:CreativeWork
    255 sg:pub.10.1023/a:1006948027674 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047079507
    256 https://doi.org/10.1023/a:1006948027674
    257 rdf:type schema:CreativeWork
    258 sg:pub.10.1023/a:1009229429250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031440554
    259 https://doi.org/10.1023/a:1009229429250
    260 rdf:type schema:CreativeWork
    261 sg:pub.10.1038/cr.2010.39 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020089756
    262 https://doi.org/10.1038/cr.2010.39
    263 rdf:type schema:CreativeWork
    264 sg:pub.10.1038/nm.2613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051306196
    265 https://doi.org/10.1038/nm.2613
    266 rdf:type schema:CreativeWork
    267 sg:pub.10.1038/nrdp.2018.16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103157573
    268 https://doi.org/10.1038/nrdp.2018.16
    269 rdf:type schema:CreativeWork
    270 sg:pub.10.1038/nrn3453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009983274
    271 https://doi.org/10.1038/nrn3453
    272 rdf:type schema:CreativeWork
    273 sg:pub.10.1038/s41380-019-0375-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112197704
    274 https://doi.org/10.1038/s41380-019-0375-7
    275 rdf:type schema:CreativeWork
    276 sg:pub.10.1038/s41419-020-2298-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1124546105
    277 https://doi.org/10.1038/s41419-020-2298-2
    278 rdf:type schema:CreativeWork
    279 sg:pub.10.1038/s41556-020-0535-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1128829037
    280 https://doi.org/10.1038/s41556-020-0535-7
    281 rdf:type schema:CreativeWork
    282 sg:pub.10.1038/s41598-017-01402-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085123010
    283 https://doi.org/10.1038/s41598-017-01402-2
    284 rdf:type schema:CreativeWork
    285 sg:pub.10.1038/s41598-017-08024-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091025374
    286 https://doi.org/10.1038/s41598-017-08024-8
    287 rdf:type schema:CreativeWork
    288 sg:pub.10.1038/s41598-018-19628-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1100671511
    289 https://doi.org/10.1038/s41598-018-19628-z
    290 rdf:type schema:CreativeWork
    291 sg:pub.10.1038/s41598-019-43345-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1113902333
    292 https://doi.org/10.1038/s41598-019-43345-w
    293 rdf:type schema:CreativeWork
    294 sg:pub.10.1038/s41598-019-56847-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1123950493
    295 https://doi.org/10.1038/s41598-019-56847-4
    296 rdf:type schema:CreativeWork
    297 sg:pub.10.1038/s41598-020-67724-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1129071534
    298 https://doi.org/10.1038/s41598-020-67724-w
    299 rdf:type schema:CreativeWork
    300 sg:pub.10.1038/s41598-020-71678-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1130841108
    301 https://doi.org/10.1038/s41598-020-71678-4
    302 rdf:type schema:CreativeWork
    303 sg:pub.10.1038/s41598-020-71971-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1131257331
    304 https://doi.org/10.1038/s41598-020-71971-2
    305 rdf:type schema:CreativeWork
    306 sg:pub.10.1038/s41598-021-87687-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1137348097
    307 https://doi.org/10.1038/s41598-021-87687-w
    308 rdf:type schema:CreativeWork
    309 sg:pub.10.1038/s42003-018-0121-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106133620
    310 https://doi.org/10.1038/s42003-018-0121-8
    311 rdf:type schema:CreativeWork
    312 sg:pub.10.1038/s42255-019-0070-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1114148232
    313 https://doi.org/10.1038/s42255-019-0070-7
    314 rdf:type schema:CreativeWork
    315 sg:pub.10.1038/srep17261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019922463
    316 https://doi.org/10.1038/srep17261
    317 rdf:type schema:CreativeWork
    318 sg:pub.10.1186/s12868-017-0369-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086300646
    319 https://doi.org/10.1186/s12868-017-0369-9
    320 rdf:type schema:CreativeWork
    321 sg:pub.10.1186/s13024-017-0218-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092310871
    322 https://doi.org/10.1186/s13024-017-0218-4
    323 rdf:type schema:CreativeWork
    324 sg:pub.10.1186/s13223-020-00434-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1127619032
    325 https://doi.org/10.1186/s13223-020-00434-0
    326 rdf:type schema:CreativeWork
    327 sg:pub.10.1186/s40360-017-0192-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1100192671
    328 https://doi.org/10.1186/s40360-017-0192-z
    329 rdf:type schema:CreativeWork
    330 sg:pub.10.1186/s40360-018-0249-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107230248
    331 https://doi.org/10.1186/s40360-018-0249-7
    332 rdf:type schema:CreativeWork
    333 sg:pub.10.2165/00002018-200326080-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045114336
    334 https://doi.org/10.2165/00002018-200326080-00003
    335 rdf:type schema:CreativeWork
    336 grid-institutes:grid.411036.1 schema:alternateName School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
    337 schema:name School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
    338 rdf:type schema:Organization
    339 grid-institutes:grid.411750.6 schema:alternateName Department of Cell and Molecular Biology & Microbiology, Faculty of Biological Science and Technology, University of Isfahan, P.O. Box: 8174673441, Isfahan, Iran
    340 schema:name Department of Cell and Molecular Biology & Microbiology, Faculty of Biological Science and Technology, University of Isfahan, P.O. Box: 8174673441, Isfahan, Iran
    341 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...