Catalytic core–shell nanoparticles with self-supplied calcium and H2O2 to enable combinational tumor inhibition View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-10-12

AUTHORS

Hanjing Kong, Chao Fang, Qiang Chu, Zefeng Hu, Yike Fu, Gaorong Han, Xiang Li, Yi Zhou

ABSTRACT

Nanoparticles, presenting catalytic activity to induce intracellular oxidative species, have been extensively explored for tumor treatment, but suffer daunting challenges in the limited intracellular H2O2 and thus suppressed therapeutic efficacy. Here in this study, a type of composite nanoparticles, consisting CaO2 core and Co-ferrocene shell, is designed and synthesized for combinational tumor treatment. The findings indicate that CaO2 core can be hydrolyzed to produce large amounts of H2O2 and calcium ions at the acidic tumor sites. Meanwhile, Co-ferrocene shell acts as an excellent Fenton catalyst, inducing considerable ROS generation following its reaction with H2O2. Excessive cellular oxidative stress triggers agitated calcium accumulation in addition to the calcium ions released from the particles. The combined effect of intracellular ROS and calcium overload causes significant tumor inhibition both in vitro and in vivo. More... »

PAGES

313

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12951-021-01055-4

DOI

http://dx.doi.org/10.1186/s12951-021-01055-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1141826038

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34641854


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