Sericin based nanoformulations: a comprehensive review on molecular mechanisms of interaction with organisms to biological applications View Full Text


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Article Info

DATE

2021-01-22

AUTHORS

Gitishree Das, Han-Seung Shin, Estefânia V. Ramos Campos, Leonardo Fernandes Fraceto, Maria del Pilar Rodriguez-Torres, Kelli Cristina Freitas Mariano, Daniele Ribeiro de Araujo, Fabián Fernández-Luqueño, Renato Grillo, Jayanta Kumar Patra

ABSTRACT

BackgroundThe advances in products based on nanotechnology have directed extensive research on low-cost, biologically compatible, and easily degradable materials.Main bodySericin (SER) is a protein mainly composed of glycine, serine, aspartic acid, and threonine amino acids removed from the silkworm cocoon (particularly Bombyx mori and other species). SER is a biocompatible material with economic viability, which can be easily functionalized due to its potential crosslink reactions. Also, SER has inherent biological properties, which makes possible its use as a component of pharmaceutical formulations with several biomedical applications, such as anti-tumor, antimicrobials, antioxidants and as scaffolds for tissue repair as well as participating in molecular mechanisms attributed to the regulation of transcription factors, reduction of inflammatory signaling molecules, stimulation of apoptosis, migration, and proliferation of mesenchymal cells.ConclusionIn this review, the recent innovations on SER-based nano-medicines (nanoparticles, micelles, films, hydrogels, and their hybrid systems) and their contributions for non-conventional therapies are discussed considering different molecular mechanisms for promoting their therapeutic applications. More... »

PAGES

30

References to SciGraph publications

  • 2018-10-08. Adaptive effect of sericin on hepatic mitochondrial conformation through its regulation of apoptosis, autophagy and energy maintenance: a proteomics approach in SCIENTIFIC REPORTS
  • 1951-10. Amino-acids of Silk Sericin in NATURE
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  • 2019-05-23. Coating of modified poly(ethylene terephthalate) fibers with sericin-capped silver nanoparticles for antimicrobial application in POLYMER BULLETIN
  • 2019-10-09. The inhibitory effect of silk sericin against ultraviolet-induced melanogenesis and its potential use in cosmeceutics as an anti-hyperpigmentation compound in PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
  • 2018-09-18. The potential use of gentamicin sulfate-loaded poly(l-lactic acid)-sericin hybrid scaffolds for bone tissue engineering in POLYMER BULLETIN
  • 2016-07-19. Further development of silk sericin as a biomaterial: comparative investigation of the procedures for its isolation from Bombyx mori silk cocoons in PROGRESS IN BIOMATERIALS
  • 2014-10-20. Silk Fibroin in ENCYCLOPEDIA OF POLYMERIC NANOMATERIALS
  • 2014-11-20. Exploring natural silk protein sericin for regenerative medicine: an injectable, photoluminescent, cell-adhesive 3D hydrogel in SCIENTIFIC REPORTS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12951-021-00774-y

    DOI

    http://dx.doi.org/10.1186/s12951-021-00774-y

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/33482828


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    27 schema:description BackgroundThe advances in products based on nanotechnology have directed extensive research on low-cost, biologically compatible, and easily degradable materials.Main bodySericin (SER) is a protein mainly composed of glycine, serine, aspartic acid, and threonine amino acids removed from the silkworm cocoon (particularly Bombyx mori and other species). SER is a biocompatible material with economic viability, which can be easily functionalized due to its potential crosslink reactions. Also, SER has inherent biological properties, which makes possible its use as a component of pharmaceutical formulations with several biomedical applications, such as anti-tumor, antimicrobials, antioxidants and as scaffolds for tissue repair as well as participating in molecular mechanisms attributed to the regulation of transcription factors, reduction of inflammatory signaling molecules, stimulation of apoptosis, migration, and proliferation of mesenchymal cells.ConclusionIn this review, the recent innovations on SER-based nano-medicines (nanoparticles, micelles, films, hydrogels, and their hybrid systems) and their contributions for non-conventional therapies are discussed considering different molecular mechanisms for promoting their therapeutic applications.
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    36 acid
    37 advances
    38 amino acids
    39 antimicrobials
    40 antioxidants
    41 apoptosis
    42 applications
    43 aspartic acid
    44 biocompatible materials
    45 biological applications
    46 biological properties
    47 biomedical applications
    48 cells
    49 cocoons
    50 components
    51 comprehensive review
    52 contribution
    53 crosslink reaction
    54 degradable materials
    55 different molecular mechanisms
    56 economic viability
    57 extensive research
    58 factors
    59 formulation
    60 glycine
    61 inherent biological properties
    62 innovation
    63 interaction
    64 materials
    65 mechanism
    66 mesenchymal cells
    67 migration
    68 molecular mechanisms
    69 molecules
    70 nanoformulations
    71 nanotechnology
    72 non-conventional therapies
    73 organisms
    74 pharmaceutical formulations
    75 products
    76 proliferation
    77 properties
    78 protein
    79 reaction
    80 recent innovations
    81 reduction
    82 regulation
    83 repair
    84 research
    85 review
    86 scaffolds
    87 sericin
    88 serine
    89 silkworm cocoons
    90 stimulation
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    92 therapeutic applications
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