Role of A2B adenosine receptor-dependent adenosine signaling in multi-walled carbon nanotube-triggered lung fibrosis in mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Biying Liu, Qizheng Bing, Siyu Li, Bing Han, Jingjing Lu, Ruiqi Baiyun, Xiaoya Zhang, Yueying Lv, Hao Wu, Zhigang Zhang

ABSTRACT

BACKGROUND: Multi-walled carbon nanotube (MWCNT)-induced lung fibrosis leads to health concerns in human. However, the mechanisms underlying fibrosis pathogenesis remains unclear. The adenosine (ADO) is produced in response to injury and serves a detrimental role in lung fibrosis. In this study, we aimed to explore the ADO signaling in the progression of lung fibrosis induced by MWCNT. RESULTS: MWCNT exposure markedly increased A2B adenosine receptor (A2BAR) expression in the lungs and ADO level in bronchoalveolar lavage fluid, combined with elevation of blood neutrophils, collagen fiber deposition, and activation of myeloperoxidase (MPO) activity in the lungs. Furthermore, MWCNT exposure elicited an activation of transforming growth factor (TGF)-β1 and follistatin-like 1 (Fstl1), leading to fibroblasts recruitment and differentiation into myofibroblasts in the lungs in an A2BAR-dependent manner. Conversely, treatment of the selective A2BAR antagonist CVT-6883 exhibited a significant reduction in levels of fibrosis mediators and efficiently decreased cytotoxicity and inflammatory in MWCNT treated mice. CONCLUSION: Our results reveal that accumulation of extracellular ADO promotes the process of the fibroblast-to-myofibroblast transition via A2BAR/TGF-β1/Fstl1 signaling in MWCNT-induced lung fibrosis. More... »

PAGES

45

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12951-019-0478-y

DOI

http://dx.doi.org/10.1186/s12951-019-0478-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113058189

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30922349


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Northeast Agricultural University", 
          "id": "https://www.grid.ac/institutes/grid.412243.2", 
          "name": [
            "College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Road, 150030, Harbin, China", 
            "Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, 600 Changjiang Road, 150030, Harbin, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Biying", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Northeast Agricultural University", 
          "id": "https://www.grid.ac/institutes/grid.412243.2", 
          "name": [
            "College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Road, 150030, Harbin, China", 
            "Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, 600 Changjiang Road, 150030, Harbin, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bing", 
        "givenName": "Qizheng", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Northeast Agricultural University", 
          "id": "https://www.grid.ac/institutes/grid.412243.2", 
          "name": [
            "College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Road, 150030, Harbin, China", 
            "Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, 600 Changjiang Road, 150030, Harbin, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Siyu", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Northeast Agricultural University", 
          "id": "https://www.grid.ac/institutes/grid.412243.2", 
          "name": [
            "College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Road, 150030, Harbin, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Han", 
        "givenName": "Bing", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Northeast Agricultural University", 
          "id": "https://www.grid.ac/institutes/grid.412243.2", 
          "name": [
            "College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Road, 150030, Harbin, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lu", 
        "givenName": "Jingjing", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Northeast Agricultural University", 
          "id": "https://www.grid.ac/institutes/grid.412243.2", 
          "name": [
            "College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Road, 150030, Harbin, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baiyun", 
        "givenName": "Ruiqi", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Northeast Agricultural University", 
          "id": "https://www.grid.ac/institutes/grid.412243.2", 
          "name": [
            "College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Road, 150030, Harbin, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Xiaoya", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Northeast Agricultural University", 
          "id": "https://www.grid.ac/institutes/grid.412243.2", 
          "name": [
            "College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Road, 150030, Harbin, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lv", 
        "givenName": "Yueying", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Northeast Agricultural University", 
          "id": "https://www.grid.ac/institutes/grid.412243.2", 
          "name": [
            "College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Road, 150030, Harbin, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "Hao", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Northeast Agricultural University", 
          "id": "https://www.grid.ac/institutes/grid.412243.2", 
          "name": [
            "College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Road, 150030, Harbin, China", 
            "Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, 600 Changjiang Road, 150030, Harbin, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Zhigang", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.3109/17435390.2015.1110758", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001889737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajpath.2012.02.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002907994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/09031936.04.00120803", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004012056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12989-016-0172-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004305921", 
          "https://doi.org/10.1186/s12989-016-0172-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12989-016-0172-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004305921", 
          "https://doi.org/10.1186/s12989-016-0172-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/17435390.2016.1262919", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005887203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/jpet.106.112250", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006292491"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.15-274845", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007763401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.2009-040gl", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009587829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/smll.201303588", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017588386"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12931-016-0320-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020137032", 
          "https://doi.org/10.1186/s12931-016-0320-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12931-016-0320-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020137032", 
          "https://doi.org/10.1186/s12931-016-0320-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.176.7.4449", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020560882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2016.11.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023448632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00109-013-0997-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028645732", 
          "https://doi.org/10.1007/s00109-013-0997-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.intimp.2013.06.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028775085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12989-016-0123-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029826884", 
          "https://doi.org/10.1186/s12989-016-0123-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20121878", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030023715"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/17435390.2015.1078852", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031701069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0009224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034320947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1165/rcmb.2013-0089oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036138839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tox.2009.10.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040256173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12989-016-0138-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041814317", 
          "https://doi.org/10.1186/s12989-016-0138-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci27303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042274622"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1002907", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045899890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplung.00258.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046209277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplung.00258.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046209277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.201343461", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048352178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/17435390802318349", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049819194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.14-260182", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050000194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1743-8977-10-57", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051346577", 
          "https://doi.org/10.1186/1743-8977-10-57"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/japplphysiol.00350.2015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063198334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-15-2310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063215960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.201601228r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084192951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/bph.13763", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084210900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/bph.13763", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084210900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mnfr.201700016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085210495"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplung.00523.2016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085465484"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12989-017-0198-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085930507", 
          "https://doi.org/10.1186/s12989-017-0198-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12989-017-0198-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085930507", 
          "https://doi.org/10.1186/s12989-017-0198-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fphar.2017.00428", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090296419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/smll.201700776", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090344013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12989-017-0204-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090608825", 
          "https://doi.org/10.1186/s12989-017-0204-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12989-017-0204-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090608825", 
          "https://doi.org/10.1186/s12989-017-0204-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.201700219r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090658013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.201612-2480oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091088975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1165/rcmb.2016-0192oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091158456"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.4979", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091415497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci94624", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091481443"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1165/rcmb.2017-0088oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091512902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/anie.201706228", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091520805"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12989-017-0218-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091608445", 
          "https://doi.org/10.1186/s12989-017-0218-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/wnan.1498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092113304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fphys.2017.00777", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092186926"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jnutbio.2017.09.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092194913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fphar.2017.00904", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099651568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/17435390.2018.1425501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100456401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/17435390.2018.1425501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100456401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/17435390.2018.1425501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100456401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fphar.2018.00054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100718958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.fct.2018.02.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100836817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.freeradbiomed.2018.10.423", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1107640616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.freeradbiomed.2018.10.423", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1107640616"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "BACKGROUND: Multi-walled carbon nanotube (MWCNT)-induced lung fibrosis leads to health concerns in human. However, the mechanisms underlying fibrosis pathogenesis remains unclear. The adenosine (ADO) is produced in response to injury and serves a detrimental role in lung fibrosis. In this study, we aimed to explore the ADO signaling in the progression of lung fibrosis induced by MWCNT.\nRESULTS: MWCNT exposure markedly increased A2B adenosine receptor (A2BAR) expression in the lungs and ADO level in bronchoalveolar lavage fluid, combined with elevation of blood neutrophils, collagen fiber deposition, and activation of myeloperoxidase (MPO) activity in the lungs. Furthermore, MWCNT exposure elicited an activation of transforming growth factor (TGF)-\u03b21 and follistatin-like 1 (Fstl1), leading to fibroblasts recruitment and differentiation into myofibroblasts in the lungs in an A2BAR-dependent manner. Conversely, treatment of the selective A2BAR antagonist CVT-6883 exhibited a significant reduction in levels of fibrosis mediators and efficiently decreased cytotoxicity and inflammatory in MWCNT treated mice.\nCONCLUSION: Our results reveal that accumulation of extracellular ADO promotes the process of the fibroblast-to-myofibroblast transition via A2BAR/TGF-\u03b21/Fstl1 signaling in MWCNT-induced lung fibrosis.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12951-019-0478-y", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6997893", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1031280", 
        "issn": [
          "1477-3155"
        ], 
        "name": "Journal of Nanobiotechnology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "17"
      }
    ], 
    "name": "Role of A2B adenosine receptor-dependent adenosine signaling in multi-walled carbon nanotube-triggered lung fibrosis in mice", 
    "pagination": "45", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12951-019-0478-y"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1113058189"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "b606461dbd4300aad961752271b64c1f2ec994b395791270146bc611c93f74e8"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101152208"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30922349"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12951-019-0478-y", 
      "https://app.dimensions.ai/details/publication/pub.1113058189"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-16T06:21", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000377_0000000377/records_106803_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12951-019-0478-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12951-019-0478-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12951-019-0478-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12951-019-0478-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12951-019-0478-y'


 

This table displays all metadata directly associated to this object as RDF triples.

295 TRIPLES      21 PREDICATES      83 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12951-019-0478-y schema:about anzsrc-for:11
2 anzsrc-for:1102
3 schema:author Nb4cab55407ff4fb58fefc0db5bd2e8de
4 schema:citation sg:pub.10.1007/s00109-013-0997-1
5 sg:pub.10.1186/1743-8977-10-57
6 sg:pub.10.1186/s12931-016-0320-0
7 sg:pub.10.1186/s12989-016-0123-y
8 sg:pub.10.1186/s12989-016-0138-4
9 sg:pub.10.1186/s12989-016-0172-2
10 sg:pub.10.1186/s12989-017-0198-0
11 sg:pub.10.1186/s12989-017-0204-6
12 sg:pub.10.1186/s12989-017-0218-0
13 https://doi.org/10.1002/anie.201706228
14 https://doi.org/10.1002/eji.201343461
15 https://doi.org/10.1002/mnfr.201700016
16 https://doi.org/10.1002/path.4979
17 https://doi.org/10.1002/smll.201303588
18 https://doi.org/10.1002/smll.201700776
19 https://doi.org/10.1002/wnan.1498
20 https://doi.org/10.1016/j.ajpath.2012.02.004
21 https://doi.org/10.1016/j.biomaterials.2016.11.005
22 https://doi.org/10.1016/j.fct.2018.02.003
23 https://doi.org/10.1016/j.freeradbiomed.2018.10.423
24 https://doi.org/10.1016/j.intimp.2013.06.005
25 https://doi.org/10.1016/j.jnutbio.2017.09.025
26 https://doi.org/10.1016/j.tox.2009.10.017
27 https://doi.org/10.1080/17435390.2016.1262919
28 https://doi.org/10.1080/17435390.2018.1425501
29 https://doi.org/10.1080/17435390802318349
30 https://doi.org/10.1084/jem.20121878
31 https://doi.org/10.1096/fj.14-260182
32 https://doi.org/10.1096/fj.15-274845
33 https://doi.org/10.1096/fj.201601228r
34 https://doi.org/10.1096/fj.201700219r
35 https://doi.org/10.1111/bph.13763
36 https://doi.org/10.1124/jpet.106.112250
37 https://doi.org/10.1152/ajplung.00258.2005
38 https://doi.org/10.1152/ajplung.00523.2016
39 https://doi.org/10.1152/japplphysiol.00350.2015
40 https://doi.org/10.1158/0008-5472.can-15-2310
41 https://doi.org/10.1164/rccm.2009-040gl
42 https://doi.org/10.1164/rccm.201612-2480oc
43 https://doi.org/10.1165/rcmb.2013-0089oc
44 https://doi.org/10.1165/rcmb.2016-0192oc
45 https://doi.org/10.1165/rcmb.2017-0088oc
46 https://doi.org/10.1172/jci27303
47 https://doi.org/10.1172/jci94624
48 https://doi.org/10.1183/09031936.04.00120803
49 https://doi.org/10.1371/journal.pone.0009224
50 https://doi.org/10.3109/17435390.2015.1078852
51 https://doi.org/10.3109/17435390.2015.1110758
52 https://doi.org/10.3389/fphar.2017.00428
53 https://doi.org/10.3389/fphar.2017.00904
54 https://doi.org/10.3389/fphar.2018.00054
55 https://doi.org/10.3389/fphys.2017.00777
56 https://doi.org/10.4049/jimmunol.1002907
57 https://doi.org/10.4049/jimmunol.176.7.4449
58 schema:datePublished 2019-12
59 schema:datePublishedReg 2019-12-01
60 schema:description BACKGROUND: Multi-walled carbon nanotube (MWCNT)-induced lung fibrosis leads to health concerns in human. However, the mechanisms underlying fibrosis pathogenesis remains unclear. The adenosine (ADO) is produced in response to injury and serves a detrimental role in lung fibrosis. In this study, we aimed to explore the ADO signaling in the progression of lung fibrosis induced by MWCNT. RESULTS: MWCNT exposure markedly increased A2B adenosine receptor (A2BAR) expression in the lungs and ADO level in bronchoalveolar lavage fluid, combined with elevation of blood neutrophils, collagen fiber deposition, and activation of myeloperoxidase (MPO) activity in the lungs. Furthermore, MWCNT exposure elicited an activation of transforming growth factor (TGF)-β1 and follistatin-like 1 (Fstl1), leading to fibroblasts recruitment and differentiation into myofibroblasts in the lungs in an A2BAR-dependent manner. Conversely, treatment of the selective A2BAR antagonist CVT-6883 exhibited a significant reduction in levels of fibrosis mediators and efficiently decreased cytotoxicity and inflammatory in MWCNT treated mice. CONCLUSION: Our results reveal that accumulation of extracellular ADO promotes the process of the fibroblast-to-myofibroblast transition via A2BAR/TGF-β1/Fstl1 signaling in MWCNT-induced lung fibrosis.
61 schema:genre research_article
62 schema:inLanguage en
63 schema:isAccessibleForFree true
64 schema:isPartOf N2ee3344f2620464581704764be1de19f
65 N917a13e4d6ed4685b5d9194aa6e81f95
66 sg:journal.1031280
67 schema:name Role of A2B adenosine receptor-dependent adenosine signaling in multi-walled carbon nanotube-triggered lung fibrosis in mice
68 schema:pagination 45
69 schema:productId N00b9a5c350724d32b6256ae89100a769
70 N04be7844716c407b966e3508e165e51b
71 N8c6b3ef4a9bc4052938d484efe96e2d4
72 Na4c7904d765e4c269f07bd4544837e5e
73 Ncbe5ce8e9b2d4afdb6362a415d4304e0
74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113058189
75 https://doi.org/10.1186/s12951-019-0478-y
76 schema:sdDatePublished 2019-04-16T06:21
77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
78 schema:sdPublisher Nb92932bce8954685922539b24e87e125
79 schema:url https://link.springer.com/10.1186%2Fs12951-019-0478-y
80 sgo:license sg:explorer/license/
81 sgo:sdDataset articles
82 rdf:type schema:ScholarlyArticle
83 N00b9a5c350724d32b6256ae89100a769 schema:name nlm_unique_id
84 schema:value 101152208
85 rdf:type schema:PropertyValue
86 N04be7844716c407b966e3508e165e51b schema:name doi
87 schema:value 10.1186/s12951-019-0478-y
88 rdf:type schema:PropertyValue
89 N04c9f718d79349b5953187b981d2e9fa schema:affiliation https://www.grid.ac/institutes/grid.412243.2
90 schema:familyName Lv
91 schema:givenName Yueying
92 rdf:type schema:Person
93 N0eca9e15266443729ff306f398cce218 schema:affiliation https://www.grid.ac/institutes/grid.412243.2
94 schema:familyName Li
95 schema:givenName Siyu
96 rdf:type schema:Person
97 N14f1abd2e5014e1d9dd976c12b56fef3 schema:affiliation https://www.grid.ac/institutes/grid.412243.2
98 schema:familyName Zhang
99 schema:givenName Zhigang
100 rdf:type schema:Person
101 N1847d306f01a4a3784174e1bbffef60a rdf:first Ncfd362c9af884c85b46c44da073cdcff
102 rdf:rest Nb9d2f2dc86c644078664f7d12f2def09
103 N2ee3344f2620464581704764be1de19f schema:volumeNumber 17
104 rdf:type schema:PublicationVolume
105 N3c63ff3638f943acb4f2746a2847c318 rdf:first N0eca9e15266443729ff306f398cce218
106 rdf:rest N1847d306f01a4a3784174e1bbffef60a
107 N3c8c38a9a9f04f24867c75e7a55d45e2 schema:affiliation https://www.grid.ac/institutes/grid.412243.2
108 schema:familyName Wu
109 schema:givenName Hao
110 rdf:type schema:Person
111 N4c2358d58422454a879bde05dc42eb5b rdf:first Nea1ab1f9f9444c80882267199bb31670
112 rdf:rest Nc210eb4305704a19adb81bbfe167bf08
113 N4fedbbeade8d482e840c58ba968942c1 schema:affiliation https://www.grid.ac/institutes/grid.412243.2
114 schema:familyName Liu
115 schema:givenName Biying
116 rdf:type schema:Person
117 N8c6b3ef4a9bc4052938d484efe96e2d4 schema:name pubmed_id
118 schema:value 30922349
119 rdf:type schema:PropertyValue
120 N917a13e4d6ed4685b5d9194aa6e81f95 schema:issueNumber 1
121 rdf:type schema:PublicationIssue
122 Na4c7904d765e4c269f07bd4544837e5e schema:name readcube_id
123 schema:value b606461dbd4300aad961752271b64c1f2ec994b395791270146bc611c93f74e8
124 rdf:type schema:PropertyValue
125 Na505e155c0164f0a9bfe27e6b152a4ff rdf:first N14f1abd2e5014e1d9dd976c12b56fef3
126 rdf:rest rdf:nil
127 Nb4cab55407ff4fb58fefc0db5bd2e8de rdf:first N4fedbbeade8d482e840c58ba968942c1
128 rdf:rest Nd452cd3b060b4add87e92bc5d4bc71bf
129 Nb92932bce8954685922539b24e87e125 schema:name Springer Nature - SN SciGraph project
130 rdf:type schema:Organization
131 Nb9d2f2dc86c644078664f7d12f2def09 rdf:first Nf123fa48c5334cd9831f85d01bc1344d
132 rdf:rest N4c2358d58422454a879bde05dc42eb5b
133 Nc210eb4305704a19adb81bbfe167bf08 rdf:first Ne71e223e1b5e4730b3e3fcd2fb857c4a
134 rdf:rest Nc76b3f74a37349439c819cf96d1225d9
135 Nc76b3f74a37349439c819cf96d1225d9 rdf:first N04c9f718d79349b5953187b981d2e9fa
136 rdf:rest Nfa1f0cbc7adf4a4c904e0a63c3fc7cfb
137 Ncbe5ce8e9b2d4afdb6362a415d4304e0 schema:name dimensions_id
138 schema:value pub.1113058189
139 rdf:type schema:PropertyValue
140 Ncfd362c9af884c85b46c44da073cdcff schema:affiliation https://www.grid.ac/institutes/grid.412243.2
141 schema:familyName Han
142 schema:givenName Bing
143 rdf:type schema:Person
144 Nd2832fbccd564cd1ac3789fe901f43ea schema:affiliation https://www.grid.ac/institutes/grid.412243.2
145 schema:familyName Bing
146 schema:givenName Qizheng
147 rdf:type schema:Person
148 Nd452cd3b060b4add87e92bc5d4bc71bf rdf:first Nd2832fbccd564cd1ac3789fe901f43ea
149 rdf:rest N3c63ff3638f943acb4f2746a2847c318
150 Ne71e223e1b5e4730b3e3fcd2fb857c4a schema:affiliation https://www.grid.ac/institutes/grid.412243.2
151 schema:familyName Zhang
152 schema:givenName Xiaoya
153 rdf:type schema:Person
154 Nea1ab1f9f9444c80882267199bb31670 schema:affiliation https://www.grid.ac/institutes/grid.412243.2
155 schema:familyName Baiyun
156 schema:givenName Ruiqi
157 rdf:type schema:Person
158 Nf123fa48c5334cd9831f85d01bc1344d schema:affiliation https://www.grid.ac/institutes/grid.412243.2
159 schema:familyName Lu
160 schema:givenName Jingjing
161 rdf:type schema:Person
162 Nfa1f0cbc7adf4a4c904e0a63c3fc7cfb rdf:first N3c8c38a9a9f04f24867c75e7a55d45e2
163 rdf:rest Na505e155c0164f0a9bfe27e6b152a4ff
164 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
165 schema:name Medical and Health Sciences
166 rdf:type schema:DefinedTerm
167 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
168 schema:name Cardiorespiratory Medicine and Haematology
169 rdf:type schema:DefinedTerm
170 sg:grant.6997893 http://pending.schema.org/fundedItem sg:pub.10.1186/s12951-019-0478-y
171 rdf:type schema:MonetaryGrant
172 sg:journal.1031280 schema:issn 1477-3155
173 schema:name Journal of Nanobiotechnology
174 rdf:type schema:Periodical
175 sg:pub.10.1007/s00109-013-0997-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028645732
176 https://doi.org/10.1007/s00109-013-0997-1
177 rdf:type schema:CreativeWork
178 sg:pub.10.1186/1743-8977-10-57 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051346577
179 https://doi.org/10.1186/1743-8977-10-57
180 rdf:type schema:CreativeWork
181 sg:pub.10.1186/s12931-016-0320-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020137032
182 https://doi.org/10.1186/s12931-016-0320-0
183 rdf:type schema:CreativeWork
184 sg:pub.10.1186/s12989-016-0123-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1029826884
185 https://doi.org/10.1186/s12989-016-0123-y
186 rdf:type schema:CreativeWork
187 sg:pub.10.1186/s12989-016-0138-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041814317
188 https://doi.org/10.1186/s12989-016-0138-4
189 rdf:type schema:CreativeWork
190 sg:pub.10.1186/s12989-016-0172-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004305921
191 https://doi.org/10.1186/s12989-016-0172-2
192 rdf:type schema:CreativeWork
193 sg:pub.10.1186/s12989-017-0198-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085930507
194 https://doi.org/10.1186/s12989-017-0198-0
195 rdf:type schema:CreativeWork
196 sg:pub.10.1186/s12989-017-0204-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090608825
197 https://doi.org/10.1186/s12989-017-0204-6
198 rdf:type schema:CreativeWork
199 sg:pub.10.1186/s12989-017-0218-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091608445
200 https://doi.org/10.1186/s12989-017-0218-0
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1002/anie.201706228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091520805
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1002/eji.201343461 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048352178
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1002/mnfr.201700016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085210495
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1002/path.4979 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091415497
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1002/smll.201303588 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017588386
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1002/smll.201700776 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090344013
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1002/wnan.1498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092113304
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1016/j.ajpath.2012.02.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002907994
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1016/j.biomaterials.2016.11.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023448632
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/j.fct.2018.02.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100836817
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/j.freeradbiomed.2018.10.423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107640616
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/j.intimp.2013.06.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028775085
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/j.jnutbio.2017.09.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092194913
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/j.tox.2009.10.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040256173
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1080/17435390.2016.1262919 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005887203
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1080/17435390.2018.1425501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100456401
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1080/17435390802318349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049819194
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1084/jem.20121878 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030023715
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1096/fj.14-260182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050000194
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1096/fj.15-274845 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007763401
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1096/fj.201601228r schema:sameAs https://app.dimensions.ai/details/publication/pub.1084192951
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1096/fj.201700219r schema:sameAs https://app.dimensions.ai/details/publication/pub.1090658013
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1111/bph.13763 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084210900
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1124/jpet.106.112250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006292491
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1152/ajplung.00258.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046209277
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1152/ajplung.00523.2016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085465484
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1152/japplphysiol.00350.2015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063198334
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1158/0008-5472.can-15-2310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063215960
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1164/rccm.2009-040gl schema:sameAs https://app.dimensions.ai/details/publication/pub.1009587829
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1164/rccm.201612-2480oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1091088975
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1165/rcmb.2013-0089oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1036138839
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1165/rcmb.2016-0192oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1091158456
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1165/rcmb.2017-0088oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1091512902
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1172/jci27303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042274622
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1172/jci94624 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091481443
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1183/09031936.04.00120803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004012056
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1371/journal.pone.0009224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034320947
275 rdf:type schema:CreativeWork
276 https://doi.org/10.3109/17435390.2015.1078852 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031701069
277 rdf:type schema:CreativeWork
278 https://doi.org/10.3109/17435390.2015.1110758 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001889737
279 rdf:type schema:CreativeWork
280 https://doi.org/10.3389/fphar.2017.00428 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090296419
281 rdf:type schema:CreativeWork
282 https://doi.org/10.3389/fphar.2017.00904 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099651568
283 rdf:type schema:CreativeWork
284 https://doi.org/10.3389/fphar.2018.00054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100718958
285 rdf:type schema:CreativeWork
286 https://doi.org/10.3389/fphys.2017.00777 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092186926
287 rdf:type schema:CreativeWork
288 https://doi.org/10.4049/jimmunol.1002907 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045899890
289 rdf:type schema:CreativeWork
290 https://doi.org/10.4049/jimmunol.176.7.4449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020560882
291 rdf:type schema:CreativeWork
292 https://www.grid.ac/institutes/grid.412243.2 schema:alternateName Northeast Agricultural University
293 schema:name College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Road, 150030, Harbin, China
294 Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, 600 Changjiang Road, 150030, Harbin, China
295 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...