The oxidative potential of differently charged silver and gold nanoparticles on three human lung epithelial cell types View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Paul Schlinkert, Eudald Casals, Matthew Boyles, Ulrike Tischler, Eva Hornig, Ngoc Tran, Jiayuan Zhao, Martin Himly, Michael Riediker, Gertie Janneke Oostingh, Victor Puntes, Albert Duschl

ABSTRACT

BACKGROUND: Nanoparticle (NPs) functionalization has been shown to affect their cellular toxicity. To study this, differently functionalized silver (Ag) and gold (Au) NPs were synthesised, characterised and tested using lung epithelial cell systems. METHODS: Monodispersed Ag and Au NPs with a size range of 7 to 10 nm were coated with either sodium citrate or chitosan resulting in surface charges from -50 mV to +70 mV. NP-induced cytotoxicity and oxidative stress were determined using A549 cells, BEAS-2B cells and primary lung epithelial cells (NHBE cells). TEER measurements and immunofluorescence staining of tight junctions were performed to test the growth characteristics of the cells. Cytotoxicity was measured by means of the CellTiter-Blue ® and the lactate dehydrogenase assay and cellular and cell-free reactive oxygen species (ROS) production was measured using the DCFH-DA assay. RESULTS: Different growth characteristics were shown in the three cell types used. A549 cells grew into a confluent mono-layer, BEAS-2B cells grew into a multilayer and NHBE cells did not form a confluent layer. A549 cells were least susceptible towards NPs, irrespective of the NP functionalization. Cytotoxicity in BEAS-2B cells increased when exposed to high positive charged (+65-75 mV) Au NPs. The greatest cytotoxicity was observed in NHBE cells, where both Ag and Au NPs with a charge above +40 mV induced cytotoxicity. ROS production was most prominent in A549 cells where Au NPs (+65-75 mV) induced the highest amount of ROS. In addition, cell-free ROS measurements showed a significant increase in ROS production with an increase in chitosan coating. CONCLUSIONS: Chitosan functionalization of NPs, with resultant high surface charges plays an important role in NP-toxicity. Au NPs, which have been shown to be inert and often non-cytotoxic, can become toxic upon coating with certain charged molecules. Notably, these effects are dependent on the core material of the particle, the cell type used for testing and the growth characteristics of these cell culture model systems. More... »

PAGES

1

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12951-014-0062-4

DOI

http://dx.doi.org/10.1186/s12951-014-0062-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014982235

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25592092


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bronchi", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Membrane", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell-Free System", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chitosan", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Culture Media", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epithelial Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gold", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lung", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Metal Nanoparticles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oxidants", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reactive Oxygen Species", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Silver", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Salzburg", 
          "id": "https://www.grid.ac/institutes/grid.7039.d", 
          "name": [
            "Department of Molecular Biology, Paris Lodron-University of Salzburg, Hellbrunnerstr. 34, A-5020, Salzburg, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schlinkert", 
        "givenName": "Paul", 
        "id": "sg:person.0755455151.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755455151.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Institute Catal\u00e1 de Nanotecnologia, Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Casals", 
        "givenName": "Eudald", 
        "id": "sg:person.0605076720.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605076720.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Salzburg", 
          "id": "https://www.grid.ac/institutes/grid.7039.d", 
          "name": [
            "Department of Molecular Biology, Paris Lodron-University of Salzburg, Hellbrunnerstr. 34, A-5020, Salzburg, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boyles", 
        "givenName": "Matthew", 
        "id": "sg:person.0746151145.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746151145.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Salzburg", 
          "id": "https://www.grid.ac/institutes/grid.7039.d", 
          "name": [
            "Department of Molecular Biology, Paris Lodron-University of Salzburg, Hellbrunnerstr. 34, A-5020, Salzburg, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tischler", 
        "givenName": "Ulrike", 
        "id": "sg:person.01235546765.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235546765.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Salzburg", 
          "id": "https://www.grid.ac/institutes/grid.7039.d", 
          "name": [
            "Department of Molecular Biology, Paris Lodron-University of Salzburg, Hellbrunnerstr. 34, A-5020, Salzburg, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hornig", 
        "givenName": "Eva", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Institute Catal\u00e1 de Nanotecnologia, Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tran", 
        "givenName": "Ngoc", 
        "id": "sg:person.01254245351.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254245351.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute for Work and Health", 
          "id": "https://www.grid.ac/institutes/grid.9976.1", 
          "name": [
            "Institute for Work and Health, Lausanne, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhao", 
        "givenName": "Jiayuan", 
        "id": "sg:person.01003635717.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003635717.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Salzburg", 
          "id": "https://www.grid.ac/institutes/grid.7039.d", 
          "name": [
            "Department of Molecular Biology, Paris Lodron-University of Salzburg, Hellbrunnerstr. 34, A-5020, Salzburg, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Himly", 
        "givenName": "Martin", 
        "id": "sg:person.0734735176.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734735176.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Occupational Medicine", 
          "id": "https://www.grid.ac/institutes/grid.483445.a", 
          "name": [
            "Institute for Work and Health, Lausanne, Switzerland", 
            "Institue for Occupational Medicine (IOM) Singapore, Downtown Core, Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Riediker", 
        "givenName": "Michael", 
        "id": "sg:person.01166307430.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166307430.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Salzburg University of Applied Sciences", 
          "id": "https://www.grid.ac/institutes/grid.452086.d", 
          "name": [
            "Department of Molecular Biology, Paris Lodron-University of Salzburg, Hellbrunnerstr. 34, A-5020, Salzburg, Austria", 
            "Biomedical Sciences, Salzburg University of Applied Sciences, Puch, Salzburg, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oostingh", 
        "givenName": "Gertie Janneke", 
        "id": "sg:person.0667175722.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667175722.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Institute Catal\u00e1 de Nanotecnologia, Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Puntes", 
        "givenName": "Victor", 
        "id": "sg:person.01070775134.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070775134.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Salzburg", 
          "id": "https://www.grid.ac/institutes/grid.7039.d", 
          "name": [
            "Department of Molecular Biology, Paris Lodron-University of Salzburg, Hellbrunnerstr. 34, A-5020, Salzburg, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Duschl", 
        "givenName": "Albert", 
        "id": "sg:person.01022661734.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022661734.54"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.3109/02770903.2012.705408", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000694421"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.toxlet.2007.08.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001314930"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/es062629t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001460962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/es062629t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001460962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cis.2008.09.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001487937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0166-1280(98)00361-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003446009"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/08958378.2011.582895", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004540779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/ijn.s28077", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005169571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/9780470747803.ch19", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005378373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c3an01463k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006101674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja107583h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008013568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja107583h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008013568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/17435390.2011.598245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008441057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1743-8977-10-56", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010496344", 
          "https://doi.org/10.1186/1743-8977-10-56"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/jamp.2013.1044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011115613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00120804", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011659745", 
          "https://doi.org/10.1007/bf00120804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00120804", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011659745", 
          "https://doi.org/10.1007/bf00120804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1743-8977-8-36", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014087541", 
          "https://doi.org/10.1186/1743-8977-8-36"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11051-011-0686-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018265190", 
          "https://doi.org/10.1007/s11051-011-0686-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-94-007-2555-3_12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019400958", 
          "https://doi.org/10.1007/978-94-007-2555-3_12"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1748-1716.2009.02039.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019734471"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1748-1716.2009.02039.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019734471"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910170110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021284189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11051-010-9900-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021383322", 
          "https://doi.org/10.1007/s11051-010-9900-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11051-010-9900-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021383322", 
          "https://doi.org/10.1007/s11051-010-9900-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1289/ehp.7339", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021597152"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/b978-0-444-53864-2.00005-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022038629"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jbm.820221002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022383105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmcl.2013.11.045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022473513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1535370213505964", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022594010"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1535370213505964", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022594010"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1165/rcmb.2013-0479oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023189904"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01797773", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025963207", 
          "https://doi.org/10.1007/bf01797773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01797773", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025963207", 
          "https://doi.org/10.1007/bf01797773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/10408444.2010.506638", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026651579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/wnan.103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026909779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/ijn.s25853", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027142563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.jid.5700828", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027991676", 
          "https://doi.org/10.1038/sj.jid.5700828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/nn3012042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030123541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.febslet.2008.04.057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030515154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/oem.57.10.685", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033526093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/oem.57.10.685", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033526093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1477-3155-11-26", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033711179", 
          "https://doi.org/10.1186/1477-3155-11-26"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1166/jnd.2013.1012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034527946"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/df9511100055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035075592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/enrs.2001.4269", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036251993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/17435391003775266", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037157088"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/1061186x.2013.878944", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038020828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11051-012-1212-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039615067", 
          "https://doi.org/10.1007/s11051-012-1212-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jps.20803", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040227261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11051-013-1930-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040504943", 
          "https://doi.org/10.1007/s11051-013-1930-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11051-013-1930-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040504943", 
          "https://doi.org/10.1007/s11051-013-1930-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.addr.2009.12.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041889518"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.freeradbiomed.2010.05.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042127336"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.colsurfb.2007.09.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043860885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/08958378.2010.642021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044492251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.toxlet.2010.12.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044675499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/smll.201101511", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044991270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jp304630q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047407858"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1114397", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047665854"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-62703-462-3_11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047859099", 
          "https://doi.org/10.1007/978-1-62703-462-3_11"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nnano.2006.69", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047929442", 
          "https://doi.org/10.1038/nnano.2006.69"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nnano.2006.69", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047929442", 
          "https://doi.org/10.1038/nnano.2006.69"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/la502144z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050141396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.freeradbiomed.2008.01.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050434116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/nn800596w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051693728"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00204-010-0545-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052652358", 
          "https://doi.org/10.1007/s00204-010-0545-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijpharm.2004.12.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053373758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/nn901372t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053487219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1745-6673-8-32", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053686089", 
          "https://doi.org/10.1186/1745-6673-8-32"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/la0104323", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056142554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/la0104323", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056142554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/la2042058", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056155415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/nn200328m", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056223295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/nano.2006.1.2.117", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069103187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v11.i13.2022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071362915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077104836", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/2008/27/smw-12153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077677801"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078710451", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jlb.43.4.304", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079415736"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/51.5.1417", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1080295273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082803365", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-12", 
    "datePublishedReg": "2015-12-01", 
    "description": "BACKGROUND: Nanoparticle (NPs) functionalization has been shown to affect their cellular toxicity. To study this, differently functionalized silver (Ag) and gold (Au) NPs were synthesised, characterised and tested using lung epithelial cell systems.\nMETHODS: Monodispersed Ag and Au NPs with a size range of 7 to 10 nm were coated with either sodium citrate or chitosan resulting in surface charges from -50 mV to +70 mV. NP-induced cytotoxicity and oxidative stress were determined using A549 cells, BEAS-2B cells and primary lung epithelial cells (NHBE cells). TEER measurements and immunofluorescence staining of tight junctions were performed to test the growth characteristics of the cells. Cytotoxicity was measured by means of the CellTiter-Blue \u00ae and the lactate dehydrogenase assay and cellular and cell-free reactive oxygen species (ROS) production was measured using the DCFH-DA assay.\nRESULTS: Different growth characteristics were shown in the three cell types used. A549 cells grew into a confluent mono-layer, BEAS-2B cells grew into a multilayer and NHBE cells did not form a confluent layer. A549 cells were least susceptible towards NPs, irrespective of the NP functionalization. Cytotoxicity in BEAS-2B cells increased when exposed to high positive charged (+65-75 mV) Au NPs. The greatest cytotoxicity was observed in NHBE cells, where both Ag and Au NPs with a charge above +40 mV induced cytotoxicity. ROS production was most prominent in A549 cells where Au NPs (+65-75 mV) induced the highest amount of ROS. In addition, cell-free ROS measurements showed a significant increase in ROS production with an increase in chitosan coating.\nCONCLUSIONS: Chitosan functionalization of NPs, with resultant high surface charges plays an important role in NP-toxicity. Au NPs, which have been shown to be inert and often non-cytotoxic, can become toxic upon coating with certain charged molecules. Notably, these effects are dependent on the core material of the particle, the cell type used for testing and the growth characteristics of these cell culture model systems.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12951-014-0062-4", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1031280", 
        "issn": [
          "1477-3155"
        ], 
        "name": "Journal of Nanobiotechnology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "13"
      }
    ], 
    "name": "The oxidative potential of differently charged silver and gold nanoparticles on three human lung epithelial cell types", 
    "pagination": "1", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "47616f4258b488610fcdfce00c269c311a9c0eaf3114e594839e92acb56ebe9a"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25592092"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101152208"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12951-014-0062-4"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1014982235"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12951-014-0062-4", 
      "https://app.dimensions.ai/details/publication/pub.1014982235"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:09", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000367_0000000367/records_88239_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2Fs12951-014-0062-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12951-014-0062-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12951-014-0062-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12951-014-0062-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12951-014-0062-4'


 

This table displays all metadata directly associated to this object as RDF triples.

450 TRIPLES      21 PREDICATES      116 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12951-014-0062-4 schema:about N18a35815c2a940a7b557a13db83fa8fd
2 N1a162508bbe1478dacd717b9346666a8
3 N24a5262dcd3b4d6396a66a44b8539718
4 N30f7ca2c6b8e4e5fb2a30860eb051838
5 N3154171242c0466bb5ebb371779e4763
6 N33a420932252414a93fee22069724c36
7 N3602c651c1374b749dad1cc9037a1832
8 N3a04b4a379f846eaa5b1c650bfe05aa1
9 N3bcf7660d4a549aabdbd9da74500ea08
10 N733783f9d1374550abf1ca7857eaffb9
11 N9286fe0efc764d12bf34d2ba45e2fd71
12 Nb19bbb31487c4aea927e7a4c61a42aef
13 Nb47a25a9074e40c483ea07fc8e8981b4
14 Nc154899d50a54617a1dd2892c22556dc
15 Ne87499e6bf5543d5997d6aa3c3281720
16 Necf624dfa51f49918bf8dcf6e3abeb76
17 anzsrc-for:06
18 anzsrc-for:0601
19 schema:author N8e9ba8e9593d4ee38a2c76e5c745dc95
20 schema:citation sg:pub.10.1007/978-1-62703-462-3_11
21 sg:pub.10.1007/978-94-007-2555-3_12
22 sg:pub.10.1007/bf00120804
23 sg:pub.10.1007/bf01797773
24 sg:pub.10.1007/s00204-010-0545-5
25 sg:pub.10.1007/s11051-010-9900-y
26 sg:pub.10.1007/s11051-011-0686-3
27 sg:pub.10.1007/s11051-012-1212-y
28 sg:pub.10.1007/s11051-013-1930-9
29 sg:pub.10.1038/nnano.2006.69
30 sg:pub.10.1038/sj.jid.5700828
31 sg:pub.10.1186/1477-3155-11-26
32 sg:pub.10.1186/1743-8977-10-56
33 sg:pub.10.1186/1743-8977-8-36
34 sg:pub.10.1186/1745-6673-8-32
35 https://app.dimensions.ai/details/publication/pub.1077104836
36 https://app.dimensions.ai/details/publication/pub.1078710451
37 https://app.dimensions.ai/details/publication/pub.1082803365
38 https://doi.org/10.1002/9780470747803.ch19
39 https://doi.org/10.1002/ijc.2910170110
40 https://doi.org/10.1002/jbm.820221002
41 https://doi.org/10.1002/jlb.43.4.304
42 https://doi.org/10.1002/jps.20803
43 https://doi.org/10.1002/smll.201101511
44 https://doi.org/10.1002/wnan.103
45 https://doi.org/10.1006/enrs.2001.4269
46 https://doi.org/10.1016/b978-0-444-53864-2.00005-0
47 https://doi.org/10.1016/j.addr.2009.12.006
48 https://doi.org/10.1016/j.bmcl.2013.11.045
49 https://doi.org/10.1016/j.cis.2008.09.002
50 https://doi.org/10.1016/j.colsurfb.2007.09.030
51 https://doi.org/10.1016/j.febslet.2008.04.057
52 https://doi.org/10.1016/j.freeradbiomed.2008.01.028
53 https://doi.org/10.1016/j.freeradbiomed.2010.05.011
54 https://doi.org/10.1016/j.ijpharm.2004.12.025
55 https://doi.org/10.1016/j.toxlet.2007.08.001
56 https://doi.org/10.1016/j.toxlet.2010.12.001
57 https://doi.org/10.1016/s0166-1280(98)00361-3
58 https://doi.org/10.1021/es062629t
59 https://doi.org/10.1021/ja107583h
60 https://doi.org/10.1021/jp304630q
61 https://doi.org/10.1021/la0104323
62 https://doi.org/10.1021/la2042058
63 https://doi.org/10.1021/la502144z
64 https://doi.org/10.1021/nn200328m
65 https://doi.org/10.1021/nn3012042
66 https://doi.org/10.1021/nn800596w
67 https://doi.org/10.1021/nn901372t
68 https://doi.org/10.1039/c3an01463k
69 https://doi.org/10.1039/df9511100055
70 https://doi.org/10.1089/jamp.2013.1044
71 https://doi.org/10.1093/jnci/51.5.1417
72 https://doi.org/10.1111/j.1748-1716.2009.02039.x
73 https://doi.org/10.1126/science.1114397
74 https://doi.org/10.1136/oem.57.10.685
75 https://doi.org/10.1165/rcmb.2013-0479oc
76 https://doi.org/10.1166/jnd.2013.1012
77 https://doi.org/10.1177/1535370213505964
78 https://doi.org/10.1289/ehp.7339
79 https://doi.org/10.2147/ijn.s25853
80 https://doi.org/10.2147/ijn.s28077
81 https://doi.org/10.2147/nano.2006.1.2.117
82 https://doi.org/10.3109/02770903.2012.705408
83 https://doi.org/10.3109/08958378.2010.642021
84 https://doi.org/10.3109/08958378.2011.582895
85 https://doi.org/10.3109/10408444.2010.506638
86 https://doi.org/10.3109/1061186x.2013.878944
87 https://doi.org/10.3109/17435390.2011.598245
88 https://doi.org/10.3109/17435391003775266
89 https://doi.org/10.3748/wjg.v11.i13.2022
90 https://doi.org/2008/27/smw-12153
91 schema:datePublished 2015-12
92 schema:datePublishedReg 2015-12-01
93 schema:description BACKGROUND: Nanoparticle (NPs) functionalization has been shown to affect their cellular toxicity. To study this, differently functionalized silver (Ag) and gold (Au) NPs were synthesised, characterised and tested using lung epithelial cell systems. METHODS: Monodispersed Ag and Au NPs with a size range of 7 to 10 nm were coated with either sodium citrate or chitosan resulting in surface charges from -50 mV to +70 mV. NP-induced cytotoxicity and oxidative stress were determined using A549 cells, BEAS-2B cells and primary lung epithelial cells (NHBE cells). TEER measurements and immunofluorescence staining of tight junctions were performed to test the growth characteristics of the cells. Cytotoxicity was measured by means of the CellTiter-Blue ® and the lactate dehydrogenase assay and cellular and cell-free reactive oxygen species (ROS) production was measured using the DCFH-DA assay. RESULTS: Different growth characteristics were shown in the three cell types used. A549 cells grew into a confluent mono-layer, BEAS-2B cells grew into a multilayer and NHBE cells did not form a confluent layer. A549 cells were least susceptible towards NPs, irrespective of the NP functionalization. Cytotoxicity in BEAS-2B cells increased when exposed to high positive charged (+65-75 mV) Au NPs. The greatest cytotoxicity was observed in NHBE cells, where both Ag and Au NPs with a charge above +40 mV induced cytotoxicity. ROS production was most prominent in A549 cells where Au NPs (+65-75 mV) induced the highest amount of ROS. In addition, cell-free ROS measurements showed a significant increase in ROS production with an increase in chitosan coating. CONCLUSIONS: Chitosan functionalization of NPs, with resultant high surface charges plays an important role in NP-toxicity. Au NPs, which have been shown to be inert and often non-cytotoxic, can become toxic upon coating with certain charged molecules. Notably, these effects are dependent on the core material of the particle, the cell type used for testing and the growth characteristics of these cell culture model systems.
94 schema:genre research_article
95 schema:inLanguage en
96 schema:isAccessibleForFree true
97 schema:isPartOf N1102708497ab43d194a438448873392d
98 N51dc5e8d38df4a968d89cd607d4d184a
99 sg:journal.1031280
100 schema:name The oxidative potential of differently charged silver and gold nanoparticles on three human lung epithelial cell types
101 schema:pagination 1
102 schema:productId N02a42f3233f1424e95db4044c234d5f6
103 N4622cc78cff445d6920d607736479adb
104 Nd4f53c5da893463db9f0af0bef938247
105 Ndfbbead406514726b90851842e374f70
106 Neb06b25662d44710bfc460c6cfb8eb32
107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014982235
108 https://doi.org/10.1186/s12951-014-0062-4
109 schema:sdDatePublished 2019-04-11T13:09
110 schema:sdLicense https://scigraph.springernature.com/explorer/license/
111 schema:sdPublisher Naea45c0233044a7cbdc193797b0377a2
112 schema:url http://link.springer.com/10.1186%2Fs12951-014-0062-4
113 sgo:license sg:explorer/license/
114 sgo:sdDataset articles
115 rdf:type schema:ScholarlyArticle
116 N00969113778d485380c6985e5ed5136c rdf:first N6cba4c43d79048aaa9fbe876b06bb627
117 rdf:rest Nc0249a4e9a6f4bbfadb78d116fc2ff99
118 N02a42f3233f1424e95db4044c234d5f6 schema:name doi
119 schema:value 10.1186/s12951-014-0062-4
120 rdf:type schema:PropertyValue
121 N032c4903969a40749b78b894f2b3aedd schema:name Institute Catalá de Nanotecnologia, Barcelona, Spain
122 rdf:type schema:Organization
123 N06e2c2b0cdc6419685c20c6ed9e31e68 rdf:first sg:person.0734735176.61
124 rdf:rest N635476e7d74f4b3b8f940340fabef015
125 N1102708497ab43d194a438448873392d schema:volumeNumber 13
126 rdf:type schema:PublicationVolume
127 N17288aa637b04f08b91256e4b75d7f88 schema:name Institute Catalá de Nanotecnologia, Barcelona, Spain
128 rdf:type schema:Organization
129 N18a35815c2a940a7b557a13db83fa8fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Cell Line
131 rdf:type schema:DefinedTerm
132 N1a162508bbe1478dacd717b9346666a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Chitosan
134 rdf:type schema:DefinedTerm
135 N24a5262dcd3b4d6396a66a44b8539718 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Cell-Free System
137 rdf:type schema:DefinedTerm
138 N30f7ca2c6b8e4e5fb2a30860eb051838 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Oxidants
140 rdf:type schema:DefinedTerm
141 N3154171242c0466bb5ebb371779e4763 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Cell Survival
143 rdf:type schema:DefinedTerm
144 N33a420932252414a93fee22069724c36 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Humans
146 rdf:type schema:DefinedTerm
147 N3602c651c1374b749dad1cc9037a1832 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Lung
149 rdf:type schema:DefinedTerm
150 N3a04b4a379f846eaa5b1c650bfe05aa1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Gold
152 rdf:type schema:DefinedTerm
153 N3bcf7660d4a549aabdbd9da74500ea08 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Reactive Oxygen Species
155 rdf:type schema:DefinedTerm
156 N4622cc78cff445d6920d607736479adb schema:name dimensions_id
157 schema:value pub.1014982235
158 rdf:type schema:PropertyValue
159 N4d4621b793c34c5b9e69ee27b32d3726 rdf:first sg:person.0746151145.37
160 rdf:rest Neaa7fcb6efb8482fa782406297d9aa7b
161 N51dc5e8d38df4a968d89cd607d4d184a schema:issueNumber 1
162 rdf:type schema:PublicationIssue
163 N5a8035d41a2340f9956764c389ef72bb rdf:first sg:person.01022661734.54
164 rdf:rest rdf:nil
165 N635476e7d74f4b3b8f940340fabef015 rdf:first sg:person.01166307430.08
166 rdf:rest Nd3b6290a4e0b4a4aa0facdc7b09850bd
167 N6cba4c43d79048aaa9fbe876b06bb627 schema:affiliation https://www.grid.ac/institutes/grid.7039.d
168 schema:familyName Hornig
169 schema:givenName Eva
170 rdf:type schema:Person
171 N733783f9d1374550abf1ca7857eaffb9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Epithelial Cells
173 rdf:type schema:DefinedTerm
174 N8e9ba8e9593d4ee38a2c76e5c745dc95 rdf:first sg:person.0755455151.40
175 rdf:rest Nfe7ef79136894db2a9ae2faf223ff9fa
176 N9286fe0efc764d12bf34d2ba45e2fd71 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Bronchi
178 rdf:type schema:DefinedTerm
179 N952269d5af0848ef8d9b291347ed7f2f rdf:first sg:person.01003635717.82
180 rdf:rest N06e2c2b0cdc6419685c20c6ed9e31e68
181 Naea45c0233044a7cbdc193797b0377a2 schema:name Springer Nature - SN SciGraph project
182 rdf:type schema:Organization
183 Nb19bbb31487c4aea927e7a4c61a42aef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Metal Nanoparticles
185 rdf:type schema:DefinedTerm
186 Nb47a25a9074e40c483ea07fc8e8981b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Cell Membrane
188 rdf:type schema:DefinedTerm
189 Nc0249a4e9a6f4bbfadb78d116fc2ff99 rdf:first sg:person.01254245351.15
190 rdf:rest N952269d5af0848ef8d9b291347ed7f2f
191 Nc154899d50a54617a1dd2892c22556dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Culture Media
193 rdf:type schema:DefinedTerm
194 Nd3b6290a4e0b4a4aa0facdc7b09850bd rdf:first sg:person.0667175722.95
195 rdf:rest Nf02ce6215f3744fbab43d603680947c9
196 Nd4f53c5da893463db9f0af0bef938247 schema:name pubmed_id
197 schema:value 25592092
198 rdf:type schema:PropertyValue
199 Ndfbbead406514726b90851842e374f70 schema:name readcube_id
200 schema:value 47616f4258b488610fcdfce00c269c311a9c0eaf3114e594839e92acb56ebe9a
201 rdf:type schema:PropertyValue
202 Ne87499e6bf5543d5997d6aa3c3281720 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Cells, Cultured
204 rdf:type schema:DefinedTerm
205 Neaa7fcb6efb8482fa782406297d9aa7b rdf:first sg:person.01235546765.01
206 rdf:rest N00969113778d485380c6985e5ed5136c
207 Neb06b25662d44710bfc460c6cfb8eb32 schema:name nlm_unique_id
208 schema:value 101152208
209 rdf:type schema:PropertyValue
210 Nec9310754d504498a5c053606a626059 schema:name Institute Catalá de Nanotecnologia, Barcelona, Spain
211 rdf:type schema:Organization
212 Necf624dfa51f49918bf8dcf6e3abeb76 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
213 schema:name Silver
214 rdf:type schema:DefinedTerm
215 Nf02ce6215f3744fbab43d603680947c9 rdf:first sg:person.01070775134.07
216 rdf:rest N5a8035d41a2340f9956764c389ef72bb
217 Nfe7ef79136894db2a9ae2faf223ff9fa rdf:first sg:person.0605076720.55
218 rdf:rest N4d4621b793c34c5b9e69ee27b32d3726
219 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
220 schema:name Biological Sciences
221 rdf:type schema:DefinedTerm
222 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
223 schema:name Biochemistry and Cell Biology
224 rdf:type schema:DefinedTerm
225 sg:journal.1031280 schema:issn 1477-3155
226 schema:name Journal of Nanobiotechnology
227 rdf:type schema:Periodical
228 sg:person.01003635717.82 schema:affiliation https://www.grid.ac/institutes/grid.9976.1
229 schema:familyName Zhao
230 schema:givenName Jiayuan
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003635717.82
232 rdf:type schema:Person
233 sg:person.01022661734.54 schema:affiliation https://www.grid.ac/institutes/grid.7039.d
234 schema:familyName Duschl
235 schema:givenName Albert
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022661734.54
237 rdf:type schema:Person
238 sg:person.01070775134.07 schema:affiliation N032c4903969a40749b78b894f2b3aedd
239 schema:familyName Puntes
240 schema:givenName Victor
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070775134.07
242 rdf:type schema:Person
243 sg:person.01166307430.08 schema:affiliation https://www.grid.ac/institutes/grid.483445.a
244 schema:familyName Riediker
245 schema:givenName Michael
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166307430.08
247 rdf:type schema:Person
248 sg:person.01235546765.01 schema:affiliation https://www.grid.ac/institutes/grid.7039.d
249 schema:familyName Tischler
250 schema:givenName Ulrike
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235546765.01
252 rdf:type schema:Person
253 sg:person.01254245351.15 schema:affiliation Nec9310754d504498a5c053606a626059
254 schema:familyName Tran
255 schema:givenName Ngoc
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254245351.15
257 rdf:type schema:Person
258 sg:person.0605076720.55 schema:affiliation N17288aa637b04f08b91256e4b75d7f88
259 schema:familyName Casals
260 schema:givenName Eudald
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605076720.55
262 rdf:type schema:Person
263 sg:person.0667175722.95 schema:affiliation https://www.grid.ac/institutes/grid.452086.d
264 schema:familyName Oostingh
265 schema:givenName Gertie Janneke
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667175722.95
267 rdf:type schema:Person
268 sg:person.0734735176.61 schema:affiliation https://www.grid.ac/institutes/grid.7039.d
269 schema:familyName Himly
270 schema:givenName Martin
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734735176.61
272 rdf:type schema:Person
273 sg:person.0746151145.37 schema:affiliation https://www.grid.ac/institutes/grid.7039.d
274 schema:familyName Boyles
275 schema:givenName Matthew
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746151145.37
277 rdf:type schema:Person
278 sg:person.0755455151.40 schema:affiliation https://www.grid.ac/institutes/grid.7039.d
279 schema:familyName Schlinkert
280 schema:givenName Paul
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755455151.40
282 rdf:type schema:Person
283 sg:pub.10.1007/978-1-62703-462-3_11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047859099
284 https://doi.org/10.1007/978-1-62703-462-3_11
285 rdf:type schema:CreativeWork
286 sg:pub.10.1007/978-94-007-2555-3_12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019400958
287 https://doi.org/10.1007/978-94-007-2555-3_12
288 rdf:type schema:CreativeWork
289 sg:pub.10.1007/bf00120804 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011659745
290 https://doi.org/10.1007/bf00120804
291 rdf:type schema:CreativeWork
292 sg:pub.10.1007/bf01797773 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025963207
293 https://doi.org/10.1007/bf01797773
294 rdf:type schema:CreativeWork
295 sg:pub.10.1007/s00204-010-0545-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052652358
296 https://doi.org/10.1007/s00204-010-0545-5
297 rdf:type schema:CreativeWork
298 sg:pub.10.1007/s11051-010-9900-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1021383322
299 https://doi.org/10.1007/s11051-010-9900-y
300 rdf:type schema:CreativeWork
301 sg:pub.10.1007/s11051-011-0686-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018265190
302 https://doi.org/10.1007/s11051-011-0686-3
303 rdf:type schema:CreativeWork
304 sg:pub.10.1007/s11051-012-1212-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1039615067
305 https://doi.org/10.1007/s11051-012-1212-y
306 rdf:type schema:CreativeWork
307 sg:pub.10.1007/s11051-013-1930-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040504943
308 https://doi.org/10.1007/s11051-013-1930-9
309 rdf:type schema:CreativeWork
310 sg:pub.10.1038/nnano.2006.69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047929442
311 https://doi.org/10.1038/nnano.2006.69
312 rdf:type schema:CreativeWork
313 sg:pub.10.1038/sj.jid.5700828 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027991676
314 https://doi.org/10.1038/sj.jid.5700828
315 rdf:type schema:CreativeWork
316 sg:pub.10.1186/1477-3155-11-26 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033711179
317 https://doi.org/10.1186/1477-3155-11-26
318 rdf:type schema:CreativeWork
319 sg:pub.10.1186/1743-8977-10-56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010496344
320 https://doi.org/10.1186/1743-8977-10-56
321 rdf:type schema:CreativeWork
322 sg:pub.10.1186/1743-8977-8-36 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014087541
323 https://doi.org/10.1186/1743-8977-8-36
324 rdf:type schema:CreativeWork
325 sg:pub.10.1186/1745-6673-8-32 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053686089
326 https://doi.org/10.1186/1745-6673-8-32
327 rdf:type schema:CreativeWork
328 https://app.dimensions.ai/details/publication/pub.1077104836 schema:CreativeWork
329 https://app.dimensions.ai/details/publication/pub.1078710451 schema:CreativeWork
330 https://app.dimensions.ai/details/publication/pub.1082803365 schema:CreativeWork
331 https://doi.org/10.1002/9780470747803.ch19 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005378373
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1002/ijc.2910170110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021284189
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1002/jbm.820221002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022383105
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1002/jlb.43.4.304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079415736
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1002/jps.20803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040227261
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1002/smll.201101511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044991270
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1002/wnan.103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026909779
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1006/enrs.2001.4269 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036251993
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1016/b978-0-444-53864-2.00005-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022038629
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1016/j.addr.2009.12.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041889518
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1016/j.bmcl.2013.11.045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022473513
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1016/j.cis.2008.09.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001487937
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1016/j.colsurfb.2007.09.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043860885
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1016/j.febslet.2008.04.057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030515154
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1016/j.freeradbiomed.2008.01.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050434116
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1016/j.freeradbiomed.2010.05.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042127336
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1016/j.ijpharm.2004.12.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053373758
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1016/j.toxlet.2007.08.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001314930
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1016/j.toxlet.2010.12.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044675499
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1016/s0166-1280(98)00361-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003446009
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1021/es062629t schema:sameAs https://app.dimensions.ai/details/publication/pub.1001460962
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1021/ja107583h schema:sameAs https://app.dimensions.ai/details/publication/pub.1008013568
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1021/jp304630q schema:sameAs https://app.dimensions.ai/details/publication/pub.1047407858
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1021/la0104323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056142554
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1021/la2042058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056155415
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1021/la502144z schema:sameAs https://app.dimensions.ai/details/publication/pub.1050141396
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1021/nn200328m schema:sameAs https://app.dimensions.ai/details/publication/pub.1056223295
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1021/nn3012042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030123541
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1021/nn800596w schema:sameAs https://app.dimensions.ai/details/publication/pub.1051693728
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1021/nn901372t schema:sameAs https://app.dimensions.ai/details/publication/pub.1053487219
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1039/c3an01463k schema:sameAs https://app.dimensions.ai/details/publication/pub.1006101674
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1039/df9511100055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035075592
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1089/jamp.2013.1044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011115613
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1093/jnci/51.5.1417 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080295273
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1111/j.1748-1716.2009.02039.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019734471
400 rdf:type schema:CreativeWork
401 https://doi.org/10.1126/science.1114397 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047665854
402 rdf:type schema:CreativeWork
403 https://doi.org/10.1136/oem.57.10.685 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033526093
404 rdf:type schema:CreativeWork
405 https://doi.org/10.1165/rcmb.2013-0479oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1023189904
406 rdf:type schema:CreativeWork
407 https://doi.org/10.1166/jnd.2013.1012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034527946
408 rdf:type schema:CreativeWork
409 https://doi.org/10.1177/1535370213505964 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022594010
410 rdf:type schema:CreativeWork
411 https://doi.org/10.1289/ehp.7339 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021597152
412 rdf:type schema:CreativeWork
413 https://doi.org/10.2147/ijn.s25853 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027142563
414 rdf:type schema:CreativeWork
415 https://doi.org/10.2147/ijn.s28077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005169571
416 rdf:type schema:CreativeWork
417 https://doi.org/10.2147/nano.2006.1.2.117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069103187
418 rdf:type schema:CreativeWork
419 https://doi.org/10.3109/02770903.2012.705408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000694421
420 rdf:type schema:CreativeWork
421 https://doi.org/10.3109/08958378.2010.642021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044492251
422 rdf:type schema:CreativeWork
423 https://doi.org/10.3109/08958378.2011.582895 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004540779
424 rdf:type schema:CreativeWork
425 https://doi.org/10.3109/10408444.2010.506638 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026651579
426 rdf:type schema:CreativeWork
427 https://doi.org/10.3109/1061186x.2013.878944 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038020828
428 rdf:type schema:CreativeWork
429 https://doi.org/10.3109/17435390.2011.598245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008441057
430 rdf:type schema:CreativeWork
431 https://doi.org/10.3109/17435391003775266 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037157088
432 rdf:type schema:CreativeWork
433 https://doi.org/10.3748/wjg.v11.i13.2022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071362915
434 rdf:type schema:CreativeWork
435 https://doi.org/2008/27/smw-12153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077677801
436 rdf:type schema:CreativeWork
437 https://www.grid.ac/institutes/grid.452086.d schema:alternateName Salzburg University of Applied Sciences
438 schema:name Biomedical Sciences, Salzburg University of Applied Sciences, Puch, Salzburg, Austria
439 Department of Molecular Biology, Paris Lodron-University of Salzburg, Hellbrunnerstr. 34, A-5020, Salzburg, Austria
440 rdf:type schema:Organization
441 https://www.grid.ac/institutes/grid.483445.a schema:alternateName Institute of Occupational Medicine
442 schema:name Institue for Occupational Medicine (IOM) Singapore, Downtown Core, Singapore
443 Institute for Work and Health, Lausanne, Switzerland
444 rdf:type schema:Organization
445 https://www.grid.ac/institutes/grid.7039.d schema:alternateName University of Salzburg
446 schema:name Department of Molecular Biology, Paris Lodron-University of Salzburg, Hellbrunnerstr. 34, A-5020, Salzburg, Austria
447 rdf:type schema:Organization
448 https://www.grid.ac/institutes/grid.9976.1 schema:alternateName Institute for Work and Health
449 schema:name Institute for Work and Health, Lausanne, Switzerland
450 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...