Are aortic coarctation and rheumatoid arthritis different models of aortic stiffness? Data from an echocardiographic study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-06-26

AUTHORS

Giorgio Faganello, Giovanni Cioffi, Maurizio Rossini, Federica Ognibeni, Alessandro Giollo, Maurizio Fisicaro, Giulia Russo, Concetta Di Nora, Sara Doimo, Luigi Tarantini, Carmine Mazzone, Antonella Cherubini, Biancamaria D’Agata Mottolesi, Claudio Pandullo, Andrea Di Lenarda, Gianfranco Sinagra, Ombretta Viapiana

ABSTRACT

BACKGROUND: Patients who underwent a successful repair of the aortic coarctation (CoA) show high risk for cardiovascular (CV) events. Mechanical and structural abnormalities in the ascending aorta (Ao) might have a role in the prognosis of CoA patients. We analyzed the elastic properties of Ao measured as aortic stiffness index (AoSI) in CoA patients in the long-term period and we compared AoSI with a cohort of 38 patients with rheumatoid arthritis (RA) and 38 non-RA matched controls. METHODS: Data from 19 CoA patients were analyzed 28 ± 13 years after surgery. Abnormally high AoSI was diagnosed if AoSI > 6.07% (95th percentile of the AoSI detected in our reference healthy population). AoSI was assessed at the level of the aortic root by two-dimensional guided M-mode evaluation. RESULTS: CoA patients showed more than two-fold higher AoSI compared to RA and controls (9.8 ± 12.6 vs 4.8 ± 2.5% and 3.1 ± 2.0%, respectively; all p < 0.05 and in 5 of 19 patients with CoA (26%) AoSI was exceptionally high. The 5 patients with abnormally high AoSI were older with higher BP, LV mass and prevalence of LV diastolic dysfunction. Multiple linear regression analysis revealed that AoSI was independently related to the presence of LV hypertrophy and higher LV relative wall thickness. CONCLUSIONS: CoA patients have higher AoSI levels than RA patients and non-RA matched controls. AoSI levels are abnormally high in a small sub-group of CoA patients who show a very high-risk clinical profile for adverse CV events. More... »

PAGES

9

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12947-018-0126-y

DOI

http://dx.doi.org/10.1186/s12947-018-0126-y

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https://app.dimensions.ai/details/publication/pub.1104981087

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29940971


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