Phytochemical analysis and Evaluation of hepatoprotective effect of Maytenus royleanus leaves extract against anti-tuberculosis drug induced liver injury in mice View Full Text


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Article Info

DATE

2020-03-16

AUTHORS

Maria Shabbir, Tayyaba Afsar, Suhail Razak, Ali Almajwal, Muhammad Rashid Khan

ABSTRACT

BackgroundMyrin®-p Forte is an anti-tuberclosis agent that can cause hepatic injuries in clinical settings. Maytenus royleanus (Celastraceae) is a medicinal plant, possesses antioxidant and anticancer activities. The hepatoprotective effect of the methanol extract of Maytenus royleanus leaves (MEM) against Myrin®-p Forte induced hepatotoxicity in mice was investigated.MethodsMice were randomly parted into six groups (n = 6). Fixed-dose combination of Myrin®-p Forte (13.5 mg/kg Rifampicin, 6.75 mg/kg Isoniazid, 36.0 mg/kg Pyrazinamide and 24.8 mg/kg Ethambutol; RIPE] was administered for 15 days to induce liver injury. In treatment groups MEM (200 mg/kg and 400 mg/kg doses) and Vitamin B6 (180mg/kg) were administered prior to RIPE. Control group received 2% DMSO. Serum liver function tests, DNA damage, tissue antioxidant enzymes and histopathological alterations were studied. HPLC analysis was performed to determine the chemical composition using standard compounds.ResultsThe quercitin, gallic acid, luteolin, viteixin, apigenin, kaempherol, hyperoside and myricetin contents of all samples were determined by reverse-phase HPLC. Quercetin (0.217 mg/g dry weight) and luteolin (0.141 mg/g dry weight) were the major flavonoids identified in MEM. Myrin®-p Forte markedly (p < 0.05) deteriorated lipid profile and upregulated the concentration of LDH, AST, ALP, ALT and γ-GT in serum along with DNA fragmentation (37.13 ± 0.47%) and histopathological injuries in hepatic tissues of mice compared with the control group. Myrin®-p Forte increased (p < 0.001) lipid peroxidation and H2O2 while decreased (p < 0.001) the activity level of CAT, SOD, POD, GPx, GST, GSR, γ-GT and GSH. Co-administration of MEM (200 mg/kg; 400 mg/kg) or the vitamin B6 (180 mg/kg) to Myrin®-p Forte administered mice significantly ameliorated LDL, cholesterol, HDL and triglyceride content. Furthermore, MEM dose dependently corrected serum liver function tests, decrease % DNA fragmentation (17.82 ± 0.35 and 7.21 ± 0.32 respectively), DNA damage. MEM treated protect RIPE induced oxidative damage by enhancing antioxidants to oxidants balance. Histological examination comprehends biochemical findings.ConclusionThe antioxidant effects of MEM exerted the hepatoprotective potential against the Myrin®-p Forte induced hepatotoxicity in mice. More... »

PAGES

46

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12944-020-01231-9

DOI

http://dx.doi.org/10.1186/s12944-020-01231-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1125680905

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32178678


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75 chemical composition
76 cholesterol
77 clinical setting
78 combination
79 composition
80 compounds
81 concentration
82 concentration of LDH
83 content
84 control group
85 damage
86 days
87 dose
88 drugs
89 effect
90 enzyme
91 evaluation
92 examination
93 extract
94 findings
95 fixed-dose combination
96 flavonoids
97 fragmentation
98 function tests
99 gallic acid
100 group
101 hepatic injury
102 hepatic tissue
103 hepatoprotective effect
104 hepatoprotective potential
105 hepatotoxicity
106 histological examination
107 histopathological alterations
108 histopathological injury
109 hyperoside
110 injury
111 kaempherol
112 leaves
113 levels
114 lipid peroxidation
115 lipid profile
116 liver function tests
117 liver injury
118 luteolin
119 major flavonoids
120 medicinal plants
121 methanol extract
122 mice
123 oxidant balance
124 oxidative damage
125 peroxidation
126 phytochemical analysis
127 plants
128 pods
129 potential
130 profile
131 quercetin
132 quercitin
133 reversed-phase HPLC
134 ripe
135 samples
136 serum
137 serum liver function tests
138 setting
139 standard compounds
140 test
141 tissue
142 tissue antioxidant enzymes
143 triglyceride content
144 vitamin B6
145 γ-GT
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