Sex hormones affect endothelial lipase-mediated lipid metabolism and atherosclerosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12-23

AUTHORS

Chuan Wang, Manabu Niimi, Shuji Kitajima, Fumikazu Matsuhisa, Haizhao Yan, Sijun Dong, Jingyan Liang, Jianglin Fan

ABSTRACT

BackgroundEndothelial lipase (EL) plays an important role in lipoprotein metabolism and atherosclerosis. To study the functional roles of EL, we recently generated transgenic (Tg) rabbits and reported that increased hepatic expression of EL in male Tg rabbits significantly reduced diet-induced hypercholesterolemia compared with non-Tg controls. This gender difference suggests that sex hormones may mediate EL functions thereby influencing lipoprotein metabolism. To examine this hypothesis, we compared the effects of orchiectomy and ovariectomy on plasma lipids and diet-induced atherosclerosis in both Tg and non-Tg rabbits.MethodsMale rabbits were under orchiectomy whereas female rabbits were under ovariectomy. We compared plasma lipids, lipoproteins, and apolipoproteins of rabbits before and after surgery in each group fed either a chow diet or cholesterol-rich diet.ResultsOn a chow diet, both male and female Tg rabbits showed lower plasma lipids than non-Tg counterparts and this lipid-lowering effect of EL was not affected by either orchiectomy in male or ovariectomy in female Tg rabbits. On a cholesterol diet; however, male Tg rabbits but not female Tg rabbits showed significant resistance to diet-induced hypercholesterolemia and atherosclerosis. The EL-mediated atheroprotective effect was eliminated after orchiectomy in male Tg rabbits. Female Tg rabbits showed similar levels of total cholesterol and lesion size of atherosclerosis compared with non-Tg rabbits and ovariectomy did not affect diet-induced hypercholesterolemia or atherosclerosis.ConclusionThese results suggest that increased EL protects against diet-induced hypercholesterolemia and atherosclerosis. The beneficial effect of EL was dependent upon the presence of androgenic hormones. More... »

PAGES

226

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12944-019-1175-4

DOI

http://dx.doi.org/10.1186/s12944-019-1175-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1123612048

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31870448


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