Several circulating miRNAs related to hyperlipidemia and atherosclerotic cardiovascular diseases View Full Text


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Article Info

DATE

2019-04-22

AUTHORS

Jiang Xu, Zixuan Chen, Yingge Wang, Xiaohong Wang, Lu Chen, Tingting Yuan, Xiangming Tang, Yaoyao Lu, Hongmei Chen, Miaolei Chen, Zuowei Duan, Jianglin Fan, Jingyan Liang, Xinjiang Zhang

ABSTRACT

BackgroundIn recent years, an increasing number of studies have proved that circulating miRNAs could be used for the early diagnosis of cardiovascular diseases and even play vital roles in the evaluation of therapeutic effects or prognosis. This study was conducted to examine the correlation between serum microRNAs and hyperlipidemia to provide a theoretical basis for the early screening and intervention of atherosclerotic cardiovascular diseases (ASCVD).MethodsThe serum samples and clinical data of 122 patients with hyperlipidemia and 168 healthy subjects were collected. Related clinical information was statistically analyzed for the two groups. Expression of circulating miRNAs was detected by miRNA microarray analysis and further verified by reverse transcription-quantitative PCR (RT-qPCR).ResultsStatistical analysis of clinical information revealed a significant difference in the incidence of ASCVD between the two groups. The MiRNA microarray analysis (n = 10) showed 22 miRNAs with significantly different expression, among which 12 showed upregulation, and the others showed downregulation. Those possessing obvious differences and stable expression in the miRNA microarray, including miRNA-191-3p, miRNA-933, and miRNA-425-3p, were chosen for further investigation using RT-qPCR. The results demonstrated that several miRNAs were related to lipid metabolism disorders, especially miRNA-933. The area under the curve (AUC) of miRNA-933 in distinguishing the hyperlipidemia and ASCVD patients was 0.739 (95% CI, 0.682–0.795; P < 0.01) and 0.703 (95% CI, 0.643–0.763, P < 0.01), respectively.ConclusionsIn conclusion, miRNA-191-3p, miRNA-933, and miRNA-425-3p may be depressed in the peripheral circulation of patients with lipid metabolism disorders (mainly LDL). Circulating miRNA-933 could be a feasible predictor for ASCVD at the early stage. More... »

PAGES

104

References to SciGraph publications

  • 2005-06. MicroRNA expression profiles classify human cancers in NATURE
  • 2017-05-22. MicroRNAs: New Therapeutic Targets for Familial Hypercholesterolemia? in CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
  • 2011-09-04. Toward the blood-borne miRNome of human diseases in NATURE METHODS
  • 2012-08-25. The function of miRNA in cardiac hypertrophy in CELLULAR AND MOLECULAR LIFE SCIENCES
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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/31010436


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    38 circulation
    39 clinical data
    40 clinical information
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    44 data
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    87 role
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    90 serum microRNAs
    91 serum samples
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