Effects of fat-to-sugar ratio in excess dietary energy on lipid abnormalities: a 7-month prospective feeding study in adult cynomolgus monkeys View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Ke-Wei Wang, Bai-Quan Xiao, Bi-Hai Li, Yi-Yan Liu, Zhi-Yuan Wei, Jun-Hua Rao, Jian-Huan Chen

ABSTRACT

BACKGROUND: Excess energy intake contributes to metabolic disorders. However, the relationship between excess sugar and fat in their contributions to metabolic abnormalities remains to be further elucidated. Here we conducted a prospective feeding experiment to evaluate effects of dietary fat-to-sugar ratio on diet-induced metabolic abnormalities in adult cynomolgus monkeys. METHODS: Four groups of adult cynomolgus monkeys were fed regular chow plus emulsion with combinations of high sugar (HS) or low sugar (HS) and low fat (LF) or high fat (HF) for 7 months. Plasma levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG) and blood glucose were measured for all the four groups of animals during the experiment. RESULTS: Plasma levels of TC and LDL-C gradually increased in all 4 diets groups, with the highest increase found in the LSHF group compared to the other three groups (P = 0.0018 and P = 0.0005 respectively). HF induced increased fasting glucose (P = 0.0077) and HS induced higher TG (P = 0.0227) respectively. Intriguingly, HSHF led to dramatically smaller magnitude of increase in LDL-C and TC levels compared to LSHF, while such difference was absent between the LSLF and LSHF groups. Our findings thus indicate interactive effects of HS and HF on TC and LDL-C. In addition, HF exhibited stronger effects on lipid abnormalities than HS. CONCLUSIONS: In the current study, our prospective feeding experiment in adult cynomolgus monkeys revealed effects of different fat-to-sugar ratios on diet-induced metabolic abnormalities. Furthermore, our findings suggest that not only excess dietary energy but also the balance of dietary fat-to-sugar ratio matters in diet-induced lipid abnormalities. More... »

PAGES

1

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12944-018-0950-y

DOI

http://dx.doi.org/10.1186/s12944-018-0950-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111158815

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30611256


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Administration, Oral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Glucose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cholesterol, HDL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cholesterol, LDL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dietary Carbohydrates", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dietary Fats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Macaca fascicularis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sugars", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Triglycerides", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Jiangnan University", 
          "id": "https://www.grid.ac/institutes/grid.258151.a", 
          "name": [
            "Department for hospital infection, Affiliated Hospital of Jiangnan University (Wuxi Third People\u2019s Hospital), 214041, Wuxi, Jiangsu, China", 
            "Laboratory of Genomic and Precision Medicine, Wuxi School of Medicine, Jiangnan University, 1800 Lihu Avenue, 214122, Wuxi, Jiangsu, China", 
            "Joint Primate Research Center for Chronic Diseases, Jiangnan University and Guangdong Institute of Applied Biological Resources, Jiangnan University, No 1800 Lihu Avenue, Wuxi, Jiangsu, 214122, Wuxi, Jiangsu, China", 
            "School of Biotechnology, Jiangnan University, 1800 Lihu Avenue, Wuxi, Jiangsu, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Ke-Wei", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Guangdong Academy of Science", 
          "id": "https://www.grid.ac/institutes/grid.464309.c", 
          "name": [
            "Guangdong Key Laboratory of Animal Conservation and Resource Utilization, 105 Xingang Rd. West, 510260, Guangzhou, Guangdong, China", 
            "Guangdong Public Laboratory of Wild Animal Conservation and Utilization, 105 Xingang Rd. West, Guangzhou, Guangdong, China", 
            "Guangdong Institute of Applied Biological Resources, 105 Xingang Rd. West, Guangzhou, Guangdong, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xiao", 
        "givenName": "Bai-Quan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Guangdong Academy of Science", 
          "id": "https://www.grid.ac/institutes/grid.464309.c", 
          "name": [
            "Guangdong Key Laboratory of Animal Conservation and Resource Utilization, 105 Xingang Rd. West, 510260, Guangzhou, Guangdong, China", 
            "Guangdong Public Laboratory of Wild Animal Conservation and Utilization, 105 Xingang Rd. West, Guangzhou, Guangdong, China", 
            "Guangdong Institute of Applied Biological Resources, 105 Xingang Rd. West, Guangzhou, Guangdong, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Bi-Hai", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Guangdong Academy of Science", 
          "id": "https://www.grid.ac/institutes/grid.464309.c", 
          "name": [
            "Guangdong Key Laboratory of Animal Conservation and Resource Utilization, 105 Xingang Rd. West, 510260, Guangzhou, Guangdong, China", 
            "Guangdong Public Laboratory of Wild Animal Conservation and Utilization, 105 Xingang Rd. West, Guangzhou, Guangdong, China", 
            "Guangdong Institute of Applied Biological Resources, 105 Xingang Rd. West, Guangzhou, Guangdong, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Yi-Yan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jiangnan University", 
          "id": "https://www.grid.ac/institutes/grid.258151.a", 
          "name": [
            "Department for hospital infection, Affiliated Hospital of Jiangnan University (Wuxi Third People\u2019s Hospital), 214041, Wuxi, Jiangsu, China", 
            "Laboratory of Genomic and Precision Medicine, Wuxi School of Medicine, Jiangnan University, 1800 Lihu Avenue, 214122, Wuxi, Jiangsu, China", 
            "Joint Primate Research Center for Chronic Diseases, Jiangnan University and Guangdong Institute of Applied Biological Resources, Jiangnan University, No 1800 Lihu Avenue, Wuxi, Jiangsu, 214122, Wuxi, Jiangsu, China", 
            "School of Biotechnology, Jiangnan University, 1800 Lihu Avenue, Wuxi, Jiangsu, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wei", 
        "givenName": "Zhi-Yuan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Guangdong Academy of Science", 
          "id": "https://www.grid.ac/institutes/grid.464309.c", 
          "name": [
            "Guangdong Key Laboratory of Animal Conservation and Resource Utilization, 105 Xingang Rd. West, 510260, Guangzhou, Guangdong, China", 
            "Guangdong Public Laboratory of Wild Animal Conservation and Utilization, 105 Xingang Rd. West, Guangzhou, Guangdong, China", 
            "Guangdong Institute of Applied Biological Resources, 105 Xingang Rd. West, Guangzhou, Guangdong, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rao", 
        "givenName": "Jun-Hua", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jiangnan University", 
          "id": "https://www.grid.ac/institutes/grid.258151.a", 
          "name": [
            "Laboratory of Genomic and Precision Medicine, Wuxi School of Medicine, Jiangnan University, 1800 Lihu Avenue, 214122, Wuxi, Jiangsu, China", 
            "Joint Primate Research Center for Chronic Diseases, Jiangnan University and Guangdong Institute of Applied Biological Resources, Jiangnan University, No 1800 Lihu Avenue, Wuxi, Jiangsu, 214122, Wuxi, Jiangsu, China", 
            "School of Biotechnology, Jiangnan University, 1800 Lihu Avenue, Wuxi, Jiangsu, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Jian-Huan", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.bbadis.2008.02.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014105926"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mco.0b013e328361c53e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020906432"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mco.0b013e328361c53e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020906432"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1074248416686187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021986052"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1074248416686187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021986052"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jnutbio.2016.09.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028319049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/aje/kws264", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030823961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0684.2011.00495.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031825843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/nu9010011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032397084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3945/ajcn.113.081521", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035857956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.lfs.2005.06.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038421538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/cs20070182", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038921235"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/cs20070182", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038921235"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.vascn.2016.03.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039182311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0007114511004454", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039942892"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2010.449", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044768449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2840-9-71", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046650374", 
          "https://doi.org/10.1186/1475-2840-9-71"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3945/ajcn.114.100461", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047398595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/2008-7802.181328", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052113905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/toxsci/kfw004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060056968"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1358/mf.2006.28.9.1037493", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1065064860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacl.2017.01.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083695136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/luts.12156", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084607336"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ebiom.2017.06.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086144775"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "BACKGROUND: Excess energy intake contributes to metabolic disorders. However, the relationship between excess sugar and fat in their contributions to metabolic abnormalities remains to be further elucidated. Here we conducted a prospective feeding experiment to evaluate effects of dietary fat-to-sugar ratio on diet-induced metabolic abnormalities in adult cynomolgus monkeys.\nMETHODS: Four groups of adult cynomolgus monkeys were fed regular chow plus emulsion with combinations of high sugar (HS) or low sugar (HS) and low fat (LF) or high fat (HF) for 7\u2009months. Plasma levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG) and blood glucose were measured for all the four groups of animals during the experiment.\nRESULTS: Plasma levels of TC and LDL-C gradually increased in all 4 diets groups, with the highest increase found in the LSHF group compared to the other three groups (P\u2009=\u20090.0018 and P\u2009=\u20090.0005 respectively). HF induced increased fasting glucose (P\u2009=\u20090.0077) and HS induced higher TG (P\u2009=\u20090.0227) respectively. Intriguingly, HSHF led to dramatically smaller magnitude of increase in LDL-C and TC levels compared to LSHF, while such difference was absent between the LSLF and LSHF groups. Our findings thus indicate interactive effects of HS and HF on TC and LDL-C. In addition, HF exhibited stronger effects on lipid abnormalities than HS.\nCONCLUSIONS: In the current study, our prospective feeding experiment in adult cynomolgus monkeys revealed effects of different fat-to-sugar ratios on diet-induced metabolic abnormalities. Furthermore, our findings suggest that not only excess dietary energy but also the balance of dietary fat-to-sugar ratio matters in diet-induced lipid abnormalities.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12944-018-0950-y", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.7024676", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1031029", 
        "issn": [
          "1476-511X"
        ], 
        "name": "Lipids in Health and Disease", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "18"
      }
    ], 
    "name": "Effects of fat-to-sugar ratio in excess dietary energy on lipid abnormalities: a 7-month prospective feeding study in adult cynomolgus monkeys", 
    "pagination": "1", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "5622c408c85b0a96c4027e3556c0a94a3c3578e6fc55f1ac614256816eb77290"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30611256"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101147696"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12944-018-0950-y"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111158815"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12944-018-0950-y", 
      "https://app.dimensions.ai/details/publication/pub.1111158815"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:15", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000361_0000000361/records_54011_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12944-018-0950-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12944-018-0950-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12944-018-0950-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12944-018-0950-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12944-018-0950-y'


 

This table displays all metadata directly associated to this object as RDF triples.

229 TRIPLES      21 PREDICATES      63 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12944-018-0950-y schema:about N10b26766162e4c52907b0d47a6fcd6e1
2 N222d49fec4cf4b668c9faea44657bade
3 N23cfb596035a4aa4a60356ad826f5816
4 N2ad2bd65c39149458d3083c5f693cb50
5 N5049accbe286435a90b8e15505ecfb21
6 N67f1e63c28fc4d39ba888a1c230c9c8a
7 N7db683036c4444ddbfa349f272d48d29
8 N8c9fe27bc9494c2bb31e3e18af845f71
9 N99cc8f7925904f85a0ea8ba72049db0a
10 N9b27bc2b2eb347f6ae129dd0f933bf98
11 Nce0b1b0b7ecd4eb4b2c017240426d9d7
12 Ndf560eeef08e4a8c9dc6949dd4bc0e70
13 Nf32072f5a0814af19496d9fe1a9caa69
14 anzsrc-for:11
15 anzsrc-for:1103
16 schema:author Ne7d0dd471ce34d84950b5d0240e0c13b
17 schema:citation sg:pub.10.1186/1475-2840-9-71
18 https://doi.org/10.1001/jama.2010.449
19 https://doi.org/10.1016/j.bbadis.2008.02.007
20 https://doi.org/10.1016/j.ebiom.2017.06.017
21 https://doi.org/10.1016/j.jacl.2017.01.016
22 https://doi.org/10.1016/j.jnutbio.2016.09.010
23 https://doi.org/10.1016/j.lfs.2005.06.009
24 https://doi.org/10.1016/j.vascn.2016.03.001
25 https://doi.org/10.1017/s0007114511004454
26 https://doi.org/10.1042/cs20070182
27 https://doi.org/10.1093/aje/kws264
28 https://doi.org/10.1093/toxsci/kfw004
29 https://doi.org/10.1097/mco.0b013e328361c53e
30 https://doi.org/10.1111/j.1600-0684.2011.00495.x
31 https://doi.org/10.1111/luts.12156
32 https://doi.org/10.1177/1074248416686187
33 https://doi.org/10.1358/mf.2006.28.9.1037493
34 https://doi.org/10.3390/nu9010011
35 https://doi.org/10.3945/ajcn.113.081521
36 https://doi.org/10.3945/ajcn.114.100461
37 https://doi.org/10.4103/2008-7802.181328
38 schema:datePublished 2019-12
39 schema:datePublishedReg 2019-12-01
40 schema:description BACKGROUND: Excess energy intake contributes to metabolic disorders. However, the relationship between excess sugar and fat in their contributions to metabolic abnormalities remains to be further elucidated. Here we conducted a prospective feeding experiment to evaluate effects of dietary fat-to-sugar ratio on diet-induced metabolic abnormalities in adult cynomolgus monkeys. METHODS: Four groups of adult cynomolgus monkeys were fed regular chow plus emulsion with combinations of high sugar (HS) or low sugar (HS) and low fat (LF) or high fat (HF) for 7 months. Plasma levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG) and blood glucose were measured for all the four groups of animals during the experiment. RESULTS: Plasma levels of TC and LDL-C gradually increased in all 4 diets groups, with the highest increase found in the LSHF group compared to the other three groups (P = 0.0018 and P = 0.0005 respectively). HF induced increased fasting glucose (P = 0.0077) and HS induced higher TG (P = 0.0227) respectively. Intriguingly, HSHF led to dramatically smaller magnitude of increase in LDL-C and TC levels compared to LSHF, while such difference was absent between the LSLF and LSHF groups. Our findings thus indicate interactive effects of HS and HF on TC and LDL-C. In addition, HF exhibited stronger effects on lipid abnormalities than HS. CONCLUSIONS: In the current study, our prospective feeding experiment in adult cynomolgus monkeys revealed effects of different fat-to-sugar ratios on diet-induced metabolic abnormalities. Furthermore, our findings suggest that not only excess dietary energy but also the balance of dietary fat-to-sugar ratio matters in diet-induced lipid abnormalities.
41 schema:genre research_article
42 schema:inLanguage en
43 schema:isAccessibleForFree true
44 schema:isPartOf N1fe950bd7c894cd0b15f91cbc986a818
45 Nb54b38e02aad4a79a5fb415fe7e7ed6d
46 sg:journal.1031029
47 schema:name Effects of fat-to-sugar ratio in excess dietary energy on lipid abnormalities: a 7-month prospective feeding study in adult cynomolgus monkeys
48 schema:pagination 1
49 schema:productId N390a24e8ac3d4f28a745167e8a272ad7
50 N4be78cc627774fcea272bfb8448e9d75
51 N9fc468230a7d4abe83dd98791b33f22a
52 Naaed8b579c0c448a9015144b7dd3f2e6
53 Nf03fbbc4159343a2b89c39e244e243c5
54 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111158815
55 https://doi.org/10.1186/s12944-018-0950-y
56 schema:sdDatePublished 2019-04-11T12:15
57 schema:sdLicense https://scigraph.springernature.com/explorer/license/
58 schema:sdPublisher N4ac5eb26242d4982afd02f6889e3ae07
59 schema:url https://link.springer.com/10.1186%2Fs12944-018-0950-y
60 sgo:license sg:explorer/license/
61 sgo:sdDataset articles
62 rdf:type schema:ScholarlyArticle
63 N08339bd887ba48338dcaec55d5e39746 rdf:first N711cf1cc40894d17a4e3f5ef082ffe4a
64 rdf:rest N22460a23431f4ff79ab2b6fcc8814fb9
65 N0b53f2452cfb46a18aa0a4cbf970730b schema:affiliation https://www.grid.ac/institutes/grid.464309.c
66 schema:familyName Rao
67 schema:givenName Jun-Hua
68 rdf:type schema:Person
69 N10b26766162e4c52907b0d47a6fcd6e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
70 schema:name Administration, Oral
71 rdf:type schema:DefinedTerm
72 N1e68570dff3e410ab37d70aa26d63cdf rdf:first Nfbb49f95233a47ce9d58444f7ff38174
73 rdf:rest rdf:nil
74 N1fe950bd7c894cd0b15f91cbc986a818 schema:volumeNumber 18
75 rdf:type schema:PublicationVolume
76 N222d49fec4cf4b668c9faea44657bade schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Cholesterol, LDL
78 rdf:type schema:DefinedTerm
79 N22460a23431f4ff79ab2b6fcc8814fb9 rdf:first N0b53f2452cfb46a18aa0a4cbf970730b
80 rdf:rest N1e68570dff3e410ab37d70aa26d63cdf
81 N23cfb596035a4aa4a60356ad826f5816 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Female
83 rdf:type schema:DefinedTerm
84 N2ad2bd65c39149458d3083c5f693cb50 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Sugars
86 rdf:type schema:DefinedTerm
87 N390a24e8ac3d4f28a745167e8a272ad7 schema:name nlm_unique_id
88 schema:value 101147696
89 rdf:type schema:PropertyValue
90 N4ac5eb26242d4982afd02f6889e3ae07 schema:name Springer Nature - SN SciGraph project
91 rdf:type schema:Organization
92 N4be78cc627774fcea272bfb8448e9d75 schema:name dimensions_id
93 schema:value pub.1111158815
94 rdf:type schema:PropertyValue
95 N5049accbe286435a90b8e15505ecfb21 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Dietary Carbohydrates
97 rdf:type schema:DefinedTerm
98 N53709c2048064ea3a3e686c666da7ff4 schema:affiliation https://www.grid.ac/institutes/grid.464309.c
99 schema:familyName Li
100 schema:givenName Bi-Hai
101 rdf:type schema:Person
102 N67f1e63c28fc4d39ba888a1c230c9c8a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Blood Glucose
104 rdf:type schema:DefinedTerm
105 N711cf1cc40894d17a4e3f5ef082ffe4a schema:affiliation https://www.grid.ac/institutes/grid.258151.a
106 schema:familyName Wei
107 schema:givenName Zhi-Yuan
108 rdf:type schema:Person
109 N748cf7c6625747789451942355c8f7d0 schema:affiliation https://www.grid.ac/institutes/grid.464309.c
110 schema:familyName Xiao
111 schema:givenName Bai-Quan
112 rdf:type schema:Person
113 N7a3b8427f4b143d58925e27fc9c64b7c rdf:first N53709c2048064ea3a3e686c666da7ff4
114 rdf:rest N80d7b0829b78439981580de5d9c70ec5
115 N7db683036c4444ddbfa349f272d48d29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Cholesterol, HDL
117 rdf:type schema:DefinedTerm
118 N80d7b0829b78439981580de5d9c70ec5 rdf:first N9709c1a9a08e406e9bfd6bae0a4c039b
119 rdf:rest N08339bd887ba48338dcaec55d5e39746
120 N8c9fe27bc9494c2bb31e3e18af845f71 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Macaca fascicularis
122 rdf:type schema:DefinedTerm
123 N9709c1a9a08e406e9bfd6bae0a4c039b schema:affiliation https://www.grid.ac/institutes/grid.464309.c
124 schema:familyName Liu
125 schema:givenName Yi-Yan
126 rdf:type schema:Person
127 N99cc8f7925904f85a0ea8ba72049db0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Dietary Fats
129 rdf:type schema:DefinedTerm
130 N9b27bc2b2eb347f6ae129dd0f933bf98 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Triglycerides
132 rdf:type schema:DefinedTerm
133 N9fc468230a7d4abe83dd98791b33f22a schema:name doi
134 schema:value 10.1186/s12944-018-0950-y
135 rdf:type schema:PropertyValue
136 Naaed8b579c0c448a9015144b7dd3f2e6 schema:name pubmed_id
137 schema:value 30611256
138 rdf:type schema:PropertyValue
139 Nb54b38e02aad4a79a5fb415fe7e7ed6d schema:issueNumber 1
140 rdf:type schema:PublicationIssue
141 Nbeff4d3292fa4a1dbc3ec9875b5d9b8d rdf:first N748cf7c6625747789451942355c8f7d0
142 rdf:rest N7a3b8427f4b143d58925e27fc9c64b7c
143 Nce0b1b0b7ecd4eb4b2c017240426d9d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Male
145 rdf:type schema:DefinedTerm
146 Ndf560eeef08e4a8c9dc6949dd4bc0e70 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Prospective Studies
148 rdf:type schema:DefinedTerm
149 Ne7d0dd471ce34d84950b5d0240e0c13b rdf:first Nef8badff166b4ba8afaa388dccc1f9a2
150 rdf:rest Nbeff4d3292fa4a1dbc3ec9875b5d9b8d
151 Nef8badff166b4ba8afaa388dccc1f9a2 schema:affiliation https://www.grid.ac/institutes/grid.258151.a
152 schema:familyName Wang
153 schema:givenName Ke-Wei
154 rdf:type schema:Person
155 Nf03fbbc4159343a2b89c39e244e243c5 schema:name readcube_id
156 schema:value 5622c408c85b0a96c4027e3556c0a94a3c3578e6fc55f1ac614256816eb77290
157 rdf:type schema:PropertyValue
158 Nf32072f5a0814af19496d9fe1a9caa69 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Animals
160 rdf:type schema:DefinedTerm
161 Nfbb49f95233a47ce9d58444f7ff38174 schema:affiliation https://www.grid.ac/institutes/grid.258151.a
162 schema:familyName Chen
163 schema:givenName Jian-Huan
164 rdf:type schema:Person
165 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
166 schema:name Medical and Health Sciences
167 rdf:type schema:DefinedTerm
168 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
169 schema:name Clinical Sciences
170 rdf:type schema:DefinedTerm
171 sg:grant.7024676 http://pending.schema.org/fundedItem sg:pub.10.1186/s12944-018-0950-y
172 rdf:type schema:MonetaryGrant
173 sg:journal.1031029 schema:issn 1476-511X
174 schema:name Lipids in Health and Disease
175 rdf:type schema:Periodical
176 sg:pub.10.1186/1475-2840-9-71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046650374
177 https://doi.org/10.1186/1475-2840-9-71
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1001/jama.2010.449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044768449
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1016/j.bbadis.2008.02.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014105926
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1016/j.ebiom.2017.06.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086144775
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1016/j.jacl.2017.01.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083695136
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1016/j.jnutbio.2016.09.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028319049
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1016/j.lfs.2005.06.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038421538
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1016/j.vascn.2016.03.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039182311
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1017/s0007114511004454 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039942892
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1042/cs20070182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038921235
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1093/aje/kws264 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030823961
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1093/toxsci/kfw004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060056968
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1097/mco.0b013e328361c53e schema:sameAs https://app.dimensions.ai/details/publication/pub.1020906432
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1111/j.1600-0684.2011.00495.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031825843
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1111/luts.12156 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084607336
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1177/1074248416686187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021986052
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1358/mf.2006.28.9.1037493 schema:sameAs https://app.dimensions.ai/details/publication/pub.1065064860
210 rdf:type schema:CreativeWork
211 https://doi.org/10.3390/nu9010011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032397084
212 rdf:type schema:CreativeWork
213 https://doi.org/10.3945/ajcn.113.081521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035857956
214 rdf:type schema:CreativeWork
215 https://doi.org/10.3945/ajcn.114.100461 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047398595
216 rdf:type schema:CreativeWork
217 https://doi.org/10.4103/2008-7802.181328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052113905
218 rdf:type schema:CreativeWork
219 https://www.grid.ac/institutes/grid.258151.a schema:alternateName Jiangnan University
220 schema:name Department for hospital infection, Affiliated Hospital of Jiangnan University (Wuxi Third People’s Hospital), 214041, Wuxi, Jiangsu, China
221 Joint Primate Research Center for Chronic Diseases, Jiangnan University and Guangdong Institute of Applied Biological Resources, Jiangnan University, No 1800 Lihu Avenue, Wuxi, Jiangsu, 214122, Wuxi, Jiangsu, China
222 Laboratory of Genomic and Precision Medicine, Wuxi School of Medicine, Jiangnan University, 1800 Lihu Avenue, 214122, Wuxi, Jiangsu, China
223 School of Biotechnology, Jiangnan University, 1800 Lihu Avenue, Wuxi, Jiangsu, China
224 rdf:type schema:Organization
225 https://www.grid.ac/institutes/grid.464309.c schema:alternateName Guangdong Academy of Science
226 schema:name Guangdong Institute of Applied Biological Resources, 105 Xingang Rd. West, Guangzhou, Guangdong, China
227 Guangdong Key Laboratory of Animal Conservation and Resource Utilization, 105 Xingang Rd. West, 510260, Guangzhou, Guangdong, China
228 Guangdong Public Laboratory of Wild Animal Conservation and Utilization, 105 Xingang Rd. West, Guangzhou, Guangdong, China
229 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...