Lipid peroxidation diminishing perspective of isolated theaflavins and thearubigins from black tea in arginine induced renal malfunctional rats View Full Text


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Article Info

DATE

2018-07-18

AUTHORS

Ali Imran, Muhammad Umair Arshad, Muhammad Sajid Arshad, Muhammad Imran, Farhan Saeed, Muhammad Sohaib

ABSTRACT

BACKGROUND: Recently oxidative stress induced maladies have amplified owing to sedentary lifestyle and monotonous diet. Introduction of plant based biomolecules may be a suitable strategy to cope with the lipid peroxidation. In this context, black tea polyphenols (theaflavin & thearubigins) are in fame among the scientific community as cost effective therapeutic agents owing to their safety, economics, structural diversity and ability to modulate various lipid peroxidation responses by halting the expression of different metabolic targets. METHODS: The mandate of present investigation was to first time check the synergism among the isolated theaflavins & thearubigins against lipid peroxidative indicators both in vitro and in vivo. Purposely, theaflavins and thearubigins were isolated from black tea through solvent partition methods by using different solvents (Aqueous ethanol, Aqueous methanol & Water) and time intervals (30, 60 & 90 min) and subjected to in vitro characterization through different antioxidant indices to access the in vitro lipid peroxidation shooting effect of these bioactive moieties. Moreover, individual theaflavins contents also estimate through HPLC. For evaluation of in vivo antioxidant effect, renal malfunction was induced through arginine and forty rats were divided in four groups (10 each after power analysis) and 04 types of diets were given i.e. T0 (control diet without supplementation), T1 (Basic experimental Diet+ theaflavins supplementation @ 1 g), T2 (Basic experimental Diet+ Thearubigins supplementation @ 1 g) & T3 (Basic experimental Diet+ Supplementation of theaflavins+ thearubigins @ 0.5 + 0.5 g, respectively) for the period of 56 days. Alongside, a control study was also carried out for comparison by involving normal rats fed on arginine free diet. The body weight, lipid profile, glycemic responses, Renal function test, liver function test, antioxidant indices and hematological parameters were estimated at the termination of study. RESULTS: The results indicated that theaflavins and thearubigins isolation was significantly affected by time of extraction and solvent. In this context, aqueous ethanol at 60 min extraction interval caused maximum extraction. Likewise, theaflavins isolate exhibited more antioxidant activity as compared to thearubigins. Moreover, the theaflavins and thearubigins based experimental diets imparted significant reduction in Lipid profile, glucose content, renal function tests and TBARS with enhancement in insulin, HDL and hematological parameters. In this context, theaflavin based diet caused maximum reduction in lipid profile and TBARS better as compared to thearubigins and theaflavins + thearubigins based. However, theaflavin+ thearubigins based diet caused highest glucose, urea & creatinine decline and maximum insulin increase & antioxidant indices as compared to other nutraceuticals. CONCLUSIONS: It was deduced that theaflavins & thearubigins have strong antioxidative potential both in in vitro as well as in vivo to tackle the menace associated with lipid peroxidation. More... »

PAGES

157

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12944-018-0808-3

DOI

http://dx.doi.org/10.1186/s12944-018-0808-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105679282

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30021615


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33 schema:description BACKGROUND: Recently oxidative stress induced maladies have amplified owing to sedentary lifestyle and monotonous diet. Introduction of plant based biomolecules may be a suitable strategy to cope with the lipid peroxidation. In this context, black tea polyphenols (theaflavin & thearubigins) are in fame among the scientific community as cost effective therapeutic agents owing to their safety, economics, structural diversity and ability to modulate various lipid peroxidation responses by halting the expression of different metabolic targets. METHODS: The mandate of present investigation was to first time check the synergism among the isolated theaflavins &amp; thearubigins against lipid peroxidative indicators both in vitro and in vivo. Purposely, theaflavins and thearubigins were isolated from black tea through solvent partition methods by using different solvents (Aqueous ethanol, Aqueous methanol &amp; Water) and time intervals (30, 60 &amp; 90 min) and subjected to in vitro characterization through different antioxidant indices to access the in vitro lipid peroxidation shooting effect of these bioactive moieties. Moreover, individual theaflavins contents also estimate through HPLC. For evaluation of in vivo antioxidant effect, renal malfunction was induced through arginine and forty rats were divided in four groups (10 each after power analysis) and 04 types of diets were given i.e. T<sub>0</sub> (control diet without supplementation), T1 (Basic experimental Diet+ theaflavins supplementation @ 1 g), T2 (Basic experimental Diet+ Thearubigins supplementation @ 1 g) &amp; T3 (Basic experimental Diet+ Supplementation of theaflavins+ thearubigins @ 0.5 + 0.5 g, respectively) for the period of 56 days. Alongside, a control study was also carried out for comparison by involving normal rats fed on arginine free diet. The body weight, lipid profile, glycemic responses, Renal function test, liver function test, antioxidant indices and hematological parameters were estimated at the termination of study. RESULTS: The results indicated that theaflavins and thearubigins isolation was significantly affected by time of extraction and solvent. In this context, aqueous ethanol at 60 min extraction interval caused maximum extraction. Likewise, theaflavins isolate exhibited more antioxidant activity as compared to thearubigins. Moreover, the theaflavins and thearubigins based experimental diets imparted significant reduction in Lipid profile, glucose content, renal function tests and TBARS with enhancement in insulin, HDL and hematological parameters. In this context, theaflavin based diet caused maximum reduction in lipid profile and TBARS better as compared to thearubigins and theaflavins + thearubigins based. However, theaflavin+ thearubigins based diet caused highest glucose, urea &amp; creatinine decline and maximum insulin increase &amp; antioxidant indices as compared to other nutraceuticals. CONCLUSIONS: It was deduced that theaflavins &amp; thearubigins have strong antioxidative potential both in in vitro as well as in vivo to tackle the menace associated with lipid peroxidation.
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41 HDL
42 HPLC
43 T1
44 T2
45 T3
46 TBARS
47 ability
48 activity
49 agents
50 antioxidant activity
51 antioxidant effects
52 antioxidant indices
53 antioxidative potential
54 aqueous ethanol
55 arginine
56 arginine-free diet
57 bioactive moieties
58 biomolecules
59 black tea
60 black tea polyphenols
61 body weight
62 characterization
63 community
64 comparison
65 content
66 context
67 control study
68 creatinine decline
69 days
70 decline
71 diet
72 different antioxidant indices
73 different metabolic targets
74 different solvents
75 diversity
76 economics
77 effect
78 effective therapeutic agent
79 enhancement
80 ethanol
81 evaluation
82 experimental diets
83 expression
84 extraction
85 extraction interval
86 fame
87 first time
88 free diet
89 function tests
90 glucose
91 glucose content
92 glycemic response
93 group
94 hematological parameters
95 high glucose
96 increase
97 index
98 indicators
99 individual theaflavins contents
100 insulin
101 insulin increase
102 intervals
103 introduction
104 introduction of plants
105 investigation
106 isolation
107 lifestyle
108 lipid peroxidation
109 lipid peroxidation response
110 lipid peroxidation shooting effect
111 lipid peroxidative indicators
112 lipid profile
113 liver function tests
114 maladies
115 malfunction
116 malfunctional rats
117 mandate
118 maximum extraction
119 maximum insulin increase
120 maximum reduction
121 menace
122 metabolic targets
123 method
124 min extraction interval
125 moiety
126 monotonous diet
127 normal rats
128 nutraceuticals
129 oxidative stress
130 parameters
131 partition method
132 period
133 peroxidation
134 peroxidation response
135 peroxidation shooting effect
136 peroxidative indicators
137 perspective
138 plants
139 polyphenols
140 potential
141 present investigation
142 profile
143 rats
144 reduction
145 renal function tests
146 renal malfunction
147 renal malfunctional rats
148 response
149 results
150 safety
151 scientific community
152 sedentary lifestyle
153 shooting effect
154 significant reduction
155 solvent
156 solvent partition method
157 strategies
158 stress
159 strong antioxidative potential
160 structural diversity
161 study
162 suitable strategy
163 synergism
164 target
165 tea
166 tea polyphenols
167 termination
168 termination of study
169 test
170 theaflavin content
171 theaflavins
172 thearubigins
173 thearubigins isolation
174 therapeutic agents
175 time
176 time interval
177 time of extraction
178 type of diet
179 types
180 urea
181 vivo
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183 weight
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