Untargeted metabolomic on urine samples after α-lipoic acid and/or eicosapentaenoic acid supplementation in healthy overweight/obese women View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Ana Romo-Hualde, Ana E. Huerta, Carlos J. González-Navarro, Omar Ramos-López, María J. Moreno-Aliaga, J. Alfredo Martínez

ABSTRACT

BACKGROUND: Eicosapentaenoic acid (EPA) and α-lipoic acid (α-LA) have been investigated for their beneficial effects on obesity and cardiovascular risk factors. In the current research, the goal was to evaluate metabolomic changes following the dietary supplementation of these two lipids, alone or combined in healthy overweight/obese sedentary women following an energy-restricted diet. For this purpose, an untargeted metabolomics approach was conducted on urine samples using liquid chromatography coupled with time of flight mass spectrometry (HPLC-TOF-MS). METHODS: This is a short-term double blind placebo-controlled study with a parallel nutritional design that lasted 10 weeks. Participants were assigned to one of the 4 experimental groups [Control, EPA (1.3 g/d), α-LA (0.3 g/d) and EPA+α-LA (1.3 g/d + 0.3 g/d)]. All intervention groups followed an energy-restricted diet of 30% less than total energy expenditure. Clinically relevant biochemical measurements were analyzed. Urine samples (24 h) were collected at baseline and after 10 weeks. Untargeted metabolomic analysis on urine samples was carried out, and principal component analysis (PCA) and partial least squares-discriminant analysis (PLS-DA) were performed for the pattern recognition and characteristic metabolites identification. RESULTS: Urine samples were scattered in the PCA scores plots in response to the supplementation with α-LA. Totally, 28 putative discriminant metabolites in positive ionization, and 6 in negative ionization were identified among groups clearly differentiated according to the α-LA administration. Remarkably is the presence of an ascorbate intermediate metabolite (one of the isomers of trihydroxy-dioxohexanoate, or dihydroxy-oxohexanedionate) in the groups supplemented with α-LA. This fact might be associated with antioxidant properties of both α-LA and ascorbic acid. Correlations between phenotypical parameters and putative metabolites of provided additional information on whether there is a direct or inverse relationship between them. Especially interesting are the negative correlation between ascorbate intermediate metabolite and asymmetric dimethylarginine (ADMA) and the positive one between superoxide dismutase (SOD) and α-LA supplementation. CONCLUSIONS: This metabolomic approach supports that the beneficial effects of α-LA administration on body weight reduction may be partly explained by the antioxidant properties of this organosulfur carboxylic acid mediated by isomers of trihydroxy-dioxohexanoate, or dihydroxy-oxohexanedionate. TRIAL REGISTRATION: Clinicaltrials.gov NCT01138774 . More... »

PAGES

103

References to SciGraph publications

  • 2015-12. A review of the effect of omega-3 polyunsaturated fatty acids on blood triacylglycerol levels in normolipidemic and borderline hyperlipidemic individuals in LIPIDS IN HEALTH AND DISEASE
  • 2012-09. An accelerated workflow for untargeted metabolomics using the METLIN database in NATURE BIOTECHNOLOGY
  • 2016-01. Plasma metabolomic profiles in association with type 2 diabetes risk and prevalence in Chinese adults in METABOLOMICS
  • 2011-12. Effect of α-lipoic acid and exercise training on cardiovascular disease risk in obesity with impaired glucose tolerance in LIPIDS IN HEALTH AND DISEASE
  • 2014-06. Metabolomics identifies changes in fatty acid and amino acid profiles in serum of overweight older adults following a weight loss intervention in JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
  • 1985-07. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man in DIABETOLOGIA
  • 2015-09. Circulating irisin and glucose metabolism in overweight/obese women: effects of α-lipoic acid and eicosapentaenoic acid in JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
  • 2016-12. Dietary marine-derived long-chain monounsaturated fatty acids and cardiovascular disease risk: a mini review in LIPIDS IN HEALTH AND DISEASE
  • 2017-12. Metabolomics study of the therapeutic mechanism of Schisandra Chinensis lignans in diet-induced hyperlipidemia mice in LIPIDS IN HEALTH AND DISEASE
  • 2015-02. Chemometric evaluation of Saccharomyces cerevisiae metabolic profiles using LC–MS in METABOLOMICS
  • 2014-04. Human metabolic correlates of body mass index in METABOLOMICS
  • 2012-12. Oxidative stress and inflammation interactions in human obesity in JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
  • 2013-12. Flaxseed oil and alpha-lipoic acid combination ameliorates hepatic oxidative stress and lipid accumulation in comparison to lard in LIPIDS IN HEALTH AND DISEASE
  • 2009-03. Lipoic acid prevents body weight gain induced by a high fat diet in rats: Effects on intestinal sugar transport in JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
  • 2013-03. Liquid chromatography quadrupole time-of-flight mass spectrometry characterization of metabolites guided by the METLIN database in NATURE PROTOCOLS
  • 2013-09. Role of omega-3 fatty acids in obesity, metabolic syndrome, and cardiovascular diseases: a review of the evidence in JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12944-018-0750-4

    DOI

    http://dx.doi.org/10.1186/s12944-018-0750-4

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29743087


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