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    "datePublished": "2016-09-22", 
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    "description": "BackgroundProprotein convertase subtilisin/kexin type 9 (PCSK9) is a key regulator of serum low-density lipoprotein (LDL) cholesterol levels. Recently, PCSK9 has additionally been related to metabolic risk factors such as the levels of triglycerides, apolipoprotein B (apoB), insulin, and glucose, as well as body mass index. The purpose of this study was to investigate correlations between serum levels of PCSK9 and apoB-containing atherogenic lipoproteins in patients with coronary artery disease (CAD).MethodsSerum levels of PCSK9 and lipoprotein(a) [Lp(a)]; small, dense LDL; and oxidized LDL were measured in 101 patients with CAD who were not receiving lipid-lowering therapy.ResultsSerum hetero-dimer PCSK9 levels were positively correlated with serum levels of Lp(a) (r\u2009=\u20090.195, p\u2009=\u20090.05); small, dense LDL (r\u2009=\u20090.336, p\u2009=\u20090.0006); and oxidized LDL (r\u2009=\u20090.268, p\u2009=\u20090.008). Multivariate regression analyses showed that serum hetero-dimer PCSK9 was a significant predictor of serum levels of Lp(a) (\u03b2\u2009=\u20090.235, p\u2009=\u20090.01); small, dense LDL (\u03b2\u2009=\u20090.143, p\u2009=\u20090.03); and oxidized LDL (\u03b2\u2009=\u20090.268, p\u2009=\u20090.008).ConclusionsSerum PCSK9 levels were positively correlated with serum levels of Lp(a); small, dense LDL; and oxidized LDL in patients with CAD. This suggests that the interaction between serum PCSK9 and apoB-containing lipoproteins plays a role in establishing the atherosclerotic status of patients.Trial registrationUMIN Clinical Trials Registry, UMIN ID: C000000311.", 
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