Combined use of probucol and cilostazol with atorvastatin attenuates atherosclerosis in moderately hypercholesterolemic rabbits View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-07-29

AUTHORS

Yanli Wang, Liang Bai, Yan Lin, Yulong Chen, Hua Guan, Ninghong Zhu, Yafeng Li, Shoucui Gao, Lijing Sun, Sihai Zhao, Jianglin Fan, Enqi Liu

ABSTRACT

BackgroundAtherosclerotic cardiovascular disease is one of the major diseases that seriously impacts human health. Combined drug therapy may be efficacious in delaying the occurrence of cardiovascular events.AimThe current study was designed to investigate whether combined use of probucol (an anti-oxidant agent) with cilostazol (a platelet aggregation inhibitor) would increase the inhibitory effect of statins (a lipid-lowering agent) on atherosclerosis in moderately hypercholesterolemic rabbits.Methods and ResultsThirty Japanese white rabbits were fed with a high cholesterol diet for 12 weeks, which was supplemented with either 0.005 % atorvastatin alone or 0.005 % atorvastatin plus 0.3 % probucol and 0.3 % cilostazol. Except for high-density lipoprotein cholesterol, no difference was found in plasma lipids among vehicle, statin, and the combined treatment group. However, atherosclerotic lesions were significantly reduced by statin treatment compared with vehicle. Moreover, we found that the anti-atherogenic effect of statin was further enhanced by the combined treatment, which was due to increased anti-inflammatory and anti-oxidant properties.ConclusionsThese data demonstrated that combined drug treatment exhibits potent athero-protective effects via pleiotropic functions, such as anti-inflammatory and anti-oxidative stress, which is independent of the lipid-lowering effect. More... »

PAGES

82

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URI

http://scigraph.springernature.com/pub.10.1186/s12944-015-0083-5

DOI

http://dx.doi.org/10.1186/s12944-015-0083-5

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https://app.dimensions.ai/details/publication/pub.1007895375

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26220196


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32 Japanese white rabbits
33 anti-atherogenic effects
34 anti-oxidant properties
35 anti-oxidative stress
36 athero-protective effects
37 atherosclerosis
38 atherosclerotic lesions
39 atorvastatin
40 cardiovascular disease
41 cardiovascular events
42 cholesterol
43 cholesterol diet
44 cilostazol
45 combined drug therapy
46 combined use
47 current study
48 data
49 diet
50 differences
51 disease
52 drug therapy
53 drug treatment
54 effect
55 events
56 function
57 group
58 health
59 high-cholesterol diet
60 high-density lipoprotein cholesterol
61 human health
62 hypercholesterolemic rabbits
63 inhibitory effect
64 lesions
65 lipid-lowering effects
66 lipids
67 lipoprotein cholesterol
68 major diseases
69 method
70 occurrence
71 plasma lipids
72 pleiotropic functions
73 probucol
74 properties
75 rabbits
76 statin treatment
77 statins
78 stress
79 study
80 therapy
81 treatment
82 treatment groups
83 use
84 use of probucol
85 vehicles
86 weeks
87 white rabbits
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