Bevacizumab treatment for radiation brain necrosis: mechanism, efficacy and issues View Full Text


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Article Info

DATE

2019-12

AUTHORS

Hongqing Zhuang, Siyu Shi, Zhiyong Yuan, Joe Y. Chang

ABSTRACT

Vascular damage is followed by vascular endothelial growth factor (VEGF) expression at high levels, which is an important mechanism forradiation brain necrosis development. Bevacizumab alleviates brain edema symptoms caused by radiation brain necrosis through inhibiting VEGF and acting on vascular tissue around the brain necrosis area. Many studies have confirmed that bevacizumab effectively relieves symptoms caused by brain necrosis, improves patients' Karnofsky performance status (KPS) scores and brain necrosis imaging. However, necrosis is irreversible, and hypoxia and ischemia localized in the brain necrosis area may easily lead to radiation brain necrosis recurrence after bevacizumab is discontinued. Further studies are necessary to investigate brain necrosis diagnoses, bevacizumab indications, and the optimal mode of administration, bevacizumab resistance and necrosis with a residual or recurrent tumor. More... »

PAGES

21

References to SciGraph publications

  • 2011-05. Repeated treatments with bevacizumab for recurrent radiation necrosis in patients with malignant brain tumors: a report of 2 cases in JOURNAL OF NEURO-ONCOLOGY
  • 2011-11. The distribution of vascular endothelial growth factor-producing cells in clinical radiation necrosis of the brain: pathological consideration of their potential roles in JOURNAL OF NEURO-ONCOLOGY
  • 2012-12. Reversal of cerebral radiation necrosis with bevacizumab treatment in 17 Chinese patients in EUROPEAN JOURNAL OF MEDICAL RESEARCH
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  • 2004-12. Biological activity of bevacizumab, a humanized anti-VEGF antibody in vitro in ANGIOGENESIS
  • 2009-08. Initial experience with bevacizumab treatment for biopsy confirmed cerebral radiation necrosis in JOURNAL OF NEURO-ONCOLOGY
  • 2014-04. An analysis of radiation necrosis of the central nervous system treated with bevacizumab in JOURNAL OF NEURO-ONCOLOGY
  • 2014-08. Bevacizumab treatment leads to observable morphological and metabolic changes in brain radiation necrosis in JOURNAL OF NEURO-ONCOLOGY
  • 2015-05. Hypofractionated radiosurgery has a better safety profile than single fraction radiosurgery for large resected brain metastases in JOURNAL OF NEURO-ONCOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12943-019-0950-1

    DOI

    http://dx.doi.org/10.1186/s12943-019-0950-1

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30732625


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