RNA-Seq profiling of circular RNAs in human colorectal Cancer liver metastasis and the potential biomarkers View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Hanchen Xu, Chunyan Wang, Haiyan Song, Yangxian Xu, Guang Ji

ABSTRACT

In this study, the secondary sequencing was used to profile circRNA expression in the tissue samples from three CRC patients with liver metastasis and three matched CRC patients. After verified some candidates in another 40 CRC and CRC-m samples by qRT-PCR, we further demonstrated that circRNA_0001178 and circRNA_0000826 were significantly upregulated in CRC-m tissues, and both of them had the potential for diagnosing liver metastases from colorectal cancer. Finally, the networks of circRNA-miRNA-mRNA base on these two circRNAs were constructed respectively. This study showed that differentially expressed circRNAs were existed between the tissue samples from colorectal cancer patients with and without liver metastasis. And also suggested that circRNA_0001178 and circRNA_0000826 may serve as a potential diagnostic biomarker for liver metastases from colorectal cancer. More... »

PAGES

8

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12943-018-0932-8

DOI

http://dx.doi.org/10.1186/s12943-018-0932-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111329585

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30630466


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Shanghai University of Traditional Chinese Medicine", 
          "id": "https://www.grid.ac/institutes/grid.412540.6", 
          "name": [
            "Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 200032, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xu", 
        "givenName": "Hanchen", 
        "id": "sg:person.015645137565.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015645137565.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shanghai University of Traditional Chinese Medicine", 
          "id": "https://www.grid.ac/institutes/grid.412540.6", 
          "name": [
            "Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 200032, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Chunyan", 
        "id": "sg:person.014122166051.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014122166051.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shanghai University of Traditional Chinese Medicine", 
          "id": "https://www.grid.ac/institutes/grid.412540.6", 
          "name": [
            "Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 200032, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Song", 
        "givenName": "Haiyan", 
        "id": "sg:person.0775077234.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775077234.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shanghai University of Traditional Chinese Medicine", 
          "id": "https://www.grid.ac/institutes/grid.412540.6", 
          "name": [
            "Department of General Surgery, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 200032, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xu", 
        "givenName": "Yangxian", 
        "id": "sg:person.01106666745.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106666745.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shanghai University of Traditional Chinese Medicine", 
          "id": "https://www.grid.ac/institutes/grid.412540.6", 
          "name": [
            "Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 200032, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ji", 
        "givenName": "Guang", 
        "id": "sg:person.01111325634.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111325634.82"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nature11928", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004715472", 
          "https://doi.org/10.1038/nature11928"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms11215", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047094596", 
          "https://doi.org/10.1038/ncomms11215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11993", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050833467", 
          "https://doi.org/10.1038/nature11993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-018-21300-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100901854", 
          "https://doi.org/10.1038/s41598-018-21300-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12943-018-0833-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103744423", 
          "https://doi.org/10.1186/s12943-018-0833-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12943-018-0833-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103744423", 
          "https://doi.org/10.1186/s12943-018-0833-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12943-018-0888-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1107120999", 
          "https://doi.org/10.1186/s12943-018-0888-8"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "In this study, the secondary sequencing was used to profile circRNA expression in the tissue samples from three CRC patients with liver metastasis and three matched CRC patients. After verified some candidates in another 40 CRC and CRC-m samples by qRT-PCR, we further demonstrated that circRNA_0001178 and circRNA_0000826 were significantly upregulated in CRC-m tissues, and both of them had the potential for diagnosing liver metastases from colorectal cancer. Finally, the networks of circRNA-miRNA-mRNA base on these two circRNAs were constructed respectively. This study showed that differentially expressed circRNAs were existed between the tissue samples from colorectal cancer patients with and without liver metastasis. And also suggested that circRNA_0001178 and circRNA_0000826 may serve as a potential diagnostic biomarker for liver metastases from colorectal cancer.", 
    "genre": "non_research_article", 
    "id": "sg:pub.10.1186/s12943-018-0932-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1031030", 
        "issn": [
          "1476-4598"
        ], 
        "name": "Molecular Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "18"
      }
    ], 
    "name": "RNA-Seq profiling of circular RNAs in human colorectal Cancer liver metastasis and the potential biomarkers", 
    "pagination": "8", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "f4ba5ed9a86c3eab27dec273fdde09ddad896acb58bec790cdf28efdc1744212"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30630466"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101147698"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12943-018-0932-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111329585"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12943-018-0932-8", 
      "https://app.dimensions.ai/details/publication/pub.1111329585"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T08:41", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000320_0000000320/records_101369_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12943-018-0932-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12943-018-0932-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12943-018-0932-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12943-018-0932-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12943-018-0932-8'


 

This table displays all metadata directly associated to this object as RDF triples.

121 TRIPLES      21 PREDICATES      35 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12943-018-0932-8 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author Na0a0ffa070144d2db3faa0b6c24aa245
4 schema:citation sg:pub.10.1038/nature11928
5 sg:pub.10.1038/nature11993
6 sg:pub.10.1038/ncomms11215
7 sg:pub.10.1038/s41598-018-21300-5
8 sg:pub.10.1186/s12943-018-0833-x
9 sg:pub.10.1186/s12943-018-0888-8
10 schema:datePublished 2019-12
11 schema:datePublishedReg 2019-12-01
12 schema:description In this study, the secondary sequencing was used to profile circRNA expression in the tissue samples from three CRC patients with liver metastasis and three matched CRC patients. After verified some candidates in another 40 CRC and CRC-m samples by qRT-PCR, we further demonstrated that circRNA_0001178 and circRNA_0000826 were significantly upregulated in CRC-m tissues, and both of them had the potential for diagnosing liver metastases from colorectal cancer. Finally, the networks of circRNA-miRNA-mRNA base on these two circRNAs were constructed respectively. This study showed that differentially expressed circRNAs were existed between the tissue samples from colorectal cancer patients with and without liver metastasis. And also suggested that circRNA_0001178 and circRNA_0000826 may serve as a potential diagnostic biomarker for liver metastases from colorectal cancer.
13 schema:genre non_research_article
14 schema:inLanguage en
15 schema:isAccessibleForFree true
16 schema:isPartOf N2560844631674d1ab57170b70d516dc9
17 Nd96946e9f30e49ab94791d23049f37d5
18 sg:journal.1031030
19 schema:name RNA-Seq profiling of circular RNAs in human colorectal Cancer liver metastasis and the potential biomarkers
20 schema:pagination 8
21 schema:productId N02e8cee0d95c4fc1900d84f442d76c00
22 N49f175af98144405b548f8f79298daa5
23 N6d8f3daa924245339eebed586a9277c8
24 Na75880e77f3d42c1abbed51b014b3462
25 Ned6b0456f8494c2893fcf3593b7a9093
26 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111329585
27 https://doi.org/10.1186/s12943-018-0932-8
28 schema:sdDatePublished 2019-04-11T08:41
29 schema:sdLicense https://scigraph.springernature.com/explorer/license/
30 schema:sdPublisher N85a6a8d7e7f54804a7f1028a08eae5eb
31 schema:url https://link.springer.com/10.1186%2Fs12943-018-0932-8
32 sgo:license sg:explorer/license/
33 sgo:sdDataset articles
34 rdf:type schema:ScholarlyArticle
35 N02e8cee0d95c4fc1900d84f442d76c00 schema:name doi
36 schema:value 10.1186/s12943-018-0932-8
37 rdf:type schema:PropertyValue
38 N2560844631674d1ab57170b70d516dc9 schema:volumeNumber 18
39 rdf:type schema:PublicationVolume
40 N49f175af98144405b548f8f79298daa5 schema:name pubmed_id
41 schema:value 30630466
42 rdf:type schema:PropertyValue
43 N6d8f3daa924245339eebed586a9277c8 schema:name nlm_unique_id
44 schema:value 101147698
45 rdf:type schema:PropertyValue
46 N85a6a8d7e7f54804a7f1028a08eae5eb schema:name Springer Nature - SN SciGraph project
47 rdf:type schema:Organization
48 N97f46b98f4704ce5a26ae6c97119b1d0 rdf:first sg:person.0775077234.79
49 rdf:rest Nca81a1872adb4847ad7ca00a3454d8cd
50 Na0a0ffa070144d2db3faa0b6c24aa245 rdf:first sg:person.015645137565.57
51 rdf:rest Nb7665695f9624d8b8a0a43d2235ce53b
52 Na75880e77f3d42c1abbed51b014b3462 schema:name dimensions_id
53 schema:value pub.1111329585
54 rdf:type schema:PropertyValue
55 Nb7665695f9624d8b8a0a43d2235ce53b rdf:first sg:person.014122166051.25
56 rdf:rest N97f46b98f4704ce5a26ae6c97119b1d0
57 Nbe21cce943fb4b77ab3bdb95fcb71894 rdf:first sg:person.01111325634.82
58 rdf:rest rdf:nil
59 Nca81a1872adb4847ad7ca00a3454d8cd rdf:first sg:person.01106666745.49
60 rdf:rest Nbe21cce943fb4b77ab3bdb95fcb71894
61 Nd96946e9f30e49ab94791d23049f37d5 schema:issueNumber 1
62 rdf:type schema:PublicationIssue
63 Ned6b0456f8494c2893fcf3593b7a9093 schema:name readcube_id
64 schema:value f4ba5ed9a86c3eab27dec273fdde09ddad896acb58bec790cdf28efdc1744212
65 rdf:type schema:PropertyValue
66 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
67 schema:name Medical and Health Sciences
68 rdf:type schema:DefinedTerm
69 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
70 schema:name Oncology and Carcinogenesis
71 rdf:type schema:DefinedTerm
72 sg:journal.1031030 schema:issn 1476-4598
73 schema:name Molecular Cancer
74 rdf:type schema:Periodical
75 sg:person.01106666745.49 schema:affiliation https://www.grid.ac/institutes/grid.412540.6
76 schema:familyName Xu
77 schema:givenName Yangxian
78 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106666745.49
79 rdf:type schema:Person
80 sg:person.01111325634.82 schema:affiliation https://www.grid.ac/institutes/grid.412540.6
81 schema:familyName Ji
82 schema:givenName Guang
83 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111325634.82
84 rdf:type schema:Person
85 sg:person.014122166051.25 schema:affiliation https://www.grid.ac/institutes/grid.412540.6
86 schema:familyName Wang
87 schema:givenName Chunyan
88 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014122166051.25
89 rdf:type schema:Person
90 sg:person.015645137565.57 schema:affiliation https://www.grid.ac/institutes/grid.412540.6
91 schema:familyName Xu
92 schema:givenName Hanchen
93 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015645137565.57
94 rdf:type schema:Person
95 sg:person.0775077234.79 schema:affiliation https://www.grid.ac/institutes/grid.412540.6
96 schema:familyName Song
97 schema:givenName Haiyan
98 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775077234.79
99 rdf:type schema:Person
100 sg:pub.10.1038/nature11928 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004715472
101 https://doi.org/10.1038/nature11928
102 rdf:type schema:CreativeWork
103 sg:pub.10.1038/nature11993 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050833467
104 https://doi.org/10.1038/nature11993
105 rdf:type schema:CreativeWork
106 sg:pub.10.1038/ncomms11215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047094596
107 https://doi.org/10.1038/ncomms11215
108 rdf:type schema:CreativeWork
109 sg:pub.10.1038/s41598-018-21300-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100901854
110 https://doi.org/10.1038/s41598-018-21300-5
111 rdf:type schema:CreativeWork
112 sg:pub.10.1186/s12943-018-0833-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1103744423
113 https://doi.org/10.1186/s12943-018-0833-x
114 rdf:type schema:CreativeWork
115 sg:pub.10.1186/s12943-018-0888-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107120999
116 https://doi.org/10.1186/s12943-018-0888-8
117 rdf:type schema:CreativeWork
118 https://www.grid.ac/institutes/grid.412540.6 schema:alternateName Shanghai University of Traditional Chinese Medicine
119 schema:name Department of General Surgery, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 200032, Shanghai, China
120 Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 200032, Shanghai, China
121 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...