Ontology type: schema:ScholarlyArticle Open Access: True
2018-12
AUTHORSWeiwei Tang, Kai Fu, Handong Sun, Dawei Rong, Hanjin Wang, Hongyong Cao
ABSTRACTCircRNA expression profiles for gastric cancer (GC) were screened using plasma samples from 10 GC patients with different TNM stages and 5 healthy individuals as controls. Results showed lower expression of circ-KIAA1244 in GC tissues, plasmas, and cells compare to normal controls. Further clinical data analysis demonstrated that a decreased expression of circ-KIAA1244 in plasmas was negatively correlated with TNM stage and lymphatic metastasis, and a shorter overall survival time of GC patients. Moreover, we found that circ-KIAA1244 could be detected in GC plasma exosomes and showed no obvious significance compared to the expression level in the corresponding plasmas. This study revealed a GC-tissues-derived circ-KIAA1244 could serve a novel circulating biomarker for detection of GC. More... »
PAGES137
http://scigraph.springernature.com/pub.10.1186/s12943-018-0888-8
DOIhttp://dx.doi.org/10.1186/s12943-018-0888-8
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