Long noncoding RNA AFAP1-AS1 predicts a poor prognosis and regulates non–small cell lung cancer cell proliferation by epigenetically repressing p21 ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Dandan Yin, Xiyi Lu, Jun Su, Xuezhi He, Wei De, Jinsong Yang, Wei Li, Liang Han, Erbao Zhang

ABSTRACT

BACKGROUND: Mounting evidence indicates that long noncoding RNAs (lncRNAs) could play a pivotal role in cancer biology. However, the role and molecular mechanism and global genes that were mediated by lncRNA AFAP1-AS1 in non-small cell lung cancer (NSCLC) remain largely unknown. METHODS: Expression of AFAP1-AS1 was analyzed in 92 NSCLC tissues and cell lines by Quantitative real time polymerase chain reaction (qRT-PCR). The effect of AFAP1-AS1 on proliferation was evaluated by function assays both in in vitro and in vivo. RNA-seq assays were performed after knockdown AFAP1-AS1. RNA immunoprecipitation (RIP) was performed to confirm the interaction between AFAP1-AS1 and EZH2. Chromatin immunoprecipitation (ChIP) was used to study the promoter region of p21. RESULTS: AFAP1-AS1 expression was increased in NSCLC tissues and was correlated with clinical outcomes of NSCLC. Further experiments revealed that inhibition of its expression in NSCLC cells resulted in diminished cell growth in vitro and in vivo. RNA-seq revealed that knockdown of AFAP1-AS1 could induce the expression of p21. Mechanistic investigations found that AFAP1-AS1 could interact with EZH2 and recruit EZH2 to the promoter regions of p21, thus epigenetically repressing p21 expression. CONCLUSIONS: Together, these results suggest that lncRNA AFAP1-AS1 may serve as a candidate prognostic biomarker and target for new therapies in human NSCLC. More... »

PAGES

92

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12943-018-0836-7

DOI

http://dx.doi.org/10.1186/s12943-018-0836-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1104168589

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29793547


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Nanjing Second Hospital", 
          "id": "https://www.grid.ac/institutes/grid.452675.7", 
          "name": [
            "Cancer Research and Biotherapy Center, the Second Affiliated Hospital of Southeast University, Nanjing, Jiangsu, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yin", 
        "givenName": "Dandan", 
        "id": "sg:person.01040655302.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040655302.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jiangsu Province Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412676.0", 
          "name": [
            "Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lu", 
        "givenName": "Xiyi", 
        "id": "sg:person.010717545347.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010717545347.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jiangyin People's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.452817.d", 
          "name": [
            "Department of Oncology, the Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, Jiangsu, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Su", 
        "givenName": "Jun", 
        "id": "sg:person.0671053251.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671053251.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nanjing Medical University", 
          "id": "https://www.grid.ac/institutes/grid.89957.3a", 
          "name": [
            "Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, Jiangsu, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "He", 
        "givenName": "Xuezhi", 
        "id": "sg:person.01106770502.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106770502.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nanjing Medical University", 
          "id": "https://www.grid.ac/institutes/grid.89957.3a", 
          "name": [
            "Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, Jiangsu, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "De", 
        "givenName": "Wei", 
        "id": "sg:person.01263631474.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263631474.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Jinsong", 
        "id": "sg:person.01171423136.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171423136.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jiangsu Province Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412676.0", 
          "name": [
            "Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Wei", 
        "id": "sg:person.016205376120.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016205376120.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Xuzhou Central Hospital", 
          "id": "https://www.grid.ac/institutes/grid.452207.6", 
          "name": [
            "Department of Oncology, Xuzhou Central Hospital, Affiliated Xuzhou Hospital, College of Medicine, Southeast University, Xuzhou, Jiangsu, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Han", 
        "givenName": "Liang", 
        "id": "sg:person.01354607445.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354607445.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nanjing Medical University", 
          "id": "https://www.grid.ac/institutes/grid.89957.3a", 
          "name": [
            "Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Erbao", 
        "id": "sg:person.01273247116.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273247116.76"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1126/science.1251456", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001729374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra0802714", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002128638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1479-5876-10-103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002235194", 
          "https://doi.org/10.1186/1479-5876-10-103"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1192002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002615413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1192002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002615413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1541-7786.mcr-10-0511", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002759304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2013.01.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005297860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tcb.2014.08.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007499690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(93)90636-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009780866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopha.2016.04.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009946219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/caac.21338", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010436755"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.24128", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011470393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2013.02.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011697893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/caac.21387", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014894112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11661", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016106186", 
          "https://doi.org/10.1038/nature11661"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11661", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016106186", 
          "https://doi.org/10.1038/nature11661"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08975", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017276958", 
          "https://doi.org/10.1038/nature08975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08975", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017276958", 
          "https://doi.org/10.1038/nature08975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08975", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017276958", 
          "https://doi.org/10.1038/nature08975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-12-2850", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018074315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ctrv.2015.02.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018620286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-15-0273", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018695209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03094", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019043910", 
          "https://doi.org/10.1038/nature03094"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03094", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019043910", 
          "https://doi.org/10.1038/nature03094"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopha.2016.10.064", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021698102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0600745103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022541994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0904715106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022579887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s13277-015-3106-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025034112", 
          "https://doi.org/10.1007/s13277-015-3106-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0463.2008.00773.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025770664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12967-015-0490-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028068554", 
          "https://doi.org/10.1186/s12967-015-0490-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12967-015-0490-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028068554", 
          "https://doi.org/10.1186/s12967-015-0490-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2011.03.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028550899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci85250", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029986813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09784", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030505833", 
          "https://doi.org/10.1038/nature09784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2657", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031760843", 
          "https://doi.org/10.1038/nrc2657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2657", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031760843", 
          "https://doi.org/10.1038/nrc2657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.4057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037067376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.4057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037067376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg2521", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040714915", 
          "https://doi.org/10.1038/nrg2521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cddis.2014.201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041753059", 
          "https://doi.org/10.1038/cddis.2014.201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2011.09.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041816546"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-14-0686", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042584347"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-04-3995", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043378487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.9.10.1149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046596837"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1076997", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050318758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07672", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051133532", 
          "https://doi.org/10.1038/nature07672"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopha.2015.07.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053247470"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkw1247", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059932162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkw1247", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059932162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.2016.3385", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071514228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.2016.3385", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071514228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/epi.27472", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072302731"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079076019", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1090397614", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "BACKGROUND: Mounting evidence indicates that long noncoding RNAs (lncRNAs) could play a pivotal role in cancer biology. However, the role and molecular mechanism and global genes that were mediated by lncRNA AFAP1-AS1 in non-small cell lung cancer (NSCLC) remain largely unknown.\nMETHODS: Expression of AFAP1-AS1 was analyzed in 92 NSCLC tissues and cell lines by Quantitative real time polymerase chain reaction (qRT-PCR). The effect of AFAP1-AS1 on proliferation was evaluated by function assays both in in vitro and in vivo. RNA-seq assays were performed after knockdown AFAP1-AS1. RNA immunoprecipitation (RIP) was performed to confirm the interaction between AFAP1-AS1 and EZH2. Chromatin immunoprecipitation (ChIP) was used to study the promoter region of p21.\nRESULTS: AFAP1-AS1 expression was increased in NSCLC tissues and was correlated with clinical outcomes of NSCLC. Further experiments revealed that inhibition of its expression in NSCLC cells resulted in diminished cell growth in vitro and in vivo. RNA-seq revealed that knockdown of AFAP1-AS1 could induce the expression of p21. Mechanistic investigations found that AFAP1-AS1 could interact with EZH2 and recruit EZH2 to the promoter regions of p21, thus epigenetically repressing p21 expression.\nCONCLUSIONS: Together, these results suggest that lncRNA AFAP1-AS1 may serve as a candidate prognostic biomarker and target for new therapies in human NSCLC.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12943-018-0836-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1031030", 
        "issn": [
          "1476-4598"
        ], 
        "name": "Molecular Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "17"
      }
    ], 
    "name": "Long noncoding RNA AFAP1-AS1 predicts a poor prognosis and regulates non\u2013small cell lung cancer cell proliferation by epigenetically repressing p21 expression", 
    "pagination": "92", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "52a1431698960d8b8a3c9466b14730482ea0bdeabed314a0c6c2856525a23e98"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29793547"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101147698"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12943-018-0836-7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1104168589"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12943-018-0836-7", 
      "https://app.dimensions.ai/details/publication/pub.1104168589"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:27", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000571.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12943-018-0836-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12943-018-0836-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12943-018-0836-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12943-018-0836-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12943-018-0836-7'


 

This table displays all metadata directly associated to this object as RDF triples.

280 TRIPLES      21 PREDICATES      73 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12943-018-0836-7 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author N4813ec418abf4787b1c884a5f7a75a52
4 schema:citation sg:pub.10.1007/s13277-015-3106-y
5 sg:pub.10.1038/cddis.2014.201
6 sg:pub.10.1038/nature03094
7 sg:pub.10.1038/nature07672
8 sg:pub.10.1038/nature08975
9 sg:pub.10.1038/nature09784
10 sg:pub.10.1038/nature11661
11 sg:pub.10.1038/nrc2657
12 sg:pub.10.1038/nrg2521
13 sg:pub.10.1186/1479-5876-10-103
14 sg:pub.10.1186/s12967-015-0490-4
15 https://app.dimensions.ai/details/publication/pub.1079076019
16 https://app.dimensions.ai/details/publication/pub.1090397614
17 https://doi.org/10.1002/cncr.24128
18 https://doi.org/10.1016/0092-8674(93)90636-5
19 https://doi.org/10.1016/j.biopha.2015.07.003
20 https://doi.org/10.1016/j.biopha.2016.04.009
21 https://doi.org/10.1016/j.biopha.2016.10.064
22 https://doi.org/10.1016/j.cell.2011.03.014
23 https://doi.org/10.1016/j.cell.2011.09.028
24 https://doi.org/10.1016/j.cell.2013.02.012
25 https://doi.org/10.1016/j.ctrv.2015.02.008
26 https://doi.org/10.1016/j.tcb.2014.08.009
27 https://doi.org/10.1053/j.gastro.2013.01.019
28 https://doi.org/10.1056/nejmra0802714
29 https://doi.org/10.1073/pnas.0600745103
30 https://doi.org/10.1073/pnas.0904715106
31 https://doi.org/10.1093/nar/gkw1247
32 https://doi.org/10.1101/gad.9.10.1149
33 https://doi.org/10.1111/j.1600-0463.2008.00773.x
34 https://doi.org/10.1126/science.1076997
35 https://doi.org/10.1126/science.1192002
36 https://doi.org/10.1126/science.1251456
37 https://doi.org/10.1158/0008-5472.can-04-3995
38 https://doi.org/10.1158/0008-5472.can-12-2850
39 https://doi.org/10.1158/0008-5472.can-14-0686
40 https://doi.org/10.1158/0008-5472.can-15-0273
41 https://doi.org/10.1158/1541-7786.mcr-10-0511
42 https://doi.org/10.1172/jci85250
43 https://doi.org/10.18632/oncotarget.4057
44 https://doi.org/10.3322/caac.21338
45 https://doi.org/10.3322/caac.21387
46 https://doi.org/10.3892/ijo.2016.3385
47 https://doi.org/10.4161/epi.27472
48 schema:datePublished 2018-12
49 schema:datePublishedReg 2018-12-01
50 schema:description BACKGROUND: Mounting evidence indicates that long noncoding RNAs (lncRNAs) could play a pivotal role in cancer biology. However, the role and molecular mechanism and global genes that were mediated by lncRNA AFAP1-AS1 in non-small cell lung cancer (NSCLC) remain largely unknown. METHODS: Expression of AFAP1-AS1 was analyzed in 92 NSCLC tissues and cell lines by Quantitative real time polymerase chain reaction (qRT-PCR). The effect of AFAP1-AS1 on proliferation was evaluated by function assays both in in vitro and in vivo. RNA-seq assays were performed after knockdown AFAP1-AS1. RNA immunoprecipitation (RIP) was performed to confirm the interaction between AFAP1-AS1 and EZH2. Chromatin immunoprecipitation (ChIP) was used to study the promoter region of p21. RESULTS: AFAP1-AS1 expression was increased in NSCLC tissues and was correlated with clinical outcomes of NSCLC. Further experiments revealed that inhibition of its expression in NSCLC cells resulted in diminished cell growth in vitro and in vivo. RNA-seq revealed that knockdown of AFAP1-AS1 could induce the expression of p21. Mechanistic investigations found that AFAP1-AS1 could interact with EZH2 and recruit EZH2 to the promoter regions of p21, thus epigenetically repressing p21 expression. CONCLUSIONS: Together, these results suggest that lncRNA AFAP1-AS1 may serve as a candidate prognostic biomarker and target for new therapies in human NSCLC.
51 schema:genre research_article
52 schema:inLanguage en
53 schema:isAccessibleForFree true
54 schema:isPartOf N7e6bc20b774e4bd49ee7e036eedac4f3
55 Nc7c838306d1146a690f46f3b400501f4
56 sg:journal.1031030
57 schema:name Long noncoding RNA AFAP1-AS1 predicts a poor prognosis and regulates non–small cell lung cancer cell proliferation by epigenetically repressing p21 expression
58 schema:pagination 92
59 schema:productId N1af8957e675e469498b175cfee7a9b0a
60 N76405505072a4641a06d54262c0f625c
61 Nbdb733095019406c8e6e3426199ae8cb
62 Nc942ba56b0e84a1aa4e87d6c31598b29
63 Nffe897b6cbf44767822890d664e6234f
64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104168589
65 https://doi.org/10.1186/s12943-018-0836-7
66 schema:sdDatePublished 2019-04-10T13:27
67 schema:sdLicense https://scigraph.springernature.com/explorer/license/
68 schema:sdPublisher Ndf66fe3788ba4fd0b1c0cbfb8538fcbe
69 schema:url https://link.springer.com/10.1186%2Fs12943-018-0836-7
70 sgo:license sg:explorer/license/
71 sgo:sdDataset articles
72 rdf:type schema:ScholarlyArticle
73 N064c84035bc84d2b8a2e361749696aa0 rdf:first sg:person.01106770502.03
74 rdf:rest Na2adc87bde1440c9a635c9b3de4df7dd
75 N1af8957e675e469498b175cfee7a9b0a schema:name nlm_unique_id
76 schema:value 101147698
77 rdf:type schema:PropertyValue
78 N25c43f18fb724755aaf141fefaf3e381 rdf:first sg:person.01273247116.76
79 rdf:rest rdf:nil
80 N28f3af7a12a744e29a7f1da7b3d7a488 rdf:first sg:person.0671053251.81
81 rdf:rest N064c84035bc84d2b8a2e361749696aa0
82 N4813ec418abf4787b1c884a5f7a75a52 rdf:first sg:person.01040655302.25
83 rdf:rest N88dfe96e12334221b8af2c42b7b00026
84 N5344b927679d4a2d8cfe98f7b275eff8 schema:name Department of Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China
85 rdf:type schema:Organization
86 N76405505072a4641a06d54262c0f625c schema:name pubmed_id
87 schema:value 29793547
88 rdf:type schema:PropertyValue
89 N7bac7b7f55e74f1fa90fd06741f1b8e4 rdf:first sg:person.01171423136.14
90 rdf:rest N826a797fc6364f6aa3f6926c3588415d
91 N7e6bc20b774e4bd49ee7e036eedac4f3 schema:volumeNumber 17
92 rdf:type schema:PublicationVolume
93 N826a797fc6364f6aa3f6926c3588415d rdf:first sg:person.016205376120.55
94 rdf:rest Nbe80c69c4dd94743bc169fc867fa3f65
95 N88dfe96e12334221b8af2c42b7b00026 rdf:first sg:person.010717545347.03
96 rdf:rest N28f3af7a12a744e29a7f1da7b3d7a488
97 Na2adc87bde1440c9a635c9b3de4df7dd rdf:first sg:person.01263631474.14
98 rdf:rest N7bac7b7f55e74f1fa90fd06741f1b8e4
99 Nbdb733095019406c8e6e3426199ae8cb schema:name dimensions_id
100 schema:value pub.1104168589
101 rdf:type schema:PropertyValue
102 Nbe80c69c4dd94743bc169fc867fa3f65 rdf:first sg:person.01354607445.17
103 rdf:rest N25c43f18fb724755aaf141fefaf3e381
104 Nc7c838306d1146a690f46f3b400501f4 schema:issueNumber 1
105 rdf:type schema:PublicationIssue
106 Nc942ba56b0e84a1aa4e87d6c31598b29 schema:name readcube_id
107 schema:value 52a1431698960d8b8a3c9466b14730482ea0bdeabed314a0c6c2856525a23e98
108 rdf:type schema:PropertyValue
109 Ndf66fe3788ba4fd0b1c0cbfb8538fcbe schema:name Springer Nature - SN SciGraph project
110 rdf:type schema:Organization
111 Nffe897b6cbf44767822890d664e6234f schema:name doi
112 schema:value 10.1186/s12943-018-0836-7
113 rdf:type schema:PropertyValue
114 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
115 schema:name Medical and Health Sciences
116 rdf:type schema:DefinedTerm
117 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
118 schema:name Oncology and Carcinogenesis
119 rdf:type schema:DefinedTerm
120 sg:journal.1031030 schema:issn 1476-4598
121 schema:name Molecular Cancer
122 rdf:type schema:Periodical
123 sg:person.01040655302.25 schema:affiliation https://www.grid.ac/institutes/grid.452675.7
124 schema:familyName Yin
125 schema:givenName Dandan
126 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040655302.25
127 rdf:type schema:Person
128 sg:person.010717545347.03 schema:affiliation https://www.grid.ac/institutes/grid.412676.0
129 schema:familyName Lu
130 schema:givenName Xiyi
131 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010717545347.03
132 rdf:type schema:Person
133 sg:person.01106770502.03 schema:affiliation https://www.grid.ac/institutes/grid.89957.3a
134 schema:familyName He
135 schema:givenName Xuezhi
136 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106770502.03
137 rdf:type schema:Person
138 sg:person.01171423136.14 schema:affiliation N5344b927679d4a2d8cfe98f7b275eff8
139 schema:familyName Yang
140 schema:givenName Jinsong
141 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171423136.14
142 rdf:type schema:Person
143 sg:person.01263631474.14 schema:affiliation https://www.grid.ac/institutes/grid.89957.3a
144 schema:familyName De
145 schema:givenName Wei
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263631474.14
147 rdf:type schema:Person
148 sg:person.01273247116.76 schema:affiliation https://www.grid.ac/institutes/grid.89957.3a
149 schema:familyName Zhang
150 schema:givenName Erbao
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273247116.76
152 rdf:type schema:Person
153 sg:person.01354607445.17 schema:affiliation https://www.grid.ac/institutes/grid.452207.6
154 schema:familyName Han
155 schema:givenName Liang
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354607445.17
157 rdf:type schema:Person
158 sg:person.016205376120.55 schema:affiliation https://www.grid.ac/institutes/grid.412676.0
159 schema:familyName Li
160 schema:givenName Wei
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016205376120.55
162 rdf:type schema:Person
163 sg:person.0671053251.81 schema:affiliation https://www.grid.ac/institutes/grid.452817.d
164 schema:familyName Su
165 schema:givenName Jun
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671053251.81
167 rdf:type schema:Person
168 sg:pub.10.1007/s13277-015-3106-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1025034112
169 https://doi.org/10.1007/s13277-015-3106-y
170 rdf:type schema:CreativeWork
171 sg:pub.10.1038/cddis.2014.201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041753059
172 https://doi.org/10.1038/cddis.2014.201
173 rdf:type schema:CreativeWork
174 sg:pub.10.1038/nature03094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019043910
175 https://doi.org/10.1038/nature03094
176 rdf:type schema:CreativeWork
177 sg:pub.10.1038/nature07672 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051133532
178 https://doi.org/10.1038/nature07672
179 rdf:type schema:CreativeWork
180 sg:pub.10.1038/nature08975 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017276958
181 https://doi.org/10.1038/nature08975
182 rdf:type schema:CreativeWork
183 sg:pub.10.1038/nature09784 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030505833
184 https://doi.org/10.1038/nature09784
185 rdf:type schema:CreativeWork
186 sg:pub.10.1038/nature11661 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016106186
187 https://doi.org/10.1038/nature11661
188 rdf:type schema:CreativeWork
189 sg:pub.10.1038/nrc2657 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031760843
190 https://doi.org/10.1038/nrc2657
191 rdf:type schema:CreativeWork
192 sg:pub.10.1038/nrg2521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040714915
193 https://doi.org/10.1038/nrg2521
194 rdf:type schema:CreativeWork
195 sg:pub.10.1186/1479-5876-10-103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002235194
196 https://doi.org/10.1186/1479-5876-10-103
197 rdf:type schema:CreativeWork
198 sg:pub.10.1186/s12967-015-0490-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028068554
199 https://doi.org/10.1186/s12967-015-0490-4
200 rdf:type schema:CreativeWork
201 https://app.dimensions.ai/details/publication/pub.1079076019 schema:CreativeWork
202 https://app.dimensions.ai/details/publication/pub.1090397614 schema:CreativeWork
203 https://doi.org/10.1002/cncr.24128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011470393
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1016/0092-8674(93)90636-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009780866
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/j.biopha.2015.07.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053247470
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/j.biopha.2016.04.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009946219
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/j.biopha.2016.10.064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021698102
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/j.cell.2011.03.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028550899
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/j.cell.2011.09.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041816546
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/j.cell.2013.02.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011697893
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/j.ctrv.2015.02.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018620286
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/j.tcb.2014.08.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007499690
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1053/j.gastro.2013.01.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005297860
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1056/nejmra0802714 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002128638
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1073/pnas.0600745103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022541994
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1073/pnas.0904715106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022579887
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1093/nar/gkw1247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059932162
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1101/gad.9.10.1149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046596837
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1111/j.1600-0463.2008.00773.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1025770664
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1126/science.1076997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050318758
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1126/science.1192002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002615413
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1126/science.1251456 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001729374
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1158/0008-5472.can-04-3995 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043378487
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1158/0008-5472.can-12-2850 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018074315
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1158/0008-5472.can-14-0686 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042584347
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1158/0008-5472.can-15-0273 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018695209
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1158/1541-7786.mcr-10-0511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002759304
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1172/jci85250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029986813
254 rdf:type schema:CreativeWork
255 https://doi.org/10.18632/oncotarget.4057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037067376
256 rdf:type schema:CreativeWork
257 https://doi.org/10.3322/caac.21338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010436755
258 rdf:type schema:CreativeWork
259 https://doi.org/10.3322/caac.21387 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014894112
260 rdf:type schema:CreativeWork
261 https://doi.org/10.3892/ijo.2016.3385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071514228
262 rdf:type schema:CreativeWork
263 https://doi.org/10.4161/epi.27472 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072302731
264 rdf:type schema:CreativeWork
265 https://www.grid.ac/institutes/grid.412676.0 schema:alternateName Jiangsu Province Hospital
266 schema:name Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China
267 rdf:type schema:Organization
268 https://www.grid.ac/institutes/grid.452207.6 schema:alternateName Xuzhou Central Hospital
269 schema:name Department of Oncology, Xuzhou Central Hospital, Affiliated Xuzhou Hospital, College of Medicine, Southeast University, Xuzhou, Jiangsu, People’s Republic of China
270 rdf:type schema:Organization
271 https://www.grid.ac/institutes/grid.452675.7 schema:alternateName Nanjing Second Hospital
272 schema:name Cancer Research and Biotherapy Center, the Second Affiliated Hospital of Southeast University, Nanjing, Jiangsu, People’s Republic of China
273 rdf:type schema:Organization
274 https://www.grid.ac/institutes/grid.452817.d schema:alternateName Jiangyin People's Hospital
275 schema:name Department of Oncology, the Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, Jiangsu, China
276 rdf:type schema:Organization
277 https://www.grid.ac/institutes/grid.89957.3a schema:alternateName Nanjing Medical University
278 schema:name Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China
279 Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, People’s Republic of China
280 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...