The polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Helen B. Pearson, Edwina McGlinn, Toby J. Phesse, Holger Schlüter, Anuratha Srikumar, Nathan J. Gödde, Christina B. Woelwer, Andrew Ryan, Wayne A. Phillips, Matthias Ernst, Pritinder Kaur, Patrick Humbert

ABSTRACT

BACKGROUND: The establishment and maintenance of polarity is vital for embryonic development and loss of polarity is a frequent characteristic of epithelial cancers, however the underlying molecular mechanisms remain unclear. Here, we identify a novel role for the polarity protein Scrib as a mediator of epidermal permeability barrier acquisition, skeletal morphogenesis, and as a potent tumor suppressor in cutaneous carcinogenesis. METHODS: To explore the role of Scrib during epidermal development, we compared the permeability of toluidine blue dye in wild-type, Scrib heterozygous and Scrib KO embryonic epidermis at E16.5, E17.5 and E18.5. Mouse embryos were stained with alcian blue and alizarin red for skeletal analysis. To establish whether Scrib plays a tumor suppressive role during skin tumorigenesis and/or progression, we evaluated an autochthonous mouse model of skin carcinogenesis in the context of Scrib loss. We utilised Cre-LoxP technology to conditionally deplete Scrib in adult epidermis, since Scrib KO embryos are neonatal lethal. RESULTS: We establish that Scrib perturbs keratinocyte maturation during embryonic development, causing impaired epidermal barrier formation, and that Scrib is required for skeletal morphogenesis in mice. Analysis of conditional transgenic mice deficient for Scrib specifically within the epidermis revealed no skin pathologies, indicating that Scrib is dispensable for normal adult epidermal homeostasis. Nevertheless, bi-allelic loss of Scrib significantly enhanced tumor multiplicity and progression in an autochthonous model of epidermal carcinogenesis in vivo, demonstrating Scrib is an epidermal tumor suppressor. Mechanistically, we show that apoptosis is the critical effector of Scrib tumor suppressor activity during skin carcinogenesis and provide new insight into the function of polarity proteins during DNA damage repair. CONCLUSIONS: For the first time, we provide genetic evidence of a unique link between skin carcinogenesis and loss of the epithelial polarity regulator Scrib, emphasizing that Scrib exerts a wide-spread tumor suppressive function in epithelia. More... »

PAGES

169

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12943-015-0440-z

DOI

http://dx.doi.org/10.1186/s12943-015-0440-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028637455

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26376988


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Polarity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Embryo, Mammalian", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epidermis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epithelial Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Tumor Suppressor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Integrases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intracellular Signaling Peptides and Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Keratinocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Skin Neoplasms", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Peter MacCallum Cancer Centre, St Andrew\u2019s Place, 3002, East Melbourne, VIC, Australia", 
            "Sir Peter MacCallum Department of Oncology, The University of Melbourne, 3010, Parkville, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pearson", 
        "givenName": "Helen B.", 
        "id": "sg:person.01026503112.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026503112.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Australian Regenerative Medicine Institute", 
          "id": "https://www.grid.ac/institutes/grid.484852.7", 
          "name": [
            "EMBL Australia, Australian Regenerative Medicine Institute, Monash University, 3800, Clayton, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McGlinn", 
        "givenName": "Edwina", 
        "id": "sg:person.01241661203.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241661203.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "La Trobe University", 
          "id": "https://www.grid.ac/institutes/grid.1018.8", 
          "name": [
            "Walter and Eliza Hall Institute of Medical Research, 3052, Melbourne, VIC, Australia", 
            "Present address: Olivia Newton-John Cancer Research Institute and School of Cancer Medicine at La Trobe University, 3084, Heidelberg, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Phesse", 
        "givenName": "Toby J.", 
        "id": "sg:person.0765456125.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765456125.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Peter MacCallum Cancer Centre, St Andrew\u2019s Place, 3002, East Melbourne, VIC, Australia", 
            "Present address: National Center for Tumor Diseases Heidelberg (NCT), German Cancer Research Centre (DKFZ), 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schl\u00fcter", 
        "givenName": "Holger", 
        "id": "sg:person.0706104754.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706104754.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peter MacCallum Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.1055.1", 
          "name": [
            "Peter MacCallum Cancer Centre, St Andrew\u2019s Place, 3002, East Melbourne, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Srikumar", 
        "givenName": "Anuratha", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peter MacCallum Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.1055.1", 
          "name": [
            "Peter MacCallum Cancer Centre, St Andrew\u2019s Place, 3002, East Melbourne, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "G\u00f6dde", 
        "givenName": "Nathan J.", 
        "id": "sg:person.01156373630.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156373630.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peter MacCallum Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.1055.1", 
          "name": [
            "Peter MacCallum Cancer Centre, St Andrew\u2019s Place, 3002, East Melbourne, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Woelwer", 
        "givenName": "Christina B.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "TissuPath Laboratories, 3149, Mount Waverley, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ryan", 
        "givenName": "Andrew", 
        "id": "sg:person.01211044712.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211044712.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Peter MacCallum Cancer Centre, St Andrew\u2019s Place, 3002, East Melbourne, VIC, Australia", 
            "Sir Peter MacCallum Department of Oncology, The University of Melbourne, 3010, Parkville, VIC, Australia", 
            "Department of Surgery (St. Vincent\u2019s Hospital), The University of Melbourne, 3010, Parkville, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Phillips", 
        "givenName": "Wayne A.", 
        "id": "sg:person.0705640631.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705640631.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "La Trobe University", 
          "id": "https://www.grid.ac/institutes/grid.1018.8", 
          "name": [
            "Walter and Eliza Hall Institute of Medical Research, 3052, Melbourne, VIC, Australia", 
            "Present address: Olivia Newton-John Cancer Research Institute and School of Cancer Medicine at La Trobe University, 3084, Heidelberg, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ernst", 
        "givenName": "Matthias", 
        "id": "sg:person.0667105561.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667105561.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Peter MacCallum Cancer Centre, St Andrew\u2019s Place, 3002, East Melbourne, VIC, Australia", 
            "Sir Peter MacCallum Department of Oncology, The University of Melbourne, 3010, Parkville, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kaur", 
        "givenName": "Pritinder", 
        "id": "sg:person.0716054141.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716054141.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Peter MacCallum Cancer Centre, St Andrew\u2019s Place, 3002, East Melbourne, VIC, Australia", 
            "Sir Peter MacCallum Department of Oncology, The University of Melbourne, 3010, Parkville, VIC, Australia", 
            "Department of Pathology, The University of Melbourne, 3010, Parkville, VIC, Australia", 
            "Department of Biochemistry and Molecular Biology, The University of Melbourne, 3010, Parkville, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Humbert", 
        "givenName": "Patrick", 
        "id": "sg:person.01351254133.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351254133.27"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1172/jci58509", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000965488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2012.08.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002764664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ydbio.2012.11.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002825606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scisignal.2005411", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005098577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.semcancer.2005.06.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005190230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.20.21.8244-8253.2000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005892509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.emboj.7600605", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005992506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.134.3.715", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006633902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.emboj.7600616", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008127885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.det.2011.08.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008896114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3727/096504010x12767359114045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009880443"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1211604", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009946710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/cancers2020436", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010540063"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2013.498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011731310", 
          "https://doi.org/10.1038/onc.2013.498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2013.498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011731310", 
          "https://doi.org/10.1038/onc.2013.498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/tera.1420220306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013756994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/tera.1420220306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013756994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0040279", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015259181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci118706", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015367393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/cshperspect.a008789", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015498126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.cellbio.22.010305.104357", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016155037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.93.12.5860", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017005994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.c100466200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017402311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb2639", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017941223", 
          "https://doi.org/10.1038/ncb2639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.151.2.389", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017995802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.01278-10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018203958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humpath.2007.01.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018547306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35001108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018732182", 
          "https://doi.org/10.1038/35001108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35001108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018732182", 
          "https://doi.org/10.1038/35001108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2006.05.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018949339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.272.49.30599", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020114866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(01)00336-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020688329"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.21.20.7047-7053.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022463702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1004323", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022959294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/jid.2009.245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024421631", 
          "https://doi.org/10.1038/jid.2009.245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2012.07.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025277174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203600", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025869176", 
          "https://doi.org/10.1038/sj.onc.1203600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203600", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025869176", 
          "https://doi.org/10.1038/sj.onc.1203600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbalip.2013.11.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026823520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1524-4725.2012.02558.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027272978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1524-4725.2012.02558.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027272978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pbio.0020219", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028181704"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200708185", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030873915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.00164", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035150770"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1107511", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036169918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev-cellbio-092910-154244", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037615003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/geno.2001.6638", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037884960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yexcr.2014.08.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038339992"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature00848", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038450342", 
          "https://doi.org/10.1038/nature00848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature00848", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038450342", 
          "https://doi.org/10.1038/nature00848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0051130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038698967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0625.2008.00786.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039542095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.1523-1747.2002.19605.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040032536", 
          "https://doi.org/10.1046/j.1523-1747.2002.19605.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1523-1747.2002.19605.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040032536"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200407158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040174096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-213x-10-87", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040229757", 
          "https://doi.org/10.1186/1471-213x-10-87"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ydbio.2006.07.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041169681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.jid.5700621", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044078008", 
          "https://doi.org/10.1038/sj.jid.5700621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0163-7258(92)90051-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044169804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0163-7258(92)90051-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044169804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-07-5169", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045173407"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.1997.6945", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045481161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/322078a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045648046", 
          "https://doi.org/10.1038/322078a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cr.7310145", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046086286", 
          "https://doi.org/10.1038/sj.cr.7310145"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cr.7310145", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046086286", 
          "https://doi.org/10.1038/sj.cr.7310145"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2008.09.045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046601166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dmm.016758", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046774167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200110122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047702118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-10-0352", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047744307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm2521", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048305179", 
          "https://doi.org/10.1038/nrm2521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2008.219", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048842159", 
          "https://doi.org/10.1038/onc.2008.219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/1523-1747.ep12873301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050545085", 
          "https://doi.org/10.1111/1523-1747.ep12873301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/1523-1747.ep12343405", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051286873", 
          "https://doi.org/10.1111/1523-1747.ep12343405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1110931108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051368055"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2008.341", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051979527", 
          "https://doi.org/10.1038/onc.2008.341"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01618", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052429227", 
          "https://doi.org/10.1038/nature01618"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01618", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052429227", 
          "https://doi.org/10.1038/nature01618"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0034343", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053022947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2011.10.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053130567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.01944", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053494418"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1203/00006450-199711000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064211396", 
          "https://doi.org/10.1203/00006450-199711000-00010"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082402574", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083227192", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-12", 
    "datePublishedReg": "2015-12-01", 
    "description": "BACKGROUND: The establishment and maintenance of polarity is vital for embryonic development and loss of polarity is a frequent characteristic of epithelial cancers, however the underlying molecular mechanisms remain unclear. Here, we identify a novel role for the polarity protein Scrib as a mediator of epidermal permeability barrier acquisition, skeletal morphogenesis, and as a potent tumor suppressor in cutaneous carcinogenesis.\nMETHODS: To explore the role of Scrib during epidermal development, we compared the permeability of toluidine blue dye in wild-type, Scrib heterozygous and Scrib KO embryonic epidermis at E16.5, E17.5 and E18.5. Mouse embryos were stained with alcian blue and alizarin red for skeletal analysis. To establish whether Scrib plays a tumor suppressive role during skin tumorigenesis and/or progression, we evaluated an autochthonous mouse model of skin carcinogenesis in the context of Scrib loss. We utilised Cre-LoxP technology to conditionally deplete Scrib in adult epidermis, since Scrib KO embryos are neonatal lethal.\nRESULTS: We establish that Scrib perturbs keratinocyte maturation during embryonic development, causing impaired epidermal barrier formation, and that Scrib is required for skeletal morphogenesis in mice. Analysis of conditional transgenic mice deficient for Scrib specifically within the epidermis revealed no skin pathologies, indicating that Scrib is dispensable for normal adult epidermal homeostasis. Nevertheless, bi-allelic loss of Scrib significantly enhanced tumor multiplicity and progression in an autochthonous model of epidermal carcinogenesis in vivo, demonstrating Scrib is an epidermal tumor suppressor. Mechanistically, we show that apoptosis is the critical effector of Scrib tumor suppressor activity during skin carcinogenesis and provide new insight into the function of polarity proteins during DNA damage repair.\nCONCLUSIONS: For the first time, we provide genetic evidence of a unique link between skin carcinogenesis and loss of the epithelial polarity regulator Scrib, emphasizing that Scrib exerts a wide-spread tumor suppressive function in epithelia.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12943-015-0440-z", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6721813", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6734449", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6736735", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6730652", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1031030", 
        "issn": [
          "1476-4598"
        ], 
        "name": "Molecular Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "14"
      }
    ], 
    "name": "The polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis", 
    "pagination": "169", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "886b861bc9fff936de058d64166fe4123f08e4e44f9c809649ed76448bf9e508"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26376988"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101147698"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12943-015-0440-z"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1028637455"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12943-015-0440-z", 
      "https://app.dimensions.ai/details/publication/pub.1028637455"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:16", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000513.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2Fs12943-015-0440-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12943-015-0440-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12943-015-0440-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12943-015-0440-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12943-015-0440-z'


 

This table displays all metadata directly associated to this object as RDF triples.

473 TRIPLES      21 PREDICATES      119 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12943-015-0440-z schema:about N136dc0266254406e8ebe485ff1c05c5b
2 N23b16a52a5224bf9a0e6bc2cc28e2e99
3 N327cc89a8c044f8d80ff64e9e1292865
4 N353505533ec34c2685b5bc42f56a0b6f
5 N40fe2e1dcc28413d85c8f7cbdc563cb5
6 N4b2c09c6e8cd4271836a0386bb383d92
7 N5bf2fd94842241e7bea86d6c412b0823
8 N65e94426369f4462b275a0ad3f9a68aa
9 N70dee23e7b184ae3b414eaf5b46ee785
10 N844ff8e99c054540a6e7875bc566e73f
11 N87f682bb662a4f139891eb40892ddb33
12 N9292e1236eff41d8bc21cf339f86aef8
13 N9c865abb6193494bba6582e58e6b7785
14 Nb9af4a7418984b299d55f9581c2b038a
15 Nc1ccadca4b1242da8d4280e4674cbde5
16 Nc1e0829176564434b61499dff2f14bae
17 anzsrc-for:06
18 anzsrc-for:0601
19 schema:author N60990c01398048e0b23b9e0a8635e421
20 schema:citation sg:pub.10.1038/322078a0
21 sg:pub.10.1038/35001108
22 sg:pub.10.1038/jid.2009.245
23 sg:pub.10.1038/nature00848
24 sg:pub.10.1038/nature01618
25 sg:pub.10.1038/ncb2639
26 sg:pub.10.1038/nrm2521
27 sg:pub.10.1038/onc.2008.219
28 sg:pub.10.1038/onc.2008.341
29 sg:pub.10.1038/onc.2013.498
30 sg:pub.10.1038/sj.cr.7310145
31 sg:pub.10.1038/sj.jid.5700621
32 sg:pub.10.1038/sj.onc.1203600
33 sg:pub.10.1046/j.1523-1747.2002.19605.x
34 sg:pub.10.1111/1523-1747.ep12343405
35 sg:pub.10.1111/1523-1747.ep12873301
36 sg:pub.10.1186/1471-213x-10-87
37 sg:pub.10.1203/00006450-199711000-00010
38 https://app.dimensions.ai/details/publication/pub.1082402574
39 https://app.dimensions.ai/details/publication/pub.1083227192
40 https://doi.org/10.1002/tera.1420220306
41 https://doi.org/10.1006/bbrc.1997.6945
42 https://doi.org/10.1006/geno.2001.6638
43 https://doi.org/10.1016/0163-7258(92)90051-z
44 https://doi.org/10.1016/j.bbalip.2013.11.007
45 https://doi.org/10.1016/j.ccr.2011.10.014
46 https://doi.org/10.1016/j.ccr.2012.08.004
47 https://doi.org/10.1016/j.cell.2008.09.045
48 https://doi.org/10.1016/j.cub.2012.07.011
49 https://doi.org/10.1016/j.det.2011.08.008
50 https://doi.org/10.1016/j.humpath.2007.01.026
51 https://doi.org/10.1016/j.molcel.2006.05.023
52 https://doi.org/10.1016/j.semcancer.2005.06.003
53 https://doi.org/10.1016/j.ydbio.2006.07.015
54 https://doi.org/10.1016/j.ydbio.2012.11.012
55 https://doi.org/10.1016/j.yexcr.2014.08.036
56 https://doi.org/10.1016/s0092-8674(01)00336-1
57 https://doi.org/10.1038/sj.emboj.7600605
58 https://doi.org/10.1038/sj.emboj.7600616
59 https://doi.org/10.1046/j.1523-1747.2002.19605.x
60 https://doi.org/10.1073/pnas.1110931108
61 https://doi.org/10.1073/pnas.93.12.5860
62 https://doi.org/10.1074/jbc.272.49.30599
63 https://doi.org/10.1074/jbc.c100466200
64 https://doi.org/10.1083/jcb.134.3.715
65 https://doi.org/10.1083/jcb.151.2.389
66 https://doi.org/10.1083/jcb.200110122
67 https://doi.org/10.1083/jcb.200407158
68 https://doi.org/10.1083/jcb.200708185
69 https://doi.org/10.1101/cshperspect.a008789
70 https://doi.org/10.1101/gad.1211604
71 https://doi.org/10.1111/j.1524-4725.2012.02558.x
72 https://doi.org/10.1111/j.1600-0625.2008.00786.x
73 https://doi.org/10.1126/science.1107511
74 https://doi.org/10.1126/scisignal.2005411
75 https://doi.org/10.1128/jvi.01278-10
76 https://doi.org/10.1128/mcb.20.21.8244-8253.2000
77 https://doi.org/10.1128/mcb.21.20.7047-7053.2001
78 https://doi.org/10.1146/annurev-cellbio-092910-154244
79 https://doi.org/10.1146/annurev.cellbio.22.010305.104357
80 https://doi.org/10.1158/0008-5472.can-07-5169
81 https://doi.org/10.1158/0008-5472.can-10-0352
82 https://doi.org/10.1172/jci118706
83 https://doi.org/10.1172/jci58509
84 https://doi.org/10.1242/dev.00164
85 https://doi.org/10.1242/dev.01944
86 https://doi.org/10.1242/dmm.016758
87 https://doi.org/10.1371/journal.pbio.0020219
88 https://doi.org/10.1371/journal.pgen.1004323
89 https://doi.org/10.1371/journal.pone.0034343
90 https://doi.org/10.1371/journal.pone.0040279
91 https://doi.org/10.1371/journal.pone.0051130
92 https://doi.org/10.3390/cancers2020436
93 https://doi.org/10.3727/096504010x12767359114045
94 schema:datePublished 2015-12
95 schema:datePublishedReg 2015-12-01
96 schema:description BACKGROUND: The establishment and maintenance of polarity is vital for embryonic development and loss of polarity is a frequent characteristic of epithelial cancers, however the underlying molecular mechanisms remain unclear. Here, we identify a novel role for the polarity protein Scrib as a mediator of epidermal permeability barrier acquisition, skeletal morphogenesis, and as a potent tumor suppressor in cutaneous carcinogenesis. METHODS: To explore the role of Scrib during epidermal development, we compared the permeability of toluidine blue dye in wild-type, Scrib heterozygous and Scrib KO embryonic epidermis at E16.5, E17.5 and E18.5. Mouse embryos were stained with alcian blue and alizarin red for skeletal analysis. To establish whether Scrib plays a tumor suppressive role during skin tumorigenesis and/or progression, we evaluated an autochthonous mouse model of skin carcinogenesis in the context of Scrib loss. We utilised Cre-LoxP technology to conditionally deplete Scrib in adult epidermis, since Scrib KO embryos are neonatal lethal. RESULTS: We establish that Scrib perturbs keratinocyte maturation during embryonic development, causing impaired epidermal barrier formation, and that Scrib is required for skeletal morphogenesis in mice. Analysis of conditional transgenic mice deficient for Scrib specifically within the epidermis revealed no skin pathologies, indicating that Scrib is dispensable for normal adult epidermal homeostasis. Nevertheless, bi-allelic loss of Scrib significantly enhanced tumor multiplicity and progression in an autochthonous model of epidermal carcinogenesis in vivo, demonstrating Scrib is an epidermal tumor suppressor. Mechanistically, we show that apoptosis is the critical effector of Scrib tumor suppressor activity during skin carcinogenesis and provide new insight into the function of polarity proteins during DNA damage repair. CONCLUSIONS: For the first time, we provide genetic evidence of a unique link between skin carcinogenesis and loss of the epithelial polarity regulator Scrib, emphasizing that Scrib exerts a wide-spread tumor suppressive function in epithelia.
97 schema:genre research_article
98 schema:inLanguage en
99 schema:isAccessibleForFree true
100 schema:isPartOf N79b9bd2e25fa44c5b13f9f01ef5481e4
101 Nfcc5a610573e4a09922f12427993a55c
102 sg:journal.1031030
103 schema:name The polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis
104 schema:pagination 169
105 schema:productId N0cde8f9cf3ed4365a0bb59d3cc02de25
106 N16ca5b50edbb431ea666aaa48e172f65
107 N9b5ad535dd7e4871b211bf48bb71a68b
108 Nd057621fd72d459a8514c3b76fa4f669
109 Nf813fcf445544fb0beb98642dc60fdb6
110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028637455
111 https://doi.org/10.1186/s12943-015-0440-z
112 schema:sdDatePublished 2019-04-11T00:16
113 schema:sdLicense https://scigraph.springernature.com/explorer/license/
114 schema:sdPublisher Nad39b8aa213f4d8198c7c9feb34d8efe
115 schema:url http://link.springer.com/10.1186%2Fs12943-015-0440-z
116 sgo:license sg:explorer/license/
117 sgo:sdDataset articles
118 rdf:type schema:ScholarlyArticle
119 N0cde8f9cf3ed4365a0bb59d3cc02de25 schema:name pubmed_id
120 schema:value 26376988
121 rdf:type schema:PropertyValue
122 N136dc0266254406e8ebe485ff1c05c5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Epidermis
124 rdf:type schema:DefinedTerm
125 N16ca5b50edbb431ea666aaa48e172f65 schema:name nlm_unique_id
126 schema:value 101147698
127 rdf:type schema:PropertyValue
128 N23b16a52a5224bf9a0e6bc2cc28e2e99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Skin Neoplasms
130 rdf:type schema:DefinedTerm
131 N24b6352344404abe99f777acca3ef99c rdf:first sg:person.0705640631.51
132 rdf:rest N590beae6bafd4770943bf3ec21d02ab3
133 N327cc89a8c044f8d80ff64e9e1292865 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Cell Polarity
135 rdf:type schema:DefinedTerm
136 N353505533ec34c2685b5bc42f56a0b6f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Mice
138 rdf:type schema:DefinedTerm
139 N40fe2e1dcc28413d85c8f7cbdc563cb5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Integrases
141 rdf:type schema:DefinedTerm
142 N4b2c09c6e8cd4271836a0386bb383d92 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Embryo, Mammalian
144 rdf:type schema:DefinedTerm
145 N590beae6bafd4770943bf3ec21d02ab3 rdf:first sg:person.0667105561.05
146 rdf:rest Nffa7e2e1c4c94f54b2d90bbe3b871dc0
147 N5bf2fd94842241e7bea86d6c412b0823 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Animals
149 rdf:type schema:DefinedTerm
150 N60990c01398048e0b23b9e0a8635e421 rdf:first sg:person.01026503112.07
151 rdf:rest Ndafd9361fb3e44ff945e510f8658eb44
152 N65e94426369f4462b275a0ad3f9a68aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Keratinocytes
154 rdf:type schema:DefinedTerm
155 N670ff42c5e6b4fcf853083c7284356ea rdf:first Nac352777557e46e5871ffa145dfdb387
156 rdf:rest N7b66e288a42f4562a8f4b7a498425315
157 N6a6d6deb05d94d13b55f971ab765f111 schema:name TissuPath Laboratories, 3149, Mount Waverley, VIC, Australia
158 rdf:type schema:Organization
159 N6ef53f20ebe647fdb15ee56faf32dc8e rdf:first sg:person.0706104754.11
160 rdf:rest N670ff42c5e6b4fcf853083c7284356ea
161 N70dee23e7b184ae3b414eaf5b46ee785 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Genes, Tumor Suppressor
163 rdf:type schema:DefinedTerm
164 N79b9bd2e25fa44c5b13f9f01ef5481e4 schema:issueNumber 1
165 rdf:type schema:PublicationIssue
166 N7b66e288a42f4562a8f4b7a498425315 rdf:first sg:person.01156373630.44
167 rdf:rest N9b2a1017b3714b2dbd56aea4a72dfd4d
168 N844ff8e99c054540a6e7875bc566e73f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Carcinogenesis
170 rdf:type schema:DefinedTerm
171 N87f682bb662a4f139891eb40892ddb33 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Intracellular Signaling Peptides and Proteins
173 rdf:type schema:DefinedTerm
174 N8ddadc031d8042a8b6ae850178ff6da6 rdf:first sg:person.0765456125.39
175 rdf:rest N6ef53f20ebe647fdb15ee56faf32dc8e
176 N9292e1236eff41d8bc21cf339f86aef8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Humans
178 rdf:type schema:DefinedTerm
179 N93385aa276b341168114ed7a903f6fbc rdf:first sg:person.01211044712.27
180 rdf:rest N24b6352344404abe99f777acca3ef99c
181 N99bb2c6150044d85ba0ca08bb1d58709 rdf:first sg:person.01351254133.27
182 rdf:rest rdf:nil
183 N9b2a1017b3714b2dbd56aea4a72dfd4d rdf:first Nb3ed39cfef38493e96edafb0850e0229
184 rdf:rest N93385aa276b341168114ed7a903f6fbc
185 N9b5ad535dd7e4871b211bf48bb71a68b schema:name dimensions_id
186 schema:value pub.1028637455
187 rdf:type schema:PropertyValue
188 N9c865abb6193494bba6582e58e6b7785 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Disease Models, Animal
190 rdf:type schema:DefinedTerm
191 Nac352777557e46e5871ffa145dfdb387 schema:affiliation https://www.grid.ac/institutes/grid.1055.1
192 schema:familyName Srikumar
193 schema:givenName Anuratha
194 rdf:type schema:Person
195 Nad39b8aa213f4d8198c7c9feb34d8efe schema:name Springer Nature - SN SciGraph project
196 rdf:type schema:Organization
197 Nb3ed39cfef38493e96edafb0850e0229 schema:affiliation https://www.grid.ac/institutes/grid.1055.1
198 schema:familyName Woelwer
199 schema:givenName Christina B.
200 rdf:type schema:Person
201 Nb9af4a7418984b299d55f9581c2b038a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Epithelial Cells
203 rdf:type schema:DefinedTerm
204 Nc1ccadca4b1242da8d4280e4674cbde5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Mice, Knockout
206 rdf:type schema:DefinedTerm
207 Nc1e0829176564434b61499dff2f14bae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Cell Differentiation
209 rdf:type schema:DefinedTerm
210 Nd057621fd72d459a8514c3b76fa4f669 schema:name doi
211 schema:value 10.1186/s12943-015-0440-z
212 rdf:type schema:PropertyValue
213 Ndafd9361fb3e44ff945e510f8658eb44 rdf:first sg:person.01241661203.23
214 rdf:rest N8ddadc031d8042a8b6ae850178ff6da6
215 Nf813fcf445544fb0beb98642dc60fdb6 schema:name readcube_id
216 schema:value 886b861bc9fff936de058d64166fe4123f08e4e44f9c809649ed76448bf9e508
217 rdf:type schema:PropertyValue
218 Nfcc5a610573e4a09922f12427993a55c schema:volumeNumber 14
219 rdf:type schema:PublicationVolume
220 Nffa7e2e1c4c94f54b2d90bbe3b871dc0 rdf:first sg:person.0716054141.73
221 rdf:rest N99bb2c6150044d85ba0ca08bb1d58709
222 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
223 schema:name Biological Sciences
224 rdf:type schema:DefinedTerm
225 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
226 schema:name Biochemistry and Cell Biology
227 rdf:type schema:DefinedTerm
228 sg:grant.6721813 http://pending.schema.org/fundedItem sg:pub.10.1186/s12943-015-0440-z
229 rdf:type schema:MonetaryGrant
230 sg:grant.6730652 http://pending.schema.org/fundedItem sg:pub.10.1186/s12943-015-0440-z
231 rdf:type schema:MonetaryGrant
232 sg:grant.6734449 http://pending.schema.org/fundedItem sg:pub.10.1186/s12943-015-0440-z
233 rdf:type schema:MonetaryGrant
234 sg:grant.6736735 http://pending.schema.org/fundedItem sg:pub.10.1186/s12943-015-0440-z
235 rdf:type schema:MonetaryGrant
236 sg:journal.1031030 schema:issn 1476-4598
237 schema:name Molecular Cancer
238 rdf:type schema:Periodical
239 sg:person.01026503112.07 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
240 schema:familyName Pearson
241 schema:givenName Helen B.
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026503112.07
243 rdf:type schema:Person
244 sg:person.01156373630.44 schema:affiliation https://www.grid.ac/institutes/grid.1055.1
245 schema:familyName Gödde
246 schema:givenName Nathan J.
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156373630.44
248 rdf:type schema:Person
249 sg:person.01211044712.27 schema:affiliation N6a6d6deb05d94d13b55f971ab765f111
250 schema:familyName Ryan
251 schema:givenName Andrew
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211044712.27
253 rdf:type schema:Person
254 sg:person.01241661203.23 schema:affiliation https://www.grid.ac/institutes/grid.484852.7
255 schema:familyName McGlinn
256 schema:givenName Edwina
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241661203.23
258 rdf:type schema:Person
259 sg:person.01351254133.27 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
260 schema:familyName Humbert
261 schema:givenName Patrick
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351254133.27
263 rdf:type schema:Person
264 sg:person.0667105561.05 schema:affiliation https://www.grid.ac/institutes/grid.1018.8
265 schema:familyName Ernst
266 schema:givenName Matthias
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667105561.05
268 rdf:type schema:Person
269 sg:person.0705640631.51 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
270 schema:familyName Phillips
271 schema:givenName Wayne A.
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705640631.51
273 rdf:type schema:Person
274 sg:person.0706104754.11 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
275 schema:familyName Schlüter
276 schema:givenName Holger
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706104754.11
278 rdf:type schema:Person
279 sg:person.0716054141.73 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
280 schema:familyName Kaur
281 schema:givenName Pritinder
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716054141.73
283 rdf:type schema:Person
284 sg:person.0765456125.39 schema:affiliation https://www.grid.ac/institutes/grid.1018.8
285 schema:familyName Phesse
286 schema:givenName Toby J.
287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765456125.39
288 rdf:type schema:Person
289 sg:pub.10.1038/322078a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045648046
290 https://doi.org/10.1038/322078a0
291 rdf:type schema:CreativeWork
292 sg:pub.10.1038/35001108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018732182
293 https://doi.org/10.1038/35001108
294 rdf:type schema:CreativeWork
295 sg:pub.10.1038/jid.2009.245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024421631
296 https://doi.org/10.1038/jid.2009.245
297 rdf:type schema:CreativeWork
298 sg:pub.10.1038/nature00848 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038450342
299 https://doi.org/10.1038/nature00848
300 rdf:type schema:CreativeWork
301 sg:pub.10.1038/nature01618 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052429227
302 https://doi.org/10.1038/nature01618
303 rdf:type schema:CreativeWork
304 sg:pub.10.1038/ncb2639 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017941223
305 https://doi.org/10.1038/ncb2639
306 rdf:type schema:CreativeWork
307 sg:pub.10.1038/nrm2521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048305179
308 https://doi.org/10.1038/nrm2521
309 rdf:type schema:CreativeWork
310 sg:pub.10.1038/onc.2008.219 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048842159
311 https://doi.org/10.1038/onc.2008.219
312 rdf:type schema:CreativeWork
313 sg:pub.10.1038/onc.2008.341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051979527
314 https://doi.org/10.1038/onc.2008.341
315 rdf:type schema:CreativeWork
316 sg:pub.10.1038/onc.2013.498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011731310
317 https://doi.org/10.1038/onc.2013.498
318 rdf:type schema:CreativeWork
319 sg:pub.10.1038/sj.cr.7310145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046086286
320 https://doi.org/10.1038/sj.cr.7310145
321 rdf:type schema:CreativeWork
322 sg:pub.10.1038/sj.jid.5700621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044078008
323 https://doi.org/10.1038/sj.jid.5700621
324 rdf:type schema:CreativeWork
325 sg:pub.10.1038/sj.onc.1203600 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025869176
326 https://doi.org/10.1038/sj.onc.1203600
327 rdf:type schema:CreativeWork
328 sg:pub.10.1046/j.1523-1747.2002.19605.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040032536
329 https://doi.org/10.1046/j.1523-1747.2002.19605.x
330 rdf:type schema:CreativeWork
331 sg:pub.10.1111/1523-1747.ep12343405 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051286873
332 https://doi.org/10.1111/1523-1747.ep12343405
333 rdf:type schema:CreativeWork
334 sg:pub.10.1111/1523-1747.ep12873301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050545085
335 https://doi.org/10.1111/1523-1747.ep12873301
336 rdf:type schema:CreativeWork
337 sg:pub.10.1186/1471-213x-10-87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040229757
338 https://doi.org/10.1186/1471-213x-10-87
339 rdf:type schema:CreativeWork
340 sg:pub.10.1203/00006450-199711000-00010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064211396
341 https://doi.org/10.1203/00006450-199711000-00010
342 rdf:type schema:CreativeWork
343 https://app.dimensions.ai/details/publication/pub.1082402574 schema:CreativeWork
344 https://app.dimensions.ai/details/publication/pub.1083227192 schema:CreativeWork
345 https://doi.org/10.1002/tera.1420220306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013756994
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1006/bbrc.1997.6945 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045481161
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1006/geno.2001.6638 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037884960
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1016/0163-7258(92)90051-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1044169804
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1016/j.bbalip.2013.11.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026823520
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1016/j.ccr.2011.10.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053130567
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1016/j.ccr.2012.08.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002764664
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1016/j.cell.2008.09.045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046601166
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1016/j.cub.2012.07.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025277174
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1016/j.det.2011.08.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008896114
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1016/j.humpath.2007.01.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018547306
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1016/j.molcel.2006.05.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018949339
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1016/j.semcancer.2005.06.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005190230
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1016/j.ydbio.2006.07.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041169681
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1016/j.ydbio.2012.11.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002825606
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1016/j.yexcr.2014.08.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038339992
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1016/s0092-8674(01)00336-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020688329
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1038/sj.emboj.7600605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005992506
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1038/sj.emboj.7600616 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008127885
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1046/j.1523-1747.2002.19605.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040032536
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1073/pnas.1110931108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051368055
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1073/pnas.93.12.5860 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017005994
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1074/jbc.272.49.30599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020114866
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1074/jbc.c100466200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017402311
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1083/jcb.134.3.715 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006633902
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1083/jcb.151.2.389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017995802
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1083/jcb.200110122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047702118
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1083/jcb.200407158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040174096
400 rdf:type schema:CreativeWork
401 https://doi.org/10.1083/jcb.200708185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030873915
402 rdf:type schema:CreativeWork
403 https://doi.org/10.1101/cshperspect.a008789 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015498126
404 rdf:type schema:CreativeWork
405 https://doi.org/10.1101/gad.1211604 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009946710
406 rdf:type schema:CreativeWork
407 https://doi.org/10.1111/j.1524-4725.2012.02558.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027272978
408 rdf:type schema:CreativeWork
409 https://doi.org/10.1111/j.1600-0625.2008.00786.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039542095
410 rdf:type schema:CreativeWork
411 https://doi.org/10.1126/science.1107511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036169918
412 rdf:type schema:CreativeWork
413 https://doi.org/10.1126/scisignal.2005411 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005098577
414 rdf:type schema:CreativeWork
415 https://doi.org/10.1128/jvi.01278-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018203958
416 rdf:type schema:CreativeWork
417 https://doi.org/10.1128/mcb.20.21.8244-8253.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005892509
418 rdf:type schema:CreativeWork
419 https://doi.org/10.1128/mcb.21.20.7047-7053.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022463702
420 rdf:type schema:CreativeWork
421 https://doi.org/10.1146/annurev-cellbio-092910-154244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037615003
422 rdf:type schema:CreativeWork
423 https://doi.org/10.1146/annurev.cellbio.22.010305.104357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016155037
424 rdf:type schema:CreativeWork
425 https://doi.org/10.1158/0008-5472.can-07-5169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045173407
426 rdf:type schema:CreativeWork
427 https://doi.org/10.1158/0008-5472.can-10-0352 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047744307
428 rdf:type schema:CreativeWork
429 https://doi.org/10.1172/jci118706 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015367393
430 rdf:type schema:CreativeWork
431 https://doi.org/10.1172/jci58509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000965488
432 rdf:type schema:CreativeWork
433 https://doi.org/10.1242/dev.00164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035150770
434 rdf:type schema:CreativeWork
435 https://doi.org/10.1242/dev.01944 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053494418
436 rdf:type schema:CreativeWork
437 https://doi.org/10.1242/dmm.016758 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046774167
438 rdf:type schema:CreativeWork
439 https://doi.org/10.1371/journal.pbio.0020219 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028181704
440 rdf:type schema:CreativeWork
441 https://doi.org/10.1371/journal.pgen.1004323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022959294
442 rdf:type schema:CreativeWork
443 https://doi.org/10.1371/journal.pone.0034343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053022947
444 rdf:type schema:CreativeWork
445 https://doi.org/10.1371/journal.pone.0040279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015259181
446 rdf:type schema:CreativeWork
447 https://doi.org/10.1371/journal.pone.0051130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038698967
448 rdf:type schema:CreativeWork
449 https://doi.org/10.3390/cancers2020436 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010540063
450 rdf:type schema:CreativeWork
451 https://doi.org/10.3727/096504010x12767359114045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009880443
452 rdf:type schema:CreativeWork
453 https://www.grid.ac/institutes/grid.1008.9 schema:alternateName University of Melbourne
454 schema:name Department of Biochemistry and Molecular Biology, The University of Melbourne, 3010, Parkville, VIC, Australia
455 Department of Pathology, The University of Melbourne, 3010, Parkville, VIC, Australia
456 Department of Surgery (St. Vincent’s Hospital), The University of Melbourne, 3010, Parkville, VIC, Australia
457 Peter MacCallum Cancer Centre, St Andrew’s Place, 3002, East Melbourne, VIC, Australia
458 Sir Peter MacCallum Department of Oncology, The University of Melbourne, 3010, Parkville, VIC, Australia
459 rdf:type schema:Organization
460 https://www.grid.ac/institutes/grid.1018.8 schema:alternateName La Trobe University
461 schema:name Present address: Olivia Newton-John Cancer Research Institute and School of Cancer Medicine at La Trobe University, 3084, Heidelberg, VIC, Australia
462 Walter and Eliza Hall Institute of Medical Research, 3052, Melbourne, VIC, Australia
463 rdf:type schema:Organization
464 https://www.grid.ac/institutes/grid.1055.1 schema:alternateName Peter MacCallum Cancer Centre
465 schema:name Peter MacCallum Cancer Centre, St Andrew’s Place, 3002, East Melbourne, VIC, Australia
466 rdf:type schema:Organization
467 https://www.grid.ac/institutes/grid.484852.7 schema:alternateName Australian Regenerative Medicine Institute
468 schema:name EMBL Australia, Australian Regenerative Medicine Institute, Monash University, 3800, Clayton, VIC, Australia
469 rdf:type schema:Organization
470 https://www.grid.ac/institutes/grid.7497.d schema:alternateName German Cancer Research Center
471 schema:name Peter MacCallum Cancer Centre, St Andrew’s Place, 3002, East Melbourne, VIC, Australia
472 Present address: National Center for Tumor Diseases Heidelberg (NCT), German Cancer Research Centre (DKFZ), 69120, Heidelberg, Germany
473 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...