A novel antibiotic combination of linezolid and polymyxin B octapeptide PBOP against clinical Pseudomonas aeruginosa strains View Full Text


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Article Info

DATE

2022-08-29

AUTHORS

Ting Huang, Mao Zeng, Huiyao Fu, Kelei Zhao, Tao Song, Yidong Guo, Jingyu Zhou, Longfei Zhai, Chaolan Liu, Balakrishnan Prithiviraj, Xinrong Wang, Yiwen Chu

ABSTRACT

BackgroundAntibiotic-resistant Gram-negative bacteria are becoming a major public health threat such as the important opportunistic pathogen Pseudomonas aeruginosa (P. aeruginosa). The present study investigated enhancement of the linezolid spectrum, which is normally used to treat Gram-positive bacteria, at inhibiting P. aeruginosa growth.MethodsThe checkerboard test or time-kill assay were carried out to determine the antibacterial effects of linezolid in cooperation with polymyxin B octapeptide PBOP (LP) against P. aeruginosa based on in vitro model. The protective effect of LP against P. aeruginosa infection was assessed based on a Caenorhabditis elegans (C. elegans) model.ResultsThe synergistic activity and antibacterial effects were significantly increased against P. aeruginosa by LP treatment, while linezolid and PBOP as monotherapies exhibited no remarkably bactericidal activity against the clinical strains. Additionally, LP treatment modified biofilm production, morphology, swimming motility of P. aeruginosa, and protected C. elegans from P. aeruginosa infection.ConclusionsThis research demonstrates that LP combination has significant synergistic activity against P. aeruginosa, and PBOP is potential to be an activity enhancer. Notably, this strategy improved the antibacterial activity spectrum of linezolid and other anti-Gram-positive agents and represents an effective choice to surmount the antibiotic resistance of bacteria in the long term. More... »

PAGES

38

Identifiers

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http://scigraph.springernature.com/pub.10.1186/s12941-022-00531-5

DOI

http://dx.doi.org/10.1186/s12941-022-00531-5

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PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/36038932


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67 enhancer
68 growth
69 health threat
70 infection
71 linezolid
72 long term
73 major public health threat
74 model
75 monotherapy
76 morphology
77 motility
78 negative bacteria
79 novel antibiotic combinations
80 opportunistic pathogen Pseudomonas aeruginosa
81 pathogen Pseudomonas aeruginosa
82 present study
83 production
84 protective effect
85 public health threat
86 research
87 resistance
88 significant synergistic activity
89 spectra
90 strains
91 strategies
92 study
93 swimming motility
94 synergistic activity
95 terms
96 test
97 threat
98 treatment
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