Evaluation of the loop-mediated isothermal amplification assay for Staphylococcus aureus detection: a systematic review and meta-analysis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2022-06-24

AUTHORS

Li-Jun Long, Min Lin, Yu-Ran Chen, Xin Meng, Ting-Ting Cui, Ya-Ping Li, Xu-Guang Guo

ABSTRACT

BackgroundStaphylococcus aureus can cause many diseases and even death. It’s important to detect Staphylococcus aureus rapidly and reliably. The accuracy of a novel test named LAMP in detecting Staphylococcus aureus is unclear. Therefore, a systematic review and meta-analysis were conducted to evaluate the accuracy of the LAMP assay for Staphylococcus aureus detection.MethodsFour databases were searched for relevant studies. Meta-DiSc 1.4.0 and Stata 12.0 were used for statistical analysis. At the same time, we used QUADAS-2 to assess the studies we included. Two groups of subgroup analysis were done to differentiate the diagnostic effects of various LAMP tests and in cases of different gold standards.Results11 studies were identified and 19 2 × 2 contingency tables were extracted in our study. The results showed that both pooled sensitivity and specificity of the LAMP assay were 99% (95% CI 99–100).ConclusionThe LAMP assay demonstrated high sensitivity and specificity in diagnosing Staphylococcus aureus. More... »

PAGES

27

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12941-022-00522-6

DOI

http://dx.doi.org/10.1186/s12941-022-00522-6

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https://app.dimensions.ai/details/publication/pub.1148951687

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/35751121


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