The effect of fluoroquinolones and antioxidans on biofilm formation by Proteus mirabilis strains View Full Text


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Article Info

DATE

2022-06-02

AUTHORS

Jana Przekwas, Jakub Gębalski, Joanna Kwiecińska-Piróg, Natalia Wiktorczyk-Kapischke, Ewa Wałecka-Zacharska, Eugenia Gospodarek-Komkowska, Dorota Rutkowska, Krzysztof Skowron

ABSTRACT

BackgroundFluoroquinolones are a group of antibiotics used in urinary tract infections. Unfortunately, resistance to this group of drugs is currently growing. The combined action of fluoroquinolones and other antibacterial and anti-biofilm substances may extend the use of this therapeutic option by clinicians. The aim of the study was to determine the effect of selected fluoroquinolones and therapeutic concentrations of ascorbic acid and rutoside on biofilm formation by Proteus mirabilis.Materials and methodsThe study included 15 strains of P. mirabilis isolated from urinary tract infections in patients of the University Hospital No. 1 dr A. Jurasz in Bydgoszcz (Poland). The metabolic activity of the biofilm treated with 0.4 mg/ml ascorbic acid, 0.02 µg/ml rutoside and chemotherapeutic agents (ciprofloxacin, norfloxacin) in the concentration range of 0.125–4.0 MIC (minimum inhibitory concentration) was assessed spectrophotometrically.ResultsBoth ciprofloxacin and norfloxacin inhibited biofilm formation by the tested strains. The biofilm reduction rate was correlated with the increasing concentration of antibiotic used. No synergism in fluoroquinolones with ascorbic acid, rutoside or both was found. The ascorbic acid and rutoside combination, however, significantly decreased biofilm production.ConclusionsOur research proves a beneficial impact of ascorbic acid with rutoside supplementation on biofilm of P. mirabilis strains causing urinary tract infections. More... »

PAGES

22

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12941-022-00515-5

DOI

http://dx.doi.org/10.1186/s12941-022-00515-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1148373282

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/35655208


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