The Ramazzini Institute 13-week pilot study glyphosate-based herbicides administered at human-equivalent dose to Sprague Dawley rats: effects on development and ... View Full Text


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Article Info

DATE

2019-12

AUTHORS

Fabiana Manservisi, Corina Lesseur, Simona Panzacchi, Daniele Mandrioli, Laura Falcioni, Luciano Bua, Marco Manservigi, Marcella Spinaci, Giovanna Galeati, Alberto Mantovani, Stefano Lorenzetti, Rossella Miglio, Anderson Martino Andrade, David Møbjerg Kristensen, Melissa J. Perry, Shanna H. Swan, Jia Chen, Fiorella Belpoggi

ABSTRACT

BACKGROUND: Glyphosate-based herbicides (GBHs) are broad-spectrum herbicides that act on the shikimate pathway in bacteria, fungi, and plants. The possible effects of GBHs on human health are the subject of an intense public debate for both its potential carcinogenic and non-carcinogenic effects, including potential effects on the endocrine system The present pilot study examine whether exposure to GBHs at the dose of glyphosate considered to be "safe" (the US Acceptable Daily Intake - ADI - of 1.75 mg/kg bw/day), starting from in utero life, affect the development and endocrine system across different life stages in Sprague Dawley (SD) rats. METHODS: Glyphosate alone and Roundup Bioflow, a commercial brand of GBHs, were administered in drinking water at 1.75 mg/kg bw/day to F0 dams starting from the gestational day (GD) 6 (in utero) up to postnatal day (PND) 120. After weaning, offspring were randomly distributed in two cohorts: 8 M + 8F/group animals belonging to the 6-week cohort were sacrificed after puberty at PND 73 ± 2; 10 M + 10F/group animals belonging to the 13-week cohort were sacrificed at adulthood at PND 125 ± 2. Effects of glyphosate or Roundup exposure were assessed on developmental landmarks and sexual characteristics of pups. RESULTS: In pups, anogenital distance (AGD) at PND 4 was statistically significantly increased both in Roundup-treated males and females and in glyphosate-treated males. Age at first estrous (FE) was significantly delayed in the Roundup-exposed group and serum testosterone concentration significantly increased in Roundup-treated female offspring from the 13-week cohort compared to control animals. A statistically significant increase in plasma TSH concentration was observed in glyphosate-treated males compared with control animals as well as a statistically significant decrease in DHT and increase in BDNF in Roundup-treated males. Hormonal status imbalances were more pronounced in Roundup-treated rats after prolonged exposure. CONCLUSIONS: The present pilot study demonstrate that GBHs exposure, from prenatal period to adulthood, induced endocrine effects and altered reproductive developmental parameters in male and female SD rats. In particular, it was associated with androgen-like effects, including a statistically significant increase of AGDs in both males and females, delay of FE and increased testosterone in female. More... »

PAGES

15

References to SciGraph publications

  • 2012-04. Glyphosate impairs male offspring reproductive development by disrupting gonadotropin expression in ARCHIVES OF TOXICOLOGY
  • 2018-12. Glyphosate exposure in pregnancy and shortened gestational length: a prospective Indiana birth cohort study in ENVIRONMENTAL HEALTH
  • 2016-12. Trends in glyphosate herbicide use in the United States and globally in ENVIRONMENTAL SCIENCES EUROPE
  • 2018-12. The Ramazzini Institute 13-week study on glyphosate-based herbicides at human-equivalent dose in Sprague Dawley rats: study design and first in-life endpoints evaluation in ENVIRONMENTAL HEALTH
  • 2012-05. Effects of Roundup® and Glyphosate on Three Food Microorganisms: Geotrichum candidum, Lactococcus lactis subsp. cremoris and Lactobacillus delbrueckii subsp. bulgaricus in CURRENT MICROBIOLOGY
  • 2016-12. Concerns over use of glyphosate-based herbicides and risks associated with exposures: a consensus statement in ENVIRONMENTAL HEALTH
  • 2007-09. Pre- and postnatal toxicity of the commercial glyphosate formulation in Wistar rats in ARCHIVES OF TOXICOLOGY
  • 2010-04. Prepubertal exposure to commercial formulation of the herbicide glyphosate alters testosterone levels and testicular morphology in ARCHIVES OF TOXICOLOGY
  • 2017-12. Development and validation of a method for precise dating of female puberty in laboratory rodents: The puberty ovarian maturation score (Pub-Score) in SCIENTIFIC REPORTS
  • 2018-08. Perinatal exposure to a glyphosate-based herbicide impairs female reproductive outcomes and induces second-generation adverse effects in Wistar rats in ARCHIVES OF TOXICOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12940-019-0453-y

    DOI

    http://dx.doi.org/10.1186/s12940-019-0453-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112682868

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30857531


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