Persistent organic pollutants and non-alcoholic fatty liver disease in morbidly obese patients: a cohort study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-09-29

AUTHORS

Panu Rantakokko, Ville Männistö, Riikka Airaksinen, Jani Koponen, Matti Viluksela, Hannu Kiviranta, Jussi Pihlajamäki

ABSTRACT

BackgroundIn animal experiments persistent organic pollutants (POPs) cause hepatosteatosis. In epidemiological studies POPs have positive associations with serum markers of nonalcoholic fatty liver disease (NAFLD) and together with obesity synergistic association with insulin resistance. Because insulin resistance and obesity are critical in NAFLD pathogenesis, we investigated the association of serum pollutant levels with liver histology and alanine aminotransferase (ALT) in morbidly obese.MethodsLiver biopsies were from 161 participants of the Kuopio Obesity Surgery Study (KOBS) who underwent bariatric surgery 2005–2011. Liver histology was categorized as normal, steatosis and non-alcoholic steatohepatitis (NASH). Liver phenotype at baseline and ALT at baseline and 12 months post-surgery were correlated to serum POP concentrations at respective time points. As lipophilic POPs concentrate to smaller fat volume during weight loss, serum levels before and 12 months after bariatric surgery were compared.ResultsBaseline serum concentration of PCB-118, β-HCH and several PFAAs had an inverse association with lobular inflammation possibly due to changes in bile acid metabolism. ALT had negative associations with many POPs at baseline that turned positive at 12 months after major clinical improvements. There was an interaction between some POPs and sex at 12 months, and in stratified data positive associations were observed mainly in females but not in males.ConclusionsWe found a negative association between serum concentrations of PCB-118, β-HCH and several PFAAs with lobular inflammation at baseline. Positive POPs-ATL associations at 12 months among women suggest that increased POP concentrations may decrease the degree of liver recovery. More... »

PAGES

79

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12940-015-0066-z

DOI

http://dx.doi.org/10.1186/s12940-015-0066-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012009217

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26420011


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