Phthalate concentrations in house dust in relation to autism spectrum disorder and developmental delay in the CHildhood Autism Risks from ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Claire Philippat, Deborah H. Bennett, Paula Krakowiak, Melissa Rose, Hyun-Min Hwang, Irva Hertz-Picciotto

ABSTRACT

BACKGROUND: Phthalates are endocrine-disrupting chemicals that influence thyroid hormones and sex steroids, both critical for brain development. AIM: We studied phthalate concentrations in house dust in relation to the risks of developing autism spectrum disorder (ASD) or developmental delay (DD). METHODS: Participants were a subset of children from the CHARGE (CHildhood Autism Risks from Genetics and the Environment) case-control study. ASD and DD cases were identified through the California Department of Developmental Services system or referrals; general population controls were randomly sampled from state birth files and frequency-matched on age, sex, and broad geographic region to ASD cases. All children (50 ASD, 27 DD, 68 typically developing (TD)) were assessed with Mullen Scales of Early Learning, Vineland Adaptive Behavior Scales (VABS) and Aberrant Behavior Checklist. We measured 5 phthalates in dust collected in the child's home using a high volume small surface sampler. RESULTS: None of the phthalates measured in dust was associated with ASD. After adjustment, we observed greater di(2-ethylhexyl) phthalate (DEHP) and butylbenzyl phthalate (BBzP) concentrations in indoor dust from homes of DD children: Odds ratios (OR) were 2.10 (95% confidence interval (CI); 1.10; 4.09) and 1.40 (95% CI; 0.97; 2.04) for a one-unit increase in the ln-transformed DEHP and BBzP concentrations, respectively. Among TD children, VABS communication, daily living, and adaptive composite standard scores were lower, in association with increased diethyl phthalate (DEP) concentrations in dust. Participants with higher dibutyl phthalate (DBP) concentrations in house dust also trended toward reduced performance on these subscales. Among ASD and DD boys, higher indoor dust concentrations of DEP and DBP were associated with greater hyperactivity-impulsivity and inattention. DISCUSSION AND CONCLUSION: House dust levels of phthalates were not associated with ASD. The inability to distinguish past from recent exposures in house dust and the fact that house dust does not capture exposure from all sources, limit the interpretation of both positive and null findings and further work is needed. However, the associations observed for DEP and DBP with impairments in several adaptive functions and greater hyperactivity, along with evidence for increased risk of DD raise concerns that these chemicals may affect neurodevelopment in children. More... »

PAGES

56

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12940-015-0024-9

DOI

http://dx.doi.org/10.1186/s12940-015-0024-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001875608

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26108271


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Air Pollution, Indoor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Autistic Disorder", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "California", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Case-Control Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child, Preschool", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Developmental Disabilities", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dust", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Environmental Exposure", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Environmental Pollutants", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Odds Ratio", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phthalic Acids", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of California, Davis", 
          "id": "https://www.grid.ac/institutes/grid.27860.3b", 
          "name": [
            "Divisions of Epidemiology and of Environmental and Occupational Health, Department of Public Health Sciences, School of Medicine, University of California, Davis, CA, USA", 
            "MIND Institute, University of California, 2825 50th Street, 95817, Sacramento, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Philippat", 
        "givenName": "Claire", 
        "id": "sg:person.01330745551.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330745551.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, Davis", 
          "id": "https://www.grid.ac/institutes/grid.27860.3b", 
          "name": [
            "Divisions of Epidemiology and of Environmental and Occupational Health, Department of Public Health Sciences, School of Medicine, University of California, Davis, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bennett", 
        "givenName": "Deborah H.", 
        "id": "sg:person.01015747036.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015747036.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, Davis", 
          "id": "https://www.grid.ac/institutes/grid.27860.3b", 
          "name": [
            "Divisions of Epidemiology and of Environmental and Occupational Health, Department of Public Health Sciences, School of Medicine, University of California, Davis, CA, USA", 
            "MIND Institute, University of California, 2825 50th Street, 95817, Sacramento, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Krakowiak", 
        "givenName": "Paula", 
        "id": "sg:person.01346536517.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346536517.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, Davis", 
          "id": "https://www.grid.ac/institutes/grid.27860.3b", 
          "name": [
            "Divisions of Epidemiology and of Environmental and Occupational Health, Department of Public Health Sciences, School of Medicine, University of California, Davis, CA, USA", 
            "MIND Institute, University of California, 2825 50th Street, 95817, Sacramento, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rose", 
        "givenName": "Melissa", 
        "id": "sg:person.01021107437.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021107437.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Texas Southern University", 
          "id": "https://www.grid.ac/institutes/grid.264771.1", 
          "name": [
            "Department of Civil and Environmental Engineering, University of California, Davis, CA, USA", 
            "Department of Environmental and Interdisciplinary Sciences, Texas Southern University, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hwang", 
        "givenName": "Hyun-Min", 
        "id": "sg:person.01252040171.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252040171.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, Davis", 
          "id": "https://www.grid.ac/institutes/grid.27860.3b", 
          "name": [
            "Divisions of Epidemiology and of Environmental and Occupational Health, Department of Public Health Sciences, School of Medicine, University of California, Davis, CA, USA", 
            "MIND Institute, University of California, 2825 50th Street, 95817, Sacramento, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hertz-Picciotto", 
        "givenName": "Irva", 
        "id": "sg:person.0775617774.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775617774.23"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1093/ije/dyt282", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002887765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.scitotenv.2008.05.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003492873"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1289/ehp.1306681", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004997203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1289/ehp.8483", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006494666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1289/ehp.1103705", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008996140"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/toxsci/kfn077", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011070023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.chi.0000227880.42780.0e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012955449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.chi.0000227880.42780.0e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012955449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuro.2010.12.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017217533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/humrep/dem205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025120244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/oem.2004.017590", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026368747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/oem.2004.017590", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026368747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/ina.12070", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027006191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1289/ehp.7199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029298115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuro.2014.01.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035726966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1289/ehp.0901470", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035779234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1289/ehp.1307261", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036145868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1005592401947", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036427450", 
          "https://doi.org/10.1023/a:1005592401947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fnhum.2014.00268", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036859821"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.scitotenv.2013.05.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039183773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuro.2009.01.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040878044"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1289/ehp.1003178", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041528029"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tox.2007.12.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042215359"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.toxlet.2009.07.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046732211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00787-004-0383-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048791509", 
          "https://doi.org/10.1007/s00787-004-0383-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1289/ehp.10749", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050151849"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.envres.2007.09.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051492622"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1539-6924.2006.00770.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051660785"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/an20120015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051795227"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.atmosenv.2007.11.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053267047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2014.4144", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053297673"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/es0264596", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055495267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/es0264596", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055495267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/es0347944", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055496188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/es0347944", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055496188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/es2002106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055502823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/es2002106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055502823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/es303316d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055505248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080071522", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-12", 
    "datePublishedReg": "2015-12-01", 
    "description": "BACKGROUND: Phthalates are endocrine-disrupting chemicals that influence thyroid hormones and sex steroids, both critical for brain development.\nAIM: We studied phthalate concentrations in house dust in relation to the risks of developing autism spectrum disorder (ASD) or developmental delay (DD).\nMETHODS: Participants were a subset of children from the CHARGE (CHildhood Autism Risks from Genetics and the Environment) case-control study. ASD and DD cases were identified through the California Department of Developmental Services system or referrals; general population controls were randomly sampled from state birth files and frequency-matched on age, sex, and broad geographic region to ASD cases. All children (50 ASD, 27 DD, 68 typically developing (TD)) were assessed with Mullen Scales of Early Learning, Vineland Adaptive Behavior Scales (VABS) and Aberrant Behavior Checklist. We measured 5 phthalates in dust collected in the child's home using a high volume small surface sampler.\nRESULTS: None of the phthalates measured in dust was associated with ASD. After adjustment, we observed greater di(2-ethylhexyl) phthalate (DEHP) and butylbenzyl phthalate (BBzP) concentrations in indoor dust from homes of DD children: Odds ratios (OR) were 2.10 (95% confidence interval (CI); 1.10; 4.09) and 1.40 (95% CI; 0.97; 2.04) for a one-unit increase in the ln-transformed DEHP and BBzP concentrations, respectively. Among TD children, VABS communication, daily living, and adaptive composite standard scores were lower, in association with increased diethyl phthalate (DEP) concentrations in dust. Participants with higher dibutyl phthalate (DBP) concentrations in house dust also trended toward reduced performance on these subscales. Among ASD and DD boys, higher indoor dust concentrations of DEP and DBP were associated with greater hyperactivity-impulsivity and inattention.\nDISCUSSION AND CONCLUSION: House dust levels of phthalates were not associated with ASD. The inability to distinguish past from recent exposures in house dust and the fact that house dust does not capture exposure from all sources, limit the interpretation of both positive and null findings and further work is needed. However, the associations observed for DEP and DBP with impairments in several adaptive functions and greater hyperactivity, along with evidence for increased risk of DD raise concerns that these chemicals may affect neurodevelopment in children.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12940-015-0024-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2503863", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2436271", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4596239", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2699307", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4594937", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1327425", 
        "issn": [
          "1476-069X"
        ], 
        "name": "Environmental Health", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "14"
      }
    ], 
    "name": "Phthalate concentrations in house dust in relation to autism spectrum disorder and developmental delay in the CHildhood Autism Risks from Genetics and the Environment (CHARGE) study", 
    "pagination": "56", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "08ef53fc5baae1f826f25f1e75699dd5ce08c55cf183bbfd3a06ca7ee85c31f4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26108271"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101147645"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12940-015-0024-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1001875608"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12940-015-0024-9", 
      "https://app.dimensions.ai/details/publication/pub.1001875608"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:11", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000367_0000000367/records_88255_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2Fs12940-015-0024-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12940-015-0024-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12940-015-0024-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12940-015-0024-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12940-015-0024-9'


 

This table displays all metadata directly associated to this object as RDF triples.

277 TRIPLES      21 PREDICATES      77 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12940-015-0024-9 schema:about N0693b56ad6d340df9600688c9bb6b447
2 N0be0c9673ac948259daac1f66d33843d
3 N35dffc6cd7c340efbb1153219a910279
4 N3ab7a79248db440c823054d8eb20691a
5 N4ac57604b908469ea3661c3a0b5a247e
6 N50c8f55c26d349f7baa3bb2f1a2b7788
7 N57ec052b093f466f8130d8f93d1798d6
8 N7416953490cf47e498b4f9722b480d99
9 Na17b40e0171b4f6bb39f3e01a06fb961
10 Ncfae4920357645428932779ac0bffdbe
11 Nd075abe25ca64baf8682de14aa4e3702
12 Nd1fd027cf4d84a15b2f214786bc89a1e
13 Ne9933f4c752747dd81728ae31a009138
14 Nfa841bfe27e147e7932ea99fa6957e4f
15 anzsrc-for:11
16 anzsrc-for:1117
17 schema:author N5cdcf7ed714c40a7918c58fd24867c96
18 schema:citation sg:pub.10.1007/s00787-004-0383-1
19 sg:pub.10.1023/a:1005592401947
20 https://app.dimensions.ai/details/publication/pub.1080071522
21 https://doi.org/10.1001/jama.2014.4144
22 https://doi.org/10.1016/j.atmosenv.2007.11.014
23 https://doi.org/10.1016/j.envres.2007.09.010
24 https://doi.org/10.1016/j.neuro.2009.01.011
25 https://doi.org/10.1016/j.neuro.2010.12.009
26 https://doi.org/10.1016/j.neuro.2014.01.007
27 https://doi.org/10.1016/j.scitotenv.2008.05.031
28 https://doi.org/10.1016/j.scitotenv.2013.05.021
29 https://doi.org/10.1016/j.tox.2007.12.028
30 https://doi.org/10.1016/j.toxlet.2009.07.019
31 https://doi.org/10.1021/es0264596
32 https://doi.org/10.1021/es0347944
33 https://doi.org/10.1021/es2002106
34 https://doi.org/10.1021/es303316d
35 https://doi.org/10.1042/an20120015
36 https://doi.org/10.1093/humrep/dem205
37 https://doi.org/10.1093/ije/dyt282
38 https://doi.org/10.1093/toxsci/kfn077
39 https://doi.org/10.1097/01.chi.0000227880.42780.0e
40 https://doi.org/10.1111/ina.12070
41 https://doi.org/10.1111/j.1539-6924.2006.00770.x
42 https://doi.org/10.1136/oem.2004.017590
43 https://doi.org/10.1289/ehp.0901470
44 https://doi.org/10.1289/ehp.1003178
45 https://doi.org/10.1289/ehp.10749
46 https://doi.org/10.1289/ehp.1103705
47 https://doi.org/10.1289/ehp.1306681
48 https://doi.org/10.1289/ehp.1307261
49 https://doi.org/10.1289/ehp.7199
50 https://doi.org/10.1289/ehp.8483
51 https://doi.org/10.3389/fnhum.2014.00268
52 schema:datePublished 2015-12
53 schema:datePublishedReg 2015-12-01
54 schema:description BACKGROUND: Phthalates are endocrine-disrupting chemicals that influence thyroid hormones and sex steroids, both critical for brain development. AIM: We studied phthalate concentrations in house dust in relation to the risks of developing autism spectrum disorder (ASD) or developmental delay (DD). METHODS: Participants were a subset of children from the CHARGE (CHildhood Autism Risks from Genetics and the Environment) case-control study. ASD and DD cases were identified through the California Department of Developmental Services system or referrals; general population controls were randomly sampled from state birth files and frequency-matched on age, sex, and broad geographic region to ASD cases. All children (50 ASD, 27 DD, 68 typically developing (TD)) were assessed with Mullen Scales of Early Learning, Vineland Adaptive Behavior Scales (VABS) and Aberrant Behavior Checklist. We measured 5 phthalates in dust collected in the child's home using a high volume small surface sampler. RESULTS: None of the phthalates measured in dust was associated with ASD. After adjustment, we observed greater di(2-ethylhexyl) phthalate (DEHP) and butylbenzyl phthalate (BBzP) concentrations in indoor dust from homes of DD children: Odds ratios (OR) were 2.10 (95% confidence interval (CI); 1.10; 4.09) and 1.40 (95% CI; 0.97; 2.04) for a one-unit increase in the ln-transformed DEHP and BBzP concentrations, respectively. Among TD children, VABS communication, daily living, and adaptive composite standard scores were lower, in association with increased diethyl phthalate (DEP) concentrations in dust. Participants with higher dibutyl phthalate (DBP) concentrations in house dust also trended toward reduced performance on these subscales. Among ASD and DD boys, higher indoor dust concentrations of DEP and DBP were associated with greater hyperactivity-impulsivity and inattention. DISCUSSION AND CONCLUSION: House dust levels of phthalates were not associated with ASD. The inability to distinguish past from recent exposures in house dust and the fact that house dust does not capture exposure from all sources, limit the interpretation of both positive and null findings and further work is needed. However, the associations observed for DEP and DBP with impairments in several adaptive functions and greater hyperactivity, along with evidence for increased risk of DD raise concerns that these chemicals may affect neurodevelopment in children.
55 schema:genre research_article
56 schema:inLanguage en
57 schema:isAccessibleForFree true
58 schema:isPartOf N8569a9d246304e64b7e08513a3c8e414
59 Na7ed6a606e69415a90643544cd446d39
60 sg:journal.1327425
61 schema:name Phthalate concentrations in house dust in relation to autism spectrum disorder and developmental delay in the CHildhood Autism Risks from Genetics and the Environment (CHARGE) study
62 schema:pagination 56
63 schema:productId N48c59970d3954d129e9aa4dbeaa0b8fd
64 N54cfae0b450f41dd8d43b1c1030505cb
65 N99180cc9be3a42789621e197e485017a
66 N9d32a955a0f14701988b584888f3af73
67 Ncabc064584844d6b944011bb7e207564
68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001875608
69 https://doi.org/10.1186/s12940-015-0024-9
70 schema:sdDatePublished 2019-04-11T13:11
71 schema:sdLicense https://scigraph.springernature.com/explorer/license/
72 schema:sdPublisher N0271b9db542f4d1587270e64886375eb
73 schema:url http://link.springer.com/10.1186%2Fs12940-015-0024-9
74 sgo:license sg:explorer/license/
75 sgo:sdDataset articles
76 rdf:type schema:ScholarlyArticle
77 N0271b9db542f4d1587270e64886375eb schema:name Springer Nature - SN SciGraph project
78 rdf:type schema:Organization
79 N0693b56ad6d340df9600688c9bb6b447 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Air Pollution, Indoor
81 rdf:type schema:DefinedTerm
82 N0be0c9673ac948259daac1f66d33843d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Child, Preschool
84 rdf:type schema:DefinedTerm
85 N2781a717660043ef8f442b80a41cf9ca rdf:first sg:person.01346536517.43
86 rdf:rest Nc6915375eb6f4878aeeb24863748cde7
87 N35dffc6cd7c340efbb1153219a910279 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Male
89 rdf:type schema:DefinedTerm
90 N3ab7a79248db440c823054d8eb20691a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Phthalic Acids
92 rdf:type schema:DefinedTerm
93 N48c59970d3954d129e9aa4dbeaa0b8fd schema:name nlm_unique_id
94 schema:value 101147645
95 rdf:type schema:PropertyValue
96 N4ac57604b908469ea3661c3a0b5a247e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Dust
98 rdf:type schema:DefinedTerm
99 N50c8f55c26d349f7baa3bb2f1a2b7788 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Environmental Exposure
101 rdf:type schema:DefinedTerm
102 N54cfae0b450f41dd8d43b1c1030505cb schema:name dimensions_id
103 schema:value pub.1001875608
104 rdf:type schema:PropertyValue
105 N56ae5b381397460e944be773c43239c5 rdf:first sg:person.01252040171.02
106 rdf:rest Nd7c867de06b7425188d000866e89dc9a
107 N57ec052b093f466f8130d8f93d1798d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Female
109 rdf:type schema:DefinedTerm
110 N5cdcf7ed714c40a7918c58fd24867c96 rdf:first sg:person.01330745551.30
111 rdf:rest Na66b2af2c62744f29096d67b6b08fdb4
112 N7416953490cf47e498b4f9722b480d99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Odds Ratio
114 rdf:type schema:DefinedTerm
115 N8569a9d246304e64b7e08513a3c8e414 schema:issueNumber 1
116 rdf:type schema:PublicationIssue
117 N99180cc9be3a42789621e197e485017a schema:name pubmed_id
118 schema:value 26108271
119 rdf:type schema:PropertyValue
120 N9d32a955a0f14701988b584888f3af73 schema:name readcube_id
121 schema:value 08ef53fc5baae1f826f25f1e75699dd5ce08c55cf183bbfd3a06ca7ee85c31f4
122 rdf:type schema:PropertyValue
123 Na17b40e0171b4f6bb39f3e01a06fb961 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Case-Control Studies
125 rdf:type schema:DefinedTerm
126 Na66b2af2c62744f29096d67b6b08fdb4 rdf:first sg:person.01015747036.70
127 rdf:rest N2781a717660043ef8f442b80a41cf9ca
128 Na7ed6a606e69415a90643544cd446d39 schema:volumeNumber 14
129 rdf:type schema:PublicationVolume
130 Nc6915375eb6f4878aeeb24863748cde7 rdf:first sg:person.01021107437.46
131 rdf:rest N56ae5b381397460e944be773c43239c5
132 Ncabc064584844d6b944011bb7e207564 schema:name doi
133 schema:value 10.1186/s12940-015-0024-9
134 rdf:type schema:PropertyValue
135 Ncfae4920357645428932779ac0bffdbe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Developmental Disabilities
137 rdf:type schema:DefinedTerm
138 Nd075abe25ca64baf8682de14aa4e3702 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Autistic Disorder
140 rdf:type schema:DefinedTerm
141 Nd1fd027cf4d84a15b2f214786bc89a1e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name California
143 rdf:type schema:DefinedTerm
144 Nd7c867de06b7425188d000866e89dc9a rdf:first sg:person.0775617774.23
145 rdf:rest rdf:nil
146 Ne9933f4c752747dd81728ae31a009138 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Environmental Pollutants
148 rdf:type schema:DefinedTerm
149 Nfa841bfe27e147e7932ea99fa6957e4f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Humans
151 rdf:type schema:DefinedTerm
152 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
153 schema:name Medical and Health Sciences
154 rdf:type schema:DefinedTerm
155 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
156 schema:name Public Health and Health Services
157 rdf:type schema:DefinedTerm
158 sg:grant.2436271 http://pending.schema.org/fundedItem sg:pub.10.1186/s12940-015-0024-9
159 rdf:type schema:MonetaryGrant
160 sg:grant.2503863 http://pending.schema.org/fundedItem sg:pub.10.1186/s12940-015-0024-9
161 rdf:type schema:MonetaryGrant
162 sg:grant.2699307 http://pending.schema.org/fundedItem sg:pub.10.1186/s12940-015-0024-9
163 rdf:type schema:MonetaryGrant
164 sg:grant.4594937 http://pending.schema.org/fundedItem sg:pub.10.1186/s12940-015-0024-9
165 rdf:type schema:MonetaryGrant
166 sg:grant.4596239 http://pending.schema.org/fundedItem sg:pub.10.1186/s12940-015-0024-9
167 rdf:type schema:MonetaryGrant
168 sg:journal.1327425 schema:issn 1476-069X
169 schema:name Environmental Health
170 rdf:type schema:Periodical
171 sg:person.01015747036.70 schema:affiliation https://www.grid.ac/institutes/grid.27860.3b
172 schema:familyName Bennett
173 schema:givenName Deborah H.
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015747036.70
175 rdf:type schema:Person
176 sg:person.01021107437.46 schema:affiliation https://www.grid.ac/institutes/grid.27860.3b
177 schema:familyName Rose
178 schema:givenName Melissa
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021107437.46
180 rdf:type schema:Person
181 sg:person.01252040171.02 schema:affiliation https://www.grid.ac/institutes/grid.264771.1
182 schema:familyName Hwang
183 schema:givenName Hyun-Min
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252040171.02
185 rdf:type schema:Person
186 sg:person.01330745551.30 schema:affiliation https://www.grid.ac/institutes/grid.27860.3b
187 schema:familyName Philippat
188 schema:givenName Claire
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330745551.30
190 rdf:type schema:Person
191 sg:person.01346536517.43 schema:affiliation https://www.grid.ac/institutes/grid.27860.3b
192 schema:familyName Krakowiak
193 schema:givenName Paula
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346536517.43
195 rdf:type schema:Person
196 sg:person.0775617774.23 schema:affiliation https://www.grid.ac/institutes/grid.27860.3b
197 schema:familyName Hertz-Picciotto
198 schema:givenName Irva
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775617774.23
200 rdf:type schema:Person
201 sg:pub.10.1007/s00787-004-0383-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048791509
202 https://doi.org/10.1007/s00787-004-0383-1
203 rdf:type schema:CreativeWork
204 sg:pub.10.1023/a:1005592401947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036427450
205 https://doi.org/10.1023/a:1005592401947
206 rdf:type schema:CreativeWork
207 https://app.dimensions.ai/details/publication/pub.1080071522 schema:CreativeWork
208 https://doi.org/10.1001/jama.2014.4144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053297673
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/j.atmosenv.2007.11.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053267047
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/j.envres.2007.09.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051492622
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1016/j.neuro.2009.01.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040878044
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1016/j.neuro.2010.12.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017217533
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1016/j.neuro.2014.01.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035726966
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/j.scitotenv.2008.05.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003492873
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/j.scitotenv.2013.05.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039183773
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/j.tox.2007.12.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042215359
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/j.toxlet.2009.07.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046732211
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1021/es0264596 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055495267
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1021/es0347944 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055496188
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1021/es2002106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055502823
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1021/es303316d schema:sameAs https://app.dimensions.ai/details/publication/pub.1055505248
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1042/an20120015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051795227
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1093/humrep/dem205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025120244
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1093/ije/dyt282 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002887765
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1093/toxsci/kfn077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011070023
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1097/01.chi.0000227880.42780.0e schema:sameAs https://app.dimensions.ai/details/publication/pub.1012955449
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1111/ina.12070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027006191
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1111/j.1539-6924.2006.00770.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051660785
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1136/oem.2004.017590 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026368747
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1289/ehp.0901470 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035779234
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1289/ehp.1003178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041528029
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1289/ehp.10749 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050151849
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1289/ehp.1103705 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008996140
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1289/ehp.1306681 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004997203
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1289/ehp.1307261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036145868
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1289/ehp.7199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029298115
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1289/ehp.8483 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006494666
267 rdf:type schema:CreativeWork
268 https://doi.org/10.3389/fnhum.2014.00268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036859821
269 rdf:type schema:CreativeWork
270 https://www.grid.ac/institutes/grid.264771.1 schema:alternateName Texas Southern University
271 schema:name Department of Civil and Environmental Engineering, University of California, Davis, CA, USA
272 Department of Environmental and Interdisciplinary Sciences, Texas Southern University, Houston, TX, USA
273 rdf:type schema:Organization
274 https://www.grid.ac/institutes/grid.27860.3b schema:alternateName University of California, Davis
275 schema:name Divisions of Epidemiology and of Environmental and Occupational Health, Department of Public Health Sciences, School of Medicine, University of California, Davis, CA, USA
276 MIND Institute, University of California, 2825 50th Street, 95817, Sacramento, CA, USA
277 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...