Correlates of whole-blood polyunsaturated fatty acids among young children with moderate acute malnutrition View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-07-13

AUTHORS

C. W. Yaméogo, B. Cichon, C. Fabiansen, M. J. H. Rytter, D. Faurholt-Jepsen, K. D. Stark, A. Briend, S. Shepherd, A. S. Traoré, V. B. Christensen, K. F. Michaelsen, H. Friis, L. Lauritzen

ABSTRACT

BackgroundSevere acute malnutrition (SAM) has been associated with low polyunsaturated fatty acid (PUFA) status. However, investigations regarding PUFA status and correlates in children with moderate acute malnutrition (MAM) from low-income countries are scarce. The aim of this study was to describe whole-blood PUFA levels in children with moderate acute malnutrition (MAM) and to identify correlates of PUFAs.MethodsWe conducted a cross-sectional study using baseline data from a prospective nutritional intervention trial among 1609 children with MAM aged 6–23 months in Burkina Faso,West Africa. Whole-blood PUFAs were measured by gas chromatography and expressed as percent of total whole-blood fatty acids (FA%). Potential correlates of PUFAs including infection, inflammation, hemoglobin, anthropometry (difference between children diagnosed as having MAM based on low mid-upper-arm-circumference (MUAC) only, low MUAC and weight-for-height z-score (WHZ), or low WHZ only) and diet were assessed by linear regression adjusted for age and sex.ResultsChildren with MAM had low concentrations of whole-blood PUFAs, particularly n-3 PUFAs. Moreover, children diagnosed with MAM based only on low MUAC had 0.32 (95% confidence interval (CI), 0.14; 0.50) and 0.40 (95% CI, 0.16; 0.63) FA% lower arachidonic acid (AA) than those recruited based on both low WHZ as well as low MUAC and those recruited with low WHZ only, respectively. Infection and inflammation were associated with low levels of all long-chain (LC)-PUFAs, while hemoglobin was positively associated with whole-blood LC-PUFAs.ConclusionWhile PUFA deficiency was not a general problem, overall whole-blood PUFA concentrations, especially of n-3 PUFAs, were low. Infection, inflammation, hemoglobin, anthropometry and diet were correlates of PUFAs concentrations in children with MAM.Trial registrationThe trial is registered at http://www.isrctn.com (ISRCTN42569496). More... »

PAGES

44

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12937-017-0264-3

DOI

http://dx.doi.org/10.1186/s12937-017-0264-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1090660128

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28705254


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28 schema:description BackgroundSevere acute malnutrition (SAM) has been associated with low polyunsaturated fatty acid (PUFA) status. However, investigations regarding PUFA status and correlates in children with moderate acute malnutrition (MAM) from low-income countries are scarce. The aim of this study was to describe whole-blood PUFA levels in children with moderate acute malnutrition (MAM) and to identify correlates of PUFAs.MethodsWe conducted a cross-sectional study using baseline data from a prospective nutritional intervention trial among 1609 children with MAM aged 6–23 months in Burkina Faso,West Africa. Whole-blood PUFAs were measured by gas chromatography and expressed as percent of total whole-blood fatty acids (FA%). Potential correlates of PUFAs including infection, inflammation, hemoglobin, anthropometry (difference between children diagnosed as having MAM based on low mid-upper-arm-circumference (MUAC) only, low MUAC and weight-for-height z-score (WHZ), or low WHZ only) and diet were assessed by linear regression adjusted for age and sex.ResultsChildren with MAM had low concentrations of whole-blood PUFAs, particularly n-3 PUFAs. Moreover, children diagnosed with MAM based only on low MUAC had 0.32 (95% confidence interval (CI), 0.14; 0.50) and 0.40 (95% CI, 0.16; 0.63) FA% lower arachidonic acid (AA) than those recruited based on both low WHZ as well as low MUAC and those recruited with low WHZ only, respectively. Infection and inflammation were associated with low levels of all long-chain (LC)-PUFAs, while hemoglobin was positively associated with whole-blood LC-PUFAs.ConclusionWhile PUFA deficiency was not a general problem, overall whole-blood PUFA concentrations, especially of n-3 PUFAs, were low. Infection, inflammation, hemoglobin, anthropometry and diet were correlates of PUFAs concentrations in children with MAM.Trial registrationThe trial is registered at http://www.isrctn.com (ISRCTN42569496).
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34 schema:keywords Africa
35 Burkina Faso
36 Faso
37 LC-PUFAs
38 MUAC
39 MethodsWe
40 PUFA
41 PUFA concentrations
42 PUFA deficiency
43 PUFA levels
44 PUFA status
45 PUFAs
46 ResultsChildren
47 Trial registrationThe trial
48 WHZ
49 West Africa
50 acid
51 acid status
52 acute malnutrition
53 age
54 aim
55 anthropometry
56 arachidonic acid
57 baseline data
58 children
59 chromatography
60 concentration
61 correlates
62 countries
63 cross-sectional study
64 data
65 deficiency
66 diet
67 fatty acid status
68 fatty acids
69 gas chromatography
70 general problem
71 hemoglobin
72 infection
73 inflammation
74 intervention trials
75 investigation
76 levels
77 linear regression
78 low MUAC
79 low WHZ
80 low concentrations
81 low levels
82 low-income countries
83 malnutrition
84 moderate acute malnutrition
85 months
86 nutritional intervention trial
87 percent
88 potential correlates
89 problem
90 regression
91 sex
92 status
93 study
94 trials
95 whole-blood fatty acids
96 young children
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