Ontology type: schema:ScholarlyArticle Open Access: True
2019-12
AUTHORSAgus Setyadi, Eggi Arguni, Enny Kenangalem, Afdhal Hasanuddin, Daniel A. Lampah, Kamala Thriemer, Nicholas M. Anstey, Paulus Sugiarto, Julie A. Simpson, Ric N. Price, Nicholas M. Douglas, Jeanne R. Poespoprodjo
ABSTRACTBACKGROUND: Primaquine (PQ) prevents relapses of vivax malaria but may induce severe haemolysis in glucose-6-phosphate dehydrogenase (G6PD) deficient patients. Data on the safety of primaquine in infants are limited. METHODS: A retrospective, hospital-based cohort study of infants aged 1-12 months with vivax malaria was carried out in Timika, Papua province, Indonesia. Risks of admission, death and severe haematological outcomes within 30 days of first presentation were compared between infants who did and did not receive primaquine. Infants were not tested routinely for G6PD deficiency as per local guidelines. RESULTS: Between 2004 and 2013, 4078 infants presented to the hospital for the first time with vivax malaria, of whom 3681 (90.3%) had data available for analysis. In total 1228 (33.4%) infants were aged between 1 and 6 months and 2453 (66.6%) between 6 and 12 months of age. Thirty-three (0.9%) patients received low-dose primaquine (LDP), 174 (4.7%) received high-dose primaquine (HDP), 3432 (93.2%) received no primaquine (NPQ) and 42 patients received either a single dose or an unknown dose of primaquine. The risk of the Hb concentration falling by > 25% to less than 5 g/dL was similar in the LDP or HDP groups (4.3%, 1/23) versus the NPQ group (3.5%, 16/461). Three infants (1.4%) died following receipt of PQ, all of whom had major comorbidities. Seventeen patients (0.5%) died in the NPQ group. None of the infants had documented massive haemolysis or renal impairment. CONCLUSIONS: Severe clinical outcomes amongst infants treated with primaquine in Papua were rare. The risks of using primaquine in infancy must be weighed against the risks of recurrent vivax malaria in early life. More... »
PAGES111
http://scigraph.springernature.com/pub.10.1186/s12936-019-2745-7
DOIhttp://dx.doi.org/10.1186/s12936-019-2745-7
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1113179479
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30940140
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Gadjah Mada University",
"id": "https://www.grid.ac/institutes/grid.8570.a",
"name": [
"Department of Child Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia"
],
"type": "Organization"
},
"familyName": "Setyadi",
"givenName": "Agus",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Gadjah Mada University",
"id": "https://www.grid.ac/institutes/grid.8570.a",
"name": [
"Department of Child Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia"
],
"type": "Organization"
},
"familyName": "Arguni",
"givenName": "Eggi",
"type": "Person"
},
{
"affiliation": {
"name": [
"Timika Malaria Research Programme, Papuan Health and Community Development Foundation, Timika, Papua, Indonesia",
"Mimika District Hospital, Timika, Papua, Indonesia"
],
"type": "Organization"
},
"familyName": "Kenangalem",
"givenName": "Enny",
"type": "Person"
},
{
"affiliation": {
"name": [
"Mitra Masyarakat Hospital, Timika, Indonesia"
],
"type": "Organization"
},
"familyName": "Hasanuddin",
"givenName": "Afdhal",
"type": "Person"
},
{
"affiliation": {
"name": [
"Timika Malaria Research Programme, Papuan Health and Community Development Foundation, Timika, Papua, Indonesia"
],
"type": "Organization"
},
"familyName": "Lampah",
"givenName": "Daniel A.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Charles Darwin University",
"id": "https://www.grid.ac/institutes/grid.1043.6",
"name": [
"Global Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia"
],
"type": "Organization"
},
"familyName": "Thriemer",
"givenName": "Kamala",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Royal Darwin Hospital",
"id": "https://www.grid.ac/institutes/grid.240634.7",
"name": [
"Global Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia",
"Division of Medicine, Royal Darwin Hospital, Darwin, NT, Australia"
],
"type": "Organization"
},
"familyName": "Anstey",
"givenName": "Nicholas M.",
"type": "Person"
},
{
"affiliation": {
"name": [
"Mitra Masyarakat Hospital, Timika, Indonesia"
],
"type": "Organization"
},
"familyName": "Sugiarto",
"givenName": "Paulus",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Melbourne",
"id": "https://www.grid.ac/institutes/grid.1008.9",
"name": [
"Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia"
],
"type": "Organization"
},
"familyName": "Simpson",
"givenName": "Julie A.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Mahidol University",
"id": "https://www.grid.ac/institutes/grid.10223.32",
"name": [
"Global Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia",
"Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK",
"Mahidol-Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand"
],
"type": "Organization"
},
"familyName": "Price",
"givenName": "Ric N.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Royal Darwin Hospital",
"id": "https://www.grid.ac/institutes/grid.240634.7",
"name": [
"Global Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia",
"Division of Medicine, Royal Darwin Hospital, Darwin, NT, Australia"
],
"type": "Organization"
},
"familyName": "Douglas",
"givenName": "Nicholas M.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Gadjah Mada University",
"id": "https://www.grid.ac/institutes/grid.8570.a",
"name": [
"Department of Child Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia",
"Timika Malaria Research Programme, Papuan Health and Community Development Foundation, Timika, Papua, Indonesia",
"Mimika District Hospital, Timika, Papua, Indonesia"
],
"type": "Organization"
},
"familyName": "Poespoprodjo",
"givenName": "Jeanne R.",
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1186/1475-2875-13-418",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000054784",
"https://doi.org/10.1186/1475-2875-13-418"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1086/599041",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006095350"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s12936-016-1588-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006419733",
"https://doi.org/10.1186/s12936-016-1588-8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s12936-016-1588-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006419733",
"https://doi.org/10.1186/s12936-016-1588-8"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/qco.0b013e32832f14c1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008828424"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/qco.0b013e32832f14c1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008828424"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/qco.0b013e32832f14c1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008828424"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pmed.1001575",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022554382"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pmed.1001339",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023509008"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pmed.1001891",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029383487"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1475-2875-8-230",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032558965",
"https://doi.org/10.1186/1475-2875-8-230"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s12916-014-0217-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032660452",
"https://doi.org/10.1186/s12916-014-0217-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s12916-014-0217-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032660452",
"https://doi.org/10.1186/s12916-014-0217-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1475-2875-7-148",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034926835",
"https://doi.org/10.1186/1475-2875-7-148"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0035-9203(96)90406-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036467758"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s12936-016-1373-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039829739",
"https://doi.org/10.1186/s12936-016-1373-8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s12936-016-1373-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039829739",
"https://doi.org/10.1186/s12936-016-1373-8"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(08)60073-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041111007"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/b978-0-12-407826-0.00004-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042166376"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pntd.0003602",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044851624"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.pt.2009.02.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049068624"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1475-2875-11-280",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049952095",
"https://doi.org/10.1186/1475-2875-11-280"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.trstmh.2006.06.008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1054751347"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1079144580",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4269/ajtmh.1997.56.621",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083120053"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4269/ajtmh.1998.59.252",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083309441"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pmed.1002379",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1091377267"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4269/ajtmh.17-0680",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1100099310"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4269/ajtmh.17-0680",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1100099310"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-12",
"datePublishedReg": "2019-12-01",
"description": "BACKGROUND: Primaquine (PQ) prevents relapses of vivax malaria but may induce severe haemolysis in glucose-6-phosphate dehydrogenase (G6PD) deficient patients. Data on the safety of primaquine in infants are limited.\nMETHODS: A retrospective, hospital-based cohort study of infants aged 1-12\u00a0months with vivax malaria was carried out in Timika, Papua province, Indonesia. Risks of admission, death and severe haematological outcomes within 30\u00a0days of first presentation were compared between infants who did and did not receive primaquine. Infants were not tested routinely for G6PD deficiency as per local guidelines.\nRESULTS: Between 2004 and 2013, 4078 infants presented to the hospital for the first time with vivax malaria, of whom 3681 (90.3%) had data available for analysis. In total 1228 (33.4%) infants were aged between 1 and 6\u00a0months and 2453 (66.6%) between 6 and 12\u00a0months of age. Thirty-three (0.9%) patients received low-dose primaquine (LDP), 174 (4.7%) received high-dose primaquine (HDP), 3432 (93.2%) received no primaquine (NPQ) and 42 patients received either a single dose or an unknown dose of primaquine. The risk of the Hb concentration falling by\u2009>\u200925% to less than 5\u00a0g/dL was similar in the LDP or HDP groups (4.3%, 1/23) versus the NPQ group (3.5%, 16/461). Three infants (1.4%) died following receipt of PQ, all of whom had major comorbidities. Seventeen patients (0.5%) died in the NPQ group. None of the infants had documented massive haemolysis or renal impairment.\nCONCLUSIONS: Severe clinical outcomes amongst infants treated with primaquine in Papua were rare. The risks of using primaquine in infancy must be weighed against the risks of recurrent vivax malaria in early life.",
"genre": "research_article",
"id": "sg:pub.10.1186/s12936-019-2745-7",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.3638128",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.7676256",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.6731900",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.7676255",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1030597",
"issn": [
"1475-2875"
],
"name": "Malaria Journal",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "18"
}
],
"name": "Safety of primaquine in infants with Plasmodium vivax malaria in Papua, Indonesia",
"pagination": "111",
"productId": [
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1186/s12936-019-2745-7"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1113179479"
]
},
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"2064ccdf1bbaceb301b3f84a40a96183689a3ac41c66ccd1ef7a045ddf9c77f4"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101139802"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30940140"
]
}
],
"sameAs": [
"https://doi.org/10.1186/s12936-019-2745-7",
"https://app.dimensions.ai/details/publication/pub.1113179479"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-16T06:24",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000377_0000000377/records_106831_00000002.jsonl",
"type": "ScholarlyArticle",
"url": "https://link.springer.com/10.1186%2Fs12936-019-2745-7"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12936-019-2745-7'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12936-019-2745-7'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12936-019-2745-7'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12936-019-2745-7'
This table displays all metadata directly associated to this object as RDF triples.
242 TRIPLES
21 PREDICATES
52 URIs
21 LITERALS
9 BLANK NODES