Biology of Plasmodium falciparum gametocyte sex ratio and implications in malaria parasite transmission View Full Text


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Article Info

DATE

2019-03-12

AUTHORS

Noëlie Béré Henry, Samuel Sindié Sermé, Giulia Siciliano, Salif Sombié, Amidou Diarra, N’fale Sagnon, Alfred S. Traoré, Sodiomon Bienvenu Sirima, Issiaka Soulama, Pietro Alano

ABSTRACT

While significant advances have been made in understanding Plasmodium falciparum gametocyte biology and its relationship with malaria parasite transmission, the gametocyte sex ratio contribution to this process still remains a relevant research question. The present review discusses the biology of sex determination in P. falciparum, the underlying host and parasite factors, the sex specific susceptibility to drugs, the effect of sex ratio dynamics on malaria parasite transmission and the development of gametocyte sex specific diagnosis tools. Despite the inherent differences across several studies and approaches, the emerging picture highlights a potentially relevant contribution of the P. falciparum gametocyte sex ratio in the modulation of malaria parasite transmission. The increasing availability of molecular methods to measure gametocyte sex ratio will enable evaluation of important parameters, such as the impact of drug treatment on gametocyte sex ratio in vitro and in vivo as well as the changes of gametocyte sex ratios in natural infections, key steps towards elucidating how these parameters affect parasite infectiousness to the mosquito vectors. More... »

PAGES

70

References to SciGraph publications

  • 2014-12-09. Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria in MALARIA JOURNAL
  • 2017-11-17. Detection of Plasmodium falciparum male and female gametocytes and determination of parasite sex ratio in human endemic populations by novel, cheap and robust RTqPCR assays in MALARIA JOURNAL
  • 2018-11-29. A multiplex assay for the sensitive detection and quantification of male and female Plasmodium falciparum gametocytes in MALARIA JOURNAL
  • 2018-11-26. Revisiting the initial steps of sexual development in the malaria parasite Plasmodium falciparum in NATURE MICROBIOLOGY
  • 2008-05. Sex ratio adjustment and kin discrimination in malaria parasites in NATURE
  • 2015-08-28. Specific expression and export of the Plasmodium falciparum Gametocyte EXported Protein-5 marks the gametocyte ring stage in MALARIA JOURNAL
  • 2018-09-03. Inducible developmental reprogramming redefines commitment to sexual development in the malaria parasite Plasmodium berghei in NATURE MICROBIOLOGY
  • 2008-07-09. Reduction of transmission from malaria patients by artemisinin combination therapies: a pooled analysis of six randomized trials in MALARIA JOURNAL
  • 2017-02-23. Malaria parasite clearance in MALARIA JOURNAL
  • 2003-02-10. Structure of a gametocyte protein essential for sexual development in Plasmodium falciparum in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2014-03-26. Information use and plasticity in the reproductive decisions of malaria parasites in MALARIA JOURNAL
  • 2014-02-23. A transcriptional switch underlies commitment to sexual development in malaria parasites in NATURE
  • 2008-09-02. Plasmodium falciparum gametocyte sex ratios in children with acute, symptomatic, uncomplicated infections treated with amodiaquine in MALARIA JOURNAL
  • Identifiers

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    http://scigraph.springernature.com/pub.10.1186/s12936-019-2707-0

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    http://dx.doi.org/10.1186/s12936-019-2707-0

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30866941


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    61 malaria parasite transmission
    62 method
    63 modulation
    64 molecular methods
    65 mosquito vectors
    66 natural infection
    67 parameters
    68 parasite factors
    69 parasite transmission
    70 picture
    71 present review
    72 process
    73 questions
    74 ratio
    75 ratio contribution
    76 ratio dynamics
    77 relationship
    78 relevant contribution
    79 relevant research questions
    80 research questions
    81 review
    82 sex determination
    83 sex ratio
    84 sex ratio dynamics
    85 sex-specific susceptibility
    86 significant advances
    87 specific diagnosis tools
    88 specific susceptibility
    89 step
    90 study
    91 susceptibility
    92 tool
    93 transmission
    94 treatment
    95 vector
    96 vitro
    97 vivo
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