Unexpected high circulation of Plasmodium vivax in asymptomatic children from Kédougou, southeastern Senegal View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Makhtar Niang, Fode Diop, Oulimata Niang, Bacary D. Sadio, Abdourahmane Sow, Ousmane Faye, Mawlouth Diallo, Amadou A. Sall, Ronald Perraut, Aissatou Toure-Balde

ABSTRACT

BACKGROUND: Malaria in Senegal is due essentially to infections by Plasmodium falciparum and, to a lesser extent to Plasmodium malariae and Plasmodium ovale. By the use of molecular methods, detection of Plasmodium vivax has been recently reported in the region of Kedougou, raising the question of appraisal of its potential prevalence in this setting. METHODS: A retrospective serological study was carried out using 188 samples taken from 2010 to 2011 in a longitudinal school survey during which 48 asymptomatic children (9-11 years) were recruited. Four collections of samples collected during two successive dry and rainy seasons were analysed for antibody responses to P. vivax and P. falciparum. Recombinant P. falciparum and P. vivax MSP1 antigens and total P. falciparum schizont lysate from African 07/03 strain (adapted to culture) were used for ELISA. Nested PCR amplification was used for molecular detection of P. vivax. RESULTS: A surprising high prevalence of IgG responses against P. vivax MSP1 was evidenced with 53% of positive samples and 58% of the individuals that were found positive to this antigen. There was 77% of responders to P. falciparum outlined by 63% of positive samples. Prevalence of responders did not differ as function of seasons. Levels of antibodies to P. falciparum fluctuated with significant increasing between dry and rainy season (P < 0.05), contrary to responses to P. vivax. There was a significant reciprocal relationship (P < 10-3) between antibody responses to the different antigens, but with weak coefficient of correlation (Rho around 0.3) underlining a variable profile at the individual level. Clear molecular signature was found in positive IgG to P. vivax msp1 samples by PCR. CONCLUSION: This cross-sectional longitudinal study highlights the unexpected high circulation of P. vivax in this endemic area. Sero-immunology and molecular methods are powerful additive tools to identify endemic sites where relevant control measures have to be settled and monitored. More... »

PAGES

497

References to SciGraph publications

  • 2013-12. Severe Plasmodium falciparum and Plasmodium vivax malaria among adults at Kassala Hospital, eastern Sudan in MALARIA JOURNAL
  • 2017-12. Evidence of non-Plasmodium falciparum malaria infection in Kédougou, Sénégal in MALARIA JOURNAL
  • 2016-12. The hide and seek of Plasmodium vivax in West Africa: report from a large-scale study in Beninese asymptomatic subjects in MALARIA JOURNAL
  • 2016-12. Geographical patterns of malaria transmission based on serological markers for falciparum and vivax malaria in Ratanakiri, Cambodia in MALARIA JOURNAL
  • 2009-12. Comparison of surveillance methods applied to a situation of low malaria prevalence at rural sites in The Gambia and Guinea Bissau in MALARIA JOURNAL
  • 2008-12. Failure to detect Plasmodium vivax in West and Central Africa by PCR species typing in MALARIA JOURNAL
  • 2015-12. The value of local malaria strains for serological studies: local strains versus Palo Alto reference strain in MALARIA JOURNAL
  • 2016-12. Seroepidemiology of Plasmodium species infections in Zimbabwean population in MALARIA JOURNAL
  • 2016-12. Concurrent malaria and arbovirus infections in Kedougou, southeastern Senegal in MALARIA JOURNAL
  • 2017-12. Molecular evidence of Plasmodium vivax infection in Duffy negative symptomatic individuals from Dschang, West Cameroon in MALARIA JOURNAL
  • 2014-12. Molecular typing reveals substantial Plasmodium vivax infection in asymptomatic adults in a rural area of Cameroon in MALARIA JOURNAL
  • 2015-12. A molecular survey of acute febrile illnesses reveals Plasmodium vivax infections in Kedougou, southeastern Senegal in MALARIA JOURNAL
  • 2016-12. Genetic diversity of Plasmodium falciparum isolates from concurrent malaria and arbovirus co-infections in Kedougou, southeastern Senegal in MALARIA JOURNAL
  • 2015-12. Serology describes a profile of declining malaria transmission in Farafenni, The Gambia in MALARIA JOURNAL
  • 2011-12. Vivax malaria in Mauritania includes infection of a Duffy-negative individual in MALARIA JOURNAL
  • 2015-12. A systematic review of sub-microscopic Plasmodium vivax infection in MALARIA JOURNAL
  • 2014-12. Comparative analysis of IgG responses to Plasmodium falciparum MSP1p19 and PF13-DBL1α1 using ELISA and a magnetic bead-based duplex assay (MAGPIX®-Luminex) in a Senegalese meso-endemic community in MALARIA JOURNAL
  • 2014-12. Dramatic declines in seropositivity as determined with crude extracts of Plasmodium falciparum schizonts between 2000 and 2010 in Dielmo and Ndiop, Senegal in MALARIA JOURNAL
  • 2008-12. Cohort study of the association of antibody levels to AMA1, MSP119, MSP3 and GLURP with protection from clinical malaria in Ghanaian children in MALARIA JOURNAL
  • Journal

    TITLE

    Malaria Journal

    ISSUE

    1

    VOLUME

    16

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12936-017-2146-8

    DOI

    http://dx.doi.org/10.1186/s12936-017-2146-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1100103443

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29284488


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical Microbiology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Institut Pasteur de Dakar", 
              "id": "https://www.grid.ac/institutes/grid.418508.0", 
              "name": [
                "Immunology Unit, Institut Pasteur de Dakar, Dakar, Senegal"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Niang", 
            "givenName": "Makhtar", 
            "id": "sg:person.015210622144.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015210622144.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut Pasteur de Dakar", 
              "id": "https://www.grid.ac/institutes/grid.418508.0", 
              "name": [
                "Immunology Unit, Institut Pasteur de Dakar, Dakar, Senegal"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Diop", 
            "givenName": "Fode", 
            "id": "sg:person.0717575256.84", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717575256.84"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut Pasteur de Dakar", 
              "id": "https://www.grid.ac/institutes/grid.418508.0", 
              "name": [
                "Immunology Unit, Institut Pasteur de Dakar, Dakar, Senegal"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Niang", 
            "givenName": "Oulimata", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut Pasteur de Dakar", 
              "id": "https://www.grid.ac/institutes/grid.418508.0", 
              "name": [
                "Arbovirus and Viral Hemorrhagic Fevers Unit, Institut Pasteur de Dakar, Dakar, Senegal"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sadio", 
            "givenName": "Bacary D.", 
            "id": "sg:person.016145262213.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016145262213.56"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut Pasteur de Dakar", 
              "id": "https://www.grid.ac/institutes/grid.418508.0", 
              "name": [
                "Arbovirus and Viral Hemorrhagic Fevers Unit, Institut Pasteur de Dakar, Dakar, Senegal", 
                "West African Health Organization, Ouagadougou, Burkina Faso"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sow", 
            "givenName": "Abdourahmane", 
            "id": "sg:person.01337143361.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337143361.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut Pasteur de Dakar", 
              "id": "https://www.grid.ac/institutes/grid.418508.0", 
              "name": [
                "Arbovirus and Viral Hemorrhagic Fevers Unit, Institut Pasteur de Dakar, Dakar, Senegal"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Faye", 
            "givenName": "Ousmane", 
            "id": "sg:person.0751331564.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751331564.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut Pasteur de Dakar", 
              "id": "https://www.grid.ac/institutes/grid.418508.0", 
              "name": [
                "Medical Entomology Unit, Institut Pasteur de Dakar, Dakar, Senegal"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Diallo", 
            "givenName": "Mawlouth", 
            "id": "sg:person.0712007366.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712007366.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut Pasteur de Dakar", 
              "id": "https://www.grid.ac/institutes/grid.418508.0", 
              "name": [
                "Arbovirus and Viral Hemorrhagic Fevers Unit, Institut Pasteur de Dakar, Dakar, Senegal"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sall", 
            "givenName": "Amadou A.", 
            "id": "sg:person.0575401220.81", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575401220.81"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut Pasteur de Dakar", 
              "id": "https://www.grid.ac/institutes/grid.418508.0", 
              "name": [
                "Immunology Unit, Institut Pasteur de Dakar, Dakar, Senegal"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Perraut", 
            "givenName": "Ronald", 
            "id": "sg:person.01241074662.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241074662.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut Pasteur de Dakar", 
              "id": "https://www.grid.ac/institutes/grid.418508.0", 
              "name": [
                "Immunology Unit, Institut Pasteur de Dakar, Dakar, Senegal"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Toure-Balde", 
            "givenName": "Aissatou", 
            "id": "sg:person.0757756450.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757756450.54"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1073/pnas.0912496107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000730824"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.88.9.4030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001352776"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1097-2765(00)80473-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001608061"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1286-4579(01)01506-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003065252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0035-9203(76)90132-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004591140"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-4894(76)90075-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004894395"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pmed.1001165", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005217873"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1475-2875-8-274", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006218439", 
              "https://doi.org/10.1186/1475-2875-8-274"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12936-016-1661-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006696871", 
              "https://doi.org/10.1186/s12936-016-1661-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12936-016-1661-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006696871", 
              "https://doi.org/10.1186/s12936-016-1661-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/426398", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007154831"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molbiopara.2005.02.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007324637"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molbiopara.2005.02.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007324637"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0001-706x(00)00181-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009137490"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0067108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009931987"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12936-015-0808-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011571041", 
              "https://doi.org/10.1186/s12936-015-0808-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-2836(03)00376-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011584488"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-2836(03)00376-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011584488"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/644510", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017367600"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0103262", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017560447"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.pt.2006.06.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017927717"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0166-6851(93)90050-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019696782"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0166-6851(93)90050-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019696782"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.vaccine.2006.04.069", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020219750"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0065-308x(09)69005-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021541894"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1475-2875-12-148", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022623291", 
              "https://doi.org/10.1186/1475-2875-12-148"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12936-016-1325-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025460871", 
              "https://doi.org/10.1186/s12936-016-1325-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1475-2875-7-174", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027411215", 
              "https://doi.org/10.1186/1475-2875-7-174"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pntd.0001192", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027994239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12936-015-0884-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031830037", 
              "https://doi.org/10.1186/s12936-015-0884-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1475-2875-7-142", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039058645", 
              "https://doi.org/10.1186/1475-2875-7-142"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pmed.1000218", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039249999"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm197608052950602", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040042587"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12936-016-1100-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040428946", 
              "https://doi.org/10.1186/s12936-016-1100-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/b978-0-12-397900-1.00001-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040585523"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12936-015-0734-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040858520", 
              "https://doi.org/10.1186/s12936-015-0734-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12936-015-0734-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040858520", 
              "https://doi.org/10.1186/s12936-015-0734-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12936-016-1620-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042422737", 
              "https://doi.org/10.1186/s12936-016-1620-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12936-016-1620-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042422737", 
              "https://doi.org/10.1186/s12936-016-1620-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pntd.0001814", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043256627"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12936-016-1208-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043270993", 
              "https://doi.org/10.1186/s12936-016-1208-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12936-015-0939-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044473517", 
              "https://doi.org/10.1186/s12936-015-0939-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1475-2875-13-83", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044799355", 
              "https://doi.org/10.1186/1475-2875-13-83"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1475-2875-10-336", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045312341", 
              "https://doi.org/10.1186/1475-2875-10-336"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1475-2875-13-410", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045424953", 
              "https://doi.org/10.1186/1475-2875-13-410"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.pt.2009.02.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049068624"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1475-2875-13-170", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050345277", 
              "https://doi.org/10.1186/1475-2875-13-170"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1749-6632.2001.tb03891.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050645398"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/trstmh/trt016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050775590"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12936-016-1558-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050838039", 
              "https://doi.org/10.1186/s12936-016-1558-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12936-016-1558-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050838039", 
              "https://doi.org/10.1186/s12936-016-1558-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/652456", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053741964"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.trstmh.2007.04.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054751465"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4269/ajtmh.1999.60.183", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074262483"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4269/ajtmh.2001.64.97", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074840495"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4269/ajtmh.2006.75.575", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077308791"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4269/ajtmh.2007.77.444", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077479414"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.1300778", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078744889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4269/ajtmh.1996.54.449", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082891943"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083237915", 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12936-017-1722-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083825878", 
              "https://doi.org/10.1186/s12936-017-1722-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12936-017-1722-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083825878", 
              "https://doi.org/10.1186/s12936-017-1722-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0172899", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084293093"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0179146", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085993577"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4269/ajtmh.17-0254", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090917393"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-12", 
        "datePublishedReg": "2017-12-01", 
        "description": "BACKGROUND: Malaria in Senegal is due essentially to infections by Plasmodium falciparum and, to a lesser extent to Plasmodium malariae and Plasmodium ovale. By the use of molecular methods, detection of Plasmodium vivax has been recently reported in the region of Kedougou, raising the question of appraisal of its potential prevalence in this setting.\nMETHODS: A retrospective serological study was carried out using 188 samples taken from 2010 to 2011 in a longitudinal school survey during which 48 asymptomatic children (9-11\u00a0years) were recruited. Four collections of samples collected during two successive dry and rainy seasons were analysed for antibody responses to P. vivax and P. falciparum. Recombinant P. falciparum and P. vivax MSP1 antigens and total P. falciparum schizont lysate from African 07/03 strain (adapted to culture) were used for ELISA. Nested PCR amplification was used for molecular detection of P. vivax.\nRESULTS: A surprising high prevalence of IgG responses against P. vivax MSP1 was evidenced with 53% of positive samples and 58% of the individuals that were found positive to this antigen. There was 77% of responders to P. falciparum outlined by 63% of positive samples. Prevalence of responders did not differ as function of seasons. Levels of antibodies to P. falciparum fluctuated with significant increasing between dry and rainy season (P\u00a0<\u00a00.05), contrary to responses to P. vivax. There was a significant reciprocal relationship (P\u00a0<\u00a010-3) between antibody responses to the different antigens, but with weak coefficient of correlation (Rho around 0.3) underlining a variable profile at the individual level. Clear molecular signature was found in positive IgG to P. vivax msp1 samples by PCR.\nCONCLUSION: This cross-sectional longitudinal study highlights the unexpected high circulation of P. vivax in this endemic area. Sero-immunology and molecular methods are powerful additive tools to identify endemic sites where relevant control measures have to be settled and monitored.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/s12936-017-2146-8", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1030597", 
            "issn": [
              "1475-2875"
            ], 
            "name": "Malaria Journal", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "16"
          }
        ], 
        "name": "Unexpected high circulation of Plasmodium vivax in asymptomatic children from K\u00e9dougou, southeastern Senegal", 
        "pagination": "497", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "6c14b1bb0853af2ddc0ec5c8442c44cd5f6dccba13ae572ab9ae850645246f00"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "29284488"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101139802"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s12936-017-2146-8"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1100103443"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s12936-017-2146-8", 
          "https://app.dimensions.ai/details/publication/pub.1100103443"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T01:03", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000493.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1186/s12936-017-2146-8"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12936-017-2146-8'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12936-017-2146-8'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12936-017-2146-8'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12936-017-2146-8'


     

    This table displays all metadata directly associated to this object as RDF triples.

    322 TRIPLES      21 PREDICATES      86 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s12936-017-2146-8 schema:about anzsrc-for:11
    2 anzsrc-for:1108
    3 schema:author Na42b05b70c864f8098a79af3cf86b3db
    4 schema:citation sg:pub.10.1186/1475-2875-10-336
    5 sg:pub.10.1186/1475-2875-12-148
    6 sg:pub.10.1186/1475-2875-13-170
    7 sg:pub.10.1186/1475-2875-13-410
    8 sg:pub.10.1186/1475-2875-13-83
    9 sg:pub.10.1186/1475-2875-7-142
    10 sg:pub.10.1186/1475-2875-7-174
    11 sg:pub.10.1186/1475-2875-8-274
    12 sg:pub.10.1186/s12936-015-0734-z
    13 sg:pub.10.1186/s12936-015-0808-y
    14 sg:pub.10.1186/s12936-015-0884-z
    15 sg:pub.10.1186/s12936-015-0939-1
    16 sg:pub.10.1186/s12936-016-1100-5
    17 sg:pub.10.1186/s12936-016-1208-7
    18 sg:pub.10.1186/s12936-016-1325-3
    19 sg:pub.10.1186/s12936-016-1558-1
    20 sg:pub.10.1186/s12936-016-1620-z
    21 sg:pub.10.1186/s12936-016-1661-3
    22 sg:pub.10.1186/s12936-017-1722-2
    23 https://app.dimensions.ai/details/publication/pub.1083237915
    24 https://doi.org/10.1016/0014-4894(76)90075-8
    25 https://doi.org/10.1016/0035-9203(76)90132-2
    26 https://doi.org/10.1016/0166-6851(93)90050-8
    27 https://doi.org/10.1016/b978-0-12-397900-1.00001-3
    28 https://doi.org/10.1016/j.molbiopara.2005.02.009
    29 https://doi.org/10.1016/j.pt.2006.06.006
    30 https://doi.org/10.1016/j.pt.2009.02.003
    31 https://doi.org/10.1016/j.trstmh.2007.04.011
    32 https://doi.org/10.1016/j.vaccine.2006.04.069
    33 https://doi.org/10.1016/s0001-706x(00)00181-9
    34 https://doi.org/10.1016/s0022-2836(03)00376-0
    35 https://doi.org/10.1016/s0065-308x(09)69005-9
    36 https://doi.org/10.1016/s1097-2765(00)80473-6
    37 https://doi.org/10.1016/s1286-4579(01)01506-4
    38 https://doi.org/10.1056/nejm197608052950602
    39 https://doi.org/10.1073/pnas.0912496107
    40 https://doi.org/10.1073/pnas.88.9.4030
    41 https://doi.org/10.1086/426398
    42 https://doi.org/10.1086/644510
    43 https://doi.org/10.1086/652456
    44 https://doi.org/10.1093/trstmh/trt016
    45 https://doi.org/10.1111/j.1749-6632.2001.tb03891.x
    46 https://doi.org/10.1371/journal.pmed.1000218
    47 https://doi.org/10.1371/journal.pmed.1001165
    48 https://doi.org/10.1371/journal.pntd.0001192
    49 https://doi.org/10.1371/journal.pntd.0001814
    50 https://doi.org/10.1371/journal.pone.0067108
    51 https://doi.org/10.1371/journal.pone.0103262
    52 https://doi.org/10.1371/journal.pone.0172899
    53 https://doi.org/10.1371/journal.pone.0179146
    54 https://doi.org/10.4049/jimmunol.1300778
    55 https://doi.org/10.4269/ajtmh.17-0254
    56 https://doi.org/10.4269/ajtmh.1996.54.449
    57 https://doi.org/10.4269/ajtmh.1999.60.183
    58 https://doi.org/10.4269/ajtmh.2001.64.97
    59 https://doi.org/10.4269/ajtmh.2006.75.575
    60 https://doi.org/10.4269/ajtmh.2007.77.444
    61 schema:datePublished 2017-12
    62 schema:datePublishedReg 2017-12-01
    63 schema:description BACKGROUND: Malaria in Senegal is due essentially to infections by Plasmodium falciparum and, to a lesser extent to Plasmodium malariae and Plasmodium ovale. By the use of molecular methods, detection of Plasmodium vivax has been recently reported in the region of Kedougou, raising the question of appraisal of its potential prevalence in this setting. METHODS: A retrospective serological study was carried out using 188 samples taken from 2010 to 2011 in a longitudinal school survey during which 48 asymptomatic children (9-11 years) were recruited. Four collections of samples collected during two successive dry and rainy seasons were analysed for antibody responses to P. vivax and P. falciparum. Recombinant P. falciparum and P. vivax MSP1 antigens and total P. falciparum schizont lysate from African 07/03 strain (adapted to culture) were used for ELISA. Nested PCR amplification was used for molecular detection of P. vivax. RESULTS: A surprising high prevalence of IgG responses against P. vivax MSP1 was evidenced with 53% of positive samples and 58% of the individuals that were found positive to this antigen. There was 77% of responders to P. falciparum outlined by 63% of positive samples. Prevalence of responders did not differ as function of seasons. Levels of antibodies to P. falciparum fluctuated with significant increasing between dry and rainy season (P < 0.05), contrary to responses to P. vivax. There was a significant reciprocal relationship (P < 10-3) between antibody responses to the different antigens, but with weak coefficient of correlation (Rho around 0.3) underlining a variable profile at the individual level. Clear molecular signature was found in positive IgG to P. vivax msp1 samples by PCR. CONCLUSION: This cross-sectional longitudinal study highlights the unexpected high circulation of P. vivax in this endemic area. Sero-immunology and molecular methods are powerful additive tools to identify endemic sites where relevant control measures have to be settled and monitored.
    64 schema:genre research_article
    65 schema:inLanguage en
    66 schema:isAccessibleForFree true
    67 schema:isPartOf N8176d06bdba04afb97402853497d549b
    68 Ncb986a8cb48e4a938b12f1d3e176cb07
    69 sg:journal.1030597
    70 schema:name Unexpected high circulation of Plasmodium vivax in asymptomatic children from Kédougou, southeastern Senegal
    71 schema:pagination 497
    72 schema:productId N1a7d488703044580b62b2aa972dd6f27
    73 N6914eb26f3a94ab2a3d2d6610a201418
    74 N7b4783a2b74147d590d29a1635f12777
    75 Nb6adddc626cc415e96a4fc822475a43a
    76 Ne4bbb85418cf4eef8ee02cace188fb56
    77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100103443
    78 https://doi.org/10.1186/s12936-017-2146-8
    79 schema:sdDatePublished 2019-04-11T01:03
    80 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    81 schema:sdPublisher Nc74758f284fa40d4b38d83dab991424a
    82 schema:url http://link.springer.com/10.1186/s12936-017-2146-8
    83 sgo:license sg:explorer/license/
    84 sgo:sdDataset articles
    85 rdf:type schema:ScholarlyArticle
    86 N1a7d488703044580b62b2aa972dd6f27 schema:name readcube_id
    87 schema:value 6c14b1bb0853af2ddc0ec5c8442c44cd5f6dccba13ae572ab9ae850645246f00
    88 rdf:type schema:PropertyValue
    89 N3b47821c54f34f0ea1696d1a7c0f5a9f rdf:first sg:person.016145262213.56
    90 rdf:rest N50d61f958c044035ba7328e3cddef280
    91 N4235ae95a69b43598b2c53b43b258cb6 rdf:first sg:person.0751331564.53
    92 rdf:rest N7300326c55514c6fbf597204f5e52e49
    93 N50d61f958c044035ba7328e3cddef280 rdf:first sg:person.01337143361.31
    94 rdf:rest N4235ae95a69b43598b2c53b43b258cb6
    95 N51813da29dfb47fe91585bde38164301 schema:affiliation https://www.grid.ac/institutes/grid.418508.0
    96 schema:familyName Niang
    97 schema:givenName Oulimata
    98 rdf:type schema:Person
    99 N6914eb26f3a94ab2a3d2d6610a201418 schema:name doi
    100 schema:value 10.1186/s12936-017-2146-8
    101 rdf:type schema:PropertyValue
    102 N6d6349fd421a40c994ce74e00090e1c8 rdf:first sg:person.01241074662.04
    103 rdf:rest Necf7582e14c742db84ae400b05482068
    104 N7300326c55514c6fbf597204f5e52e49 rdf:first sg:person.0712007366.13
    105 rdf:rest Na9c146d6390041939902ff147b3f94a7
    106 N7b4783a2b74147d590d29a1635f12777 schema:name pubmed_id
    107 schema:value 29284488
    108 rdf:type schema:PropertyValue
    109 N7ea6cb6db1fd470ea850af580c9b0300 rdf:first sg:person.0717575256.84
    110 rdf:rest Ndc1551dd538746dca4d2ff3935545d20
    111 N8176d06bdba04afb97402853497d549b schema:volumeNumber 16
    112 rdf:type schema:PublicationVolume
    113 Na42b05b70c864f8098a79af3cf86b3db rdf:first sg:person.015210622144.63
    114 rdf:rest N7ea6cb6db1fd470ea850af580c9b0300
    115 Na9c146d6390041939902ff147b3f94a7 rdf:first sg:person.0575401220.81
    116 rdf:rest N6d6349fd421a40c994ce74e00090e1c8
    117 Nb6adddc626cc415e96a4fc822475a43a schema:name dimensions_id
    118 schema:value pub.1100103443
    119 rdf:type schema:PropertyValue
    120 Nc74758f284fa40d4b38d83dab991424a schema:name Springer Nature - SN SciGraph project
    121 rdf:type schema:Organization
    122 Ncb986a8cb48e4a938b12f1d3e176cb07 schema:issueNumber 1
    123 rdf:type schema:PublicationIssue
    124 Ndc1551dd538746dca4d2ff3935545d20 rdf:first N51813da29dfb47fe91585bde38164301
    125 rdf:rest N3b47821c54f34f0ea1696d1a7c0f5a9f
    126 Ne4bbb85418cf4eef8ee02cace188fb56 schema:name nlm_unique_id
    127 schema:value 101139802
    128 rdf:type schema:PropertyValue
    129 Necf7582e14c742db84ae400b05482068 rdf:first sg:person.0757756450.54
    130 rdf:rest rdf:nil
    131 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    132 schema:name Medical and Health Sciences
    133 rdf:type schema:DefinedTerm
    134 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
    135 schema:name Medical Microbiology
    136 rdf:type schema:DefinedTerm
    137 sg:journal.1030597 schema:issn 1475-2875
    138 schema:name Malaria Journal
    139 rdf:type schema:Periodical
    140 sg:person.01241074662.04 schema:affiliation https://www.grid.ac/institutes/grid.418508.0
    141 schema:familyName Perraut
    142 schema:givenName Ronald
    143 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241074662.04
    144 rdf:type schema:Person
    145 sg:person.01337143361.31 schema:affiliation https://www.grid.ac/institutes/grid.418508.0
    146 schema:familyName Sow
    147 schema:givenName Abdourahmane
    148 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337143361.31
    149 rdf:type schema:Person
    150 sg:person.015210622144.63 schema:affiliation https://www.grid.ac/institutes/grid.418508.0
    151 schema:familyName Niang
    152 schema:givenName Makhtar
    153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015210622144.63
    154 rdf:type schema:Person
    155 sg:person.016145262213.56 schema:affiliation https://www.grid.ac/institutes/grid.418508.0
    156 schema:familyName Sadio
    157 schema:givenName Bacary D.
    158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016145262213.56
    159 rdf:type schema:Person
    160 sg:person.0575401220.81 schema:affiliation https://www.grid.ac/institutes/grid.418508.0
    161 schema:familyName Sall
    162 schema:givenName Amadou A.
    163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575401220.81
    164 rdf:type schema:Person
    165 sg:person.0712007366.13 schema:affiliation https://www.grid.ac/institutes/grid.418508.0
    166 schema:familyName Diallo
    167 schema:givenName Mawlouth
    168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712007366.13
    169 rdf:type schema:Person
    170 sg:person.0717575256.84 schema:affiliation https://www.grid.ac/institutes/grid.418508.0
    171 schema:familyName Diop
    172 schema:givenName Fode
    173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717575256.84
    174 rdf:type schema:Person
    175 sg:person.0751331564.53 schema:affiliation https://www.grid.ac/institutes/grid.418508.0
    176 schema:familyName Faye
    177 schema:givenName Ousmane
    178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751331564.53
    179 rdf:type schema:Person
    180 sg:person.0757756450.54 schema:affiliation https://www.grid.ac/institutes/grid.418508.0
    181 schema:familyName Toure-Balde
    182 schema:givenName Aissatou
    183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757756450.54
    184 rdf:type schema:Person
    185 sg:pub.10.1186/1475-2875-10-336 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045312341
    186 https://doi.org/10.1186/1475-2875-10-336
    187 rdf:type schema:CreativeWork
    188 sg:pub.10.1186/1475-2875-12-148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022623291
    189 https://doi.org/10.1186/1475-2875-12-148
    190 rdf:type schema:CreativeWork
    191 sg:pub.10.1186/1475-2875-13-170 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050345277
    192 https://doi.org/10.1186/1475-2875-13-170
    193 rdf:type schema:CreativeWork
    194 sg:pub.10.1186/1475-2875-13-410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045424953
    195 https://doi.org/10.1186/1475-2875-13-410
    196 rdf:type schema:CreativeWork
    197 sg:pub.10.1186/1475-2875-13-83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044799355
    198 https://doi.org/10.1186/1475-2875-13-83
    199 rdf:type schema:CreativeWork
    200 sg:pub.10.1186/1475-2875-7-142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039058645
    201 https://doi.org/10.1186/1475-2875-7-142
    202 rdf:type schema:CreativeWork
    203 sg:pub.10.1186/1475-2875-7-174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027411215
    204 https://doi.org/10.1186/1475-2875-7-174
    205 rdf:type schema:CreativeWork
    206 sg:pub.10.1186/1475-2875-8-274 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006218439
    207 https://doi.org/10.1186/1475-2875-8-274
    208 rdf:type schema:CreativeWork
    209 sg:pub.10.1186/s12936-015-0734-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1040858520
    210 https://doi.org/10.1186/s12936-015-0734-z
    211 rdf:type schema:CreativeWork
    212 sg:pub.10.1186/s12936-015-0808-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1011571041
    213 https://doi.org/10.1186/s12936-015-0808-y
    214 rdf:type schema:CreativeWork
    215 sg:pub.10.1186/s12936-015-0884-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1031830037
    216 https://doi.org/10.1186/s12936-015-0884-z
    217 rdf:type schema:CreativeWork
    218 sg:pub.10.1186/s12936-015-0939-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044473517
    219 https://doi.org/10.1186/s12936-015-0939-1
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1186/s12936-016-1100-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040428946
    222 https://doi.org/10.1186/s12936-016-1100-5
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1186/s12936-016-1208-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043270993
    225 https://doi.org/10.1186/s12936-016-1208-7
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1186/s12936-016-1325-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025460871
    228 https://doi.org/10.1186/s12936-016-1325-3
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1186/s12936-016-1558-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050838039
    231 https://doi.org/10.1186/s12936-016-1558-1
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1186/s12936-016-1620-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1042422737
    234 https://doi.org/10.1186/s12936-016-1620-z
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1186/s12936-016-1661-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006696871
    237 https://doi.org/10.1186/s12936-016-1661-3
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1186/s12936-017-1722-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083825878
    240 https://doi.org/10.1186/s12936-017-1722-2
    241 rdf:type schema:CreativeWork
    242 https://app.dimensions.ai/details/publication/pub.1083237915 schema:CreativeWork
    243 https://doi.org/10.1016/0014-4894(76)90075-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004894395
    244 rdf:type schema:CreativeWork
    245 https://doi.org/10.1016/0035-9203(76)90132-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004591140
    246 rdf:type schema:CreativeWork
    247 https://doi.org/10.1016/0166-6851(93)90050-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019696782
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1016/b978-0-12-397900-1.00001-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040585523
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.1016/j.molbiopara.2005.02.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007324637
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.1016/j.pt.2006.06.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017927717
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.1016/j.pt.2009.02.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049068624
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.1016/j.trstmh.2007.04.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054751465
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1016/j.vaccine.2006.04.069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020219750
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1016/s0001-706x(00)00181-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009137490
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1016/s0022-2836(03)00376-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011584488
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1016/s0065-308x(09)69005-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021541894
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1016/s1097-2765(00)80473-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001608061
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1016/s1286-4579(01)01506-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003065252
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1056/nejm197608052950602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040042587
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1073/pnas.0912496107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000730824
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1073/pnas.88.9.4030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001352776
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1086/426398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007154831
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1086/644510 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017367600
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1086/652456 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053741964
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1093/trstmh/trt016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050775590
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1111/j.1749-6632.2001.tb03891.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050645398
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1371/journal.pmed.1000218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039249999
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1371/journal.pmed.1001165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005217873
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1371/journal.pntd.0001192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027994239
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1371/journal.pntd.0001814 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043256627
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1371/journal.pone.0067108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009931987
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1371/journal.pone.0103262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017560447
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1371/journal.pone.0172899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084293093
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1371/journal.pone.0179146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085993577
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.4049/jimmunol.1300778 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078744889
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.4269/ajtmh.17-0254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090917393
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.4269/ajtmh.1996.54.449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082891943
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.4269/ajtmh.1999.60.183 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074262483
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.4269/ajtmh.2001.64.97 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074840495
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.4269/ajtmh.2006.75.575 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077308791
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.4269/ajtmh.2007.77.444 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077479414
    316 rdf:type schema:CreativeWork
    317 https://www.grid.ac/institutes/grid.418508.0 schema:alternateName Institut Pasteur de Dakar
    318 schema:name Arbovirus and Viral Hemorrhagic Fevers Unit, Institut Pasteur de Dakar, Dakar, Senegal
    319 Immunology Unit, Institut Pasteur de Dakar, Dakar, Senegal
    320 Medical Entomology Unit, Institut Pasteur de Dakar, Dakar, Senegal
    321 West African Health Organization, Ouagadougou, Burkina Faso
    322 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...