Submicroscopic Plasmodium prevalence in relation to malaria incidence in 20 villages in western Cambodia View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Rupam Tripura, Thomas J. Peto, Christianne C. Veugen, Chea Nguon, Chan Davoeung, Nicola James, Mehul Dhorda, Richard J. Maude, Jureeporn Duanguppama, Krittaya Patumrat, Mallika Imwong, Lorenz von Seidlein, Martin P. Grobusch, Nicholas J. White, Arjen M. Dondorp

ABSTRACT

BACKGROUND: Cambodia has seen a marked reduction in the incidence of Plasmodium falciparum over the past decade without a corresponding decline in Plasmodium vivax incidence. It is unknown to what extent local transmission is sustained by a chain of clinical and sub-clinical infections or by continued re-introduction via migration. Using an ultrasensitive molecular technique, 20 villages in western Cambodia were surveyed to detect the low season prevalence of P. falciparum and P. vivax and local treatment records were reviewed. METHODS: During March to May 2015 cross-sectional surveys were conducted in 20 villages in Battambang, western Cambodia. Demographic and epidemiological data and venous blood samples were collected from 50 randomly selected adult volunteers in each village. Blood was tested for Plasmodium infections by rapid diagnostic test (RDT), microscopy and high volume (0.5 ml packed red blood cell) quantitative polymerase chain reaction (uPCR). Positive samples were analysed by nested PCR to determine the Plasmodium species. Malaria case records were collected from the Provincial Health Department and village malaria workers to determine incidence and migration status. RESULTS: Among the 1000 participants, 91 (9.1%) were positive for any Plasmodium infection by uPCR, seven (0.7%) by microscopy, and two (0.2%) by RDT. uPCR P. vivax prevalence was 6.6%, P. falciparum 0.7%, and undetermined Plasmodium species 1.8%. Being male (adjusted OR 2.0; 95% CI 1.2-3.4); being a young adult <30 years (aOR 2.1; 95% CI 1.3-3.4); recent forest travel (aOR 2.8; 95% CI 1.6-4.8); and, a history of malaria (aOR 5.2; 95% CI 2.5-10.7) were independent risk factors for parasitaemia. Of the clinical malaria cases diagnosed by village malaria workers, 43.9% (297/634) and 38.4% (201/523) were among migrants in 2013 and in 2014, respectively. Plasmodium vivax prevalence determined by uPCR significantly correlated with vivax malaria incidences in both 2014 and 2015 (p = 0.001 and 0.002, respectively), whereas no relationship was observed in falciparum malaria (p = 0.36 and p = 0.59, respectively). DISCUSSION: There was heterogeneity in the malaria parasite reservoir between villages, and Plasmodium prevalence correlated with subsequent malaria incidence. The association was attributable chiefly to P. vivax infections, which were nine-fold more prevalent than P. falciparum infections. In the absence of a radical cure with 8-aminoquinolines, P. vivax transmission will continue even as P. falciparum prevalence declines. Migration was associated with over a third of incident cases of clinical malaria. Trial registration clinicaltrials.gov (NCT01872702). Registered 4 June 2013. More... »

PAGES

56

References to SciGraph publications

  • 2015-12. The epidemiology of subclinical malaria infections in South-East Asia: findings from cross-sectional surveys in Thailand–Myanmar border areas, Cambodia, and Vietnam in MALARIA JOURNAL
  • 2016-12. History of malaria treatment as a predictor of subsequent subclinical parasitaemia: a cross-sectional survey and malaria case records from three villages in Pailin, western Cambodia in MALARIA JOURNAL
  • 2016-12. Persistent Plasmodium falciparum and Plasmodium vivax infections in a western Cambodian population: implications for prevention, treatment and elimination strategies in MALARIA JOURNAL
  • 2014-12. Spatial and temporal epidemiology of clinical malaria in Cambodia 2004–2013 in MALARIA JOURNAL
  • 2014-12. Spatial clustering and risk factors of malaria infections in Ratanakiri Province, Cambodia in MALARIA JOURNAL
  • 2010-12. Sub-microscopic malaria cases and mixed malaria infection in a remote area of high malaria endemicity in Rattanakiri province, Cambodia: implication for malaria elimination in MALARIA JOURNAL
  • 2009-12. The last man standing is the most resistant: eliminating artemisinin-resistant malaria in Cambodia in MALARIA JOURNAL
  • 2016-12. Asymptomatic Plasmodium infections in 18 villages of southern Savannakhet Province, Lao PDR (Laos) in MALARIA JOURNAL
  • 2010-12. Rapid and effective malaria control in Cambodia through mass administration of artemisinin-piperaquine in MALARIA JOURNAL
  • 2007-12. Large-scale malaria survey in Cambodia: Novel insights on species distribution and risk factors in MALARIA JOURNAL
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    http://scigraph.springernature.com/pub.10.1186/s12936-017-1703-5

    DOI

    http://dx.doi.org/10.1186/s12936-017-1703-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1083399611

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28143518


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