Serological markers to measure recent changes in malaria at population level in Cambodia View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Karen Kerkhof, Vincent Sluydts, Laura Willen, Saorin Kim, Lydie Canier, Somony Heng, Takafumi Tsuboi, Tho Sochantha, Siv Sovannaroth, Didier Ménard, Marc Coosemans, Lies Durnez

ABSTRACT

BACKGROUND: Serological markers for exposure to different Plasmodium species have recently been used in multiplex immunoassays based on the Luminex technology. However, interpretation of the assay results requires consideration of the half-life of specific antibodies against these markers. Therefore, the aim of the present study was to document the half-life of malaria specific serological makers, as well as assessing the sensitivity of these markers to pick up recent changes in malaria exposure. METHODS: A recently developed multiplex immunoassay was used to measure the intensity of antibody (Ab) responses against 19 different Plasmodium specific antigens, covering different human malaria parasites and two vector saliva antigens. Therefore, 8439 blood samples from five cross-sectional surveys in Ratanakiri, Cambodia, were analysed. These involve a random selection from two selected surveys, and an additional set of blood samples of individuals that were randomly re-sampled three, four or five times. A generalized estimating equation model and linear regression models were fitted on log transformed antibody intensity data. RESULTS: Results showed that most (17/21) Ab-responses are higher in PCR positive than PCR negative individuals. Furthermore, these antibody-responses follow the same upward trend within each age group. Estimation of the half-lives showed differences between serological markers that reflect short- (seasonal) and long-term (year round) transmission trends. Ab levels declined significantly together with a decrease of PCR prevalence in a group of malaria endemic villages. CONCLUSION: For Plasmodium falciparum, antibodies against LSA3.RE, GLURP and Pf.GLURP.R2 are most likely to be a reflexion of recent (range from 6 to 8 months) exposure in the Mekong Subregion. PvEBP is the only Plasmodium vivax Ag responding reasonably well, in spite of an estimated Ab half-life of more than 1 year. The use of Ab intensity data rather dichotomizing the continuous Ab-titre data (positive vs negative) will lead to an improved approach for serological surveillance. More... »

PAGES

529

References to SciGraph publications

  • 2014-12. Anti-sporozoite antibodies as alternative markers for malaria transmission intensity estimation in MALARIA JOURNAL
  • 2014-12. Age-specific malaria seroprevalence rates: a cross-sectional analysis of malaria transmission in the Ouest and Sud-Est departments of Haiti in MALARIA JOURNAL
  • 2014-12. Serological markers for monitoring historical changes in malaria transmission intensity in a highly endemic region of Western Kenya, 1994–2009 in MALARIA JOURNAL
  • 2014-12. Spatial clustering and risk factors of malaria infections in Ratanakiri Province, Cambodia in MALARIA JOURNAL
  • 2012-12. Sero-epidemiological evaluation of changes in Plasmodium falciparum and Plasmodium vivax transmission patterns over the rainy season in Cambodia in MALARIA JOURNAL
  • 2014-12. Malaria elimination without stigmatization: a note of caution about the use of terminology in elimination settings in MALARIA JOURNAL
  • 2010-12. A multiplex assay for the simultaneous detection of antibodies against 15 Plasmodium falciparum and Anopheles gambiae saliva antigens in MALARIA JOURNAL
  • 2008-12. A semi-automated multiplex high-throughput assay for measuring IgG antibodies against Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) domains in small volumes of plasma in MALARIA JOURNAL
  • 2010-12. Using serological measures to monitor changes in malaria transmission in Vanuatu in MALARIA JOURNAL
  • 2012-12. Outlier Detection using Projection Quantile Regression for Mass Spectrometry Data with Low Replication in BMC RESEARCH NOTES
  • 2012-12. Plasmodium vivax and Plasmodium falciparum infections in the Republic of Djibouti: evaluation of their prevalence and potential determinants in MALARIA JOURNAL
  • 2014-12. Spatial and temporal epidemiology of clinical malaria in Cambodia 2004–2013 in MALARIA JOURNAL
  • 2015-12. Implementation and application of a multiplex assay to detect malaria-specific antibodies: a promising tool for assessing malaria transmission in Southeast Asian pre-elimination areas in MALARIA JOURNAL
  • 2013-12. An innovative tool for moving malaria PCR detection of parasite reservoir into the field in MALARIA JOURNAL
  • 2012-12. Standardization and validation of a cytometric bead assay to assess antibodies to multiple Plasmodium falciparum recombinant antigens in MALARIA JOURNAL
  • 2012-12. Marked variation in MSP-119 antibody responses to malaria in western Kenyan highlands in BMC INFECTIOUS DISEASES
  • 2010-12. Naturally-acquired humoral immune responses against the N- and C-termini of the Plasmodium vivax MSP1 protein in endemic regions of Brazil and Papua New Guinea using a multiplex assay in MALARIA JOURNAL
  • 2015-12. Multiple comparisons analysis of serological data from an area of low Plasmodium falciparum transmission in MALARIA JOURNAL
  • 2015-12. Serology describes a profile of declining malaria transmission in Farafenni, The Gambia in MALARIA JOURNAL
  • 2013-12. Serological responses to a soluble recombinant chimeric Plasmodium vivax circumsporozoite protein in VK210 and VK247 population in MALARIA JOURNAL
  • 2014-12. Towards a comprehensive Plasmodium falciparum merozoite cell surface and secreted recombinant protein library in MALARIA JOURNAL
  • 2007-12. IgG antibody responses to Plasmodium falciparum merozoite antigens in Kenyan children have a short half-life in MALARIA JOURNAL
  • 2016-05. Antibody acquisition models: A new tool for serological surveillance of malaria transmission intensity in SCIENTIFIC REPORTS
  • 2011-12. Assessment of exposure to Plasmodium falciparum transmission in a low endemicity area by using multiplex fluorescent microsphere-based serological assays in FILARIA JOURNAL
  • 2012. Modeling Infectious Disease Parameters Based on Serological and Social Contact Data, A Modern Statistical Perspective in NONE
  • 2015-12. Analysis of antibody profiles in symptomatic malaria in three sentinel sites of Ivory Coast by using multiplex, fluorescent, magnetic, bead-based serological assay (MAGPIX™) in MALARIA JOURNAL
  • 2007-12. Large-scale malaria survey in Cambodia: Novel insights on species distribution and risk factors in MALARIA JOURNAL
  • 2013-12. Measurement of Plasmodium falciparum transmission intensity using serological cohort data from Indonesian schoolchildren in MALARIA JOURNAL
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12936-016-1576-z

    DOI

    http://dx.doi.org/10.1186/s12936-016-1576-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1020110223

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27809852


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