Species-specific escape of Plasmodium sporozoites from oocysts of avian, rodent, and human malarial parasites View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Alessandra S. Orfano, Rafael Nacif-Pimenta, Ana P. M. Duarte, Luis M. Villegas, Nilton B. Rodrigues, Luciana C. Pinto, Keillen M. M. Campos, Yudi T. Pinilla, Bárbara Chaves, Maria G. V. Barbosa Guerra, Wuelton M. Monteiro, Ryan C. Smith, Alvaro Molina-Cruz, Marcus V. G. Lacerda, Nágila F. C. Secundino, Marcelo Jacobs-Lorena, Carolina Barillas-Mury, Paulo F. P. Pimenta

ABSTRACT

BACKGROUND: Malaria is transmitted when an infected mosquito delivers Plasmodium sporozoites into a vertebrate host. There are many species of Plasmodium and, in general, the infection is host-specific. For example, Plasmodium gallinaceum is an avian parasite, while Plasmodium berghei infects mice. These two parasites have been extensively used as experimental models of malaria transmission. Plasmodium falciparum and Plasmodium vivax are the most important agents of human malaria, a life-threatening disease of global importance. To complete their life cycle, Plasmodium parasites must traverse the mosquito midgut and form an oocyst that will divide continuously. Mature oocysts release thousands of sporozoites into the mosquito haemolymph that must reach the salivary gland to infect a new vertebrate host. The current understanding of the biology of oocyst formation and sporozoite release is mostly based on experimental infections with P. berghei, and the conclusions are generalized to other Plasmodium species that infect humans without further morphological analyses. RESULTS: Here, it is described the microanatomy of sporozoite escape from oocysts of four Plasmodium species: the two laboratory models, P. gallinaceum and P. berghei, and the two main species that cause malaria in humans, P. vivax and P. falciparum. It was found that sporozoites have species-specific mechanisms of escape from the oocyst. The two model species of Plasmodium had a common mechanism, in which the oocyst wall breaks down before sporozoites emerge. In contrast, P. vivax and P. falciparum sporozoites show a dynamic escape mechanism from the oocyst via polarized propulsion. CONCLUSIONS: This study demonstrated that Plasmodium species do not share a common mechanism of sporozoite escape, as previously thought, but show complex and species-specific mechanisms. In addition, the knowledge of this phenomenon in human Plasmodium can facilitate transmission-blocking studies and not those ones only based on the murine and avian models. More... »

PAGES

394

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12936-016-1451-y

DOI

http://dx.doi.org/10.1186/s12936-016-1451-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042441501

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27480269


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Birds", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Life Cycle Stages", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microscopy, Electron, Scanning", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oocysts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plasmodium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sporozoites", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Oswaldo Cruz Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418068.3", 
          "name": [
            "Centro de Pesquisas Ren\u00e9 Rachou-Fiocruz, Belo Horizonte, MG, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Orfano", 
        "givenName": "Alessandra S.", 
        "id": "sg:person.01037761705.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037761705.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oswaldo Cruz Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418068.3", 
          "name": [
            "Centro de Pesquisas Ren\u00e9 Rachou-Fiocruz, Belo Horizonte, MG, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nacif-Pimenta", 
        "givenName": "Rafael", 
        "id": "sg:person.01325125743.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325125743.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Funda\u00e7\u00e3o de Medicina Tropical", 
          "id": "https://www.grid.ac/institutes/grid.418153.a", 
          "name": [
            "Centro de Pesquisas Ren\u00e9 Rachou-Fiocruz, Belo Horizonte, MG, Brazil", 
            "Funda\u00e7\u00e3o de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, AM, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Duarte", 
        "givenName": "Ana P. M.", 
        "id": "sg:person.016450471012.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016450471012.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oswaldo Cruz Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418068.3", 
          "name": [
            "Centro de Pesquisas Ren\u00e9 Rachou-Fiocruz, Belo Horizonte, MG, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Villegas", 
        "givenName": "Luis M.", 
        "id": "sg:person.01344740224.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344740224.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oswaldo Cruz Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418068.3", 
          "name": [
            "Centro de Pesquisas Ren\u00e9 Rachou-Fiocruz, Belo Horizonte, MG, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rodrigues", 
        "givenName": "Nilton B.", 
        "id": "sg:person.012043346002.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012043346002.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oswaldo Cruz Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418068.3", 
          "name": [
            "Centro de Pesquisas Ren\u00e9 Rachou-Fiocruz, Belo Horizonte, MG, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pinto", 
        "givenName": "Luciana C.", 
        "id": "sg:person.0744615015.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744615015.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Funda\u00e7\u00e3o de Medicina Tropical", 
          "id": "https://www.grid.ac/institutes/grid.418153.a", 
          "name": [
            "Funda\u00e7\u00e3o de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, AM, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Campos", 
        "givenName": "Keillen M. M.", 
        "id": "sg:person.0661261205.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661261205.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Funda\u00e7\u00e3o de Medicina Tropical", 
          "id": "https://www.grid.ac/institutes/grid.418153.a", 
          "name": [
            "Funda\u00e7\u00e3o de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, AM, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pinilla", 
        "givenName": "Yudi T.", 
        "id": "sg:person.01264274150.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264274150.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Funda\u00e7\u00e3o de Medicina Tropical", 
          "id": "https://www.grid.ac/institutes/grid.418153.a", 
          "name": [
            "Centro de Pesquisas Ren\u00e9 Rachou-Fiocruz, Belo Horizonte, MG, Brazil", 
            "Funda\u00e7\u00e3o de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, AM, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chaves", 
        "givenName": "B\u00e1rbara", 
        "id": "sg:person.01155523070.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155523070.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Funda\u00e7\u00e3o de Medicina Tropical", 
          "id": "https://www.grid.ac/institutes/grid.418153.a", 
          "name": [
            "Funda\u00e7\u00e3o de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, AM, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Barbosa Guerra", 
        "givenName": "Maria G. V.", 
        "id": "sg:person.012172500325.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012172500325.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Funda\u00e7\u00e3o de Medicina Tropical", 
          "id": "https://www.grid.ac/institutes/grid.418153.a", 
          "name": [
            "Funda\u00e7\u00e3o de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, AM, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Monteiro", 
        "givenName": "Wuelton M.", 
        "id": "sg:person.01141171601.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141171601.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Entomology, Iowa State University, Ames, IA, USA", 
            "Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Smith", 
        "givenName": "Ryan C.", 
        "id": "sg:person.01347760527.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347760527.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institutes of Health", 
          "id": "https://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "Laboratory of Malaria and Vector Research, National Institutes of Health, Rockville, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Molina-Cruz", 
        "givenName": "Alvaro", 
        "id": "sg:person.01160647074.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160647074.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Funda\u00e7\u00e3o de Medicina Tropical", 
          "id": "https://www.grid.ac/institutes/grid.418153.a", 
          "name": [
            "Funda\u00e7\u00e3o de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, AM, Brazil", 
            "Instituto Le\u00f4nidas e Maria Deane-Fiocruz, Manaus, AM, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lacerda", 
        "givenName": "Marcus V. G.", 
        "id": "sg:person.016300655744.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016300655744.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oswaldo Cruz Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418068.3", 
          "name": [
            "Centro de Pesquisas Ren\u00e9 Rachou-Fiocruz, Belo Horizonte, MG, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Secundino", 
        "givenName": "N\u00e1gila F. C.", 
        "id": "sg:person.014311376364.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014311376364.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jacobs-Lorena", 
        "givenName": "Marcelo", 
        "id": "sg:person.01256105377.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256105377.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institutes of Health", 
          "id": "https://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "Laboratory of Malaria and Vector Research, National Institutes of Health, Rockville, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Barillas-Mury", 
        "givenName": "Carolina", 
        "id": "sg:person.01365616276.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365616276.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Funda\u00e7\u00e3o de Medicina Tropical", 
          "id": "https://www.grid.ac/institutes/grid.418153.a", 
          "name": [
            "Centro de Pesquisas Ren\u00e9 Rachou-Fiocruz, Belo Horizonte, MG, Brazil", 
            "Funda\u00e7\u00e3o de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, AM, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pimenta", 
        "givenName": "Paulo F. P.", 
        "id": "sg:person.0754702364.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754702364.63"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0014-4894(74)90119-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000261450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0031182097008895", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000559987"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80511-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002101823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/38.4.2181019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002514789"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/38.4.2181019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002514789"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1005273", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005709102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/385336a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007627869", 
          "https://doi.org/10.1038/385336a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1462-5822.2001.00117.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008800314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pt.2007.05.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009313966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/294364a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009500497", 
          "https://doi.org/10.1038/294364a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0031182099004874", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012345508"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ibmb.2008.10.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012562099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pt.2006.12.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012697395"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijpara.2010.05.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013463781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pt.2005.08.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015612799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pt.2005.08.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015612799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1590/0074-0276130597", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016843673"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1103/physreve.90.042720", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018665724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1103/physreve.90.042720", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018665724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.32.3.c7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020094351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0020-7519(98)00076-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020267544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m509807200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021286988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1590/0074-02760140266", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021975778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-4894(71)90094-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022276606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.asd.2005.01.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024494268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2958.2008.06407.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024976166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.0105-2896.2004.0127.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025761899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.0010009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027344942"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1586/14760584.2015.993383", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029322856"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1550-7408.1994.tb01523.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030589830"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chom.2009.11.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030604715"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0854.2011.01313.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030673728"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0020-7519(01)00298-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031990567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.dci.2009.12.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032470954"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1550-7408.1974.tb03693.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032708646"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-3024.2006.00804.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034750838"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-3024.2006.00804.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034750838"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20050545", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035152790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1000539", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036384938"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000058845", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036590623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m109.054916", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037094572"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijpara.2006.12.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037493182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.micro.091208.073403", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038490177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0001-706x(92)90079-d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039298604"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0001-706x(92)90079-d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039298604"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.cellbio.20.011603.150935", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040083525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/iai.00262-15", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041080684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1462-5822.2011.01597.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041314520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0169-4758(99)01626-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041536381"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1590/s0074-02762004000700008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042677485"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20011876", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042920004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000180268", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043151215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0035-9203(78)90167-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043554794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0052480", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045336737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/ec.00347-08", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046771868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mib.2013.07.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049617392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0035-9203(93)90396-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050137649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.embor.7400831", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050747645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.ento.43.1.519", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052355671"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2875-12-460", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052741433", 
          "https://doi.org/10.1186/1475-2875-12-460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0113923", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052803554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.781840", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062649809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074702153", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-12", 
    "datePublishedReg": "2016-12-01", 
    "description": "BACKGROUND: Malaria is transmitted when an infected mosquito delivers Plasmodium sporozoites into a vertebrate host. There are many species of Plasmodium and, in general, the infection is host-specific. For example, Plasmodium gallinaceum is an avian parasite, while Plasmodium berghei infects mice. These two parasites have been extensively used as experimental models of malaria transmission. Plasmodium falciparum and Plasmodium vivax are the most important agents of human malaria, a life-threatening disease of global importance. To complete their life cycle, Plasmodium parasites must traverse the mosquito midgut and form an oocyst that will divide continuously. Mature oocysts release thousands of sporozoites into the mosquito haemolymph that must reach the salivary gland to infect a new vertebrate host. The current understanding of the biology of oocyst formation and sporozoite release is mostly based on experimental infections with P. berghei, and the conclusions are generalized to other Plasmodium species that infect humans without further morphological analyses.\nRESULTS: Here, it is described the microanatomy of sporozoite escape from oocysts of four Plasmodium species: the two laboratory models, P. gallinaceum and P. berghei, and the two main species that cause malaria in humans, P. vivax and P. falciparum. It was found that sporozoites have species-specific mechanisms of escape from the oocyst. The two model species of Plasmodium had a common mechanism, in which the oocyst wall breaks down before sporozoites emerge. In contrast, P. vivax and P. falciparum sporozoites show a dynamic escape mechanism from the oocyst via polarized propulsion.\nCONCLUSIONS: This study demonstrated that Plasmodium species do not share a common mechanism of sporozoite escape, as previously thought, but show complex and species-specific mechanisms. In addition, the knowledge of this phenomenon in human Plasmodium can facilitate transmission-blocking studies and not those ones only based on the murine and avian models.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12936-016-1451-y", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2452235", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2723171", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1030597", 
        "issn": [
          "1475-2875"
        ], 
        "name": "Malaria Journal", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "15"
      }
    ], 
    "name": "Species-specific escape of Plasmodium sporozoites from oocysts of avian, rodent, and human malarial parasites", 
    "pagination": "394", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "ca2b3b5d47146e8e849c90c2541fcbf861d17611e07e7f49beefefe328c6bef7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27480269"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101139802"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12936-016-1451-y"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1042441501"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12936-016-1451-y", 
      "https://app.dimensions.ai/details/publication/pub.1042441501"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:39", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000363_0000000363/records_70043_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12936-016-1451-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12936-016-1451-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12936-016-1451-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12936-016-1451-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12936-016-1451-y'


 

This table displays all metadata directly associated to this object as RDF triples.

419 TRIPLES      21 PREDICATES      97 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12936-016-1451-y schema:about N15bd8520f1774c358071d8235539eac7
2 N1c014082497e43c4908f9f947074d14f
3 N49a600c57c7e4c9cb282560858a02b6b
4 N6087073b978844be9a3c920ccaa95517
5 N68e78f441fa94293b14480727f61c367
6 N91c1844f2c92424482ada1085190c3d1
7 Nbedd1ddf24014af4b8f5260030eb794c
8 Nc78970b7093b46d2a8f92077c80d7e77
9 Ne76b88d968eb45f891c7f3201307da13
10 Nf68023f2e31e41c7a199e09d33fea447
11 anzsrc-for:11
12 anzsrc-for:1108
13 schema:author Nf707f901c01c420e9559670cc060c776
14 schema:citation sg:pub.10.1038/294364a0
15 sg:pub.10.1038/385336a0
16 sg:pub.10.1186/1475-2875-12-460
17 https://app.dimensions.ai/details/publication/pub.1074702153
18 https://doi.org/10.1016/0001-706x(92)90079-d
19 https://doi.org/10.1016/0014-4894(71)90094-4
20 https://doi.org/10.1016/0014-4894(74)90119-2
21 https://doi.org/10.1016/0035-9203(78)90167-0
22 https://doi.org/10.1016/0035-9203(93)90396-8
23 https://doi.org/10.1016/j.asd.2005.01.002
24 https://doi.org/10.1016/j.chom.2009.11.007
25 https://doi.org/10.1016/j.dci.2009.12.005
26 https://doi.org/10.1016/j.ibmb.2008.10.010
27 https://doi.org/10.1016/j.ijpara.2006.12.007
28 https://doi.org/10.1016/j.ijpara.2010.05.005
29 https://doi.org/10.1016/j.mib.2013.07.004
30 https://doi.org/10.1016/j.pt.2005.08.012
31 https://doi.org/10.1016/j.pt.2006.12.009
32 https://doi.org/10.1016/j.pt.2007.05.001
33 https://doi.org/10.1016/s0020-7519(01)00298-3
34 https://doi.org/10.1016/s0020-7519(98)00076-9
35 https://doi.org/10.1016/s0092-8674(00)80511-5
36 https://doi.org/10.1016/s0169-4758(99)01626-9
37 https://doi.org/10.1017/s0031182097008895
38 https://doi.org/10.1017/s0031182099004874
39 https://doi.org/10.1038/sj.embor.7400831
40 https://doi.org/10.1046/j.1462-5822.2001.00117.x
41 https://doi.org/10.1074/jbc.m109.054916
42 https://doi.org/10.1074/jbc.m509807200
43 https://doi.org/10.1083/jcb.32.3.c7
44 https://doi.org/10.1084/jem.20011876
45 https://doi.org/10.1084/jem.20050545
46 https://doi.org/10.1103/physreve.90.042720
47 https://doi.org/10.1111/j.0105-2896.2004.0127.x
48 https://doi.org/10.1111/j.1365-2958.2008.06407.x
49 https://doi.org/10.1111/j.1365-3024.2006.00804.x
50 https://doi.org/10.1111/j.1462-5822.2011.01597.x
51 https://doi.org/10.1111/j.1550-7408.1974.tb03693.x
52 https://doi.org/10.1111/j.1550-7408.1994.tb01523.x
53 https://doi.org/10.1111/j.1600-0854.2011.01313.x
54 https://doi.org/10.1126/science.781840
55 https://doi.org/10.1128/ec.00347-08
56 https://doi.org/10.1128/iai.00262-15
57 https://doi.org/10.1146/annurev.cellbio.20.011603.150935
58 https://doi.org/10.1146/annurev.ento.43.1.519
59 https://doi.org/10.1146/annurev.micro.091208.073403
60 https://doi.org/10.1159/000058845
61 https://doi.org/10.1159/000180268
62 https://doi.org/10.1177/38.4.2181019
63 https://doi.org/10.1371/journal.pone.0052480
64 https://doi.org/10.1371/journal.pone.0113923
65 https://doi.org/10.1371/journal.ppat.0010009
66 https://doi.org/10.1371/journal.ppat.1000539
67 https://doi.org/10.1371/journal.ppat.1005273
68 https://doi.org/10.1586/14760584.2015.993383
69 https://doi.org/10.1590/0074-02760140266
70 https://doi.org/10.1590/0074-0276130597
71 https://doi.org/10.1590/s0074-02762004000700008
72 schema:datePublished 2016-12
73 schema:datePublishedReg 2016-12-01
74 schema:description BACKGROUND: Malaria is transmitted when an infected mosquito delivers Plasmodium sporozoites into a vertebrate host. There are many species of Plasmodium and, in general, the infection is host-specific. For example, Plasmodium gallinaceum is an avian parasite, while Plasmodium berghei infects mice. These two parasites have been extensively used as experimental models of malaria transmission. Plasmodium falciparum and Plasmodium vivax are the most important agents of human malaria, a life-threatening disease of global importance. To complete their life cycle, Plasmodium parasites must traverse the mosquito midgut and form an oocyst that will divide continuously. Mature oocysts release thousands of sporozoites into the mosquito haemolymph that must reach the salivary gland to infect a new vertebrate host. The current understanding of the biology of oocyst formation and sporozoite release is mostly based on experimental infections with P. berghei, and the conclusions are generalized to other Plasmodium species that infect humans without further morphological analyses. RESULTS: Here, it is described the microanatomy of sporozoite escape from oocysts of four Plasmodium species: the two laboratory models, P. gallinaceum and P. berghei, and the two main species that cause malaria in humans, P. vivax and P. falciparum. It was found that sporozoites have species-specific mechanisms of escape from the oocyst. The two model species of Plasmodium had a common mechanism, in which the oocyst wall breaks down before sporozoites emerge. In contrast, P. vivax and P. falciparum sporozoites show a dynamic escape mechanism from the oocyst via polarized propulsion. CONCLUSIONS: This study demonstrated that Plasmodium species do not share a common mechanism of sporozoite escape, as previously thought, but show complex and species-specific mechanisms. In addition, the knowledge of this phenomenon in human Plasmodium can facilitate transmission-blocking studies and not those ones only based on the murine and avian models.
75 schema:genre research_article
76 schema:inLanguage en
77 schema:isAccessibleForFree true
78 schema:isPartOf N966f8a55f9ab4f3c871c53ce60197d41
79 N9d5e2707a20b4728998c913fa1901fad
80 sg:journal.1030597
81 schema:name Species-specific escape of Plasmodium sporozoites from oocysts of avian, rodent, and human malarial parasites
82 schema:pagination 394
83 schema:productId N023a6189c06242ee95474914964823f6
84 N1b3f446ed5d64062bd78368595bab7d8
85 N67824ce5b13342b3b7dcb89114bb41c3
86 N92b80d9a0d3a48bf98cb309512ef0a20
87 Nde9c6bba15334a7b865ebb0d016471cb
88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042441501
89 https://doi.org/10.1186/s12936-016-1451-y
90 schema:sdDatePublished 2019-04-11T12:39
91 schema:sdLicense https://scigraph.springernature.com/explorer/license/
92 schema:sdPublisher N8cc1141fa45c4607b6db9db4b98fd3b1
93 schema:url https://link.springer.com/10.1186%2Fs12936-016-1451-y
94 sgo:license sg:explorer/license/
95 sgo:sdDataset articles
96 rdf:type schema:ScholarlyArticle
97 N023a6189c06242ee95474914964823f6 schema:name pubmed_id
98 schema:value 27480269
99 rdf:type schema:PropertyValue
100 N0e070a45043e406c80f64c1a29e8e837 rdf:first sg:person.01325125743.41
101 rdf:rest N2db2f2f484c4461caec3fd347e17a084
102 N0ebd1fa9d2d446678184adcac9966821 rdf:first sg:person.0754702364.63
103 rdf:rest rdf:nil
104 N15bd8520f1774c358071d8235539eac7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Sporozoites
106 rdf:type schema:DefinedTerm
107 N1b3f446ed5d64062bd78368595bab7d8 schema:name doi
108 schema:value 10.1186/s12936-016-1451-y
109 rdf:type schema:PropertyValue
110 N1c014082497e43c4908f9f947074d14f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Animals
112 rdf:type schema:DefinedTerm
113 N2db2f2f484c4461caec3fd347e17a084 rdf:first sg:person.016450471012.15
114 rdf:rest Neacf37d4cd7348d6b5156bdca3e374fb
115 N36b0f420a6f14474bbd60d6492e7273e rdf:first sg:person.01264274150.96
116 rdf:rest N669bad657d724f6993a34ee12d34cec6
117 N49a600c57c7e4c9cb282560858a02b6b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Microscopy, Electron, Scanning
119 rdf:type schema:DefinedTerm
120 N49b3279372d7439c9fd4de9bd2e6625a rdf:first sg:person.016300655744.42
121 rdf:rest N76d0e940c00a4ca7836143599169604d
122 N5469ac765a1d4dc2b0e5a7e758688b71 rdf:first sg:person.01256105377.09
123 rdf:rest Nbf59a96a296c493cbf28185969ec556c
124 N6087073b978844be9a3c920ccaa95517 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Female
126 rdf:type schema:DefinedTerm
127 N669bad657d724f6993a34ee12d34cec6 rdf:first sg:person.01155523070.42
128 rdf:rest N87fe92dccb14477485c942d8407be9ad
129 N67824ce5b13342b3b7dcb89114bb41c3 schema:name dimensions_id
130 schema:value pub.1042441501
131 rdf:type schema:PropertyValue
132 N68e78f441fa94293b14480727f61c367 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Life Cycle Stages
134 rdf:type schema:DefinedTerm
135 N76d0e940c00a4ca7836143599169604d rdf:first sg:person.014311376364.38
136 rdf:rest N5469ac765a1d4dc2b0e5a7e758688b71
137 N779845b00be643b084d2e6857ab2241b rdf:first sg:person.012043346002.33
138 rdf:rest N7ed7def9099f4a618eaa187146a30c35
139 N7ed7def9099f4a618eaa187146a30c35 rdf:first sg:person.0744615015.54
140 rdf:rest Nfb026751e71c488fba7dca45c3780e8a
141 N87fe92dccb14477485c942d8407be9ad rdf:first sg:person.012172500325.76
142 rdf:rest N9fa9bbc7a72c4a08adc65fe14c058f2a
143 N8cc1141fa45c4607b6db9db4b98fd3b1 schema:name Springer Nature - SN SciGraph project
144 rdf:type schema:Organization
145 N91c1844f2c92424482ada1085190c3d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Mice
147 rdf:type schema:DefinedTerm
148 N92b80d9a0d3a48bf98cb309512ef0a20 schema:name readcube_id
149 schema:value ca2b3b5d47146e8e849c90c2541fcbf861d17611e07e7f49beefefe328c6bef7
150 rdf:type schema:PropertyValue
151 N966f8a55f9ab4f3c871c53ce60197d41 schema:volumeNumber 15
152 rdf:type schema:PublicationVolume
153 N9d5e2707a20b4728998c913fa1901fad schema:issueNumber 1
154 rdf:type schema:PublicationIssue
155 N9fa9bbc7a72c4a08adc65fe14c058f2a rdf:first sg:person.01141171601.76
156 rdf:rest Ndc16fae1fbc04c6ba05b675533b5bfd8
157 Nbedd1ddf24014af4b8f5260030eb794c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Humans
159 rdf:type schema:DefinedTerm
160 Nbf59a96a296c493cbf28185969ec556c rdf:first sg:person.01365616276.40
161 rdf:rest N0ebd1fa9d2d446678184adcac9966821
162 Nc78970b7093b46d2a8f92077c80d7e77 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Plasmodium
164 rdf:type schema:DefinedTerm
165 Nc94c3409d394431196375e860e3dbd8e rdf:first sg:person.01160647074.41
166 rdf:rest N49b3279372d7439c9fd4de9bd2e6625a
167 Ndc16fae1fbc04c6ba05b675533b5bfd8 rdf:first sg:person.01347760527.08
168 rdf:rest Nc94c3409d394431196375e860e3dbd8e
169 Nde9c6bba15334a7b865ebb0d016471cb schema:name nlm_unique_id
170 schema:value 101139802
171 rdf:type schema:PropertyValue
172 Ne76b88d968eb45f891c7f3201307da13 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Oocysts
174 rdf:type schema:DefinedTerm
175 Neacf37d4cd7348d6b5156bdca3e374fb rdf:first sg:person.01344740224.49
176 rdf:rest N779845b00be643b084d2e6857ab2241b
177 Nf68023f2e31e41c7a199e09d33fea447 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Birds
179 rdf:type schema:DefinedTerm
180 Nf707f901c01c420e9559670cc060c776 rdf:first sg:person.01037761705.55
181 rdf:rest N0e070a45043e406c80f64c1a29e8e837
182 Nfb026751e71c488fba7dca45c3780e8a rdf:first sg:person.0661261205.70
183 rdf:rest N36b0f420a6f14474bbd60d6492e7273e
184 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
185 schema:name Medical and Health Sciences
186 rdf:type schema:DefinedTerm
187 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
188 schema:name Medical Microbiology
189 rdf:type schema:DefinedTerm
190 sg:grant.2452235 http://pending.schema.org/fundedItem sg:pub.10.1186/s12936-016-1451-y
191 rdf:type schema:MonetaryGrant
192 sg:grant.2723171 http://pending.schema.org/fundedItem sg:pub.10.1186/s12936-016-1451-y
193 rdf:type schema:MonetaryGrant
194 sg:journal.1030597 schema:issn 1475-2875
195 schema:name Malaria Journal
196 rdf:type schema:Periodical
197 sg:person.01037761705.55 schema:affiliation https://www.grid.ac/institutes/grid.418068.3
198 schema:familyName Orfano
199 schema:givenName Alessandra S.
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037761705.55
201 rdf:type schema:Person
202 sg:person.01141171601.76 schema:affiliation https://www.grid.ac/institutes/grid.418153.a
203 schema:familyName Monteiro
204 schema:givenName Wuelton M.
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141171601.76
206 rdf:type schema:Person
207 sg:person.01155523070.42 schema:affiliation https://www.grid.ac/institutes/grid.418153.a
208 schema:familyName Chaves
209 schema:givenName Bárbara
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155523070.42
211 rdf:type schema:Person
212 sg:person.01160647074.41 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
213 schema:familyName Molina-Cruz
214 schema:givenName Alvaro
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160647074.41
216 rdf:type schema:Person
217 sg:person.012043346002.33 schema:affiliation https://www.grid.ac/institutes/grid.418068.3
218 schema:familyName Rodrigues
219 schema:givenName Nilton B.
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012043346002.33
221 rdf:type schema:Person
222 sg:person.012172500325.76 schema:affiliation https://www.grid.ac/institutes/grid.418153.a
223 schema:familyName Barbosa Guerra
224 schema:givenName Maria G. V.
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012172500325.76
226 rdf:type schema:Person
227 sg:person.01256105377.09 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
228 schema:familyName Jacobs-Lorena
229 schema:givenName Marcelo
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256105377.09
231 rdf:type schema:Person
232 sg:person.01264274150.96 schema:affiliation https://www.grid.ac/institutes/grid.418153.a
233 schema:familyName Pinilla
234 schema:givenName Yudi T.
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264274150.96
236 rdf:type schema:Person
237 sg:person.01325125743.41 schema:affiliation https://www.grid.ac/institutes/grid.418068.3
238 schema:familyName Nacif-Pimenta
239 schema:givenName Rafael
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325125743.41
241 rdf:type schema:Person
242 sg:person.01344740224.49 schema:affiliation https://www.grid.ac/institutes/grid.418068.3
243 schema:familyName Villegas
244 schema:givenName Luis M.
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344740224.49
246 rdf:type schema:Person
247 sg:person.01347760527.08 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
248 schema:familyName Smith
249 schema:givenName Ryan C.
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347760527.08
251 rdf:type schema:Person
252 sg:person.01365616276.40 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
253 schema:familyName Barillas-Mury
254 schema:givenName Carolina
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365616276.40
256 rdf:type schema:Person
257 sg:person.014311376364.38 schema:affiliation https://www.grid.ac/institutes/grid.418068.3
258 schema:familyName Secundino
259 schema:givenName Nágila F. C.
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014311376364.38
261 rdf:type schema:Person
262 sg:person.016300655744.42 schema:affiliation https://www.grid.ac/institutes/grid.418153.a
263 schema:familyName Lacerda
264 schema:givenName Marcus V. G.
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016300655744.42
266 rdf:type schema:Person
267 sg:person.016450471012.15 schema:affiliation https://www.grid.ac/institutes/grid.418153.a
268 schema:familyName Duarte
269 schema:givenName Ana P. M.
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016450471012.15
271 rdf:type schema:Person
272 sg:person.0661261205.70 schema:affiliation https://www.grid.ac/institutes/grid.418153.a
273 schema:familyName Campos
274 schema:givenName Keillen M. M.
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661261205.70
276 rdf:type schema:Person
277 sg:person.0744615015.54 schema:affiliation https://www.grid.ac/institutes/grid.418068.3
278 schema:familyName Pinto
279 schema:givenName Luciana C.
280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744615015.54
281 rdf:type schema:Person
282 sg:person.0754702364.63 schema:affiliation https://www.grid.ac/institutes/grid.418153.a
283 schema:familyName Pimenta
284 schema:givenName Paulo F. P.
285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754702364.63
286 rdf:type schema:Person
287 sg:pub.10.1038/294364a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009500497
288 https://doi.org/10.1038/294364a0
289 rdf:type schema:CreativeWork
290 sg:pub.10.1038/385336a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007627869
291 https://doi.org/10.1038/385336a0
292 rdf:type schema:CreativeWork
293 sg:pub.10.1186/1475-2875-12-460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052741433
294 https://doi.org/10.1186/1475-2875-12-460
295 rdf:type schema:CreativeWork
296 https://app.dimensions.ai/details/publication/pub.1074702153 schema:CreativeWork
297 https://doi.org/10.1016/0001-706x(92)90079-d schema:sameAs https://app.dimensions.ai/details/publication/pub.1039298604
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1016/0014-4894(71)90094-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022276606
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/0014-4894(74)90119-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000261450
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1016/0035-9203(78)90167-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043554794
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1016/0035-9203(93)90396-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050137649
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1016/j.asd.2005.01.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024494268
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1016/j.chom.2009.11.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030604715
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1016/j.dci.2009.12.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032470954
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1016/j.ibmb.2008.10.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012562099
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/j.ijpara.2006.12.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037493182
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/j.ijpara.2010.05.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013463781
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1016/j.mib.2013.07.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049617392
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1016/j.pt.2005.08.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015612799
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1016/j.pt.2006.12.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012697395
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1016/j.pt.2007.05.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009313966
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1016/s0020-7519(01)00298-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031990567
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1016/s0020-7519(98)00076-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020267544
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1016/s0092-8674(00)80511-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002101823
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1016/s0169-4758(99)01626-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041536381
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1017/s0031182097008895 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000559987
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1017/s0031182099004874 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012345508
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1038/sj.embor.7400831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050747645
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1046/j.1462-5822.2001.00117.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008800314
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1074/jbc.m109.054916 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037094572
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1074/jbc.m509807200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021286988
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1083/jcb.32.3.c7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020094351
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1084/jem.20011876 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042920004
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1084/jem.20050545 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035152790
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1103/physreve.90.042720 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018665724
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1111/j.0105-2896.2004.0127.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1025761899
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1111/j.1365-2958.2008.06407.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024976166
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1111/j.1365-3024.2006.00804.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034750838
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1111/j.1462-5822.2011.01597.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041314520
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1111/j.1550-7408.1974.tb03693.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032708646
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1111/j.1550-7408.1994.tb01523.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030589830
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1111/j.1600-0854.2011.01313.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030673728
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1126/science.781840 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062649809
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1128/ec.00347-08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046771868
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1128/iai.00262-15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041080684
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1146/annurev.cellbio.20.011603.150935 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040083525
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1146/annurev.ento.43.1.519 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052355671
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1146/annurev.micro.091208.073403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038490177
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1159/000058845 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036590623
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1159/000180268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043151215
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1177/38.4.2181019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002514789
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1371/journal.pone.0052480 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045336737
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1371/journal.pone.0113923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052803554
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1371/journal.ppat.0010009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027344942
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1371/journal.ppat.1000539 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036384938
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1371/journal.ppat.1005273 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005709102
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1586/14760584.2015.993383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029322856
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1590/0074-02760140266 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021975778
400 rdf:type schema:CreativeWork
401 https://doi.org/10.1590/0074-0276130597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016843673
402 rdf:type schema:CreativeWork
403 https://doi.org/10.1590/s0074-02762004000700008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042677485
404 rdf:type schema:CreativeWork
405 https://www.grid.ac/institutes/grid.21107.35 schema:alternateName Johns Hopkins University
406 schema:name Department of Entomology, Iowa State University, Ames, IA, USA
407 Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
408 rdf:type schema:Organization
409 https://www.grid.ac/institutes/grid.418068.3 schema:alternateName Oswaldo Cruz Foundation
410 schema:name Centro de Pesquisas René Rachou-Fiocruz, Belo Horizonte, MG, Brazil
411 rdf:type schema:Organization
412 https://www.grid.ac/institutes/grid.418153.a schema:alternateName Fundação de Medicina Tropical
413 schema:name Centro de Pesquisas René Rachou-Fiocruz, Belo Horizonte, MG, Brazil
414 Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, AM, Brazil
415 Instituto Leônidas e Maria Deane-Fiocruz, Manaus, AM, Brazil
416 rdf:type schema:Organization
417 https://www.grid.ac/institutes/grid.94365.3d schema:alternateName National Institutes of Health
418 schema:name Laboratory of Malaria and Vector Research, National Institutes of Health, Rockville, MD, USA
419 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...