Establishing research priorities for malaria elimination in the context of the emergency response to artemisinin resistance framework-the Cambodian approach View Full Text


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Article Info

DATE

2016-02-25

AUTHORS

Sara E. Canavati, Harriet L. S. Lawford, Bayo S. Fatunmbi, Dysoley Lek, Narann Top-Samphor, Rithea Leang, Arjen M. Dondorp, Rekol Huy, Walter M. Kazadi

ABSTRACT

BACKGROUND: Countries of the greater Mekong subregion have made a transition from malaria control to an aim for falciparum and vivax malaria elimination. The elimination of falciparum malaria will have to be achieved against a background of increasing artemisinin and multi-drug resistance. This ambitious goal requires an operational research (OR) agenda that addresses the dynamic challenges encountered on the path to elimination, which will need to be flexible and developed in close relation with the cambodian national programme for parasitology, entomology and malaria control (CNM). In Cambodia, a number of meetings with stakeholders were convened by the CNM and emergency response to artemisinin resistance (ERAR) hub, producing an initial list of priority OR topics. The process and outcome of these meetings are described, which could serve as a template for other countries in the region. METHODS: A landscaping exercise was conducted to gather all past, on-going and planned malaria focussed OR activities conducted by the cambodian research consortium in Cambodia and categorized according to research theme. The six themes included (1) malaria epidemiology, surveillance and response, (2) malaria case management, (3) malaria vector control, (4) malaria behavioural issues, (5) malaria clinical studies, and (6) other vector-borne diseases (dengue, neglected tropical diseases, soil-transmitted helminths). The different themes were discussed in small focus groups, which made an initial prioritization list which was then presented to a plenary group for further discussion. This produced a list of research questions ranked according to priority. RESULTS: OR priorities produced by the thematic groups were discussed in the plenary meeting and given a priority score by group voting. A list of 17 OR questions were developed, finalized and listed, which included questions on surveillance, active case detection and treatment efficacy. CONCLUSION: This paper describes ERAR's work on supporting Cambodia's transition to malaria elimination by identifying national operational research priorities. ERAR has initiated and currently plays a critical role in the development of country specific research agendas for malaria elimination. The first example of this has been the described exercise in Cambodia, which could serve a template for setting OR priorities in the wider region. More... »

PAGES

120

References to SciGraph publications

  • 2012-03-30. Operational research to inform a sub-national surveillance intervention for malaria elimination in Solomon Islands in MALARIA JOURNAL
  • 2012-07-02. Contribution mapping: a method for mapping the contribution of research to enhance its impact in HEALTH RESEARCH POLICY AND SYSTEMS
  • 2014-09-30. Spatial and temporal epidemiology of clinical malaria in Cambodia 2004–2013 in MALARIA JOURNAL
  • 2009-12-04. Priority setting and health policy and systems research in HEALTH RESEARCH POLICY AND SYSTEMS
  • 2004-08-05. Health policy and systems research agendas in developing countries in HEALTH RESEARCH POLICY AND SYSTEMS
  • 2012-04-24. Malaria resurgence: a systematic review and assessment of its causes in MALARIA JOURNAL
  • 2015-06-20. Malaria and the mobile and migrant population in Cambodia: a population movement framework to inform strategies for malaria control and elimination in MALARIA JOURNAL
  • 2014-07-14. New directions in evidence-based policy research: a critical analysis of the literature in HEALTH RESEARCH POLICY AND SYSTEMS
  • 2010-10-31. Research workshop to research work: initial steps in establishing health research systems on Malaita, Solomon Islands in HEALTH RESEARCH POLICY AND SYSTEMS
  • 2011-05-10. Respondent-driven sampling on the Thailand-Cambodia border. I. Can malaria cases be contained in mobile migrant workers? in MALARIA JOURNAL
  • 2016-01-04. The Cambodia Research Consortium: expediting research for malaria elimination with the emergency response to artemisinin resistance framework in MALARIA JOURNAL
  • Identifiers

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    http://scigraph.springernature.com/pub.10.1186/s12936-016-1117-9

    DOI

    http://dx.doi.org/10.1186/s12936-016-1117-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1010020393

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26916933


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    28 schema:description BACKGROUND: Countries of the greater Mekong subregion have made a transition from malaria control to an aim for falciparum and vivax malaria elimination. The elimination of falciparum malaria will have to be achieved against a background of increasing artemisinin and multi-drug resistance. This ambitious goal requires an operational research (OR) agenda that addresses the dynamic challenges encountered on the path to elimination, which will need to be flexible and developed in close relation with the cambodian national programme for parasitology, entomology and malaria control (CNM). In Cambodia, a number of meetings with stakeholders were convened by the CNM and emergency response to artemisinin resistance (ERAR) hub, producing an initial list of priority OR topics. The process and outcome of these meetings are described, which could serve as a template for other countries in the region. METHODS: A landscaping exercise was conducted to gather all past, on-going and planned malaria focussed OR activities conducted by the cambodian research consortium in Cambodia and categorized according to research theme. The six themes included (1) malaria epidemiology, surveillance and response, (2) malaria case management, (3) malaria vector control, (4) malaria behavioural issues, (5) malaria clinical studies, and (6) other vector-borne diseases (dengue, neglected tropical diseases, soil-transmitted helminths). The different themes were discussed in small focus groups, which made an initial prioritization list which was then presented to a plenary group for further discussion. This produced a list of research questions ranked according to priority. RESULTS: OR priorities produced by the thematic groups were discussed in the plenary meeting and given a priority score by group voting. A list of 17 OR questions were developed, finalized and listed, which included questions on surveillance, active case detection and treatment efficacy. CONCLUSION: This paper describes ERAR's work on supporting Cambodia's transition to malaria elimination by identifying national operational research priorities. ERAR has initiated and currently plays a critical role in the development of country specific research agendas for malaria elimination. The first example of this has been the described exercise in Cambodia, which could serve a template for setting OR priorities in the wider region.
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    36 Cambodia
    37 Cambodian approach
    38 Cambodia’s transition
    39 ERAR
    40 ERAR's work
    41 Mekong Subregion
    42 Research Consortium
    43 active case detection
    44 activity
    45 agenda
    46 aim
    47 ambitious goal
    48 approach
    49 artemisinin
    50 background
    51 behavioral issues
    52 cambodian national programme
    53 cambodian research consortium
    54 case detection
    55 case management
    56 challenges
    57 clinical studies
    58 close relation
    59 consortium
    60 context
    61 control
    62 countries
    63 country specific research agendas
    64 critical role
    65 detection
    66 development
    67 different themes
    68 discussion
    69 disease
    70 dynamic challenges
    71 efficacy
    72 elimination
    73 emergency response
    74 entomology
    75 epidemiology
    76 example
    77 exercise
    78 falciparum
    79 falciparum malaria
    80 first example
    81 focus groups
    82 framework
    83 further discussion
    84 goal
    85 greater Mekong subregion
    86 group
    87 group voting
    88 hub
    89 initial list
    90 initial prioritization list
    91 issues
    92 list
    93 malaria
    94 malaria behavioural issues
    95 malaria case management
    96 malaria clinical studies
    97 malaria control
    98 malaria elimination
    99 malaria epidemiology
    100 malaria vector control
    101 management
    102 meeting
    103 multi-drug resistance
    104 national operational research priorities
    105 national program
    106 number
    107 number of meetings
    108 operational research agenda
    109 operational research priorities
    110 outcomes
    111 paper
    112 parasitology
    113 past
    114 path
    115 plenary group
    116 plenary meeting
    117 prioritization list
    118 priority
    119 priority score
    120 process
    121 program
    122 questions
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    129 resistance
    130 resistance (ERAR) hub
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    135 small focus groups
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    141 template
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    146 treatment efficacy
    147 vector control
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