Antibodies to Plasmodium falciparum merozoite surface protein-1p19 malaria vaccine candidate induce antibody-dependent respiratory burst in human neutrophils View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Charlotte Joos, Marie-Louise Varela, Babacar Mbengue, Annick Mansourou, Laurence Marrama, Cheikh Sokhna, Adama Tall, Jean-François Trape, Aissatou Touré, Odile Mercereau-Puijalon, Ronald Perraut

ABSTRACT

BACKGROUND: Identification of plasmodial antigens targeted by protective immune mechanisms is important for malaria vaccine development. Among functional assays, the neutrophil antibody-dependent respiratory burst (ADRB) induced by opsonized Plasmodium falciparum merozoites has been correlated with acquired immunity to clinical malaria in endemic areas, but the target merozoite antigens are unknown. Here, the contribution of antibodies to the conserved C-terminal domain of the P. falciparum merozoite surface protein-1 (PfMSP1p19) in mediating ADRB was investigated in sera from individuals living in two Senegalese villages with differing malaria endemicity. METHODS: Anti-PfMSP1p19 antibody levels in sera from 233 villagers were investigated and the involvement of anti-PfMSP1p19 antibodies in ADRB was explored in a subset of samples using (1) isogenic P. falciparum parasite clones expressing P. falciparum or Plasmodium chabaudi MSP1p19; (2) PfMSP1p19-coated plaque ADRB; and, (3) ADRB triggering using sera depleted from PfMSP1p19 antibodies by absorption onto the baculovirus recombinant antigen. RESULTS: ADRB activity correlated with anti-PfMSP1p19 IgG levels (P < 10(-3)). A substantial contribution of PfMSP1p19 antibody responses to ADRB was confirmed (P < 10(-4)) in an age-adjusted linear regression model. PfMSP1p19 antibodies accounted for 33.1 % (range 7-54 %) and 33.2 % (range 0-70 %) of ADRB activity evaluated using isogenic merozoites (P < 10(-3)) and depleted sera (P = 0.0017), respectively. Coating of PfMSP1p19 on plates induced strong ADRB in anti-PfMSP1p19-positive sera. CONCLUSION: These data show that naturally acquired P. falciparum MSP1p19 antibodies are potent inducers of neutrophil ADRB and support the development of PfMSP1p19-based malaria vaccine using ADRB assay as a functional surrogate for protection. More... »

PAGES

409

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12936-015-0935-5

DOI

http://dx.doi.org/10.1186/s12936-015-0935-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047215837

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26471813


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Protozoan", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child, Preschool", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cross-Sectional Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Longitudinal Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Merozoite Surface Protein 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neutrophils", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plasmodium chabaudi", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plasmodium falciparum", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Respiratory Burst", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Senegal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Institut Pasteur", 
          "id": "https://www.grid.ac/institutes/grid.428999.7", 
          "name": [
            "Unit\u00e9 d\u2019Immunologie, Institut Pasteur de Dakar, Dakar, Senegal", 
            "Unit\u00e9 d\u2019Immunologie Mol\u00e9culaire des Parasites, Institut Pasteur, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Joos", 
        "givenName": "Charlotte", 
        "id": "sg:person.01317650277.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317650277.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Pasteur de Dakar", 
          "id": "https://www.grid.ac/institutes/grid.418508.0", 
          "name": [
            "Unit\u00e9 d\u2019Immunologie, Institut Pasteur de Dakar, Dakar, Senegal"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Varela", 
        "givenName": "Marie-Louise", 
        "id": "sg:person.01246523262.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246523262.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Pasteur de Dakar", 
          "id": "https://www.grid.ac/institutes/grid.418508.0", 
          "name": [
            "Unit\u00e9 d\u2019Immunog\u00e9n\u00e9tique/UCAD, Institut Pasteur de Dakar, Dakar, Senegal"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mbengue", 
        "givenName": "Babacar", 
        "id": "sg:person.0657003425.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657003425.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Pasteur de Dakar", 
          "id": "https://www.grid.ac/institutes/grid.418508.0", 
          "name": [
            "Unit\u00e9 d\u2019Immunologie, Institut Pasteur de Dakar, Dakar, Senegal"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mansourou", 
        "givenName": "Annick", 
        "id": "sg:person.01226364731.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226364731.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Pasteur de Dakar", 
          "id": "https://www.grid.ac/institutes/grid.418508.0", 
          "name": [
            "Unit\u00e9 d\u2019Epid\u00e9miologie, Institut Pasteur de Dakar, Dakar, Senegal"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marrama", 
        "givenName": "Laurence", 
        "id": "sg:person.01365763477.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365763477.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut de Recherche pour le D\u00e9veloppement", 
          "id": "https://www.grid.ac/institutes/grid.418291.7", 
          "name": [
            "Institut de Recherche pour le D\u00e9veloppement (IRD), URMITE, Dakar, Senegal"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sokhna", 
        "givenName": "Cheikh", 
        "id": "sg:person.01370574675.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370574675.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Pasteur de Dakar", 
          "id": "https://www.grid.ac/institutes/grid.418508.0", 
          "name": [
            "Unit\u00e9 d\u2019Epid\u00e9miologie, Institut Pasteur de Dakar, Dakar, Senegal"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tall", 
        "givenName": "Adama", 
        "id": "sg:person.01113653146.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113653146.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut de Recherche pour le D\u00e9veloppement", 
          "id": "https://www.grid.ac/institutes/grid.418291.7", 
          "name": [
            "Institut de Recherche pour le D\u00e9veloppement (IRD), URMITE, Dakar, Senegal"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Trape", 
        "givenName": "Jean-Fran\u00e7ois", 
        "id": "sg:person.0577360635.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577360635.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Pasteur de Dakar", 
          "id": "https://www.grid.ac/institutes/grid.418508.0", 
          "name": [
            "Unit\u00e9 d\u2019Immunologie, Institut Pasteur de Dakar, Dakar, Senegal"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tour\u00e9", 
        "givenName": "Aissatou", 
        "id": "sg:person.01130356263.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130356263.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Pasteur", 
          "id": "https://www.grid.ac/institutes/grid.428999.7", 
          "name": [
            "Unit\u00e9 d\u2019Immunologie Mol\u00e9culaire des Parasites, Institut Pasteur, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mercereau-Puijalon", 
        "givenName": "Odile", 
        "id": "sg:person.0106442510.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0106442510.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Pasteur de Dakar", 
          "id": "https://www.grid.ac/institutes/grid.418508.0", 
          "name": [
            "Unit\u00e9 d\u2019Immunologie, Institut Pasteur de Dakar, Dakar, Senegal"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Perraut", 
        "givenName": "Ronald", 
        "id": "sg:person.01241074662.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241074662.04"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s1097-2765(00)80473-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001608061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1471-4906(02)00012-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003436275"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1471-4906(02)00012-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003436275"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/426398", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007154831"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.vaccine.2006.09.074", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009860591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1471-4922(02)02249-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010392287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1189/jlb.4a0614-283rr", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010909299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.193.12.1403", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011171607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-2836(03)00376-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011584488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-2836(03)00376-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011584488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0808859", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011738279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pmed.0040320", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012557119"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0022525", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017040181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.talanta.2009.02.050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019219225"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.vaccine.2006.04.069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020219750"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2875-7-173", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020507420", 
          "https://doi.org/10.1186/1475-2875-7-173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.182.2.409", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024033910"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1473-3099(15)70032-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024317843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0166-6851(97)00128-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024828444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/cvi.00172-08", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029865115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1189/jlb.0513274", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030137266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/71595", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030988759", 
          "https://doi.org/10.1038/71595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/71595", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030988759", 
          "https://doi.org/10.1038/71595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/iai.01679-05", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032130702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0009871", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032498617"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.vaccine.2007.10.064", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035095281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2003-02-0583", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038115104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2875-7-142", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039058645", 
          "https://doi.org/10.1186/1475-2875-7-142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pmed.1000218", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039249999"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0002000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043594523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2875-13-410", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045424953", 
          "https://doi.org/10.1186/1475-2875-13-410"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1472-6750-11-77", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046821155", 
          "https://doi.org/10.1186/1472-6750-11-77"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2006.02.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050338063"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/379838", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052186474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074366577", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076805201", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.173.1.666", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076855557"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.2004.71.239", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076883992"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077024762", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079794154", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.1994.51.123", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082639193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.1996.54.449", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082891943"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-12", 
    "datePublishedReg": "2015-12-01", 
    "description": "BACKGROUND: Identification of plasmodial antigens targeted by protective immune mechanisms is important for malaria vaccine development. Among functional assays, the neutrophil antibody-dependent respiratory burst (ADRB) induced by opsonized Plasmodium falciparum merozoites has been correlated with acquired immunity to clinical malaria in endemic areas, but the target merozoite antigens are unknown. Here, the contribution of antibodies to the conserved C-terminal domain of the P. falciparum merozoite surface protein-1 (PfMSP1p19) in mediating ADRB was investigated in sera from individuals living in two Senegalese villages with differing malaria endemicity.\nMETHODS: Anti-PfMSP1p19 antibody levels in sera from 233 villagers were investigated and the involvement of anti-PfMSP1p19 antibodies in ADRB was explored in a subset of samples using (1) isogenic P. falciparum parasite clones expressing P. falciparum or Plasmodium chabaudi MSP1p19; (2) PfMSP1p19-coated plaque ADRB; and, (3) ADRB triggering using sera depleted from PfMSP1p19 antibodies by absorption onto the baculovirus recombinant antigen.\nRESULTS: ADRB activity correlated with anti-PfMSP1p19 IgG levels (P < 10(-3)). A substantial contribution of PfMSP1p19 antibody responses to ADRB was confirmed (P < 10(-4)) in an age-adjusted linear regression model. PfMSP1p19 antibodies accounted for 33.1 % (range 7-54 %) and 33.2 % (range 0-70 %) of ADRB activity evaluated using isogenic merozoites (P < 10(-3)) and depleted sera (P = 0.0017), respectively. Coating of PfMSP1p19 on plates induced strong ADRB in anti-PfMSP1p19-positive sera.\nCONCLUSION: These data show that naturally acquired P. falciparum MSP1p19 antibodies are potent inducers of neutrophil ADRB and support the development of PfMSP1p19-based malaria vaccine using ADRB assay as a functional surrogate for protection.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12936-015-0935-5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1030597", 
        "issn": [
          "1475-2875"
        ], 
        "name": "Malaria Journal", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "14"
      }
    ], 
    "name": "Antibodies to Plasmodium falciparum merozoite surface protein-1p19 malaria vaccine candidate induce antibody-dependent respiratory burst in human neutrophils", 
    "pagination": "409", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e0ebe3e7fdf00719d26b72f7d9414df284ae44b6113ec43bfb9d569338ab5d71"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26471813"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101139802"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12936-015-0935-5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1047215837"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12936-015-0935-5", 
      "https://app.dimensions.ai/details/publication/pub.1047215837"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T21:38", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000515.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2Fs12936-015-0935-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12936-015-0935-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12936-015-0935-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12936-015-0935-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12936-015-0935-5'


 

This table displays all metadata directly associated to this object as RDF triples.

345 TRIPLES      21 PREDICATES      88 URIs      41 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12936-015-0935-5 schema:about N0ac1ad3f8f324ad8a7e8493216c80ede
2 N0ce91087c10e4ffeb557800cbb4e3919
3 N0edf94ec7b054b068adf274bb7d6439e
4 N1b195a22a64c44c3b030aa4fb7543298
5 N2f6c7f1788f34600b37d43a851078689
6 N36464351255548a5bf2da8f29a8d24d0
7 N39e1035e46c649a988c6dcf38f7ff9fc
8 N7a674d5e0398465abb9278e1e65a9c9b
9 N88341d0d78b4429bb01c5959586baa3b
10 N8bdc8ebbd5094a559f861aa4bc965fc2
11 N95ce4589186a427792b95873a5b2edbc
12 N9c88edcb4e814c79b8ba17dc69a222a7
13 N9e7d81a93df94174bde5bc3c9afd7c2e
14 Naf5b9710ccda4dc3a8ac2ccac8f23226
15 Nb093d1755ad24c51a288239a06e993d5
16 Nb337f83519f74661ab469da1f7e0082d
17 Nb63397c2c8914cbba624769aad892bcc
18 Nca897a2bc29b46ddbae8ad67bfb56d12
19 Ne9446b5b98aa4880bf7e64aec97fbb5b
20 Nfba9e7147a8e4d97a3e26177e6b7ea67
21 anzsrc-for:11
22 anzsrc-for:1107
23 schema:author N2f051f52105c4d629a6dc0e40e99738e
24 schema:citation sg:pub.10.1038/71595
25 sg:pub.10.1186/1472-6750-11-77
26 sg:pub.10.1186/1475-2875-13-410
27 sg:pub.10.1186/1475-2875-7-142
28 sg:pub.10.1186/1475-2875-7-173
29 https://app.dimensions.ai/details/publication/pub.1074366577
30 https://app.dimensions.ai/details/publication/pub.1076805201
31 https://app.dimensions.ai/details/publication/pub.1077024762
32 https://app.dimensions.ai/details/publication/pub.1079794154
33 https://doi.org/10.1016/j.cell.2006.02.006
34 https://doi.org/10.1016/j.talanta.2009.02.050
35 https://doi.org/10.1016/j.vaccine.2006.04.069
36 https://doi.org/10.1016/j.vaccine.2006.09.074
37 https://doi.org/10.1016/j.vaccine.2007.10.064
38 https://doi.org/10.1016/s0022-2836(03)00376-0
39 https://doi.org/10.1016/s0166-6851(97)00128-x
40 https://doi.org/10.1016/s1097-2765(00)80473-6
41 https://doi.org/10.1016/s1471-4906(02)00012-1
42 https://doi.org/10.1016/s1471-4922(02)02249-3
43 https://doi.org/10.1016/s1473-3099(15)70032-0
44 https://doi.org/10.1056/nejmoa0808859
45 https://doi.org/10.1084/jem.182.2.409
46 https://doi.org/10.1084/jem.193.12.1403
47 https://doi.org/10.1086/379838
48 https://doi.org/10.1086/426398
49 https://doi.org/10.1128/cvi.00172-08
50 https://doi.org/10.1128/iai.01679-05
51 https://doi.org/10.1182/blood-2003-02-0583
52 https://doi.org/10.1189/jlb.0513274
53 https://doi.org/10.1189/jlb.4a0614-283rr
54 https://doi.org/10.1371/journal.pmed.0040320
55 https://doi.org/10.1371/journal.pmed.1000218
56 https://doi.org/10.1371/journal.pone.0002000
57 https://doi.org/10.1371/journal.pone.0009871
58 https://doi.org/10.1371/journal.pone.0022525
59 https://doi.org/10.4049/jimmunol.173.1.666
60 https://doi.org/10.4269/ajtmh.1994.51.123
61 https://doi.org/10.4269/ajtmh.1996.54.449
62 https://doi.org/10.4269/ajtmh.2004.71.239
63 schema:datePublished 2015-12
64 schema:datePublishedReg 2015-12-01
65 schema:description BACKGROUND: Identification of plasmodial antigens targeted by protective immune mechanisms is important for malaria vaccine development. Among functional assays, the neutrophil antibody-dependent respiratory burst (ADRB) induced by opsonized Plasmodium falciparum merozoites has been correlated with acquired immunity to clinical malaria in endemic areas, but the target merozoite antigens are unknown. Here, the contribution of antibodies to the conserved C-terminal domain of the P. falciparum merozoite surface protein-1 (PfMSP1p19) in mediating ADRB was investigated in sera from individuals living in two Senegalese villages with differing malaria endemicity. METHODS: Anti-PfMSP1p19 antibody levels in sera from 233 villagers were investigated and the involvement of anti-PfMSP1p19 antibodies in ADRB was explored in a subset of samples using (1) isogenic P. falciparum parasite clones expressing P. falciparum or Plasmodium chabaudi MSP1p19; (2) PfMSP1p19-coated plaque ADRB; and, (3) ADRB triggering using sera depleted from PfMSP1p19 antibodies by absorption onto the baculovirus recombinant antigen. RESULTS: ADRB activity correlated with anti-PfMSP1p19 IgG levels (P < 10(-3)). A substantial contribution of PfMSP1p19 antibody responses to ADRB was confirmed (P < 10(-4)) in an age-adjusted linear regression model. PfMSP1p19 antibodies accounted for 33.1 % (range 7-54 %) and 33.2 % (range 0-70 %) of ADRB activity evaluated using isogenic merozoites (P < 10(-3)) and depleted sera (P = 0.0017), respectively. Coating of PfMSP1p19 on plates induced strong ADRB in anti-PfMSP1p19-positive sera. CONCLUSION: These data show that naturally acquired P. falciparum MSP1p19 antibodies are potent inducers of neutrophil ADRB and support the development of PfMSP1p19-based malaria vaccine using ADRB assay as a functional surrogate for protection.
66 schema:genre research_article
67 schema:inLanguage en
68 schema:isAccessibleForFree true
69 schema:isPartOf Na53d2162f12b4d4fb44e05ccccf65d93
70 Nbaf3f1e0c2d14cf1ace449a2104994c2
71 sg:journal.1030597
72 schema:name Antibodies to Plasmodium falciparum merozoite surface protein-1p19 malaria vaccine candidate induce antibody-dependent respiratory burst in human neutrophils
73 schema:pagination 409
74 schema:productId N16975f0a8aff41d9a83249f1f7b470ca
75 N5ae385ffa42f4db5b0b1d3a912a704b7
76 N722c6d6f53cb47d486393c95ead54cb1
77 N77016b1eff5a4ff7b14683ea51567e50
78 N8986bf9de89e4786aa6bcb5f2744c485
79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047215837
80 https://doi.org/10.1186/s12936-015-0935-5
81 schema:sdDatePublished 2019-04-10T21:38
82 schema:sdLicense https://scigraph.springernature.com/explorer/license/
83 schema:sdPublisher Ne3b52e277cf941fb96b2a006518791d9
84 schema:url http://link.springer.com/10.1186%2Fs12936-015-0935-5
85 sgo:license sg:explorer/license/
86 sgo:sdDataset articles
87 rdf:type schema:ScholarlyArticle
88 N08359f8771634de8a28a3dfdb01ddfe1 rdf:first sg:person.0657003425.78
89 rdf:rest N08e5269a254549a2a4883c27c8178d14
90 N08e5269a254549a2a4883c27c8178d14 rdf:first sg:person.01226364731.06
91 rdf:rest Nafc5d97157f8456d9d3d9ef8bbc64482
92 N0ac1ad3f8f324ad8a7e8493216c80ede schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Humans
94 rdf:type schema:DefinedTerm
95 N0ce91087c10e4ffeb557800cbb4e3919 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Plasmodium falciparum
97 rdf:type schema:DefinedTerm
98 N0edf94ec7b054b068adf274bb7d6439e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Antibodies, Protozoan
100 rdf:type schema:DefinedTerm
101 N16975f0a8aff41d9a83249f1f7b470ca schema:name doi
102 schema:value 10.1186/s12936-015-0935-5
103 rdf:type schema:PropertyValue
104 N1ae46ae37d6c4fc28e9dc290fe73ec54 rdf:first sg:person.01246523262.39
105 rdf:rest N08359f8771634de8a28a3dfdb01ddfe1
106 N1b195a22a64c44c3b030aa4fb7543298 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Middle Aged
108 rdf:type schema:DefinedTerm
109 N248f650bcb544353b7641ffb5c57370b rdf:first sg:person.01241074662.04
110 rdf:rest rdf:nil
111 N293590f363194c4fa9a8503374d1c12f rdf:first sg:person.0106442510.63
112 rdf:rest N248f650bcb544353b7641ffb5c57370b
113 N2f051f52105c4d629a6dc0e40e99738e rdf:first sg:person.01317650277.87
114 rdf:rest N1ae46ae37d6c4fc28e9dc290fe73ec54
115 N2f6c7f1788f34600b37d43a851078689 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Child
117 rdf:type schema:DefinedTerm
118 N36464351255548a5bf2da8f29a8d24d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Female
120 rdf:type schema:DefinedTerm
121 N39e1035e46c649a988c6dcf38f7ff9fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Cross-Sectional Studies
123 rdf:type schema:DefinedTerm
124 N5ae385ffa42f4db5b0b1d3a912a704b7 schema:name dimensions_id
125 schema:value pub.1047215837
126 rdf:type schema:PropertyValue
127 N722c6d6f53cb47d486393c95ead54cb1 schema:name readcube_id
128 schema:value e0ebe3e7fdf00719d26b72f7d9414df284ae44b6113ec43bfb9d569338ab5d71
129 rdf:type schema:PropertyValue
130 N77016b1eff5a4ff7b14683ea51567e50 schema:name pubmed_id
131 schema:value 26471813
132 rdf:type schema:PropertyValue
133 N7a674d5e0398465abb9278e1e65a9c9b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Adult
135 rdf:type schema:DefinedTerm
136 N8434a2def5374fdab6d11f20bb786b19 rdf:first sg:person.0577360635.21
137 rdf:rest Nf76c97a06f9b429a83e7abdcd553849e
138 N88341d0d78b4429bb01c5959586baa3b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Longitudinal Studies
140 rdf:type schema:DefinedTerm
141 N8986bf9de89e4786aa6bcb5f2744c485 schema:name nlm_unique_id
142 schema:value 101139802
143 rdf:type schema:PropertyValue
144 N8bdc8ebbd5094a559f861aa4bc965fc2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Neutrophils
146 rdf:type schema:DefinedTerm
147 N95ce4589186a427792b95873a5b2edbc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Adolescent
149 rdf:type schema:DefinedTerm
150 N9c88edcb4e814c79b8ba17dc69a222a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Respiratory Burst
152 rdf:type schema:DefinedTerm
153 N9e7d81a93df94174bde5bc3c9afd7c2e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Young Adult
155 rdf:type schema:DefinedTerm
156 Na53d2162f12b4d4fb44e05ccccf65d93 schema:issueNumber 1
157 rdf:type schema:PublicationIssue
158 Naf5b9710ccda4dc3a8ac2ccac8f23226 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Merozoite Surface Protein 1
160 rdf:type schema:DefinedTerm
161 Nafc5d97157f8456d9d3d9ef8bbc64482 rdf:first sg:person.01365763477.10
162 rdf:rest Nec70d0f5e5b347e7a9bc2b147a6b0dbb
163 Nb093d1755ad24c51a288239a06e993d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Male
165 rdf:type schema:DefinedTerm
166 Nb337f83519f74661ab469da1f7e0082d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Aged, 80 and over
168 rdf:type schema:DefinedTerm
169 Nb63397c2c8914cbba624769aad892bcc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Plasmodium chabaudi
171 rdf:type schema:DefinedTerm
172 Nbaf3f1e0c2d14cf1ace449a2104994c2 schema:volumeNumber 14
173 rdf:type schema:PublicationVolume
174 Nca897a2bc29b46ddbae8ad67bfb56d12 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Child, Preschool
176 rdf:type schema:DefinedTerm
177 Ne01e4034142d4a198f632f2a0d3d7abc rdf:first sg:person.01113653146.35
178 rdf:rest N8434a2def5374fdab6d11f20bb786b19
179 Ne3b52e277cf941fb96b2a006518791d9 schema:name Springer Nature - SN SciGraph project
180 rdf:type schema:Organization
181 Ne9446b5b98aa4880bf7e64aec97fbb5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Senegal
183 rdf:type schema:DefinedTerm
184 Nec70d0f5e5b347e7a9bc2b147a6b0dbb rdf:first sg:person.01370574675.51
185 rdf:rest Ne01e4034142d4a198f632f2a0d3d7abc
186 Nf76c97a06f9b429a83e7abdcd553849e rdf:first sg:person.01130356263.21
187 rdf:rest N293590f363194c4fa9a8503374d1c12f
188 Nfba9e7147a8e4d97a3e26177e6b7ea67 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Aged
190 rdf:type schema:DefinedTerm
191 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
192 schema:name Medical and Health Sciences
193 rdf:type schema:DefinedTerm
194 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
195 schema:name Immunology
196 rdf:type schema:DefinedTerm
197 sg:journal.1030597 schema:issn 1475-2875
198 schema:name Malaria Journal
199 rdf:type schema:Periodical
200 sg:person.0106442510.63 schema:affiliation https://www.grid.ac/institutes/grid.428999.7
201 schema:familyName Mercereau-Puijalon
202 schema:givenName Odile
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0106442510.63
204 rdf:type schema:Person
205 sg:person.01113653146.35 schema:affiliation https://www.grid.ac/institutes/grid.418508.0
206 schema:familyName Tall
207 schema:givenName Adama
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113653146.35
209 rdf:type schema:Person
210 sg:person.01130356263.21 schema:affiliation https://www.grid.ac/institutes/grid.418508.0
211 schema:familyName Touré
212 schema:givenName Aissatou
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130356263.21
214 rdf:type schema:Person
215 sg:person.01226364731.06 schema:affiliation https://www.grid.ac/institutes/grid.418508.0
216 schema:familyName Mansourou
217 schema:givenName Annick
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226364731.06
219 rdf:type schema:Person
220 sg:person.01241074662.04 schema:affiliation https://www.grid.ac/institutes/grid.418508.0
221 schema:familyName Perraut
222 schema:givenName Ronald
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241074662.04
224 rdf:type schema:Person
225 sg:person.01246523262.39 schema:affiliation https://www.grid.ac/institutes/grid.418508.0
226 schema:familyName Varela
227 schema:givenName Marie-Louise
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246523262.39
229 rdf:type schema:Person
230 sg:person.01317650277.87 schema:affiliation https://www.grid.ac/institutes/grid.428999.7
231 schema:familyName Joos
232 schema:givenName Charlotte
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317650277.87
234 rdf:type schema:Person
235 sg:person.01365763477.10 schema:affiliation https://www.grid.ac/institutes/grid.418508.0
236 schema:familyName Marrama
237 schema:givenName Laurence
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365763477.10
239 rdf:type schema:Person
240 sg:person.01370574675.51 schema:affiliation https://www.grid.ac/institutes/grid.418291.7
241 schema:familyName Sokhna
242 schema:givenName Cheikh
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370574675.51
244 rdf:type schema:Person
245 sg:person.0577360635.21 schema:affiliation https://www.grid.ac/institutes/grid.418291.7
246 schema:familyName Trape
247 schema:givenName Jean-François
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577360635.21
249 rdf:type schema:Person
250 sg:person.0657003425.78 schema:affiliation https://www.grid.ac/institutes/grid.418508.0
251 schema:familyName Mbengue
252 schema:givenName Babacar
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657003425.78
254 rdf:type schema:Person
255 sg:pub.10.1038/71595 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030988759
256 https://doi.org/10.1038/71595
257 rdf:type schema:CreativeWork
258 sg:pub.10.1186/1472-6750-11-77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046821155
259 https://doi.org/10.1186/1472-6750-11-77
260 rdf:type schema:CreativeWork
261 sg:pub.10.1186/1475-2875-13-410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045424953
262 https://doi.org/10.1186/1475-2875-13-410
263 rdf:type schema:CreativeWork
264 sg:pub.10.1186/1475-2875-7-142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039058645
265 https://doi.org/10.1186/1475-2875-7-142
266 rdf:type schema:CreativeWork
267 sg:pub.10.1186/1475-2875-7-173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020507420
268 https://doi.org/10.1186/1475-2875-7-173
269 rdf:type schema:CreativeWork
270 https://app.dimensions.ai/details/publication/pub.1074366577 schema:CreativeWork
271 https://app.dimensions.ai/details/publication/pub.1076805201 schema:CreativeWork
272 https://app.dimensions.ai/details/publication/pub.1077024762 schema:CreativeWork
273 https://app.dimensions.ai/details/publication/pub.1079794154 schema:CreativeWork
274 https://doi.org/10.1016/j.cell.2006.02.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050338063
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/j.talanta.2009.02.050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019219225
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1016/j.vaccine.2006.04.069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020219750
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/j.vaccine.2006.09.074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009860591
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1016/j.vaccine.2007.10.064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035095281
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1016/s0022-2836(03)00376-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011584488
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1016/s0166-6851(97)00128-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024828444
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1016/s1097-2765(00)80473-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001608061
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1016/s1471-4906(02)00012-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003436275
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1016/s1471-4922(02)02249-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010392287
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1016/s1473-3099(15)70032-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024317843
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1056/nejmoa0808859 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011738279
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1084/jem.182.2.409 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024033910
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1084/jem.193.12.1403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011171607
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1086/379838 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052186474
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1086/426398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007154831
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1128/cvi.00172-08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029865115
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1128/iai.01679-05 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032130702
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1182/blood-2003-02-0583 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038115104
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1189/jlb.0513274 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030137266
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1189/jlb.4a0614-283rr schema:sameAs https://app.dimensions.ai/details/publication/pub.1010909299
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1371/journal.pmed.0040320 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012557119
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1371/journal.pmed.1000218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039249999
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1371/journal.pone.0002000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043594523
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1371/journal.pone.0009871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032498617
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1371/journal.pone.0022525 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017040181
325 rdf:type schema:CreativeWork
326 https://doi.org/10.4049/jimmunol.173.1.666 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076855557
327 rdf:type schema:CreativeWork
328 https://doi.org/10.4269/ajtmh.1994.51.123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082639193
329 rdf:type schema:CreativeWork
330 https://doi.org/10.4269/ajtmh.1996.54.449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082891943
331 rdf:type schema:CreativeWork
332 https://doi.org/10.4269/ajtmh.2004.71.239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076883992
333 rdf:type schema:CreativeWork
334 https://www.grid.ac/institutes/grid.418291.7 schema:alternateName Institut de Recherche pour le Développement
335 schema:name Institut de Recherche pour le Développement (IRD), URMITE, Dakar, Senegal
336 rdf:type schema:Organization
337 https://www.grid.ac/institutes/grid.418508.0 schema:alternateName Institut Pasteur de Dakar
338 schema:name Unité d’Epidémiologie, Institut Pasteur de Dakar, Dakar, Senegal
339 Unité d’Immunogénétique/UCAD, Institut Pasteur de Dakar, Dakar, Senegal
340 Unité d’Immunologie, Institut Pasteur de Dakar, Dakar, Senegal
341 rdf:type schema:Organization
342 https://www.grid.ac/institutes/grid.428999.7 schema:alternateName Institut Pasteur
343 schema:name Unité d’Immunologie Moléculaire des Parasites, Institut Pasteur, Paris, France
344 Unité d’Immunologie, Institut Pasteur de Dakar, Dakar, Senegal
345 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...