G6PD deficiency in male individuals infected by Plasmodium vivax malaria in the Brazilian Amazon: a cost study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Henry M Peixoto, Marcelo AM Brito, Gustavo AS Romero, Wuelton M Monteiro, Marcus VG de Lacerda, Maria Regina F de Oliveira

ABSTRACT

BACKGROUND: Deficiency of the enzyme G6PD (G6PDd) is caused by mutations in the gene G6PD, which plays an important role in protecting the red blood cell against oxidizing agents; it is linked to chromosome X, and it may affects both sexes. The clinically relevant manifestations, such as acute haemolytic anaemia, mainly occur in men, however. The 8-aminoquinoline primaquine, which is the medication used in the radical treatment of malaria caused by Plasmodium vivax, represents the main factor that triggers complications associated with G6PDd. The current study aims to estimate the costs of G6PDd among male individuals infected by P. vivax in the Brazilian Amazon. METHODS: This is an economic analysis developed within the Brazilian National Health System perspective for the years of 2009, 2010 and 2011. Direct medical and non-medical costs were estimated for G6PDd in the Brazilian Amazon, considering among those suffering from the deficiency the costs of diagnosing infection by P. vivax, its treatment and severe adverse events that require hospitalization and were connected to the use of primaquine. RESULTS: The estimates of the average costs of diagnosing vivax malaria, of its treatment and of severe adverse events after using primaquine among the carriers of G6PDd, over the three evaluated years, corresponded to US$ 739,410.42; US$ 2,120.04 and US$ 4,858,108.87, respectively. The results indicate that the average total cost in the study period corresponded to US$ 5,599,639.33, varying in accordance with the sensitivity analysis between US$ 4,439,512.14 and US$ 6,702,619.24. CONCLUSION: The results indicate that the use of primaquine among men with G6PDd who are infected by P. vivax represents a heavy burden on the public health service of Brazil. More... »

PAGES

126

References to SciGraph publications

  • 2010-12. Malaria in Brazil: an overview in MALARIA JOURNAL
  • 2012-12. Cost-effectiveness of diagnostic for malaria in Extra-Amazon Region, Brazil in MALARIA JOURNAL
  • 2014-12. Estimation of malaria haplotype and genotype frequencies: a statistical approach to overcome the challenge associated with multiclonal infections in MALARIA JOURNAL
  • 2009-12. Malaria is associated with poor school performance in an endemic area of the Brazilian Amazon in MALARIA JOURNAL
  • 2013-12. G6PD testing in support of treatment and elimination of malaria: recommendations for evaluation of G6PD tests in MALARIA JOURNAL
  • 2014-09. Household responses to malaria: illness perception, cost implications and treatment-seeking behavior of mothers in Calabar, Nigeria in MALARIA JOURNAL
  • 2014-12. Clinical complications of G6PD deficiency in Latin American and Caribbean populations: systematic review and implications for malaria elimination programmes in MALARIA JOURNAL
  • 2010-12. Cost effectiveness of OptiMal® rapid diagnostic test for malaria in remote areas of the Amazon Region, Brazil in MALARIA JOURNAL
  • 2013-12. Review of key knowledge gaps in glucose-6-phosphate dehydrogenase deficiency detection with regard to the safe clinical deployment of 8-aminoquinoline treatment regimens: a workshop report in MALARIA JOURNAL
  • 2011-12. Costs and cost-effectiveness of malaria control interventions - a systematic review in MALARIA JOURNAL
  • 2014-12. Mass primaquine treatment to eliminate vivax malaria: lessons from the past in MALARIA JOURNAL
  • 2014-12. Geographical variation in Plasmodium vivax relapse in MALARIA JOURNAL
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12936-015-0647-x

    DOI

    http://dx.doi.org/10.1186/s12936-015-0647-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1008138602

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25889063


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antimalarials", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Brazil", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Glucosephosphate Dehydrogenase Deficiency", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Malaria, Vivax", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Plasmodium vivax", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Primaquine", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Bras\u00edlia", 
              "id": "https://www.grid.ac/institutes/grid.7632.0", 
              "name": [
                "Centre for Tropical Medicine, University of Bras\u00edlia, Bras\u00edlia, Federal District, Brazil", 
                "University Centre of Bras\u00edlia, Bras\u00edlia, Federal District, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Peixoto", 
            "givenName": "Henry M", 
            "id": "sg:person.01041352151.95", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041352151.95"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of the State of Amazonas", 
              "id": "https://www.grid.ac/institutes/grid.412290.c", 
              "name": [
                "Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Manaus, Amazonas, Brazil", 
                "University of the State of Amazonas, Manaus, Amazonas, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Brito", 
            "givenName": "Marcelo AM", 
            "id": "sg:person.013311620512.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013311620512.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Bras\u00edlia", 
              "id": "https://www.grid.ac/institutes/grid.7632.0", 
              "name": [
                "Centre for Tropical Medicine, University of Bras\u00edlia, Bras\u00edlia, Federal District, Brazil", 
                "National Institute for Science and Technology for Health Technology Assessment (IATS/CNPq), Porto Alegre, RS, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Romero", 
            "givenName": "Gustavo AS", 
            "id": "sg:person.013605754232.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013605754232.64"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of the State of Amazonas", 
              "id": "https://www.grid.ac/institutes/grid.412290.c", 
              "name": [
                "Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Manaus, Amazonas, Brazil", 
                "University of the State of Amazonas, Manaus, Amazonas, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Monteiro", 
            "givenName": "Wuelton M", 
            "id": "sg:person.01141171601.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141171601.76"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Oswaldo Cruz Foundation", 
              "id": "https://www.grid.ac/institutes/grid.418068.3", 
              "name": [
                "Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Manaus, Amazonas, Brazil", 
                "University of the State of Amazonas, Manaus, Amazonas, Brazil", 
                "Centro de Pesquisas Le\u00f4nidas & Maria Deane, FIOCRUZ, Manaus, Amazonas, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "de Lacerda", 
            "givenName": "Marcus VG", 
            "id": "sg:person.011421652101.60", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011421652101.60"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Bras\u00edlia", 
              "id": "https://www.grid.ac/institutes/grid.7632.0", 
              "name": [
                "Centre for Tropical Medicine, University of Bras\u00edlia, Bras\u00edlia, Federal District, Brazil", 
                "National Institute for Science and Technology for Health Technology Assessment (IATS/CNPq), Porto Alegre, RS, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "de Oliveira", 
            "givenName": "Maria Regina F", 
            "id": "sg:person.01352020523.80", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352020523.80"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/s0140-6736(13)62568-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006223748"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1475-2875-13-102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009180426", 
              "https://doi.org/10.1186/1475-2875-13-102"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1475-2875-11-390", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010267764", 
              "https://doi.org/10.1186/1475-2875-11-390"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/cmr.15.4.564-594.2002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013510676"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/heapol/17.1.112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015401833"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/cid/cis615", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016099152"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1475-2875-13-51", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016589097", 
              "https://doi.org/10.1186/1475-2875-13-51"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2007-04-077412", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017016897"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1590/s0034-89102009000300023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017032381"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1590/s0034-89102009000300023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017032381"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.socscimed.2004.05.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017408664"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1475-2875-13-70", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017594771", 
              "https://doi.org/10.1186/1475-2875-13-70"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1475-2875-12-112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020631200", 
              "https://doi.org/10.1186/1475-2875-12-112"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pmed.1001339", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023509008"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bcmd.2012.01.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025191794"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1475-2875-13-144", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025459768", 
              "https://doi.org/10.1186/1475-2875-13-144"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1475-2875-9-277", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029590846", 
              "https://doi.org/10.1186/1475-2875-9-277"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pmed.1000402", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031792447"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1475-2875-8-230", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032558965", 
              "https://doi.org/10.1186/1475-2875-8-230"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0028357", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033543585"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1179/000349804225003064", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034620174"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.pt.2009.12.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036226939"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1475-2875-12-391", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040573899", 
              "https://doi.org/10.1186/1475-2875-12-391"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(08)60073-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041111007"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1475-2875-10-337", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041782838", 
              "https://doi.org/10.1186/1475-2875-10-337"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1413-8670(10)70084-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042939304"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1475-2875-13-s1-p102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043243532", 
              "https://doi.org/10.1186/1475-2875-13-s1-p102"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pntd.0001814", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043256627"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4269/ajtmh.14-0298", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044688106"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4269/ajtmh.14-0298", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044688106"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4269/ajtmh.14-0298", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044688106"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.1996.03540150055031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046507870"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1590/s0104-11692011000600002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050919386"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1475-2875-9-115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052046916", 
              "https://doi.org/10.1186/1475-2875-9-115"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pmed.1000406", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052309395"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/trstmh/trt015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060061625"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1590/0074-0276140123", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068096225"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077508175", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4269/ajtmh.2007.77.779", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077511202"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078246787", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2015-12", 
        "datePublishedReg": "2015-12-01", 
        "description": "BACKGROUND: Deficiency of the enzyme G6PD (G6PDd) is caused by mutations in the gene G6PD, which plays an important role in protecting the red blood cell against oxidizing agents; it is linked to chromosome X, and it may affects both sexes. The clinically relevant manifestations, such as acute haemolytic anaemia, mainly occur in men, however. The 8-aminoquinoline primaquine, which is the medication used in the radical treatment of malaria caused by Plasmodium vivax, represents the main factor that triggers complications associated with G6PDd. The current study aims to estimate the costs of G6PDd among male individuals infected by P. vivax in the Brazilian Amazon.\nMETHODS: This is an economic analysis developed within the Brazilian National Health System perspective for the years of 2009, 2010 and 2011. Direct medical and non-medical costs were estimated for G6PDd in the Brazilian Amazon, considering among those suffering from the deficiency the costs of diagnosing infection by P. vivax, its treatment and severe adverse events that require hospitalization and were connected to the use of primaquine.\nRESULTS: The estimates of the average costs of diagnosing vivax malaria, of its treatment and of severe adverse events after using primaquine among the carriers of G6PDd, over the three evaluated years, corresponded to US$ 739,410.42; US$ 2,120.04 and US$ 4,858,108.87, respectively. The results indicate that the average total cost in the study period corresponded to US$ 5,599,639.33, varying in accordance with the sensitivity analysis between US$ 4,439,512.14 and US$ 6,702,619.24.\nCONCLUSION: The results indicate that the use of primaquine among men with G6PDd who are infected by P. vivax represents a heavy burden on the public health service of Brazil.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/s12936-015-0647-x", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1030597", 
            "issn": [
              "1475-2875"
            ], 
            "name": "Malaria Journal", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "14"
          }
        ], 
        "name": "G6PD deficiency in male individuals infected by Plasmodium vivax malaria in the Brazilian Amazon: a cost study", 
        "pagination": "126", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "26c5d85c63dbf25fd92d5257d44735232bafdde30566ac76c1cd30d401b01518"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "25889063"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101139802"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s12936-015-0647-x"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1008138602"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s12936-015-0647-x", 
          "https://app.dimensions.ai/details/publication/pub.1008138602"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T13:08", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000367_0000000367/records_88230_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1186%2Fs12936-015-0647-x"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12936-015-0647-x'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12936-015-0647-x'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12936-015-0647-x'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12936-015-0647-x'


     

    This table displays all metadata directly associated to this object as RDF triples.

    267 TRIPLES      21 PREDICATES      74 URIs      29 LITERALS      17 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s12936-015-0647-x schema:about N60d01067e05045759e1a0d02752fed45
    2 N6787e9a561204cefbba64010734af8cd
    3 N7b5dab2eb44e496d9483735379a20953
    4 N7b75241a8e51472b9972bbc8b889b495
    5 N8edb2b032b0a4a948ff8778b9e8e823d
    6 Na634dd2657aa4fe0a527083beccad2ab
    7 Naaa0109daf394c4986f1d219e2bbf6e2
    8 Nf194ec0df39341f2bb7e07fcca75673a
    9 anzsrc-for:11
    10 anzsrc-for:1103
    11 schema:author Nf85ef152fece467ca350b5044fa1ce18
    12 schema:citation sg:pub.10.1186/1475-2875-10-337
    13 sg:pub.10.1186/1475-2875-11-390
    14 sg:pub.10.1186/1475-2875-12-112
    15 sg:pub.10.1186/1475-2875-12-391
    16 sg:pub.10.1186/1475-2875-13-102
    17 sg:pub.10.1186/1475-2875-13-144
    18 sg:pub.10.1186/1475-2875-13-51
    19 sg:pub.10.1186/1475-2875-13-70
    20 sg:pub.10.1186/1475-2875-13-s1-p102
    21 sg:pub.10.1186/1475-2875-8-230
    22 sg:pub.10.1186/1475-2875-9-115
    23 sg:pub.10.1186/1475-2875-9-277
    24 https://app.dimensions.ai/details/publication/pub.1077508175
    25 https://app.dimensions.ai/details/publication/pub.1078246787
    26 https://doi.org/10.1001/jama.1996.03540150055031
    27 https://doi.org/10.1016/j.bcmd.2012.01.001
    28 https://doi.org/10.1016/j.pt.2009.12.005
    29 https://doi.org/10.1016/j.socscimed.2004.05.025
    30 https://doi.org/10.1016/s0140-6736(08)60073-2
    31 https://doi.org/10.1016/s0140-6736(13)62568-4
    32 https://doi.org/10.1016/s1413-8670(10)70084-2
    33 https://doi.org/10.1093/cid/cis615
    34 https://doi.org/10.1093/heapol/17.1.112
    35 https://doi.org/10.1093/trstmh/trt015
    36 https://doi.org/10.1128/cmr.15.4.564-594.2002
    37 https://doi.org/10.1179/000349804225003064
    38 https://doi.org/10.1182/blood-2007-04-077412
    39 https://doi.org/10.1371/journal.pmed.1000402
    40 https://doi.org/10.1371/journal.pmed.1000406
    41 https://doi.org/10.1371/journal.pmed.1001339
    42 https://doi.org/10.1371/journal.pntd.0001814
    43 https://doi.org/10.1371/journal.pone.0028357
    44 https://doi.org/10.1590/0074-0276140123
    45 https://doi.org/10.1590/s0034-89102009000300023
    46 https://doi.org/10.1590/s0104-11692011000600002
    47 https://doi.org/10.4269/ajtmh.14-0298
    48 https://doi.org/10.4269/ajtmh.2007.77.779
    49 schema:datePublished 2015-12
    50 schema:datePublishedReg 2015-12-01
    51 schema:description BACKGROUND: Deficiency of the enzyme G6PD (G6PDd) is caused by mutations in the gene G6PD, which plays an important role in protecting the red blood cell against oxidizing agents; it is linked to chromosome X, and it may affects both sexes. The clinically relevant manifestations, such as acute haemolytic anaemia, mainly occur in men, however. The 8-aminoquinoline primaquine, which is the medication used in the radical treatment of malaria caused by Plasmodium vivax, represents the main factor that triggers complications associated with G6PDd. The current study aims to estimate the costs of G6PDd among male individuals infected by P. vivax in the Brazilian Amazon. METHODS: This is an economic analysis developed within the Brazilian National Health System perspective for the years of 2009, 2010 and 2011. Direct medical and non-medical costs were estimated for G6PDd in the Brazilian Amazon, considering among those suffering from the deficiency the costs of diagnosing infection by P. vivax, its treatment and severe adverse events that require hospitalization and were connected to the use of primaquine. RESULTS: The estimates of the average costs of diagnosing vivax malaria, of its treatment and of severe adverse events after using primaquine among the carriers of G6PDd, over the three evaluated years, corresponded to US$ 739,410.42; US$ 2,120.04 and US$ 4,858,108.87, respectively. The results indicate that the average total cost in the study period corresponded to US$ 5,599,639.33, varying in accordance with the sensitivity analysis between US$ 4,439,512.14 and US$ 6,702,619.24. CONCLUSION: The results indicate that the use of primaquine among men with G6PDd who are infected by P. vivax represents a heavy burden on the public health service of Brazil.
    52 schema:genre research_article
    53 schema:inLanguage en
    54 schema:isAccessibleForFree true
    55 schema:isPartOf Nd17f002398654b4d9677d3cb17636de9
    56 Nead94468aa3946efa81863cf5dbade36
    57 sg:journal.1030597
    58 schema:name G6PD deficiency in male individuals infected by Plasmodium vivax malaria in the Brazilian Amazon: a cost study
    59 schema:pagination 126
    60 schema:productId N2812bbd79fb247aa87621cf2f41811a4
    61 N4906bfc205594da0b585b59c4205ef72
    62 N885751eba0ed44249d591ff9b91b1678
    63 Naa2be095ae4c4c44998c52568cdd2736
    64 Nc9843ab3d77d4874ad3d08e746fa171f
    65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008138602
    66 https://doi.org/10.1186/s12936-015-0647-x
    67 schema:sdDatePublished 2019-04-11T13:08
    68 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    69 schema:sdPublisher N50da05349e3e4f9c84100ac75ac5eafb
    70 schema:url http://link.springer.com/10.1186%2Fs12936-015-0647-x
    71 sgo:license sg:explorer/license/
    72 sgo:sdDataset articles
    73 rdf:type schema:ScholarlyArticle
    74 N02987d062f8d4967ab6bc9bc27b6aede rdf:first sg:person.013311620512.03
    75 rdf:rest N1d8aa032657047bca209f725f1615b48
    76 N1d8aa032657047bca209f725f1615b48 rdf:first sg:person.013605754232.64
    77 rdf:rest N3895d9ec763940eca6a3fc05335cafb4
    78 N2812bbd79fb247aa87621cf2f41811a4 schema:name nlm_unique_id
    79 schema:value 101139802
    80 rdf:type schema:PropertyValue
    81 N3895d9ec763940eca6a3fc05335cafb4 rdf:first sg:person.01141171601.76
    82 rdf:rest Nc8b50e7ea42e42c59215c32120740a44
    83 N4906bfc205594da0b585b59c4205ef72 schema:name readcube_id
    84 schema:value 26c5d85c63dbf25fd92d5257d44735232bafdde30566ac76c1cd30d401b01518
    85 rdf:type schema:PropertyValue
    86 N50da05349e3e4f9c84100ac75ac5eafb schema:name Springer Nature - SN SciGraph project
    87 rdf:type schema:Organization
    88 N60d01067e05045759e1a0d02752fed45 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    89 schema:name Glucosephosphate Dehydrogenase Deficiency
    90 rdf:type schema:DefinedTerm
    91 N6787e9a561204cefbba64010734af8cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    92 schema:name Humans
    93 rdf:type schema:DefinedTerm
    94 N7b5dab2eb44e496d9483735379a20953 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    95 schema:name Plasmodium vivax
    96 rdf:type schema:DefinedTerm
    97 N7b75241a8e51472b9972bbc8b889b495 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    98 schema:name Brazil
    99 rdf:type schema:DefinedTerm
    100 N885751eba0ed44249d591ff9b91b1678 schema:name dimensions_id
    101 schema:value pub.1008138602
    102 rdf:type schema:PropertyValue
    103 N8edb2b032b0a4a948ff8778b9e8e823d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    104 schema:name Primaquine
    105 rdf:type schema:DefinedTerm
    106 Na634dd2657aa4fe0a527083beccad2ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    107 schema:name Antimalarials
    108 rdf:type schema:DefinedTerm
    109 Naa2be095ae4c4c44998c52568cdd2736 schema:name pubmed_id
    110 schema:value 25889063
    111 rdf:type schema:PropertyValue
    112 Naaa0109daf394c4986f1d219e2bbf6e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    113 schema:name Malaria, Vivax
    114 rdf:type schema:DefinedTerm
    115 Nc8b50e7ea42e42c59215c32120740a44 rdf:first sg:person.011421652101.60
    116 rdf:rest Nfd7831119f6e4f09925dbd6407f2c574
    117 Nc9843ab3d77d4874ad3d08e746fa171f schema:name doi
    118 schema:value 10.1186/s12936-015-0647-x
    119 rdf:type schema:PropertyValue
    120 Nd17f002398654b4d9677d3cb17636de9 schema:issueNumber 1
    121 rdf:type schema:PublicationIssue
    122 Nead94468aa3946efa81863cf5dbade36 schema:volumeNumber 14
    123 rdf:type schema:PublicationVolume
    124 Nf194ec0df39341f2bb7e07fcca75673a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Male
    126 rdf:type schema:DefinedTerm
    127 Nf85ef152fece467ca350b5044fa1ce18 rdf:first sg:person.01041352151.95
    128 rdf:rest N02987d062f8d4967ab6bc9bc27b6aede
    129 Nfd7831119f6e4f09925dbd6407f2c574 rdf:first sg:person.01352020523.80
    130 rdf:rest rdf:nil
    131 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    132 schema:name Medical and Health Sciences
    133 rdf:type schema:DefinedTerm
    134 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    135 schema:name Clinical Sciences
    136 rdf:type schema:DefinedTerm
    137 sg:journal.1030597 schema:issn 1475-2875
    138 schema:name Malaria Journal
    139 rdf:type schema:Periodical
    140 sg:person.01041352151.95 schema:affiliation https://www.grid.ac/institutes/grid.7632.0
    141 schema:familyName Peixoto
    142 schema:givenName Henry M
    143 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041352151.95
    144 rdf:type schema:Person
    145 sg:person.01141171601.76 schema:affiliation https://www.grid.ac/institutes/grid.412290.c
    146 schema:familyName Monteiro
    147 schema:givenName Wuelton M
    148 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141171601.76
    149 rdf:type schema:Person
    150 sg:person.011421652101.60 schema:affiliation https://www.grid.ac/institutes/grid.418068.3
    151 schema:familyName de Lacerda
    152 schema:givenName Marcus VG
    153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011421652101.60
    154 rdf:type schema:Person
    155 sg:person.013311620512.03 schema:affiliation https://www.grid.ac/institutes/grid.412290.c
    156 schema:familyName Brito
    157 schema:givenName Marcelo AM
    158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013311620512.03
    159 rdf:type schema:Person
    160 sg:person.01352020523.80 schema:affiliation https://www.grid.ac/institutes/grid.7632.0
    161 schema:familyName de Oliveira
    162 schema:givenName Maria Regina F
    163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352020523.80
    164 rdf:type schema:Person
    165 sg:person.013605754232.64 schema:affiliation https://www.grid.ac/institutes/grid.7632.0
    166 schema:familyName Romero
    167 schema:givenName Gustavo AS
    168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013605754232.64
    169 rdf:type schema:Person
    170 sg:pub.10.1186/1475-2875-10-337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041782838
    171 https://doi.org/10.1186/1475-2875-10-337
    172 rdf:type schema:CreativeWork
    173 sg:pub.10.1186/1475-2875-11-390 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010267764
    174 https://doi.org/10.1186/1475-2875-11-390
    175 rdf:type schema:CreativeWork
    176 sg:pub.10.1186/1475-2875-12-112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020631200
    177 https://doi.org/10.1186/1475-2875-12-112
    178 rdf:type schema:CreativeWork
    179 sg:pub.10.1186/1475-2875-12-391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040573899
    180 https://doi.org/10.1186/1475-2875-12-391
    181 rdf:type schema:CreativeWork
    182 sg:pub.10.1186/1475-2875-13-102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009180426
    183 https://doi.org/10.1186/1475-2875-13-102
    184 rdf:type schema:CreativeWork
    185 sg:pub.10.1186/1475-2875-13-144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025459768
    186 https://doi.org/10.1186/1475-2875-13-144
    187 rdf:type schema:CreativeWork
    188 sg:pub.10.1186/1475-2875-13-51 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016589097
    189 https://doi.org/10.1186/1475-2875-13-51
    190 rdf:type schema:CreativeWork
    191 sg:pub.10.1186/1475-2875-13-70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017594771
    192 https://doi.org/10.1186/1475-2875-13-70
    193 rdf:type schema:CreativeWork
    194 sg:pub.10.1186/1475-2875-13-s1-p102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043243532
    195 https://doi.org/10.1186/1475-2875-13-s1-p102
    196 rdf:type schema:CreativeWork
    197 sg:pub.10.1186/1475-2875-8-230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032558965
    198 https://doi.org/10.1186/1475-2875-8-230
    199 rdf:type schema:CreativeWork
    200 sg:pub.10.1186/1475-2875-9-115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052046916
    201 https://doi.org/10.1186/1475-2875-9-115
    202 rdf:type schema:CreativeWork
    203 sg:pub.10.1186/1475-2875-9-277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029590846
    204 https://doi.org/10.1186/1475-2875-9-277
    205 rdf:type schema:CreativeWork
    206 https://app.dimensions.ai/details/publication/pub.1077508175 schema:CreativeWork
    207 https://app.dimensions.ai/details/publication/pub.1078246787 schema:CreativeWork
    208 https://doi.org/10.1001/jama.1996.03540150055031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046507870
    209 rdf:type schema:CreativeWork
    210 https://doi.org/10.1016/j.bcmd.2012.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025191794
    211 rdf:type schema:CreativeWork
    212 https://doi.org/10.1016/j.pt.2009.12.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036226939
    213 rdf:type schema:CreativeWork
    214 https://doi.org/10.1016/j.socscimed.2004.05.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017408664
    215 rdf:type schema:CreativeWork
    216 https://doi.org/10.1016/s0140-6736(08)60073-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041111007
    217 rdf:type schema:CreativeWork
    218 https://doi.org/10.1016/s0140-6736(13)62568-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006223748
    219 rdf:type schema:CreativeWork
    220 https://doi.org/10.1016/s1413-8670(10)70084-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042939304
    221 rdf:type schema:CreativeWork
    222 https://doi.org/10.1093/cid/cis615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016099152
    223 rdf:type schema:CreativeWork
    224 https://doi.org/10.1093/heapol/17.1.112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015401833
    225 rdf:type schema:CreativeWork
    226 https://doi.org/10.1093/trstmh/trt015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060061625
    227 rdf:type schema:CreativeWork
    228 https://doi.org/10.1128/cmr.15.4.564-594.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013510676
    229 rdf:type schema:CreativeWork
    230 https://doi.org/10.1179/000349804225003064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034620174
    231 rdf:type schema:CreativeWork
    232 https://doi.org/10.1182/blood-2007-04-077412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017016897
    233 rdf:type schema:CreativeWork
    234 https://doi.org/10.1371/journal.pmed.1000402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031792447
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.1371/journal.pmed.1000406 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052309395
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1371/journal.pmed.1001339 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023509008
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1371/journal.pntd.0001814 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043256627
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1371/journal.pone.0028357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033543585
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1590/0074-0276140123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068096225
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1590/s0034-89102009000300023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017032381
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1590/s0104-11692011000600002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050919386
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.4269/ajtmh.14-0298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044688106
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.4269/ajtmh.2007.77.779 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077511202
    253 rdf:type schema:CreativeWork
    254 https://www.grid.ac/institutes/grid.412290.c schema:alternateName University of the State of Amazonas
    255 schema:name Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Manaus, Amazonas, Brazil
    256 University of the State of Amazonas, Manaus, Amazonas, Brazil
    257 rdf:type schema:Organization
    258 https://www.grid.ac/institutes/grid.418068.3 schema:alternateName Oswaldo Cruz Foundation
    259 schema:name Centro de Pesquisas Leônidas & Maria Deane, FIOCRUZ, Manaus, Amazonas, Brazil
    260 Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Manaus, Amazonas, Brazil
    261 University of the State of Amazonas, Manaus, Amazonas, Brazil
    262 rdf:type schema:Organization
    263 https://www.grid.ac/institutes/grid.7632.0 schema:alternateName University of Brasília
    264 schema:name Centre for Tropical Medicine, University of Brasília, Brasília, Federal District, Brazil
    265 National Institute for Science and Technology for Health Technology Assessment (IATS/CNPq), Porto Alegre, RS, Brazil
    266 University Centre of Brasília, Brasília, Federal District, Brazil
    267 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...