G6PD deficiency in male individuals infected by Plasmodium vivax malaria in the Brazilian Amazon: a cost study View Full Text


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Article Info

DATE

2015-12

AUTHORS

Henry M Peixoto, Marcelo AM Brito, Gustavo AS Romero, Wuelton M Monteiro, Marcus VG de Lacerda, Maria Regina F de Oliveira

ABSTRACT

BACKGROUND: Deficiency of the enzyme G6PD (G6PDd) is caused by mutations in the gene G6PD, which plays an important role in protecting the red blood cell against oxidizing agents; it is linked to chromosome X, and it may affects both sexes. The clinically relevant manifestations, such as acute haemolytic anaemia, mainly occur in men, however. The 8-aminoquinoline primaquine, which is the medication used in the radical treatment of malaria caused by Plasmodium vivax, represents the main factor that triggers complications associated with G6PDd. The current study aims to estimate the costs of G6PDd among male individuals infected by P. vivax in the Brazilian Amazon. METHODS: This is an economic analysis developed within the Brazilian National Health System perspective for the years of 2009, 2010 and 2011. Direct medical and non-medical costs were estimated for G6PDd in the Brazilian Amazon, considering among those suffering from the deficiency the costs of diagnosing infection by P. vivax, its treatment and severe adverse events that require hospitalization and were connected to the use of primaquine. RESULTS: The estimates of the average costs of diagnosing vivax malaria, of its treatment and of severe adverse events after using primaquine among the carriers of G6PDd, over the three evaluated years, corresponded to US$ 739,410.42; US$ 2,120.04 and US$ 4,858,108.87, respectively. The results indicate that the average total cost in the study period corresponded to US$ 5,599,639.33, varying in accordance with the sensitivity analysis between US$ 4,439,512.14 and US$ 6,702,619.24. CONCLUSION: The results indicate that the use of primaquine among men with G6PDd who are infected by P. vivax represents a heavy burden on the public health service of Brazil. More... »

PAGES

126

References to SciGraph publications

  • 2010-12. Malaria in Brazil: an overview in MALARIA JOURNAL
  • 2012-12. Cost-effectiveness of diagnostic for malaria in Extra-Amazon Region, Brazil in MALARIA JOURNAL
  • 2014-12. Estimation of malaria haplotype and genotype frequencies: a statistical approach to overcome the challenge associated with multiclonal infections in MALARIA JOURNAL
  • 2009-12. Malaria is associated with poor school performance in an endemic area of the Brazilian Amazon in MALARIA JOURNAL
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  • 2014-09. Household responses to malaria: illness perception, cost implications and treatment-seeking behavior of mothers in Calabar, Nigeria in MALARIA JOURNAL
  • 2014-12. Clinical complications of G6PD deficiency in Latin American and Caribbean populations: systematic review and implications for malaria elimination programmes in MALARIA JOURNAL
  • 2010-12. Cost effectiveness of OptiMal® rapid diagnostic test for malaria in remote areas of the Amazon Region, Brazil in MALARIA JOURNAL
  • 2013-12. Review of key knowledge gaps in glucose-6-phosphate dehydrogenase deficiency detection with regard to the safe clinical deployment of 8-aminoquinoline treatment regimens: a workshop report in MALARIA JOURNAL
  • 2011-12. Costs and cost-effectiveness of malaria control interventions - a systematic review in MALARIA JOURNAL
  • 2014-12. Mass primaquine treatment to eliminate vivax malaria: lessons from the past in MALARIA JOURNAL
  • 2014-12. Geographical variation in Plasmodium vivax relapse in MALARIA JOURNAL
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    http://scigraph.springernature.com/pub.10.1186/s12936-015-0647-x

    DOI

    http://dx.doi.org/10.1186/s12936-015-0647-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1008138602

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25889063


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    HOW TO GET THIS DATA PROGRAMMATICALLY:

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