Systems metabolic engineering for citric acid production by Aspergillus niger in the post-genomic era View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Zhenyu Tong, Xiaomei Zheng, Yi Tong, Yong-Cheng Shi, Jibin Sun

ABSTRACT

Citric acid is the world's largest consumed organic acid and is widely used in beverage, food and pharmaceutical industries. Aspergillus niger is the main industrial workhorse for citric acid production. Since the release of the genome sequence, extensive multi-omic data are being rapidly obtained, which greatly boost our understanding of the citric acid accumulation mechanism in A. niger to a molecular and system level. Most recently, the rapid development of CRISPR/Cas9 system facilitates highly efficient genome-scale genetic perturbation in A. niger. In this review, we summarize the impact of systems biology on the citric acid molecular regulatory mechanisms, the advances in metabolic engineering strategies for enhancing citric acid production and discuss the development and application of CRISPR/Cas9 systems for genome editing in A. niger. We believe that future systems metabolic engineering efforts will redesign and engineer A. niger as a highly optimized cell factory for industrial citric acid production. More... »

PAGES

28

References to SciGraph publications

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    http://scigraph.springernature.com/pub.10.1186/s12934-019-1064-6

    DOI

    http://dx.doi.org/10.1186/s12934-019-1064-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111909524

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30717739


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