Diabetes status-related differences in risk factors and mediators of heart failure in the general population: results from the MORGAM/BiomarCaRE consortium View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-09-28

AUTHORS

Matti A. Vuori, Jaakko Reinikainen, Stefan Söderberg, Ellinor Bergdahl, Pekka Jousilahti, Hugh Tunstall-Pedoe, Tanja Zeller, Dirk Westermann, Susana Sans, Allan Linneberg, Licia Iacoviello, Simona Costanzo, Veikko Salomaa, Stefan Blankenberg, Kari Kuulasmaa, Teemu J. Niiranen

ABSTRACT

BackgroundThe risk of heart failure among diabetic individuals is high, even under tight glycemic control. The correlates and mediators of heart failure risk in individuals with diabetes need more elucidation in large population-based cohorts with long follow-up times and a wide panel of biologically relevant biomarkers.MethodsIn a population-based sample of 3834 diabetic and 90,177 non-diabetic individuals, proportional hazards models and mediation analysis were used to assess the relation of conventional heart failure risk factors and biomarkers with incident heart failure.ResultsOver a median follow-up of 13.8 years, a total of 652 (17.0%) and 5524 (6.1%) cases of incident heart failure were observed in participants with and without diabetes, respectively. 51.4% were women and the mean age at baseline was 48.7 (standard deviation [SD] 12.5) years. The multivariable-adjusted hazard ratio (HR) for heart failure among diabetic individuals was 2.70 (95% confidence interval, 2.49–2.93) compared to non-diabetic participants. In the multivariable-adjusted Cox models, conventional cardiovascular disease risk factors, such as smoking (diabetes: HR 2.07 [1.59–2.69]; non-diabetes: HR 1.85 [1.68–2.02]), BMI (diabetes: HR 1.30 [1.18–1.42]; non-diabetes: HR 1.40 [1.35–1.47]), baseline myocardial infarction (diabetes: HR 2.06 [1.55–2.75]; non-diabetes: HR 2.86 [2.50–3.28]), and baseline atrial fibrillation (diabetes: HR 1.51 [0.82–2.80]; non-diabetes: HR 2.97 [2.21–4.00]) had the strongest associations with incident heart failure. In addition, biomarkers for cardiac strain (represented by nT-proBNP, diabetes: HR 1.26 [1.19–1.34]; non-diabetes: HR 1.43 [1.39–1.47]), myocardial injury (hs-TnI, diabetes: HR 1.10 [1.04–1.16]; non-diabetes: HR 1.13 [1.10–1.16]), and inflammation (hs-CRP, diabetes: HR 1.13 [1.03–1.24]; non-diabetes: HR 1.29 [1.25–1.34]) were also associated with incident heart failure. In general, all these associations were equally strong in non-diabetic and diabetic individuals. However, the strongest mediators of heart failure in diabetes were the direct effect of diabetes status itself (relative effect share 43.1% [33.9–52.3] and indirect effects (effect share 56.9% [47.7-66.1]) mediated by obesity (BMI, 13.2% [10.3–16.2]), cardiac strain/volume overload (nT-proBNP, 8.4% [-0.7–17.4]), and hyperglycemia (glucose, 12.0% [4.2–19.9]).ConclusionsThe findings suggest that the main mediators of heart failure in diabetes are obesity, hyperglycemia, and cardiac strain/volume overload. Conventional cardiovascular risk factors are strongly related to incident heart failure, but these associations are not stronger in diabetic than in non-diabetic individuals. Active measurement of relevant biomarkers could potentially be used to improve prevention and prediction of heart failure in high-risk diabetic patients. More... »

PAGES

195

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12933-021-01378-4

DOI

http://dx.doi.org/10.1186/s12933-021-01378-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1141460023

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34583686


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Glucose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "C-Reactive Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diabetes Mellitus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Europe", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Health Status", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heart Disease Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heart Failure", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Incidence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inflammation Mediators", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Natriuretic Peptide, Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Obesity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peptide Fragments", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prevalence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Assessment", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Troponin I", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, Finland", 
          "id": "http://www.grid.ac/institutes/grid.14758.3f", 
          "name": [
            "Division of Medicine, University of Turku and Turku University Hospital, Kiinanmyllynkatu 2, 20521, Turku, Finland", 
            "Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vuori", 
        "givenName": "Matti A.", 
        "id": "sg:person.07741011675.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07741011675.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, Finland", 
          "id": "http://www.grid.ac/institutes/grid.14758.3f", 
          "name": [
            "Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Reinikainen", 
        "givenName": "Jaakko", 
        "id": "sg:person.0661365230.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661365230.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Public Health and Clinical Medicine, Ume\u00e5 University, Ume\u00e5, Sweden", 
          "id": "http://www.grid.ac/institutes/grid.12650.30", 
          "name": [
            "Department of Public Health and Clinical Medicine, Ume\u00e5 University, Ume\u00e5, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "S\u00f6derberg", 
        "givenName": "Stefan", 
        "id": "sg:person.016465323374.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016465323374.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Public Health and Clinical Medicine, Ume\u00e5 University, Ume\u00e5, Sweden", 
          "id": "http://www.grid.ac/institutes/grid.12650.30", 
          "name": [
            "Department of Public Health and Clinical Medicine, Ume\u00e5 University, Ume\u00e5, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bergdahl", 
        "givenName": "Ellinor", 
        "id": "sg:person.01105351071.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105351071.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, Finland", 
          "id": "http://www.grid.ac/institutes/grid.14758.3f", 
          "name": [
            "Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jousilahti", 
        "givenName": "Pekka", 
        "id": "sg:person.0660107161.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660107161.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cardiovascular Epidemiology Unit, Institute of Cardiovascular Research, University of Dundee, Dundee, UK", 
          "id": "http://www.grid.ac/institutes/grid.8241.f", 
          "name": [
            "Cardiovascular Epidemiology Unit, Institute of Cardiovascular Research, University of Dundee, Dundee, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tunstall-Pedoe", 
        "givenName": "Hugh", 
        "id": "sg:person.01017535604.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017535604.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Heart Center Hamburg, Hamburg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.13648.38", 
          "name": [
            "University Heart Center Hamburg, Hamburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zeller", 
        "givenName": "Tanja", 
        "id": "sg:person.0765171035.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765171035.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Heart Center Hamburg, Hamburg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.13648.38", 
          "name": [
            "University Heart Center Hamburg, Hamburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Westermann", 
        "givenName": "Dirk", 
        "id": "sg:person.01205330340.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205330340.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Catalan Department of Health, Barcelona, Spain", 
          "id": "http://www.grid.ac/institutes/grid.425910.b", 
          "name": [
            "Catalan Department of Health, Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sans", 
        "givenName": "Susana", 
        "id": "sg:person.016241124507.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016241124507.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark", 
          "id": "http://www.grid.ac/institutes/grid.5254.6", 
          "name": [
            "Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark", 
            "Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Linneberg", 
        "givenName": "Allan", 
        "id": "sg:person.0637662640.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637662640.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Research Center in Epidemiology and Preventive Medicine, Department of Medicine and Surgery, University of Insubria, Varese, Italy", 
          "id": "http://www.grid.ac/institutes/grid.18147.3b", 
          "name": [
            "Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy", 
            "Research Center in Epidemiology and Preventive Medicine, Department of Medicine and Surgery, University of Insubria, Varese, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iacoviello", 
        "givenName": "Licia", 
        "id": "sg:person.01054443021.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054443021.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark", 
          "id": "http://www.grid.ac/institutes/grid.5254.6", 
          "name": [
            "Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Costanzo", 
        "givenName": "Simona", 
        "id": "sg:person.01255556215.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255556215.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, Finland", 
          "id": "http://www.grid.ac/institutes/grid.14758.3f", 
          "name": [
            "Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Salomaa", 
        "givenName": "Veikko", 
        "id": "sg:person.01022740164.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022740164.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Heart Center Hamburg, Hamburg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.13648.38", 
          "name": [
            "University Heart Center Hamburg, Hamburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Blankenberg", 
        "givenName": "Stefan", 
        "id": "sg:person.01365524177.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365524177.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, Finland", 
          "id": "http://www.grid.ac/institutes/grid.14758.3f", 
          "name": [
            "Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kuulasmaa", 
        "givenName": "Kari", 
        "id": "sg:person.01255257303.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255257303.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, Finland", 
          "id": "http://www.grid.ac/institutes/grid.14758.3f", 
          "name": [
            "Division of Medicine, University of Turku and Turku University Hospital, Kiinanmyllynkatu 2, 20521, Turku, Finland", 
            "Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Niiranen", 
        "givenName": "Teemu J.", 
        "id": "sg:person.0605152476.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605152476.70"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s11897-017-0337-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090312262", 
          "https://doi.org/10.1007/s11897-017-0337-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-017-18521-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100172381", 
          "https://doi.org/10.1038/s41598-017-18521-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41569-020-0381-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1127792290", 
          "https://doi.org/10.1038/s41569-020-0381-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12574-019-00446-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1121828459", 
          "https://doi.org/10.1007/s12574-019-00446-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-017-4390-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090957321", 
          "https://doi.org/10.1007/s00125-017-4390-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-018-19708-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100352024", 
          "https://doi.org/10.1038/s41598-018-19708-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11154-017-9423-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084817520", 
          "https://doi.org/10.1007/s11154-017-9423-2"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2021-09-28", 
    "datePublishedReg": "2021-09-28", 
    "description": "BackgroundThe risk of heart failure among diabetic individuals is high, even under tight glycemic control. The correlates and mediators of heart failure risk in individuals with diabetes need more elucidation in large population-based cohorts with long follow-up times and a wide panel of biologically relevant biomarkers.MethodsIn a population-based sample of 3834 diabetic and 90,177 non-diabetic individuals, proportional hazards models and mediation analysis were used to assess the relation of conventional heart failure risk factors and biomarkers with incident heart failure.ResultsOver a median follow-up of 13.8\u00a0years, a total of 652 (17.0%) and 5524 (6.1%) cases of incident heart failure were observed in participants with and without diabetes, respectively. 51.4% were women and the\u00a0mean age at baseline was 48.7 (standard deviation [SD] 12.5) years. The multivariable-adjusted hazard ratio (HR) for heart failure among diabetic individuals was 2.70 (95% confidence interval, 2.49\u20132.93) compared to non-diabetic participants. In the multivariable-adjusted Cox models, conventional cardiovascular disease risk factors, such as smoking (diabetes: HR 2.07 [1.59\u20132.69]; non-diabetes: HR 1.85 [1.68\u20132.02]), BMI (diabetes: HR 1.30 [1.18\u20131.42]; non-diabetes: HR 1.40 [1.35\u20131.47]), baseline myocardial infarction (diabetes: HR 2.06 [1.55\u20132.75]; non-diabetes: HR 2.86 [2.50\u20133.28]), and baseline atrial fibrillation (diabetes: HR 1.51 [0.82\u20132.80]; non-diabetes: HR 2.97 [2.21\u20134.00]) had the strongest associations with incident heart failure. In addition, biomarkers for cardiac strain (represented by nT-proBNP, diabetes: HR 1.26 [1.19\u20131.34]; non-diabetes: HR 1.43 [1.39\u20131.47]), myocardial injury (hs-TnI, diabetes: HR 1.10 [1.04\u20131.16]; non-diabetes: HR 1.13 [1.10\u20131.16]), and inflammation (hs-CRP, diabetes: HR 1.13 [1.03\u20131.24]; non-diabetes: HR 1.29 [1.25\u20131.34]) were also associated with incident heart failure. In general, all these associations were equally strong in non-diabetic and diabetic individuals. However, the strongest mediators of heart failure in diabetes were the direct effect of diabetes status itself (relative effect share 43.1% [33.9\u201352.3] and indirect effects (effect share 56.9% [47.7-66.1])\u00a0mediated by obesity (BMI, 13.2% [10.3\u201316.2]), cardiac strain/volume overload (nT-proBNP, 8.4% [-0.7\u201317.4]), and hyperglycemia (glucose, 12.0% [4.2\u201319.9]).ConclusionsThe findings suggest that the main mediators of heart failure in diabetes are obesity, hyperglycemia, and cardiac strain/volume overload. Conventional cardiovascular risk factors are strongly related to incident heart failure, but these associations are not stronger in diabetic than in non-diabetic individuals. Active measurement of relevant biomarkers could potentially be used to improve prevention and prediction of heart failure in high-risk diabetic patients.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s12933-021-01378-4", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.8840034", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3754454", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2757803", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.8104183", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.8964144", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1031021", 
        "issn": [
          "1475-2840"
        ], 
        "name": "Cardiovascular Diabetology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "20"
      }
    ], 
    "keywords": [
      "incident heart failure", 
      "heart failure", 
      "diabetic individuals", 
      "hazard ratio", 
      "risk factors", 
      "conventional cardiovascular disease risk factors", 
      "heart failure risk factors", 
      "multivariable-adjusted hazard ratios", 
      "cardiovascular disease risk factors", 
      "multivariable-adjusted Cox models", 
      "large population-based cohort", 
      "baseline atrial fibrillation", 
      "heart failure risk", 
      "non-diabetic participants", 
      "disease risk factors", 
      "population-based cohort", 
      "non-diabetic individuals", 
      "tight glycemic control", 
      "proportional hazards model", 
      "failure risk factors", 
      "population-based sample", 
      "diabetes status", 
      "glycemic control", 
      "long follow", 
      "atrial fibrillation", 
      "myocardial injury", 
      "mean age", 
      "myocardial infarction", 
      "Cox model", 
      "hazards model", 
      "diabetes", 
      "relevant biomarkers", 
      "cardiac strain", 
      "strong association", 
      "biomarkers", 
      "more elucidation", 
      "wide panel", 
      "failure", 
      "mediators", 
      "risk", 
      "direct effect", 
      "strong mediator", 
      "mediation analysis", 
      "association", 
      "individuals", 
      "participants", 
      "smoking", 
      "BMI", 
      "infarction", 
      "inflammation", 
      "fibrillation", 
      "ResultsOver", 
      "injury", 
      "cohort", 
      "follow", 
      "years", 
      "MethodsIn", 
      "baseline", 
      "women", 
      "age", 
      "factors", 
      "total", 
      "failure risk", 
      "correlates", 
      "status", 
      "control", 
      "cases", 
      "effect", 
      "panel", 
      "strains", 
      "samples", 
      "addition", 
      "elucidation", 
      "ratio", 
      "time", 
      "analysis", 
      "model", 
      "relation"
    ], 
    "name": "Diabetes status-related differences in risk factors and mediators of heart failure in the general population: results from the MORGAM/BiomarCaRE consortium", 
    "pagination": "195", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1141460023"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12933-021-01378-4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "34583686"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12933-021-01378-4", 
      "https://app.dimensions.ai/details/publication/pub.1141460023"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-11-24T21:08", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_889.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s12933-021-01378-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12933-021-01378-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12933-021-01378-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12933-021-01378-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12933-021-01378-4'


 

This table displays all metadata directly associated to this object as RDF triples.

398 TRIPLES      21 PREDICATES      134 URIs      118 LITERALS      30 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12933-021-01378-4 schema:about N00cc1d7f9a6d43e3a62ddff2fc74a6ed
2 N01c1211d790245c2949ad4c74ef4c6a7
3 N0224ea2f17c444428894c9063f417fea
4 N0c30f179b8644a17a0d1416e067fb247
5 N0d716e851e5c44dbb12ddc3856dd32f7
6 N0e3ffe65b4974a08b7bff55219c19435
7 N1283e93a39a74a608a3901dc35590752
8 N17341f38dd494bb4a8e5707bc9240eb3
9 N1d042f9122fc48a19cb716600ec22d96
10 N2f8d8f37962149a084b303b2e9e20cc6
11 N3693c17cb4ef4099b07c565153dbb9e6
12 N378a994570124e83b7782c09a2f0d1ed
13 N3b5a31d08c9f43d1b88c3c16bba45ee6
14 N46f8881bc8a044509e6f55fe0724a6a0
15 N744602248ba04a5fba0ff35d169edcb6
16 N778b80e6198b49878fdfd6a1e3229cc8
17 N7c6c9a123b5048468617ffa231820430
18 N8ec6e31a33b34ba0a7d3599874862062
19 N92588ee5db5e48019be4703f75363ea8
20 Na19558defa354dbf900cec92e5b099c2
21 Nc448bb7a0778472b9e9e3db05219ec3e
22 Nd1574280c2d140bab961aef1d01700ea
23 Nf3ef7e8b1bbe4867bed2c88f482bea8a
24 anzsrc-for:11
25 anzsrc-for:1102
26 anzsrc-for:1117
27 schema:author N8a5b5477addf4056afd76ddcd9a570e7
28 schema:citation sg:pub.10.1007/s00125-017-4390-4
29 sg:pub.10.1007/s11154-017-9423-2
30 sg:pub.10.1007/s11897-017-0337-9
31 sg:pub.10.1007/s12574-019-00446-9
32 sg:pub.10.1038/s41569-020-0381-0
33 sg:pub.10.1038/s41598-017-18521-5
34 sg:pub.10.1038/s41598-018-19708-0
35 schema:datePublished 2021-09-28
36 schema:datePublishedReg 2021-09-28
37 schema:description BackgroundThe risk of heart failure among diabetic individuals is high, even under tight glycemic control. The correlates and mediators of heart failure risk in individuals with diabetes need more elucidation in large population-based cohorts with long follow-up times and a wide panel of biologically relevant biomarkers.MethodsIn a population-based sample of 3834 diabetic and 90,177 non-diabetic individuals, proportional hazards models and mediation analysis were used to assess the relation of conventional heart failure risk factors and biomarkers with incident heart failure.ResultsOver a median follow-up of 13.8 years, a total of 652 (17.0%) and 5524 (6.1%) cases of incident heart failure were observed in participants with and without diabetes, respectively. 51.4% were women and the mean age at baseline was 48.7 (standard deviation [SD] 12.5) years. The multivariable-adjusted hazard ratio (HR) for heart failure among diabetic individuals was 2.70 (95% confidence interval, 2.49–2.93) compared to non-diabetic participants. In the multivariable-adjusted Cox models, conventional cardiovascular disease risk factors, such as smoking (diabetes: HR 2.07 [1.59–2.69]; non-diabetes: HR 1.85 [1.68–2.02]), BMI (diabetes: HR 1.30 [1.18–1.42]; non-diabetes: HR 1.40 [1.35–1.47]), baseline myocardial infarction (diabetes: HR 2.06 [1.55–2.75]; non-diabetes: HR 2.86 [2.50–3.28]), and baseline atrial fibrillation (diabetes: HR 1.51 [0.82–2.80]; non-diabetes: HR 2.97 [2.21–4.00]) had the strongest associations with incident heart failure. In addition, biomarkers for cardiac strain (represented by nT-proBNP, diabetes: HR 1.26 [1.19–1.34]; non-diabetes: HR 1.43 [1.39–1.47]), myocardial injury (hs-TnI, diabetes: HR 1.10 [1.04–1.16]; non-diabetes: HR 1.13 [1.10–1.16]), and inflammation (hs-CRP, diabetes: HR 1.13 [1.03–1.24]; non-diabetes: HR 1.29 [1.25–1.34]) were also associated with incident heart failure. In general, all these associations were equally strong in non-diabetic and diabetic individuals. However, the strongest mediators of heart failure in diabetes were the direct effect of diabetes status itself (relative effect share 43.1% [33.9–52.3] and indirect effects (effect share 56.9% [47.7-66.1]) mediated by obesity (BMI, 13.2% [10.3–16.2]), cardiac strain/volume overload (nT-proBNP, 8.4% [-0.7–17.4]), and hyperglycemia (glucose, 12.0% [4.2–19.9]).ConclusionsThe findings suggest that the main mediators of heart failure in diabetes are obesity, hyperglycemia, and cardiac strain/volume overload. Conventional cardiovascular risk factors are strongly related to incident heart failure, but these associations are not stronger in diabetic than in non-diabetic individuals. Active measurement of relevant biomarkers could potentially be used to improve prevention and prediction of heart failure in high-risk diabetic patients.
38 schema:genre article
39 schema:isAccessibleForFree true
40 schema:isPartOf N3dff3e172ca64e9185acacd36a83a906
41 Naae95c5ef9ba43b599e8630708c73cb1
42 sg:journal.1031021
43 schema:keywords BMI
44 Cox model
45 MethodsIn
46 ResultsOver
47 addition
48 age
49 analysis
50 association
51 atrial fibrillation
52 baseline
53 baseline atrial fibrillation
54 biomarkers
55 cardiac strain
56 cardiovascular disease risk factors
57 cases
58 cohort
59 control
60 conventional cardiovascular disease risk factors
61 correlates
62 diabetes
63 diabetes status
64 diabetic individuals
65 direct effect
66 disease risk factors
67 effect
68 elucidation
69 factors
70 failure
71 failure risk
72 failure risk factors
73 fibrillation
74 follow
75 glycemic control
76 hazard ratio
77 hazards model
78 heart failure
79 heart failure risk
80 heart failure risk factors
81 incident heart failure
82 individuals
83 infarction
84 inflammation
85 injury
86 large population-based cohort
87 long follow
88 mean age
89 mediation analysis
90 mediators
91 model
92 more elucidation
93 multivariable-adjusted Cox models
94 multivariable-adjusted hazard ratios
95 myocardial infarction
96 myocardial injury
97 non-diabetic individuals
98 non-diabetic participants
99 panel
100 participants
101 population-based cohort
102 population-based sample
103 proportional hazards model
104 ratio
105 relation
106 relevant biomarkers
107 risk
108 risk factors
109 samples
110 smoking
111 status
112 strains
113 strong association
114 strong mediator
115 tight glycemic control
116 time
117 total
118 wide panel
119 women
120 years
121 schema:name Diabetes status-related differences in risk factors and mediators of heart failure in the general population: results from the MORGAM/BiomarCaRE consortium
122 schema:pagination 195
123 schema:productId N2cb1e9194816418db160432e2e6b3970
124 N76b37811bd0a4235806b312096b66d15
125 N960afcc875534c3cad83b046206a6b41
126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1141460023
127 https://doi.org/10.1186/s12933-021-01378-4
128 schema:sdDatePublished 2022-11-24T21:08
129 schema:sdLicense https://scigraph.springernature.com/explorer/license/
130 schema:sdPublisher N7d8af61d0dea4d83b41a5f0af4523eef
131 schema:url https://doi.org/10.1186/s12933-021-01378-4
132 sgo:license sg:explorer/license/
133 sgo:sdDataset articles
134 rdf:type schema:ScholarlyArticle
135 N00cc1d7f9a6d43e3a62ddff2fc74a6ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Europe
137 rdf:type schema:DefinedTerm
138 N01c1211d790245c2949ad4c74ef4c6a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Health Status
140 rdf:type schema:DefinedTerm
141 N0224ea2f17c444428894c9063f417fea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Blood Glucose
143 rdf:type schema:DefinedTerm
144 N05437fc672cd415cbe2fe914c8b20073 rdf:first sg:person.0660107161.47
145 rdf:rest N72113560974044deb489129bdc473068
146 N0c30f179b8644a17a0d1416e067fb247 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Prognosis
148 rdf:type schema:DefinedTerm
149 N0d716e851e5c44dbb12ddc3856dd32f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Inflammation Mediators
151 rdf:type schema:DefinedTerm
152 N0e3ffe65b4974a08b7bff55219c19435 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Heart Disease Risk Factors
154 rdf:type schema:DefinedTerm
155 N1283e93a39a74a608a3901dc35590752 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Humans
157 rdf:type schema:DefinedTerm
158 N17341f38dd494bb4a8e5707bc9240eb3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Incidence
160 rdf:type schema:DefinedTerm
161 N1d042f9122fc48a19cb716600ec22d96 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Diabetes Mellitus
163 rdf:type schema:DefinedTerm
164 N27fb10db83b841268c86f9f0ef0c2202 rdf:first sg:person.0637662640.88
165 rdf:rest Na84565ebc59e4363b62a64d6d4d9d340
166 N2cb1e9194816418db160432e2e6b3970 schema:name dimensions_id
167 schema:value pub.1141460023
168 rdf:type schema:PropertyValue
169 N2e8343a4adc446dabff016e702020b4a rdf:first sg:person.01105351071.67
170 rdf:rest N05437fc672cd415cbe2fe914c8b20073
171 N2f8d8f37962149a084b303b2e9e20cc6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Time Factors
173 rdf:type schema:DefinedTerm
174 N34689007bea142188843e1be99f65f17 rdf:first sg:person.01255556215.22
175 rdf:rest Nf1065874e4194b63a2724335b1c519fc
176 N3693c17cb4ef4099b07c565153dbb9e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name C-Reactive Protein
178 rdf:type schema:DefinedTerm
179 N378a994570124e83b7782c09a2f0d1ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Risk Assessment
181 rdf:type schema:DefinedTerm
182 N3a64af7414d247bebe57ea34db6da1b8 rdf:first sg:person.0605152476.70
183 rdf:rest rdf:nil
184 N3b5a31d08c9f43d1b88c3c16bba45ee6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Natriuretic Peptide, Brain
186 rdf:type schema:DefinedTerm
187 N3dff3e172ca64e9185acacd36a83a906 schema:issueNumber 1
188 rdf:type schema:PublicationIssue
189 N46f8881bc8a044509e6f55fe0724a6a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Peptide Fragments
191 rdf:type schema:DefinedTerm
192 N4896a29a3a1f4afea718ffcc43a91c5a rdf:first sg:person.0661365230.54
193 rdf:rest Nc682b26b01db410ebcc40b7948339c9f
194 N4d3b9d47e276422881c687824b706d21 rdf:first sg:person.01255257303.12
195 rdf:rest N3a64af7414d247bebe57ea34db6da1b8
196 N54eec1dba3bf40d8a9241151cfbc359f rdf:first sg:person.0765171035.15
197 rdf:rest Nd69f25da95ce47468c3347dd1621a546
198 N5cc5f26dd36843d7af01630166519e5a rdf:first sg:person.016241124507.72
199 rdf:rest N27fb10db83b841268c86f9f0ef0c2202
200 N72113560974044deb489129bdc473068 rdf:first sg:person.01017535604.76
201 rdf:rest N54eec1dba3bf40d8a9241151cfbc359f
202 N744602248ba04a5fba0ff35d169edcb6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Troponin I
204 rdf:type schema:DefinedTerm
205 N76b37811bd0a4235806b312096b66d15 schema:name doi
206 schema:value 10.1186/s12933-021-01378-4
207 rdf:type schema:PropertyValue
208 N778b80e6198b49878fdfd6a1e3229cc8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Biomarkers
210 rdf:type schema:DefinedTerm
211 N7c6c9a123b5048468617ffa231820430 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
212 schema:name Adult
213 rdf:type schema:DefinedTerm
214 N7d8af61d0dea4d83b41a5f0af4523eef schema:name Springer Nature - SN SciGraph project
215 rdf:type schema:Organization
216 N8a5b5477addf4056afd76ddcd9a570e7 rdf:first sg:person.07741011675.55
217 rdf:rest N4896a29a3a1f4afea718ffcc43a91c5a
218 N8ec6e31a33b34ba0a7d3599874862062 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
219 schema:name Heart Failure
220 rdf:type schema:DefinedTerm
221 N92588ee5db5e48019be4703f75363ea8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
222 schema:name Prevalence
223 rdf:type schema:DefinedTerm
224 N960afcc875534c3cad83b046206a6b41 schema:name pubmed_id
225 schema:value 34583686
226 rdf:type schema:PropertyValue
227 Na19558defa354dbf900cec92e5b099c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
228 schema:name Obesity
229 rdf:type schema:DefinedTerm
230 Na84565ebc59e4363b62a64d6d4d9d340 rdf:first sg:person.01054443021.99
231 rdf:rest N34689007bea142188843e1be99f65f17
232 Naae95c5ef9ba43b599e8630708c73cb1 schema:volumeNumber 20
233 rdf:type schema:PublicationVolume
234 Nc448bb7a0778472b9e9e3db05219ec3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
235 schema:name Male
236 rdf:type schema:DefinedTerm
237 Nc682b26b01db410ebcc40b7948339c9f rdf:first sg:person.016465323374.03
238 rdf:rest N2e8343a4adc446dabff016e702020b4a
239 Nd1574280c2d140bab961aef1d01700ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
240 schema:name Female
241 rdf:type schema:DefinedTerm
242 Nd69f25da95ce47468c3347dd1621a546 rdf:first sg:person.01205330340.33
243 rdf:rest N5cc5f26dd36843d7af01630166519e5a
244 Nf1065874e4194b63a2724335b1c519fc rdf:first sg:person.01022740164.96
245 rdf:rest Nfade720ab14e4d6c82a20be9103fb9eb
246 Nf3ef7e8b1bbe4867bed2c88f482bea8a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
247 schema:name Middle Aged
248 rdf:type schema:DefinedTerm
249 Nfade720ab14e4d6c82a20be9103fb9eb rdf:first sg:person.01365524177.17
250 rdf:rest N4d3b9d47e276422881c687824b706d21
251 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
252 schema:name Medical and Health Sciences
253 rdf:type schema:DefinedTerm
254 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
255 schema:name Cardiorespiratory Medicine and Haematology
256 rdf:type schema:DefinedTerm
257 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
258 schema:name Public Health and Health Services
259 rdf:type schema:DefinedTerm
260 sg:grant.2757803 http://pending.schema.org/fundedItem sg:pub.10.1186/s12933-021-01378-4
261 rdf:type schema:MonetaryGrant
262 sg:grant.3754454 http://pending.schema.org/fundedItem sg:pub.10.1186/s12933-021-01378-4
263 rdf:type schema:MonetaryGrant
264 sg:grant.8104183 http://pending.schema.org/fundedItem sg:pub.10.1186/s12933-021-01378-4
265 rdf:type schema:MonetaryGrant
266 sg:grant.8840034 http://pending.schema.org/fundedItem sg:pub.10.1186/s12933-021-01378-4
267 rdf:type schema:MonetaryGrant
268 sg:grant.8964144 http://pending.schema.org/fundedItem sg:pub.10.1186/s12933-021-01378-4
269 rdf:type schema:MonetaryGrant
270 sg:journal.1031021 schema:issn 1475-2840
271 schema:name Cardiovascular Diabetology
272 schema:publisher Springer Nature
273 rdf:type schema:Periodical
274 sg:person.01017535604.76 schema:affiliation grid-institutes:grid.8241.f
275 schema:familyName Tunstall-Pedoe
276 schema:givenName Hugh
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017535604.76
278 rdf:type schema:Person
279 sg:person.01022740164.96 schema:affiliation grid-institutes:grid.14758.3f
280 schema:familyName Salomaa
281 schema:givenName Veikko
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022740164.96
283 rdf:type schema:Person
284 sg:person.01054443021.99 schema:affiliation grid-institutes:grid.18147.3b
285 schema:familyName Iacoviello
286 schema:givenName Licia
287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054443021.99
288 rdf:type schema:Person
289 sg:person.01105351071.67 schema:affiliation grid-institutes:grid.12650.30
290 schema:familyName Bergdahl
291 schema:givenName Ellinor
292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105351071.67
293 rdf:type schema:Person
294 sg:person.01205330340.33 schema:affiliation grid-institutes:grid.13648.38
295 schema:familyName Westermann
296 schema:givenName Dirk
297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205330340.33
298 rdf:type schema:Person
299 sg:person.01255257303.12 schema:affiliation grid-institutes:grid.14758.3f
300 schema:familyName Kuulasmaa
301 schema:givenName Kari
302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255257303.12
303 rdf:type schema:Person
304 sg:person.01255556215.22 schema:affiliation grid-institutes:grid.5254.6
305 schema:familyName Costanzo
306 schema:givenName Simona
307 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255556215.22
308 rdf:type schema:Person
309 sg:person.01365524177.17 schema:affiliation grid-institutes:grid.13648.38
310 schema:familyName Blankenberg
311 schema:givenName Stefan
312 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365524177.17
313 rdf:type schema:Person
314 sg:person.016241124507.72 schema:affiliation grid-institutes:grid.425910.b
315 schema:familyName Sans
316 schema:givenName Susana
317 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016241124507.72
318 rdf:type schema:Person
319 sg:person.016465323374.03 schema:affiliation grid-institutes:grid.12650.30
320 schema:familyName Söderberg
321 schema:givenName Stefan
322 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016465323374.03
323 rdf:type schema:Person
324 sg:person.0605152476.70 schema:affiliation grid-institutes:grid.14758.3f
325 schema:familyName Niiranen
326 schema:givenName Teemu J.
327 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605152476.70
328 rdf:type schema:Person
329 sg:person.0637662640.88 schema:affiliation grid-institutes:grid.5254.6
330 schema:familyName Linneberg
331 schema:givenName Allan
332 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637662640.88
333 rdf:type schema:Person
334 sg:person.0660107161.47 schema:affiliation grid-institutes:grid.14758.3f
335 schema:familyName Jousilahti
336 schema:givenName Pekka
337 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660107161.47
338 rdf:type schema:Person
339 sg:person.0661365230.54 schema:affiliation grid-institutes:grid.14758.3f
340 schema:familyName Reinikainen
341 schema:givenName Jaakko
342 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661365230.54
343 rdf:type schema:Person
344 sg:person.0765171035.15 schema:affiliation grid-institutes:grid.13648.38
345 schema:familyName Zeller
346 schema:givenName Tanja
347 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765171035.15
348 rdf:type schema:Person
349 sg:person.07741011675.55 schema:affiliation grid-institutes:grid.14758.3f
350 schema:familyName Vuori
351 schema:givenName Matti A.
352 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07741011675.55
353 rdf:type schema:Person
354 sg:pub.10.1007/s00125-017-4390-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090957321
355 https://doi.org/10.1007/s00125-017-4390-4
356 rdf:type schema:CreativeWork
357 sg:pub.10.1007/s11154-017-9423-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084817520
358 https://doi.org/10.1007/s11154-017-9423-2
359 rdf:type schema:CreativeWork
360 sg:pub.10.1007/s11897-017-0337-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090312262
361 https://doi.org/10.1007/s11897-017-0337-9
362 rdf:type schema:CreativeWork
363 sg:pub.10.1007/s12574-019-00446-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1121828459
364 https://doi.org/10.1007/s12574-019-00446-9
365 rdf:type schema:CreativeWork
366 sg:pub.10.1038/s41569-020-0381-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1127792290
367 https://doi.org/10.1038/s41569-020-0381-0
368 rdf:type schema:CreativeWork
369 sg:pub.10.1038/s41598-017-18521-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100172381
370 https://doi.org/10.1038/s41598-017-18521-5
371 rdf:type schema:CreativeWork
372 sg:pub.10.1038/s41598-018-19708-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100352024
373 https://doi.org/10.1038/s41598-018-19708-0
374 rdf:type schema:CreativeWork
375 grid-institutes:grid.12650.30 schema:alternateName Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden
376 schema:name Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden
377 rdf:type schema:Organization
378 grid-institutes:grid.13648.38 schema:alternateName University Heart Center Hamburg, Hamburg, Germany
379 schema:name University Heart Center Hamburg, Hamburg, Germany
380 rdf:type schema:Organization
381 grid-institutes:grid.14758.3f schema:alternateName Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, Finland
382 schema:name Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, Finland
383 Division of Medicine, University of Turku and Turku University Hospital, Kiinanmyllynkatu 2, 20521, Turku, Finland
384 rdf:type schema:Organization
385 grid-institutes:grid.18147.3b schema:alternateName Research Center in Epidemiology and Preventive Medicine, Department of Medicine and Surgery, University of Insubria, Varese, Italy
386 schema:name Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy
387 Research Center in Epidemiology and Preventive Medicine, Department of Medicine and Surgery, University of Insubria, Varese, Italy
388 rdf:type schema:Organization
389 grid-institutes:grid.425910.b schema:alternateName Catalan Department of Health, Barcelona, Spain
390 schema:name Catalan Department of Health, Barcelona, Spain
391 rdf:type schema:Organization
392 grid-institutes:grid.5254.6 schema:alternateName Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
393 schema:name Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark
394 Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
395 rdf:type schema:Organization
396 grid-institutes:grid.8241.f schema:alternateName Cardiovascular Epidemiology Unit, Institute of Cardiovascular Research, University of Dundee, Dundee, UK
397 schema:name Cardiovascular Epidemiology Unit, Institute of Cardiovascular Research, University of Dundee, Dundee, UK
398 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...