Lysine pathway metabolites and the risk of type 2 diabetes and cardiovascular disease in the PREDIMED study: results from two ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-11-13

AUTHORS

Cristina Razquin, Miguel Ruiz-Canela, Clary B. Clish, Jun Li, Estefania Toledo, Courtney Dennis, Liming Liang, Albert Salas-Huetos, Kerry A. Pierce, Marta Guasch-Ferré, Dolores Corella, Emilio Ros, Ramon Estruch, Enrique Gómez-Gracia, Montse Fitó, Jose Lapetra, Dora Romaguera, Angel Alonso-Gómez, Lluis Serra-Majem, Jordi Salas-Salvadó, Frank B. Hu, Miguel A. Martínez-González

ABSTRACT

BackgroundThe pandemic of cardiovascular disease (CVD) and type 2 diabetes (T2D) requires the identification of new predictor biomarkers. Biomarkers potentially modifiable with lifestyle changes deserve a special interest. Our aims were to analyze: (a) The associations of lysine, 2-aminoadipic acid (2-AAA) or pipecolic acid with the risk of T2D or CVD in the PREDIMED trial; (b) the effect of the dietary intervention on 1-year changes in these metabolites, and (c) whether the Mediterranean diet (MedDiet) interventions can modify the effects of these metabolites on CVD or T2D risk.MethodsTwo unstratified case-cohort studies nested within the PREDIMED trial were used. For CVD analyses, we selected 696 non-cases and 221 incident CVD cases; for T2D, we included 610 non-cases and 243 type 2 diabetes incident cases. Metabolites were quantified using liquid chromatography–tandem mass spectrometry, at baseline and after 1-year of intervention.ResultsIn weighted Cox regression models, we found that baseline lysine (HR+1 SD increase = 1.26; 95% CI 1.06–1.51) and 2-AAA (HR+1 SD increase = 1.28; 95% CI 1.05–1.55) were both associated with a higher risk of T2D, but not with CVD. A significant interaction (p = 0.032) between baseline lysine and T2D on the risk of CVD was observed: subjects with prevalent T2D and high levels of lysine exhibited the highest risk of CVD. The intervention with MedDiet did not have a significant effect on 1-year changes of the metabolites.ConclusionsOur results provide an independent prospective replication of the association of 2-AAA with future risk of T2D. We show an association of lysine with subsequent CVD risk, which is apparently diabetes-dependent. No evidence of effects of MedDiet intervention on lysine, 2-AAA or pipecolic acid changes was found.Trial registration ISRCTN35739639; registration date: 05/10/2005; recruitment start date 01/10/2003 More... »

PAGES

151

Journal

TITLE

Cardiovascular Diabetology

ISSUE

1

VOLUME

18

Author Affiliations

  • CIBER Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain
  • Broad Institute of MIT and Harvard University, Cambridge, USA
  • Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA
  • Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, USA
  • Human Nutrition Unit, Faculty of Medicine and Health Sciences, Institut d’Investigació Sanitària Pere Virgili, Rovira i Virgili University, Reus, Spain
  • Department of Preventive Medicine, University of Valencia, Valencia, Spain
  • Lipid Clinic, Department of Endocrinology and Nutrition, Institut d’Investigacions Biomediques August Pi Sunyer (IDI- BAPS), Hospital Clinic, University of Barcelona, Barcelona, Spain
  • Department of Internal Medicine, Institut d’Investigacions Biomediques August Pi Sunyer (IDI-BAPS), Barcelona, Spain
  • Department of Preventive Medicine, University of Malaga, Malaga, Spain
  • Cardiovascular and Nutrition Research Group, Institut de Recerca Hospital del Mar (IMIM), Barcelona, Spain
  • Department of Family Medicine, Research Unit, Distrito Sanitario Atención Primaria Sevilla, Seville, Spain
  • Instituto de Investigación Sanitaria de Palma (IdISPa), University Hospital of Son Espases, Palma de Mallorca, Spain
  • Department of Cardiology, University Hospital of Alava, Vitoria, Spain
  • Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, Las Palmas, Spain
  • Channing Division for Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA
  • Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Spain
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12933-019-0958-2

    DOI

    http://dx.doi.org/10.1186/s12933-019-0958-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1122548475

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/31722714


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