Effect of SGLT2 inhibitors on body composition, fluid status and renin-angiotensin-aldosterone system in type 2 diabetes: a prospective study using ... View Full Text


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Article Info

DATE

2019-12

AUTHORS

Anja Schork, Janine Saynisch, Andreas Vosseler, Benjamin Assad Jaghutriz, Nils Heyne, Andreas Peter, Hans-Ulrich Häring, Norbert Stefan, Andreas Fritsche, Ferruh Artunc

ABSTRACT

BACKGROUND: SGLT2-inhibitors are potent antihyperglycemic drugs for patients with type 2 diabetes and have been shown to reduce body weight. However, it is unclear which body compartments are reduced and to what extent. METHODS: In this longitudinal observational study, we analyzed the body composition of 27 outpatients with type 2 diabetes mellitus during the first week and up to 6 months after initiation of treatment with SGLT2-inhibitors (n = 18 empagliflozin, n = 9 dapagliflozin) using bioimpedance spectroscopy (BCM, Fresenius). Fluid status of hypertensive patients taking medication with hydrochlorothiazide (n = 14) and healthy persons (n = 16) were analyzed for comparison. RESULTS: At 6 months, HbA1c decreased by 0.8% (IQR 2.3; 0.4), body weight and BMI by 2.6 kg (1.5; 9.3) and 0.9 kg/m2 (0.4; 3.3), respectively. Bioimpedance spectroscopy revealed significant decrease in adipose tissue mass and fat tissue index while lean tissue parameters remained stable. Overhydration (OH) and extracellular water (ECW) decreased by - 0.5 L/1.73 m2 (- 0.1; - 0.9) and - 0.4 L/1.73 m2 (- 0.1; - 0.8) at day 3, respectively, and returned to the initial value after 3 and 6 months. Plasma renin activity increased by 2.1-fold (0.5; 3.6) at 1 month and returned to the initial level at month 3 and 6. Fluid status of patients with SGLT2 inhibitors after 6 months showed no difference from that of hypertensive patients taking hydrochlorothiazide or healthy persons. CONCLUSIONS: Body weight reduction under the treatment with SGLT2-inhibitors is caused by reduction of adipose tissue mass and transient loss of extracellular fluid, which is accompanied by upregulation of renin-angiotensin-aldosterone system (RAAS). Permanent loss of extracellular water does not occur under SGLT2 inhibition. More... »

PAGES

46

References to SciGraph publications

  • 2017-12. SGLT2 inhibitors: a novel choice for the combination therapy in diabetic kidney disease in CARDIOVASCULAR DIABETOLOGY
  • 2018-10. The actions of SGLT2 inhibitors on metabolism, renal function and blood pressure in DIABETOLOGIA
  • 2015-12. Comparison of Adipose Distribution Indices with Gold Standard Body Composition Assessments in the EMPA-REG H2H SU Trial: A Body Composition Sub-Study in DIABETES THERAPY
  • 2018-12. Dapagliflozin improves treatment satisfaction in overweight patients with type 2 diabetes mellitus: a patient reported outcome study (PRO study) in DIABETOLOGY & METABOLIC SYNDROME
  • 2018-12. The effect of dapagliflozin treatment on epicardial adipose tissue volume in CARDIOVASCULAR DIABETOLOGY
  • 2017-12. Effectiveness of dapagliflozin on vascular endothelial function and glycemic control in patients with early-stage type 2 diabetes mellitus: DEFENCE study in CARDIOVASCULAR DIABETOLOGY
  • 2018-10. SGLT2 inhibitors and mechanisms of cardiovascular benefit: a state-of-the-art review in DIABETOLOGIA
  • 2017-02. Factors Affecting Canagliflozin-Induced Transient Urine Volume Increase in Patients with Type 2 Diabetes Mellitus in ADVANCES IN THERAPY
  • 2017-12. Luseogliflozin reduces epicardial fat accumulation in patients with type 2 diabetes: a pilot study in CARDIOVASCULAR DIABETOLOGY
  • 2017-12. Efficacy and safety of canagliflozin in patients with type 2 diabetes based on history of cardiovascular disease or cardiovascular risk factors: a post hoc analysis of pooled data in CARDIOVASCULAR DIABETOLOGY
  • 2019-04. The effect of dapagliflozin on glycaemic control and other cardiovascular disease risk factors in type 2 diabetes mellitus: a real-world observational study in DIABETOLOGIA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12933-019-0852-y

    DOI

    http://dx.doi.org/10.1186/s12933-019-0852-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113262102

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30953516


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